Norman Huebert

ScholarGPS® ID: 63972748764790

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Medicinal Chemistry | Pharmacokinetics | Chromatography

Metrics Summary

Publication Count

Predicted Citations

1,171

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists (journal article) Song, Fengbin \| Xu, Guozhang \| Gaul, Michael D. \| Zhao, Baoping \| Lu, Tianbao \| Zhang, Rui \| DesJarlais, Renee L. \| DiLoreto, Karen \| Huebert, Norman \| Shook, Brian \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 15, pages 1974-1980 (2019). 10.1016/j.bmcl.2019.05.036 Cited by (15) \| Cite \| Source
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors (journal article) Xu, Guozhang \| Gaul, Michael D. \| Kuo, Gee-Hong \| Du, Fuyong \| Xu, June Zhi \| Wallace, Nathaniel \| Hinke, Simon \| Kirchner, Thomas \| Silva, Jose \| Huebert, Norman D. \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 28, issue 21, pages 3446-3453 (2018). 10.1016/j.bmcl.2018.09.025 Cited by (9) \| Cite \| Source
Erratum to “Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes” Bioorg. Med. Chem. Lett. 28 (2018) [841–846] (journal article) Winters, Michael P. \| Sui, Zhihua \| Wall, Mark \| Wang, Yuanping \| Gunnet, Joseph \| Leonard, James \| Hua, Hong \| Yan, Wen \| Suckow, Arthur \| Bell, Austin \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 28, issue 9, pages 1676-1678 (2018). 10.1016/j.bmcl.2018.03.053 Cite \| Source
Discovery of N -arylpyrroles as agonists of GPR120 for the treatment of type II diabetes (journal article) Winters, Michael P. \| Sui, Zhihua \| Wall, Mark \| Wang, Yuanping \| Gunnet, Joseph \| Leonard, James \| Hua, Hong \| Yan, Wen \| Suckow, Arthur \| Bell, Austin \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 28, issue 5, pages 841-846 (2018). 10.1016/j.bmcl.2018.02.013 Cited by (16) \| Cite \| Source
FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques (journal article) Muzammil, Salman \| Mabus, John R. \| Cooper, Philip R. \| Brezski, Randall J. \| Bement, Courtney B. \| Perkinson, Rob \| Huebert, Norman D. \| Thompson, Suzanne \| Levine, Dalia \| Kliwinski, Connie \| ... \| Hornby, Pamela J. Pharmacology Research & Perspectives, volume 4, issue 3 (2016). 10.1002/prp2.218 Cited by (9) \| Cite \| Source \| Open Access
Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes (journal article) Peterson, Richard G. \| Jackson, Charles V. \| Zimmerman, Karen \| de Winter, Willem \| Huebert, Norman \| Hansen, Michael K. Journal of Diabetes Research, volume 2015 (2015). 10.1155/2015/487816 Cited by (43) \| Cite \| Source \| Open Access
Enteric‐coated capsule intestinal delivery of human immunoglobulin G in cynomolgus macaques (LB603) (journal article) Mabus, John \| Muzammil, Salman \| Cooper, Philip \| Brezski, Randall \| Kunta, Jeevan \| Huebert, Norman \| Kliwinski, Connie \| Bradley, Dino \| Giles‐Komar, Jill \| Hornby, Pamela The FASEB Journal, volume 28, issue S1 (2014). 10.1096/fasebj.28.1_supplement.lb603 Cited by (1) \| Cite \| Source
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article) Subasinghe, Nalin L. \| Khalil, Ehab \| Travins, Jeremy M. \| Ali, Farah \| Ballentine, Shelley K. \| Hufnagel, Heather R. \| Pan, Wenxi \| Leonard, Kristi \| Bone, Roger F. \| Soll, Richard M. \| ... \| Gaul, Michael D. Bioorganic & Medicinal Chemistry Letters, volume 22, issue 16, pages 5303-5307 (2012). 10.1016/j.bmcl.2012.06.030 Cited by (12) \| Cite \| Source
Isotopically labeled trapping agent and method for identifying reactive metabolites (patent) Huebert, Norman D. \| Yan, Zhengyin Patent Number: 7884186 (2011) Cited by (1) \| Cite \| Source
Improved Pharmacokinetic and Bioavailability Support of Drug Discovery Using Serial Blood Sampling in Mice (journal article) Peng, Sean X. \| Rockafellow, Beth A. \| Skedzielewski, Tina M. \| Huebert, Norman D. \| Hageman, William Journal of Pharmaceutical Sciences, volume 98, issue 5, pages 1877-1884 (2009). 10.1002/jps.21533 Cited by (39) \| Cite \| Source
Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix (journal article) Yan, Zhengyin \| Maher, Noureddine \| Torres, Rhoda \| Cotto, Carlos \| Hastings, Becki \| Dasgupta, Malini \| Hyman, Rolanda \| Huebert, Norman \| Caldwell, Gary W. Rapid Communications in Mass Spectrometry, volume 22, issue 13, pages 2021-2028 (2008). 10.1002/rcm.3577 Cited by (38) \| Cite \| Source
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif (journal article) Kreutter, Kevin D. \| Lu, Tianbao \| Lee, Lily \| Giardino, Edward C. \| Patel, Sharmila \| Huang, Hui \| Xu, Guozhang \| Fitzgerald, Mark \| Haertlein, Barbara J. \| Mohan, Venkatraman \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 9, pages 2865-2870 (2008). 10.1016/j.bmcl.2008.03.087 Cited by (29) \| Cite \| Source
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article) Travins, Jeremy M. \| Ali, Farah \| Huang, Hui \| Ballentine, Shelley K. \| Khalil, Ehab \| Hufnagel, Heather R. \| Pan, Wenxi \| Gushue, Joan \| Leonard, Kristi \| Bone, Roger F. \| ... \| Subasinghe, Nalin L. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 5, pages 1603-1606 (2008). 10.1016/j.bmcl.2008.01.064 Cited by (16) \| Cite \| Source
Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats (journal article) Santulli, Rosemary J. \| Kinney, William A. \| Ghosh, Shyamali \| DeCorte, Bart L. \| Liu, Li \| Tuman, Robert W. A. \| Zhou, Zhao \| Huebert, Norman \| Bursell, Sven E. \| Clermont, Alan C. \| ... \| Damiano, Bruce P. Journal of Pharmacology and Experimental Therapeutics, volume 324, issue 3, pages 894-901 (2008). 10.1124/jpet.107.131656 Cited by (59) \| Cite \| Source \| Open Access
Pharmacokinetics of TDP223206 following intravenous and oral administration to intact rats and intravenous administration to bile duct‐cannulated rats (journal article) Chen, Yanmin \| Cheng, Deping \| Marugan, Juan Jose \| Manthey, Carl \| Tomczuk, Bruce \| Huebert, Norman Biopharmaceutics & Drug Disposition, volume 29, issue 4, pages 219-230 (2008). 10.1002/bdd.601 Cited by (2) \| Cite \| Source
Pharmacokinetic properties of TDP4815 after single intravenous and oral administrations to rat, rabbit, monkey, dog and in vitro drug metabolism (journal article) Chen, Yanmin \| Cheng, Deping \| Tio, Cesar \| Kagan, Natashia \| Eisennagel, Stephen \| Dasgupta, Malini \| Tomczuk, Bruce \| Bone, Roger \| Huebert, Norman Biopharmaceutics & Drug Disposition, volume 29, issue 3, pages 127-138 (2008). 10.1002/bdd.592 Cited by (1) \| Cite \| Source
Use of a Trapping Agent for Simultaneous Capturing and High-Throughput Screening of Both “Soft” and “Hard” Reactive Metabolites (journal article) Yan, Zhengyin \| Maher, Noureddine \| Torres, Rhoda \| Huebert, Norman Analytical Chemistry, volume 79, issue 11, pages 4206-4214 (2007). 10.1021/ac0701029 Cited by (50) \| Cite \| Source
Human oral drugs absorption is correlated to their in vitro uptake by brush border membrane vesicles (journal article) Oulianova, Nathalie \| Cheng, Deping \| Huebert, Norman \| Chen, Yanmin International Journal of Pharmaceutics, volume 336, issue 1, pages 115-121 (2007). 10.1016/j.ijpharm.2006.11.045 Cited by (9) \| Cite \| Source
Metabolism and Bioactivation of 3-Methylindole by Human Liver Microsomes (journal article) Yan, Zhengyin \| Easterwood, LaHoma M. \| Maher, Noureddine \| Torres, Rhoda \| Huebert, Norman \| Yost, Garold S. Chemical Research in Toxicology, volume 20, issue 1, pages 140-148 (2007). 10.1021/tx060239e Cited by (42) \| Cite \| Source
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors (journal article) Qiao, Lei \| Baumann, Christian A. \| Crysler, Carl S. \| Ninan, Nisha S. \| Abad, Marta C. \| Spurlino, John C. \| DesJarlais, Renee L. \| Kervinen, Jukka \| Neeper, Mike P. \| Bayoumy, Shariff S. \| ... \| Moriarty, Kevin J. Bioorganic & Medicinal Chemistry Letters, volume 16, issue 1, pages 123-128 (2006). 10.1016/j.bmcl.2005.09.037 Cited by (35) \| Cite \| Source