Luca Gobbi

ScholarGPS® ID: 62955947383306

Affiliation

Roche Holding AG, Basel, Switzerland

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

1,720

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer ( R )‐[11 C]YH132: Application in Drug Development and Neurodegenerative Diseases (journal article) He, Yingfang \| Delparente, Aro \| Jie, Caitlin V. M. L \| Keller, Claudia \| Humm, Roland \| Heer, Dominik \| Collin, Ludovic \| Schibli, Roger \| Gobbi, Luca \| Grether, Uwe \| Mu, Linjing ChemBioChem, volume 25, issue 7 (2024). 10.1002/cbic.202300819 Cite \| Source
Identification of ( R )-[18 F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development (journal article) He, Yingfang \| Krämer, Stefanie D. \| Grether, Uwe \| Wittwer, Matthias B. \| Collin, Ludovic \| Kuhn, Bernd \| Topp, Andreas \| Heer, Dominik \| O’Hara, Fionn \| Honer, Michael \| ... \| Mu, Linjing Journal of Nuclear Medicine, volume 65, issue 2, pages 300-305 (2024). 10.2967/jnumed.123.266426 Cite \| Source
Identification of (R)-[18F]YH134 as a promising reversible MAGL PET tracer and the impact of peripheral MAGL blockade on its brain uptake (journal article) Mu, Linjing \| He, Yingfang \| Krämer, Stefanie \| Grether, Uwe \| Wittwer, Matthias \| Honer, Michael \| Keller, Claudia \| Schibli, Roger \| Gobbi, Luca Nuclear Medicine and Biology, volume 126-127 (2023). 10.1016/j.nucmedbio.2023.108546 Cite \| Source
Evaluation of Tetrazine Tracers for Pretargeted Imaging within the Central Nervous System (journal article) Edelmann, Martin R. \| Bredack, Christoph \| Belli, Sara \| Mohr, Peter \| Imhoff, Marie-Paule \| Reggiani, Flore \| Kusznir, Eric A. \| Rufer, Arne C. \| Holt, Daniel P. \| Valentine, Heather \| ... \| Gobbi, Luca C. Bioconjugate Chemistry, volume 34, issue 10, pages 1882-1893 (2023). 10.1021/acs.bioconjchem.3c00385 Cited by (1) \| Cite \| Source
RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta‐site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain (journal article) Honer, Michael \| Polara, Alessandra \| Kuwabara, Hiroto \| Jacobsen, Helmut \| Pähler, Axel \| Hartung, Thomas \| Caruso, Antonello \| Esterhazy, Daria \| Stoffel, Markus \| Dannals, Robert F. \| ... \| Gobbi, Luca C. Journal of Labelled Compounds and Radiopharmaceuticals, volume 66, issue 9, pages 222-236 (2023). 10.1002/jlcr.4025 Cite \| Source
Antibody-Based In Vivo Imaging of Central Nervous System Targets—Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines (journal article) Bredack, Christoph \| Edelmann, Martin R. \| Borroni, Edilio \| Gobbi, Luca C. \| Honer, Michael Pharmaceuticals, volume 15, issue 12, pages 1445- (2022). 10.3390/ph15121445 Cited by (7) \| Cite \| Source
Development of a novel reversible monoacylglycerol lipase PET tracer bearing a morpholine-3-one scaffold (journal article) He, Yingfang \| Grether, Uwe \| Taddio, Marco \| Keller, Claudia \| Honer, Michael \| Huber, Sywia \| Edelmann, Martin \| Krämer, Stefanie \| Schibli, Roger \| Gobbi, Luca \| Mu, Linjing Nuclear Medicine and Biology, volume 108-109 (2022). 10.1016/S0969-8051(22)00062-2 Cite \| Source
Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold (journal article) He, Yingfang \| Gobbi, Luca C. \| Herde, Adrienne Müller \| Rombach, Didier \| Ritter, Martin \| Kuhn, Bernd \| Wittwer, Matthias B. \| Heer, Dominik \| Hornsperger, Benoit \| Bell, Charles \| ... \| Mu, Linjing Nuclear Medicine and Biology, volume 108-109 (2022). 10.1016/j.nucmedbio.2022.02.002 Cited by (6) \| Cite \| Source
Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging (journal article) He, Yingfang \| Schild, Matthias \| Grether, Uwe \| Benz, Jörg \| Leibrock, Lea \| Heer, Dominik \| Topp, Andreas \| Collin, Ludovic \| Kuhn, Bernd \| Wittwer, Matthias \| ... \| Mu, Linjing Journal of Medicinal Chemistry, volume 65, issue 3, pages 2191-2207 (2022). 10.1021/acs.jmedchem.1c01706 Cited by (10) \| Cite \| Source
The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO (journal article) Chen, Zhen \| Haider, Ahmed \| Chen, Jiahui \| Xiao, Zhiwei \| Gobbi, Luca \| Honer, Michael \| Grether, Uwe \| Arnold, Steven E. \| Josephson, Lee \| Liang, Steven H. Journal of Medicinal Chemistry, volume 64, issue 24, pages 17656-17689 (2021). 10.1021/acs.jmedchem.1c01571 Cited by (29) \| Cite \| Source
Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors (journal article) Haider, Ahmed \| Gobbi, Luca \| Kretz, Julian \| Ullmer, Christoph \| Brink, Andreas \| Honer, Michael \| Woltering, Thomas J. \| Muri, Dieter \| Iding, Hans \| Bürkler, Markus \| ... \| Ametamey, Simon M. Journal of Medicinal Chemistry, volume 63, issue 18, pages 10287-10306 (2020). 10.1021/acs.jmedchem.0c00778 Cited by (25) \| Cite \| Source
Cover Feature: A Comparative Study of in vitro Assays for Predicting the Nonspecific Binding of PET Imaging Agents in vivo (ChemMedChem 7/2020) (journal article) Gobbi, Luca \| Mercier, Joël \| Bang‐Andersen, Benny \| Nicolas, Jean‐Marie \| Reilly, John \| Wagner, Björn \| Whitehead, David \| Briard, Emmanuelle \| Maguire, R. Paul \| Borroni, Edilio \| Auberson, Yves P. ChemMedChem, volume 15, issue 7, pages 560-560 (2020). 10.1002/cmdc.201000140 Cite \| Source
A Comparative Study of in vitro Assays for Predicting the Nonspecific Binding of PET Imaging Agents in vivo (journal article) Gobbi, Luca \| Mercier, Joël \| Bang‐Andersen, Benny \| Nicolas, Jean‐Marie \| Reilly, John \| Wagner, Björn \| Whitehead, David \| Briard, Emmanuelle \| Maguire, R. Paul \| Borroni, Edilio \| Auberson, Yves P. ChemMedChem, volume 15, issue 7, pages 585-592 (2020). 10.1002/cmdc.201900608 Cited by (8) \| Cite \| Source
Structure–Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors (journal article) Haider, Ahmed \| Kretz, Julian \| Gobbi, Luca \| Ahmed, Hazem \| Atz, Kenneth \| Bürkler, Markus \| Bartelmus, Christian \| Fingerle, Jürgen \| Guba, Wolfgang \| Ullmer, Christoph \| ... \| Ametamey, Simon M. Journal of Medicinal Chemistry, volume 62, issue 24, pages 11165-11181 (2019). 10.1021/acs.jmedchem.9b01280 Cited by (21) \| Cite \| Source
[1,2,3]triazolo[4,5-D]pyrimidine derivatives (patent) Gobbi, Luca \| Grether, Uwe \| Guba, Wolfgang \| Kretz, Julian \| Martin, Rainer E. \| Westphal, Matthias Valentin Patent Number: 10457686 (2019) Cite \| Source
[1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor (patent) Gobbi, Luca \| Grether, Uwe \| Guba, Wolfgang \| Kretz, Julian \| Martin, Rainer E. \| Westphal, Matthias Valentin \| Ijzerman, Adriaan Pieter Patent Number: 10457685 (2019) Cite \| Source
[1,2,3]triazolo[4,5-d]pyrimidine derivatives (patent) Gobbi, Luca \| Grether, Uwe \| Guba, Wolfgang \| Kretz, Julian \| Martin, Rainer E. \| Westphal, Matthias Valentin Patent Number: 10457684 (2019) Cite \| Source
[1,2,3]triazolo[4,5-D]pyrimidine derivatives (patent) Gobbi, Luca \| Grether, Uwe \| Guba, Wolfgang \| Kretz, Julian \| Martin, Rainer E. \| Westphal, Matthias Valentin \| Ijzerman, Adriaan Pieter Patent Number: 10450321 (2019) Cited by (1) \| Cite \| Source
Radiolabeled cannabinoid receptor 2 ligand (patent) Ametamey, Simon M. \| Fingerle, Juergen \| Gobbi, Luca \| Grether, Uwe \| Haider, Ahmed \| Hartung, Thomas \| Mu, Linjing \| Nicholls, Leo \| Rogers-Evans, Mark \| Ullmer, Christoph Patent Number: 10227308 (2019) Cited by (1) \| Cite \| Source
Characterization of 3 Novel Tau Radiopharmaceuticals,11 C-RO-963,11 C-RO-643, and18 F-RO-948, in Healthy Controls and in Alzheimer Subjects (journal article) Wong, Dean F. \| Comley, Robert A. \| Kuwabara, Hiroto \| Rosenberg, Paul B. \| Resnick, Susan M. \| Ostrowitzki, Susanne \| Vozzi, Cristina \| Boess, Frank \| Oh, Esther \| Lyketsos, Constantine G. \| ... \| Borroni, Edilio Journal of Nuclear Medicine, volume 59, issue 12, pages 1869-1876 (2018). 10.2967/jnumed.118.209916 Cited by (81) \| Cite \| Source