Fleur M. Ferguson

ScholarGPS® ID: 63952774354256

Affiliation

Dana-Farber Cancer Institute, Boston, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Medicinal Chemistry | Chemical Biology | Structure–activity Relationship

Metrics Summary

Publication Count

Predicted Citations

1,728

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Application of induced proximity for therapeutic discovery (journal article) Cacace, Angela \| Daniels, Danette \| Ferguson, Fleur M. \| Mayor-Ruiz, Cristina \| Woo, Christina Cell Chemical Biology, volume 31, issue 6, pages 1036-1038 (2024). 10.1016/j.chembiol.2024.05.015 Cite \| Source
A new avenue for molecular glues: Rapid discovery of a NFKB1 degrader (journal article) Fan, Angela T. \| Boyle, Bridget T. \| Ferguson, Fleur M. Cell Chemical Biology, volume 30, issue 4, pages 340-342 (2023). 10.1016/j.chembiol.2023.04.002 Cited by (1) \| Cite \| Source
Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy (journal article) Silva, M. Catarina \| Nandi, Ghata \| Donovan, Katherine A. \| Cai, Quan \| Berry, Bethany C. \| Nowak, Radoslaw P. \| Fischer, Eric S. \| Gray, Nathanael S. \| Ferguson, Fleur M. \| Haggarty, Stephen J. Frontiers in Cellular Neuroscience, volume 16 (2022). 10.3389/fncel.2022.801179 Cited by (16) \| Cite \| Source
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma (journal article) Jiang, Baishan \| Jiang, Jie \| Kaltheuner, Ines H. \| Iniguez, Amanda Balboni \| Anand, Kanchan \| Ferguson, Fleur M. \| Ficarro, Scott B. \| Seong, Bo Kyung Alex \| Greifenberg, Ann Katrin \| Dust, Sofia \| ... \| Gray, Nathanael S. European Journal of Medicinal Chemistry, volume 221 (2021). 10.1016/j.ejmech.2021.113481 Cited by (27) \| Cite \| Source
Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells (journal article) Carli, Annalisa L. E. \| Afshar‐Sterle, Shoukat \| Rai, Alin \| Fang, Haoyun \| O'Keefe, Ryan \| Tse, Janson \| Ferguson, Fleur M. \| Gray, Nathanael S. \| Ernst, Matthias \| Greening, David W. \| Buchert, Michael PROTEOMICS, volume 21, issue 13-14 (2021). 10.1002/pmic.202000098 Cited by (14) \| Cite \| Source
Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9 (journal article) Ryu, SeongShick \| Gadbois, Gillian E. \| Tao, Andrew J. \| Fram, Benjamin J. \| Jiang, Jie \| Boyle, Bridget \| Donovan, Katherine A. \| Krupnick, Noah M. \| Berry, Bethany C. \| Bhunia, Debabrata \| ... \| Ferguson, Fleur M. Current Research in Chemical Biology, volume 1 (2021). 10.1016/j.crchbi.2021.100008 Cited by (2) \| Cite \| Source
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing (journal article) Liu, Yan \| Ferguson, Fleur M. \| Li, Lianbo \| Kuljanin, Miljan \| Mills, Caitlin E. \| Subramanian, Kartik \| Harshbarger, Wayne \| Gondi, Sudershan \| Wang, Jinhua \| Sorger, Peter K. \| ... \| Westover, Kenneth D. Cell Chemical Biology, volume 27, issue 10, pages 1229-1240.e4 (2020). 10.1016/j.chembiol.2020.07.011 Cited by (15) \| Cite \| Source
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules (journal article) Nabet, Behnam \| Ferguson, Fleur M. \| Seong, Bo Kyung A. \| Kuljanin, Miljan \| Leggett, Alan L. \| Mohardt, Mikaela L. \| Robichaud, Amanda \| Conway, Amy S. \| Buckley, Dennis L. \| Mancias, Joseph D. \| ... \| Gray, Nathanael S. Nature Communications, volume 11, issue 1 (2020). 10.1038/s41467-020-18377-w Cited by (122) \| Cite \| Source
Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 H -benzo[ e ]pyrimido[5,4- b ][1,4]diazepin-6-one Scaffold (journal article) Ferguson, Fleur M. \| Liu, Yan \| Harshbarger, Wayne \| Huang, Ling \| Wang, Jinhua \| Deng, Xianming \| Capuzzi, Stephen J. \| Muratov, Eugene N. \| Tropsha, Alexander \| Muthuswamy, Senthil \| ... \| Gray, Nathanael S. Journal of Medicinal Chemistry, volume 63, issue 14, pages 7817-7826 (2020). 10.1021/acs.jmedchem.0c00596 Cited by (15) \| Cite \| Source
Selective Mediator dependence of cell-type-specifying transcription (journal article) Jaeger, Martin G. \| Schwalb, Björn \| Mackowiak, Sebastian D. \| Velychko, Taras \| Hanzl, Alexander \| Imrichova, Hana \| Brand, Matthias \| Agerer, Benedikt \| Chorn, Someth \| Nabet, Behnam \| ... \| Winter, Georg E. Nature Genetics, volume 52, issue 7, pages 719-727 (2020). 10.1038/s41588-020-0635-0 Cited by (79) \| Cite \| Source
Discovery and Structure–Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors (journal article) Manz, Theresa D. \| Sivakumaren, Sindhu Carmen \| Ferguson, Fleur M. \| Zhang, Tinghu \| Yasgar, Adam \| Seo, Hyuk-Soo \| Ficarro, Scott B. \| Card, Joseph D. \| Shim, Hyeseok \| Miduturu, Chandrasekhar V. \| ... \| Gray, Nathanael S. Journal of Medicinal Chemistry, volume 63, issue 9, pages 4880-4895 (2020). 10.1021/acs.jmedchem.0c00227 Cited by (21) \| Cite \| Source
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors (journal article) Sivakumaren, Sindhu Carmen \| Shim, Hyeseok \| Zhang, Tinghu \| Ferguson, Fleur M. \| Lundquist, Mark R. \| Browne, Christopher M. \| Seo, Hyuk-Soo \| Paddock, Marcia N. \| Manz, Theresa D. \| Jiang, Baishan \| ... \| Gray, Nathanael S. Cell Chemical Biology, volume 27, issue 5, pages 525-537.e6 (2020). 10.1016/j.chembiol.2020.02.003 Cited by (35) \| Cite \| Source
Structure–Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors (journal article) Manz, Theresa D. \| Sivakumaren, Sindhu C. \| Yasgar, Adam \| Hall, Matthew D. \| Davis, Mindy I. \| Seo, Hyuk-Soo \| Card, Joseph D. \| Ficarro, Scott B. \| Shim, Hyeseok \| Marto, Jarrod A. \| ... \| Gray, Nathanael S. ACS Medicinal Chemistry Letters, volume 11, issue 3, pages 346-352 (2020). 10.1021/acsmedchemlett.9b00402 Cited by (14) \| Cite \| Source
Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold (journal article) Remillard, David \| Buckley, Dennis L. \| Seo, Hyuk-Soo \| Ferguson, Fleur M. \| Dhe-Paganon, Sirano \| Bradner, James E. \| Gray, Nathanael S. ACS Medicinal Chemistry Letters, volume 10, issue 10, pages 1443-1449 (2019). 10.1021/acsmedchemlett.9b00243 Cited by (11) \| Cite \| Source
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14 (journal article) Ferguson, Fleur M. \| Doctor, Zainab M. \| Ficarro, Scott B. \| Marto, Jarrod A. \| Kim, Nam Doo \| Sim, Taebo \| Gray, Nathanael S. Bioorganic & Medicinal Chemistry Letters, volume 29, issue 15, pages 1985-1993 (2019). 10.1016/j.bmcl.2019.05.024 Cited by (5) \| Cite \| Source
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity (journal article) Ferguson, Fleur M. \| Doctor, Zainab M. \| Ficarro, Scott B. \| Browne, Christopher M. \| Marto, Jarrod A. \| Johnson, Jared L. \| Yaron, Tomer M. \| Cantley, Lewis C. \| Kim, Nam Doo \| Sim, Taebo \| ... \| Gray, Nathanael S. Cell Chemical Biology, volume 26, issue 6, pages 804-817.e12 (2019). 10.1016/j.chembiol.2019.02.015 Cited by (19) \| Cite \| Source
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (journal article) Silva, M Catarina \| Ferguson, Fleur M \| Cai, Quan \| Donovan, Katherine A \| Nandi, Ghata \| Patnaik, Debasis \| Zhang, Tinghu \| Huang, Hai-Tsang \| Lucente, Diane E \| Dickerson, Bradford C \| ... \| Haggarty, Stephen J eLife, volume 8 (2019). 10.7554/eLife.45457 Cited by (186) \| Cite \| Source
Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. (journal article) Wang, Jinhua \| Erazo, Tatiana \| Ferguson, Fleur M. \| Buckley, Dennis L. \| Gómez, Néstor \| Muñoz-Guardiola, Pau \| Diéguez-Martínez, Nora \| Deng, Xianming \| Hao, Mingfeng \| Massefski, Walter \| ... \| Gray, Nathanael S. ACS Chemical Biology, volume 13, issue 9, pages 2438-2448 (2018). 10.2210/pdb6cd4/pdb Cite \| Source
Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains (journal article) Wang, Jinhua \| Erazo, Tatiana \| Ferguson, Fleur M. \| Buckley, Dennis L. \| Gomez, Nestor \| Muñoz-Guardiola, Pau \| Diéguez-Martínez, Nora \| Deng, Xianming \| Hao, Mingfeng \| Massefski, Walter \| ... \| Gray, Nathanael S. ACS Chemical Biology, volume 13, issue 9, pages 2438-2448 (2018). 10.1021/acschembio.7b00638 Cited by (44) \| Cite \| Source \| Open Access
Kinase inhibitors: the road ahead (journal article) Ferguson, Fleur M. \| Gray, Nathanael S. Nature Reviews Drug Discovery, volume 17, issue 5, pages 353-377 (2018). 10.1038/nrd.2018.21 Cited by (650) \| Cite \| Source