Jennifer L. Meagher

ScholarGPS® ID: 63748384369537

Affiliation

University of Michigan, Ann Arbor, United States

Affiliation History

Field

Medicine

Discipline

Internal Medicine

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

4,386

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer (journal article) Cárdenas, Emilio L. \| O’Rourke, Rachel L. \| Menon, Arya \| Meagher, Jennifer \| Stuckey, Jeanne \| Garner, Amanda L. Journal of Medicinal Chemistry, volume 66, issue 15, pages 10734-10745 (2023). 10.1021/acs.jmedchem.3c00917 Cited by (1) \| Cite \| Source
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo (journal article) Kaneshige, Atsunori \| Bai, Longchuan \| Wang, Mi \| McEachern, Donna \| Meagher, Jennifer L. \| Xu, Renqi \| Wang, Yu \| Jiang, Wei \| Metwally, Hoda \| Kirchhoff, Paul D. \| ... \| Wang, Shaomeng Nature Chemical Biology, volume 19, issue 6, pages 703-711 (2023). 10.1038/s41589-022-01248-4 Cited by (23) \| Cite \| Source
Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia (journal article) Kaneshige, Atsunori \| Bai, Longchuan \| Wang, Mi \| McEachern, Donna \| Meagher, Jennifer L. \| Xu, Renqi \| Kirchhoff, Paul D. \| Wen, Bo \| Sun, Duxin \| Stuckey, Jeanne A. \| Wang, Shaomeng Journal of Medicinal Chemistry, volume 66, issue 4, pages 2717-2743 (2023). 10.1021/acs.jmedchem.2c01665 Cited by (12) \| Cite \| Source
A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA (journal article) Pham, Vincent V. \| Gao, Michael \| Meagher, Jennifer L. \| Smith, Janet L. \| D’Souza, Victoria M. Communications Biology, volume 5, issue 1 (2022). 10.1038/s42003-022-03734-w Cited by (2) \| Cite \| Source
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression (journal article) Zhou, Haibin \| Bai, Longchuan \| Xu, Renqi \| McEachern, Donna \| Chinnaswamy, Krishnapriya \| Li, Ruiting \| Wen, Bo \| Wang, Mi \| Yang, Chao-Yie \| Meagher, Jennifer L. \| ... \| Wang, Shaomeng ACS Medicinal Chemistry Letters, volume 12, issue 6, pages 996-1004 (2021). 10.1021/acsmedchemlett.1c00155 Cited by (25) \| Cite \| Source
Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2 (journal article) Park, Kyung Soo \| Bazzill, Joseph D. \| Son, Sejin \| Nam, Jutaek \| Shin, Seung Won \| Ochyl, Lukasz J. \| Stuckey, Jeanne A. \| Meagher, Jennifer L. \| Chang, Louise \| Song, Jun \| ... \| Moon, James J. Journal of Controlled Release, volume 330 (2021). 10.1016/j.jconrel.2020.12.031 Cited by (32) \| Cite \| Source
Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity (journal article) Covés-Datson, Evelyn M. \| King, Steven R. \| Legendre, Maureen \| Swanson, Michael D. \| Gupta, Auroni \| Claes, Sandra \| Meagher, Jennifer L. \| Boonen, Arnaud \| Zhang, Lihong \| Kalveram, Birte \| ... \| Markovitz, David M. Scientific Reports, volume 11, issue 1 (2021). 10.1038/s41598-020-80577-7 Cited by (17) \| Cite \| Source
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins (journal article) Kump, Karson J. \| Miao, Lei \| Mady, Ahmed S. A. \| Ansari, Nurul H. \| Shrestha, Uttar K. \| Yang, Yuting \| Pal, Mohan \| Liao, Chenzhong \| Perdih, Andrej \| Abulwerdi, Fardokht A. \| ... \| Nikolovska-Coleska, Zaneta Journal of Medicinal Chemistry, volume 63, issue 5, pages 2489-2510 (2020). 10.1021/acs.jmedchem.9b01442 Cited by (26) \| Cite \| Source
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein (journal article) Zhou, Haibin \| Bai, Longchuan \| Xu, Renqi \| Zhao, Yujun \| Chen, Jianyong \| McEachern, Donna \| Chinnaswamy, Krishnapriya \| Wen, Bo \| Dai, Lipeng \| Kumar, Praveen \| ... \| Wang, Shaomeng Journal of Medicinal Chemistry, volume 62, issue 24, pages 11280-11300 (2019). 10.1021/acs.jmedchem.9b01530 Cited by (140) \| Cite \| Source
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences (journal article) Meagher, Jennifer L. \| Takata, Matthew \| Gonçalves-Carneiro, Daniel \| Keane, Sarah C. \| Rebendenne, Antoine \| Ong, Heley \| Orr, Victoria K. \| MacDonald, Margaret R. \| Stuckey, Jeanne A. \| Bieniasz, Paul D. \| Smith, Janet L. Proceedings of the National Academy of Sciences, volume 116, issue 48, pages 24303-24309 (2019). 10.1073/pnas.1913232116 Cited by (89) \| Cite \| Source
