Myles C. Cabot

ScholarGPS® ID: 61259277472272

Affiliation
East Carolina University, Greenville, United States
Affiliation History

Field
Life Sciences
Discipline
Biochemistry
Top Specialties
Cancer | Cancer Cell | Lipid | Metabolism | Multiple Drug Resistance | Tamoxifen | Leukemia | Apoptosis | Drug Resistance | Lipid Metabolism | Breast Cancer | Chemotherapy | Glycoprotein
Metrics Summary
Publication Count
126
Predicted Citations
9,604
Predicted h-index
52
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia (journal article)
Ung, Johnson | Tan, Su-Fern | Fox, Todd E. | Shaw, Jeremy J. P. | Taori, Maansi | Horton, Bethany J. | Golla, Upendarrao | Sharma, Arati | Szulc, Zdzislaw M. | Wang, Hong-Gang | ... | Feith, David J.
Cancers, volume 15, issue 24, pages 5866- (2023).
10.3390/cancers15245866
Cite | Source
Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types (journal article)
Boykov, Ilya N. | Montgomery, McLane M. | Hagen, James T. | Aruleba, Raphael T. | McLaughlin, Kelsey L. | Coalson, Hannah S. | Nelson, Margaret A. | Pereyra, Andrea S. | Ellis, Jessica M. | Zeczycki, Tonya N. | ... | Fisher-Wellman, Kelsey H.
Scientific Reports, volume 13, issue 1 (2023).
10.1038/s41598-023-43963-5
Cite | Source
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia (journal article)
Fisher-Wellman, Kelsey H. | Kassai, Miki | Hagen, James T. | Neufer, P. Darrell | Kester, Mark | Loughran, Thomas P. | Chalfant, Charles E. | Feith, David J. | Tan, Su-Fern | Fox, Todd E. | ... | Cabot, Myles C.
Cancers, volume 15, issue 6, pages 1883- (2023).
10.3390/cancers15061883
Cited by (2) | Cite | Source
Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells (journal article)
Hagen, James T. | Montgomery, McLane M. | Biagioni, Ericka M. | Krassovskaia, Polina | Jevtovic, Filip | Shookster, Daniel | Sharma, Uma | Tung, Kang | Broskey, Nickolas T. | May, Linda | ... | Fisher-Wellman, Kelsey H.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, volume 1863, issue 8, pages 148915- (2022).
10.1016/j.bbabio.2022.148915
Cited by (4) | Cite | Source
Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia (journal article)
Khokhlatchev, Andrei V. | Sharma, Arati | Deering, Tye G. | Shaw, Jeremy J. P. | Costa‐Pinheiro, Pedro | Golla, Upendarrao | Annageldiyev, Charyguly | Cabot, Myles C. | Conaway, Mark R. | Tan, Su‐Fern | ... | Kester, Mark
The FASEB Journal, volume 36, issue 10 (2022).
10.1096/fj.202200765R
Cited by (7) | Cite | Source
Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia (journal article)
Ung, Johnson | Tan, Su-Fern | Fox, Todd E. | Shaw, Jeremy J.P. | Vass, Luke R. | Costa-Pinheiro, Pedro | Garrett-Bakelman, Francine E. | Keng, Michael K. | Sharma, Arati | Claxton, David F. | ... | Loughran, Thomas P.
Blood Reviews, volume 55 (2022).
10.1016/j.blre.2022.100950
Cited by (8) | Cite | Source
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia (journal article)
Fisher‐Wellman, Kelsey H. | Hagen, James T. | Kassai, Miki | Kao, Li‐Pin | Nelson, Margaret A. M. | McLaughlin, Kelsey L. | Coalson, Hannah S. | Fox, Todd E. | Tan, Su‐Fern | Feith, David J. | ... | Cabot, Myles C.
The FASEB Journal, volume 36, issue 1 (2022).
10.1096/fj.202101194RRR
Cited by (5) | Cite | Source
Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia (journal article)
Nelson, Margaret AM | McLaughlin, Kelsey L | Hagen, James T | Coalson, Hannah S | Schmidt, Cameron | Kassai, Miki | Kew, Kimberly A | McClung, Joseph M | Neufer, P Darrell | Brophy, Patricia | ... | Fisher-Wellman, Kelsey H
eLife, volume 10 (2021).
10.7554/eLife.63104
Cited by (24) | Cite | Source
On the nature of ceramide-mitochondria interactions – Dissection using comprehensive mitochondrial phenotyping (journal article)
Fisher-Wellman, Kelsey H. | Hagen, James T. | Neufer, P. Darrell | Kassai, Miki | Cabot, Myles C.
Cellular Signalling, volume 78 (2021).
10.1016/j.cellsig.2020.109838
Cited by (11) | Cite | Source
A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer (journal article)
Madigan, James P. | Robey, Robert W. | Poprawski, Joanna E. | Huang, Huakang | Clarke, Christopher J. | Gottesman, Michael M. | Cabot, Myles C. | Rosenberg, Daniel W.
Experimental Cell Research, volume 388, issue 2, pages 111860- (2020).
10.1016/j.yexcr.2020.111860
Cited by (23) | Cite | Source
Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia (journal article)
Pearson, Jennifer M. | Tan, Su-Fern | Sharma, Arati | Annageldiyev, Charyguly | Fox, Todd E. | Abad, Jose Luis | Fabrias, Gemma | Desai, Dhimant | Amin, Shantu | Wang, Hong-Gang | ... | Loughran, Thomas P.
Molecular Cancer Research, volume 18, issue 3, pages 352-363 (2020).
10.1158/1541-7786.MCR-19-0619
Cited by (22) | Cite | Source
Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells (journal article)
Kao, Li-Pin | Morad, Samy A.F. | Davis, Traci S. | MacDougall, Matthew R. | Kassai, Miki | Abdelmageed, Noha | Fox, Todd E. | Kester, Mark | Loughran, Thomas P. | Abad, Jose' L. | ... | Cabot, Myles C.
Journal of Lipid Research, volume 60, issue 9, pages 1590-1602 (2019).
10.1194/jlr.RA119000251
Cited by (19) | Cite | Source
Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen (journal article)
Morad, Samy A.F. | MacDougall, Matthew R. | Abdelmageed, Noha | Kao, Li-Pin | Feith, David J. | Tan, Su-Fern | Kester, Mark | Loughran, Thomas P. | Wang, Hong-Gang | Cabot, Myles C.
Experimental Cell Research, volume 381, issue 2, pages 256-264 (2019).
10.1016/j.yexcr.2019.05.021
Cited by (14) | Cite | Source
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation (journal article)
Tan, Su-Fern | Dunton, Wendy | Liu, Xin | Fox, Todd E. | Morad, Samy A.F. | Desai, Dhimant | Doi, Kenichiro | Conaway, Mark R. | Amin, Shantu | Claxton, David F. | ... | Loughran, Thomas P.
Journal of Lipid Research, volume 60, issue 6, pages 1078-1086 (2019).
10.1194/jlr.M091876
Cited by (32) | Cite | Source
The Onus of Sphingolipid Enzymes in Cancer Drug Resistance (book chapter)
In Sphingolipids in Cancer
Morad, Samy A.F. | Cabot, Myles C.
Elsevier (2018)
10.1016/bs.acr.2018.04.013
Cited by (16) | Cite | Source
Oleanolic acid methyl ester, a novel cytotoxic mitocan, induces cell cycle arrest and ROS-Mediated cell death in castration-resistant prostate cancer PC-3 cells (journal article)
Abdelmageed, Noha | Morad, Samy A.F. | Elghoneimy, Ashraf A. | Syrovets, Tatiana | Simmet, Thomas | El-zorba, Hesham | El-Banna, Hossney A. | Cabot, Myles | Abdel-Aziz, Magdy I.
Biomedicine & Pharmacotherapy, volume 96 (2017).
10.1016/j.biopha.2017.10.027
Cited by (20) | Cite | Source
Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer (journal article)
Morad, Samy A.F. | Davis, Traci S. | MacDougall, Matthew R. | Tan, Su-Fern | Feith, David J. | Desai, Dhimant H. | Amin, Shantu G. | Kester, Mark | Loughran, Thomas P. | Cabot, Myles C.
Biochemical Pharmacology, volume 130 (2017).
10.1016/j.bcp.2017.02.002
Cited by (16) | Cite | Source | Open Access
Repurposing P‐glycoprotein Inhibitors as Modifiers of Sphingolipid Metabolism— Therapeutic Implications in Cancer (journal article)
Cabot, Myles C
The FASEB Journal, volume 31, issue S1 (2017).
10.1096/fasebj.31.1_supplement.629.6
Cite | Source
Short-chain ceramides depress integrin cell surface expression and function in colorectal cancer cells (journal article)
Morad, Samy A.F. | Bridges, Lance C. | Almeida Larrea, Alex D. | Mayen, Anthony L. | MacDougall, Matthew R. | Davis, Traci S. | Kester, Mark | Cabot, Myles C.
Cancer Letters, volume 376, issue 2, pages 199-204 (2016).
10.1016/j.canlet.2016.03.049
Cited by (14) | Cite | Source
Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia (journal article)
Morad, Samy A.F. | Ryan, Terence E. | Neufer, P. Darrell | Zeczycki, Tonya N. | Davis, Traci S. | MacDougall, Matthew R. | Fox, Todd E. | Tan, Su-Fern | Feith, David J. | Loughran, Thomas P. | ... | Cabot, Myles C.
Journal of Lipid Research, volume 57, issue 7, pages 1231-1242 (2016).
10.1194/jlr.M067389
Cited by (27) | Cite | Source | Open Access