Jeffrey Tom

ScholarGPS® ID: 59808186553418

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Peptide | Chemical Biology | Growth Factor | HIV

Metrics Summary

Publication Count

Predicted Citations

3,408

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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N - tert -Butoxycarbonyl- N -(2-(tritylthio)ethoxy)glycine as a Building Block for Peptide Ubiquitination (journal article) Peng, Lingling \| Helgason, Elizabeth \| Miranda, Rafael \| Tom, Jeffrey \| Zhang, Jennifer \| Dueber, Erin C. \| Song, Aimin Bioconjugate Chemistry, volume 35, issue 2, pages 245-253 (2024). 10.1021/acs.bioconjchem.3c00541 Cite \| Source
Evaluating Translational Efficiency of Noncanonical Amino Acids to Inform the Design of Druglike Peptide Libraries (journal article) Chan, Alix I \| Sawant, Manali S. \| Burdick, Daniel J. \| Tom, Jeffrey \| Song, Aimin \| Cunningham, Christian N. ACS Chemical Biology, volume 18, issue 1, pages 81-90 (2023). 10.1021/acschembio.2c00712 Cited by (5) \| Cite \| Source
Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation (journal article) Miller, Gregory M. \| Flynn, E. Megan \| Tom, Jeffrey \| Song, Aimin \| Cochran, Andrea G. ACS Chemical Biology, volume 17, issue 5, pages 1022-1029 (2022). 10.1021/acschembio.2c00016 Cited by (2) \| Cite \| Source
Incorporating NOE-Derived Distances in Conformer Generation of Cyclic Peptides with Distance Geometry (journal article) Wang, Shuzhe \| Krummenacher, Kajo \| Landrum, Gregory A. \| Sellers, Benjamin D. \| Di Lello, Paola \| Robinson, Sarah J. \| Martin, Bryan \| Holden, Jeffrey K. \| Tom, Jeffrey Y. K. \| Murthy, Anastasia C. \| ... \| Riniker, Sereina Journal of Chemical Information and Modeling, volume 62, issue 3, pages 472-485 (2022). 10.1021/acs.jcim.1c01165 Cited by (8) \| Cite \| Source
A novel method to produce synthetic murine CXCL10 for efficient screening of functional variants (journal article) Decalf, Jérémie \| Tom, Jeffrey \| Mai, Elaine \| Hernandez-Barry, Hilda \| Noland, Cameron L. \| Vollmar, Breanna S. \| Li, Alice \| Li, Hong \| Xie, Daniel \| Zhu, Lunchao \| ... \| Song, Aimin Bioorganic Chemistry, volume 116 (2021). 10.1016/j.bioorg.2021.105376 Cited by (1) \| Cite \| Source
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling (journal article) Holden, Jeffrey K. \| Crawford, James J. \| Noland, Cameron L. \| Schmidt, Stephen \| Zbieg, Jason R. \| Lacap, Jennifer A. \| Zang, Richard \| Miller, Gregory M. \| Zhang, Yue \| Beroza, Paul \| ... \| Cunningham, Christian N. Cell Reports, volume 31, issue 12, pages 107809- (2020). 10.1016/j.celrep.2020.107809 Cited by (87) \| Cite \| Source
Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study (journal article) Yamazoe, Sayumi \| Tom, Jeffrey \| Fu, Yue \| Wu, Wenqiong \| Zeng, Liang \| Sun, Changlei \| Liu, Qi \| Lin, Jie \| Lin, Kui \| Fairbrother, Wayne J. \| Staben, Steven T. Journal of Medicinal Chemistry, volume 63, issue 6, pages 2807-2813 (2020). 10.1021/acs.jmedchem.9b01167 Cited by (85) \| Cite \| Source
Development of Orthogonally Protected Hypusine for Solid-Phase Peptide Synthesis (journal article) Song, Aimin \| Tom, Jeffrey \| Yu, Zhiyong \| Pham, Victoria \| Tan, Dajin \| Zhang, Dengxiong \| Fang, Guoyong \| Yu, Tao \| Deshayes, Kurt The Journal of Organic Chemistry, volume 80, issue 7, pages 3677-3681 (2015). 10.1021/acs.joc.5b00110 Cited by (3) \| Cite \| Source
An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides (journal article) Landgraf, Kyle E \| Steffek, Micah \| Quan, Clifford \| Tom, Jeffrey \| Yu, Christine \| Santell, Lydia \| Maun, Henry R \| Eigenbrot, Charles \| Lazarus, Robert A Nature Chemical Biology, volume 10, issue 7, pages 567-573 (2014). 10.1038/nchembio.1533 Cited by (22) \| Cite \| Source
Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor (journal article) Zhang, Yingnan \| Eigenbrot, Charles \| Zhou, Lijuan \| Shia, Steven \| Li, Wei \| Quan, Clifford \| Tom, Jeffrey \| Moran, Paul \| Di Lello, Paola \| Skelton, Nicholas J. \| ... \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 289, issue 2, pages 942-955 (2014). 10.1074/jbc.M113.514067 Cited by (138) \| Cite \| Source \| Open Access
Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain (journal article) Zhang, Yingnan \| Zhou, Lijuan \| Kong-Beltran, Monica \| Li, Wei \| Moran, Paul \| Wang, Jianyong \| Quan, Clifford \| Tom, Jeffrey \| Kolumam, Ganesh \| Elliott, J. Michael \| ... \| Kirchhofer, Daniel Journal of Molecular Biology, volume 422, issue 5, pages 685-696 (2012). 10.1016/j.jmb.2012.06.018 Cited by (34) \| Cite \| Source
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization (journal article) Stanger, Karen \| Steffek, Micah \| Zhou, Lijuan \| Pozniak, Christine D \| Quan, Clifford \| Franke, Yvonne \| Tom, Jeff \| Tam, Christine \| Krylova, Irina \| Elliott, J Michael \| ... \| Hannoush, Rami N Nature Chemical Biology, volume 8, issue 7, pages 655-660 (2012). 10.1038/nchembio.967 Cited by (33) \| Cite \| Source
Structural and Functional Analysis of HtrA1 and Its Subdomains (journal article) Eigenbrot, Charles \| Ultsch, Mark \| Lipari, Michael T. \| Moran, Paul \| Lin, S. Jack \| Ganesan, Rajkumar \| Quan, Clifford \| Tom, Jeffrey \| Sandoval, Wendy \| van Lookeren Campagne, Menno \| Kirchhofer, Daniel Structure, volume 20, issue 6, pages 1040-1050 (2012). 10.1016/j.str.2012.03.021 Cited by (85) \| Cite \| Source \| Open Access
Multiple Protein Interactions Involving Proposed Extracellular Loop Domains of the Tight Junction Protein Occludin (journal article) Nusrat, Asma \| Brown, G. Thomas \| Tom, Jeffrey \| Drake, Alex \| Bui, Tam T.T. \| Quan, Cliff \| Mrsny, Randall J. Molecular Biology of the Cell, volume 16, issue 4, pages 1725-1734 (2005). 10.1091/mbc.e04-06-0465 Cited by (66) \| Cite \| Source \| Open Access
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease (journal article) Zolotarevsky, Yevgeny \| Hecht, Gail \| Koutsouris, Athanasia \| Gonzalez, Deborah E. \| Quan, Cliff \| Tom, Jeffrey \| Mrsny, Randall J. \| Turner, Jerrold R. Gastroenterology, volume 123, issue 1, pages 163-172 (2002). 10.1053/gast.2002.34235 Cited by (328) \| Cite \| Source
Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor (journal article) Pan, Borlan \| Li, Bing \| Russell, Stephen J \| Tom, Jeffrey Y.K \| Cochran, Andrea G \| Fairbrother, Wayne J Journal of Molecular Biology, volume 316, issue 3, pages 769-787 (2002). 10.1006/jmbi.2001.5370 Cited by (67) \| Cite \| Source
The Coiled-coil Domain of Occludin Can Act to Organize Structural and Functional Elements of the Epithelial Tight Junction (journal article) Nusrat, Asma \| Chen, Jason A. \| Foley, Chris S. \| Liang, Tony W. \| Tom, Jeffrey \| Cromwell, M. \| Quan, Cliff \| Mrsny, Randall J. Journal of Biological Chemistry, volume 275, issue 38, pages 29816-29822 (2000). 10.1074/jbc.M002450200 Cited by (173) \| Cite \| Source \| Open Access
Use of phage display for the generation of human antibodies that neutralize factor IXa function (journal article) Suggett, S. \| Kirchhofer, D. \| Hass, P. \| Lipari, T. \| Moran, P. \| Nagel, M. \| Judice, K. \| Schroeder, K. \| Tom, J. \| Lowman, H. \| ... \| Devaux, B. Blood Coagulation & Fibrinolysis, volume 11, issue 1, pages 27-42 (2000). 10.1097/00001721-200001000-00004 Cited by (11) \| Cite \| Source
Novel Peptides Selected to Bind Vascular Endothelial Growth Factor Target the Receptor-Binding Site (journal article) Fairbrother, Wayne J. \| Christinger, Hans W. \| Cochran, Andrea G. \| Fuh, Germaine \| Keenan, Christopher J. \| Quan, Clifford \| Shriver, Stephanie K. \| Tom, Jeffrey Y. K. \| Wells, James A. \| Cunningham, Brian C. Biochemistry, volume 37, issue 51, pages 17754-17764 (1998). 10.1021/bi981931e Cited by (191) \| Cite \| Source
Receptor-specific ligands distinguish natriuretic peptide receptors-A and -C in primate tissues. (journal article) