Brian C. Shook

ScholarGPS® ID: 62686880035325

Affiliation

Enanta Pharmaceuticals, Inc.

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

3,124

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies (journal article) Alford, Joshua S. \| Lampe, John W. \| Brach, Dorothy \| Chesworth, Richard \| Cosmopoulos, Kat \| Duncan, Kenneth W. \| Eckley, Sean T. \| Kutok, Jeffrey L. \| Raimondi, Alejandra \| Riera, Thomas V. \| ... \| Farrow, Neil A. ACS Medicinal Chemistry Letters, volume 13, issue 7, pages 1137-1143 (2022). 10.1021/acsmedchemlett.2c00167 Cited by (11) \| Cite \| Source
EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model (journal article) Rhodin, Michael H. J. \| McAllister, Nicole V. \| Castillo, Jonathan \| Noton, Sarah L. \| Fearns, Rachel \| Kim, In Jong \| Yu, Jianming \| Blaisdell, Thomas P. \| Panarese, Joseph \| Shook, Brian C. \| ... \| Lin, Kai PLOS Pathogens, volume 17, issue 3, pages e1009428- (2021). 10.1371/journal.ppat.1009428 Cited by (19) \| Cite \| Source
Benzodiazepine derivatives as RSV inhibitors (patent) Shook, Brian C. \| Kim, In Jong \| Blaisdell, Thomas P. \| Yu, Jianming \| Panarese, Joseph \| Or, Yat Sun Patent Number: 10865215 (2020) Cite \| Source
Heterocyclic compounds as RSV inhibitors (patent) Kim, In Jong \| Panarese, Joseph \| Blaisdell, Thomas P. \| Yu, Jianming \| Shook, Brian C. \| Or, Yat Sun Patent Number: 10851115 (2020) Cite \| Source
Heterocyclic compounds as RSV inhibitors (patent) Yu, Jianming \| Shook, Brian C. \| Blaisdell, Thomas P. \| Kim, In Jong \| Panarese, Joseph \| McGrath, Kevin \| Negretti-Emmanuelli, Solymar \| Or, Yat Sun Patent Number: 10759816 (2020) Cite \| Source
Aryldiazepine derivatives as RSV inhibitors (patent) Or, Yat Sun \| Blaisdell, Thomas P. \| Shook, Brian C. \| Kim, In Jong Patent Number: 10752598 (2020) Cite \| Source
Azepin-2-one derivatives as RSV inhibitors (patent) Blaisdell, Thomas P. \| Shook, Brian C. \| Kim, In Jong \| Or, Yat Sun Patent Number: 10647711 (2020) Cite \| Source
Benzodiazepine derivatives as RSV inhibitors (patent) Shook, Brian C. \| Kim, In Jong \| Blaisdell, Thomas P. \| Yu, Jianming \| Panarese, Joseph \| Or, Yat Sun Patent Number: 10570153 (2020) Cite \| Source
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes (journal article) Xu, Guozhang \| Gaul, Michael D. \| Song, Fengbin \| Du, Fuyong \| Liang, Yin \| DesJarlais, Renee L. \| DiLoreto, Karen \| Shook, Brian \| Rentzeperis, Dennis \| Santulli, Rosie \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 20, pages 126668- (2019). 10.1016/j.bmcl.2019.126668 Cited by (3) \| Cite \| Source
Heteroaryldiazepine derivatives as RSV inhibitors (patent) Shook, Brian C. \| Kim, In Jong \| Yu, Jianming \| Blaisdell, Thomas P. \| Panarese, Joseph \| Or, Yat Sun Patent Number: 10398706 (2019) Cited by (5) \| Cite \| Source
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists (journal article) Song, Fengbin \| Xu, Guozhang \| Gaul, Michael D. \| Zhao, Baoping \| Lu, Tianbao \| Zhang, Rui \| DesJarlais, Renee L. \| DiLoreto, Karen \| Huebert, Norman \| Shook, Brian \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 15, pages 1974-1980 (2019). 10.1016/j.bmcl.2019.05.036 Cited by (15) \| Cite \| Source
Processes for the preparation of benzodiazepine derivatives (patent) Kim, In Jong \| Yu, Jianming \| Blaisdell, Thomas P. \| Panarese, Joseph \| Shook, Brian C. \| Or, Yat Sun Patent Number: 10358441 (2019) Cited by (5) \| Cite \| Source
Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age (journal article) Lam, Carol J. \| Rankin, Matthew M. \| King, Kourtney B. \| Wang, Melinda C. \| Shook, Brian C. \| Kushner, Jake A. Diabetes, volume 68, issue 5, pages 963-974 (2019). 10.2337/db18-1293 Cited by (10) \| Cite \| Source
Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine (journal article) Haanes, Kristian A. \| Labastida-Ramírez, Alejandro \| Chan, Kayi Y. \| de Vries, René \| Shook, Brian \| Jackson, Paul \| Zhang, Jimmy \| Flores, Christopher M. \| Danser, Alexander H. J. \| Villalón, Carlos M. \| MaassenVanDenBrink, Antoinette The Journal of Headache and Pain, volume 19, issue 1 (2018). 10.1186/s10194-018-0867-x Cited by (20) \| Cite \| Source \| Open Access
Benzodiazepine derivatives as RSV inhibitors (patent) Shook, Brian C. \| Kim, In Jong \| Blaisdell, Thomas P. \| Yu, Jianming \| Panarese, Joseph \| Or, Yat Sun Patent Number: 9957281 (2018) Cited by (9) \| Cite \| Source
Recent Advances in Developing Antiviral Therapies for Respiratory Syncytial Virus (journal article) Shook, Brian C. \| Lin, Kai Topics in Current Chemistry, volume 375, issue 2 (2017). 10.1007/s41061-017-0129-4 Cited by (19) \| Cite \| Source
BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS (patent) Shook, Brian C. \| Kim, In Jong \| Blaisdell, Thomas P. \| Yu, Jianming \| Panarese, Joseph \| Or, Yat Sun Patent Number: 20170022221 (2017) Cited by (3) \| Cite \| Source
Biphenyl derivatives useful as glucagon receptor antagonists (patent) Chakravarty, Devraj \| Greco, Michael \| Shook, Brian \| Xu, Guozhang \| Zhang, Rui Patent Number: 9045389 (2015) Cite \| Source
JNJ-40255293, a Novel Adenosine A2A /A1 Antagonist with Efficacy in Preclinical Models of Parkinson’s Disease (journal article) Atack, John R. \| Shook, Brian C. \| Rassnick, Stefanie \| Jackson, Paul F. \| Rhodes, Kenneth \| Drinkenburg, Wilhelmus H. \| Ahnaou, Abdallah \| te Riele, Paula \| Langlois, Xavier \| Hrupka, Brian \| ... \| Megens, Anton A. H. P. ACS Chemical Neuroscience, volume 5, issue 10, pages 1005-1019 (2014). 10.1021/cn5001606 Cited by (37) \| Cite \| Source
Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists (patent) Chakravarty, Devraj \| Kreutter, Kevin \| Powell, Mark \| Shook, Brian \| Song, Fengbin \| Xu, Guozhang \| Yang, Shyh-Ming \| Zhang, Rui \| Zhao, Bao-Ping Patent Number: 8748624 (2014) Cite \| Source