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo (journal article) Bai, Longchuan \| Zhou, Haibin \| Xu, Renqi \| Zhao, Yujun \| Chinnaswamy, Krishnapriya \| McEachern, Donna \| Chen, Jianyong \| Yang, Chao-Yie \| Liu, Zhaomin \| Wang, Mi \| ... \| Wang, Shaomeng Cancer Cell, volume 36, issue 5, pages 498-511.e17 (2019). 10.1016/j.ccell.2019.10.002 Cited by (376) \| Cite \| Source
Lectins and uses thereof (patent) Markovitz, David M. \| Stuckey, Jeanne A. \| Boudreaux, Daniel M. \| Meagher, Jennifer \| Al-Hashimi, Hashim \| Salmon, Loic Patent Number: 10450355 (2019) Cited by (1) \| Cite \| Source
BET bromodomain inhibitors and therapeutic methods using the same (patent) Wang, Shaomeng \| Ran, Xu \| Zhao, Yujun \| Yang, Chao-Yie \| Liu, Liu \| Bai, Longchuan \| McEachern, Donna \| Stuckey, Jeanne \| Meagher, Jennifer Lynn \| Sun, Duxin \| ... \| Asangani, Irfan A. Patent Number: 10391175 (2019) Cited by (1) \| Cite \| Source
9H-pyrimido [4,5-b]indoles and related analogs as BET bromodomain inhibitors (patent) Wang, Shaomeng \| Zhao, Yujun \| Zhou, Bing \| Aguilar, Angelo \| Liu, Liu \| Bai, Longchuan \| McEachern, Donna \| Sun, Duxin \| Wen, Bo \| Luo, Ruijuan \| ... \| Hu, Yang Patent Number: 10253044 (2019) Cited by (2) \| Cite \| Source
HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry (journal article) Pham, V.V. \| Salguero, C. \| Salguero, C. \| Khan, S.N. \| Khan, S.N. \| Meagher, J.L. \| Brown, W.C. \| Humbert, N. \| Rocquigny, H. de \| Rocquigny, H. de \| ... \| D'Souza, V.M. Nature Communications, volume 9, issue 1, pages 4266-4266 (2018). 10.2210/pdb6mcf/pdb Cited by (8) \| Cite \| Source
HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry (journal article) Pham, Vincent V. \| Salguero, Carolina \| Khan, Shamsun Nahar \| Meagher, Jennifer L. \| Brown, W. Clay \| Humbert, Nicolas \| de Rocquigny, Hugues \| Smith, Janet L. \| D’Souza, Victoria M. Nature Communications, volume 9, issue 1 (2018). 10.1038/s41467-018-06591-6 Cited by (57) \| Cite \| Source
Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein (journal article) Koebke, Karl J. \| Ruckthong, Leela \| Meagher, Jennifer L. \| Mathieu, Emilie \| Harland, Jill \| Deb, Aniruddha \| Lehnert, Nicolai \| Policar, Clotilde \| Tard, Cédric \| Penner-Hahn, James E. \| ... \| Pecoraro, Vincent L. Inorganic Chemistry, volume 57, issue 19, pages 12291-12302 (2018). 10.1021/acs.inorgchem.8b01989 Cited by (19) \| Cite \| Source
Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H (journal article) Penumutchu, Srinivasa R. \| Chiu, Liang-Yuan \| Meagher, Jennifer L. \| Hansen, Alexandar L. \| Stuckey, Jeanne A. \| Tolbert, Blanton S. Journal of the American Chemical Society, volume 140, issue 37, pages 11661-11673 (2018). 10.1021/jacs.8b05366 Cited by (9) \| Cite \| Source
Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H. (journal article) Penumutchu, Srinivasa R. \| Chiu, Liang-Yuan \| Meagher, Jennifer L. \| Hansen, Alexandar L. \| Stuckey, Jeanne A. \| Tolbert, Blanton S. Journal of the American Chemical Society (2018). 10.2210/pdb6dhs/pdb Cite \| Source
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression (journal article) Qin, Chong \| Hu, Yang \| Zhou, Bing \| Fernandez-Salas, Ester \| Yang, Chao-Yie \| Liu, Liu \| McEachern, Donna \| Przybranowski, Sally \| Wang, Mi \| Stuckey, Jeanne \| ... \| Wang, Shaomeng Journal of Medicinal Chemistry, volume 61, issue 15, pages 6685-6704 (2018). 10.1021/acs.jmedchem.8b00506 Cited by (204) \| Cite \| Source

Title	Investigators	Year	Cost	Agency
Structural Insights into a Bacterial Type III Cytotoxin	Meagher, Jennifer L	2003	$48,148	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Structural Insights into a Bacterial Type III Cytotoxin	Meagher, Jennifer L	2002	$44,212	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Structural Insights into a Bacterial Type III Cytotoxin	Meagher, Jennifer L	2001	$34,832	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES