Matthias Wittwer

ScholarGPS® ID: 60689200013875

Affiliation

Roche Holding AG, Basel, Switzerland

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmaceutical Sciences

Top Specialties

Medicinal Chemistry | Chemical Synthesis | Glycoprotein | Biosynthesis | Clinical Pharmacology

Metrics Summary

Publication Count

Predicted Citations

2,328

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice (journal article) Gonzalo-Consuegra, Claudia \| Santos-García, Irene \| García-Toscano, Laura \| Martín-Baquero, Raquel \| Rodríguez-Cueto, Carmen \| Wittwer, Matthias B. \| Dzygiel, Pawel \| Grether, Uwe \| de Lago, Eva \| Fernández-Ruiz, Javier Biomedicine & Pharmacotherapy, volume 174 (2024). 10.1016/j.biopha.2024.116473 Cite \| Source
Identification of ( R )-[18 F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development (journal article) He, Yingfang \| Krämer, Stefanie D. \| Grether, Uwe \| Wittwer, Matthias B. \| Collin, Ludovic \| Kuhn, Bernd \| Topp, Andreas \| Heer, Dominik \| O’Hara, Fionn \| Honer, Michael \| ... \| Mu, Linjing Journal of Nuclear Medicine, volume 65, issue 2, pages 300-305 (2024). 10.2967/jnumed.123.266426 Cite \| Source
Identification of (R)-[18F]YH134 as a promising reversible MAGL PET tracer and the impact of peripheral MAGL blockade on its brain uptake (journal article) Mu, Linjing \| He, Yingfang \| Krämer, Stefanie \| Grether, Uwe \| Wittwer, Matthias \| Honer, Michael \| Keller, Claudia \| Schibli, Roger \| Gobbi, Luca Nuclear Medicine and Biology, volume 126-127 (2023). 10.1016/j.nucmedbio.2023.108546 Cite \| Source
Diagnostic challenges within the Bacillus cereus-group: finding the beast without teeth (journal article) Muigg, Veronika \| Cuénod, Aline \| Purushothaman, Srinithi \| Siegemund, Martin \| Wittwer, Matthias \| Pflüger, Valentin \| Schmidt, Kristina M. \| Weisser, Maja \| Ritz, Nicole \| Widmer, Andreas \| ... \| Seth-Smith, Helena M.B. New Microbes and New Infections, volume 49-50 (2022). 10.1016/j.nmni.2022.101040 Cited by (4) \| Cite \| Source
A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature (journal article) Kemble, Alicia M. \| Hornsperger, Benoit \| Ruf, Iris \| Richter, Hans \| Benz, Jörg \| Kuhn, Bernd \| Heer, Dominik \| Wittwer, Matthias \| Engelhardt, Britta \| Grether, Uwe \| Collin, Ludovic PLOS ONE, volume 17, issue 9, pages e0268590- (2022). 10.1371/journal.pone.0268590 Cited by (2) \| Cite \| Source
Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance (journal article) Zamek‐Gliszczynski, Maciej J. \| Sangha, Vishal \| Shen, Hong \| Feng, Bo \| Wittwer, Matthias B. \| Varma, Manthena V. S. \| Liang, Xiaomin \| Sugiyama, Yuichi \| Zhang, Lei \| Bendayan, Reina Clinical Pharmacology & Therapeutics, volume 112, issue 3, pages 485-500 (2022). 10.1002/cpt.2644 Cited by (27) \| Cite \| Source
Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold (journal article) He, Yingfang \| Gobbi, Luca C. \| Herde, Adrienne Müller \| Rombach, Didier \| Ritter, Martin \| Kuhn, Bernd \| Wittwer, Matthias B. \| Heer, Dominik \| Hornsperger, Benoit \| Bell, Charles \| ... \| Mu, Linjing Nuclear Medicine and Biology, volume 108-109 (2022). 10.1016/j.nucmedbio.2022.02.002 Cited by (6) \| Cite \| Source
Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging (journal article) He, Yingfang \| Schild, Matthias \| Grether, Uwe \| Benz, Jörg \| Leibrock, Lea \| Heer, Dominik \| Topp, Andreas \| Collin, Ludovic \| Kuhn, Bernd \| Wittwer, Matthias \| ... \| Mu, Linjing Journal of Medicinal Chemistry, volume 65, issue 3, pages 2191-2207 (2022). 10.1021/acs.jmedchem.1c01706 Cited by (10) \| Cite \| Source
Whole-Genome Assemblies of 16 Burkholderia pseudomallei Isolates from Rivers in Laos (journal article) Liechti, Nicole \| Zimmermann, Rosalie E. \| Zopfi, Jakob \| Robinson, Matthew T. \| Pierret, Alain \| Ribolzi, Olivier \| Rattanavong, Sayaphet \| Davong, Viengmon \| Newton, Paul N. \| Wittwer, Matthias \| Dance, David A. B. Microbiology Resource Announcements, volume 10, issue 4 (2021). 10.1128/MRA.01226-20 Cited by (4) \| Cite \| Source
Amide-substituted phenyltriazole derivatives and uses thereof (patent) Collin-Kröpelin, Marie-Pierre \| Kolkhof, Peter \| Neubauer, Thomas \| Fürstner, Chantal \| Pook, Elisabeth \| Wittwer, Matthias Beat \| Lustig, Klemens \| Buchmüller, Anja \| Tinel, Hanna \| Dröbner, Karoline \| ... \| Cernecka, Hana Patent Number: 10815205 (2020) Cite \| Source
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction (journal article) Umehara, Kenichi \| Cantrill, Carina \| Wittwer, Matthias Beat \| Di Lenarda, Elisa \| Klammers, Florian \| Ekiciler, Aynur \| Parrott, Neil \| Fowler, Stephen \| Ullah, Mohammed Drug Metabolism and Disposition, volume 48, issue 10, pages 849-860 (2020). 10.1124/dmd.120.000133 Cited by (24) \| Cite \| Source
Structure–Permeability Relationship of Semipeptidic Macrocycles—Understanding and Optimizing Passive Permeability and Efflux Ratio (journal article) Le Roux, Antoine \| Blaise, Émilie \| Boudreault, Pierre-Luc \| Comeau, Christian \| Doucet, Annie \| Giarrusso, Marilena \| Collin, Marie-Pierre \| Neubauer, Thomas \| Kölling, Florian \| Göller, Andreas H. \| ... \| Marsault, Eric Journal of Medicinal Chemistry, volume 63, issue 13, pages 6774-6783 (2020). 10.1021/acs.jmedchem.0c00013 Cited by (22) \| Cite \| Source
Fundamental aspects of DMPK optimization of targeted protein degraders (journal article) Cantrill, Carina \| Chaturvedi, Prasoon \| Rynn, Caroline \| Petrig Schaffland, Jeannine \| Walter, Isabelle \| Wittwer, Matthias B. Drug Discovery Today, volume 25, issue 6, pages 969-982 (2020). 10.1016/j.drudis.2020.03.012 Cited by (99) \| Cite \| Source
Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof (patent) Collin-Kröpelin, Marie-Pierre \| Kolkhof, Peter \| Neubauer, Thomas \| Fürstner, Chantal \| Pook, Elisabeth \| Wittwer, Matthias Beat \| Schmeck, Carsten \| Wasnaire, Pierre \| Tinel, Hanna \| Schirmer, Heiko Patent Number: 10526314 (2020) Cite \| Source
Fluoroalkyl-substituted aryltriazole derivatives and uses thereof (patent) Neubauer, Thomas \| Collin-Kröpelin, Marie-Pierre \| Kolkhof, Peter \| Pook, Elisabeth \| Wittwer, Matthias Beat \| Lustig, Klemens \| Schmeck, Carsten \| Wasnaire, Pierre \| Schirmer, Heiko Patent Number: 10525041 (2020) Cite \| Source
7-substituted 1-pyridyl-naphthyridine-3-carboxylic acid amides and use thereof (patent) Teller, Henrik \| Boultadakis Arapinis, Melissa \| Vakalopoulos, Alexandros \| Rebstock, Anne-Sophie \| Straub, Alexander \| Tinel, Hanna \| Brechmann, Markus \| Wittwer, Matthias Beat \| Kullmann, Maximillian Andreas \| Münter, Klaus \| ... \| Marquardt, Tobias Patent Number: 10519154 (2019) Cite \| Source
Amide-substituted pyridinyltriazole derivatives and uses thereof (patent) Collin, Marie-Pierre \| Kolkhof, Peter \| Neubauer, Thomas \| Fürstner, Chantal \| Pook, Elisabeth \| Wittwer, Matthias Beat \| Lustig, Klemens \| Buchmüller, Anja \| Tinel, Hanna \| Dröbner, Karoline \| ... \| Cernecka, Hana Patent Number: 10472348 (2019) Cite \| Source
Positive allosteric modulators of muscarinic M2 receptor (patent) Teller, Henrik \| Straub, Alexander \| Brechmann, Markus \| Müller, Thomas \| Meininghaus, Mark \| Nowak-Reppel, Katrin \| Tinel, Hanna \| Münter, Klaus \| Fliegner, Daniela \| Mondritzki, Thomas \| ... \| Wittwer, Matthias Beat Patent Number: 10435403 (2019) Cite \| Source
ITC Commentary on Metformin Clinical Drug–Drug Interaction Study Design That Enables an Efficacy‐ and Safety‐Based Dose Adjustment Decision (journal article) Zamek‐Gliszczynski, Maciej J. \| Chu, Xiaoyan \| Cook, Jack A. \| Custodio, Joseph M. \| Galetin, Aleksandra \| Giacomini, Kathleen M. \| Lee, Caroline A. \| Paine, Mary F. \| Ray, Adrian S. \| Ware, Joseph A. \| ... \| Zhang, Lei Clinical Pharmacology & Therapeutics, volume 104, issue 5, pages 781-784 (2018). 10.1002/cpt.1082 Cited by (30) \| Cite \| Source
Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance (journal article) Zamek‐Gliszczynski, Maciej J. \| Taub, Mitchell E. \| Chothe, Paresh P. \| Chu, Xiaoyan \| Giacomini, Kathleen M. \| Kim, Richard B. \| Ray, Adrian S. \| Stocker, Sophie L. \| Unadkat, Jashvant D. \| Wittwer, Matthias B. \| ... \| Zhang, Yan Clinical Pharmacology & Therapeutics, volume 104, issue 5, pages 890-899 (2018). 10.1002/cpt.1112 Cited by (182) \| Cite \| Source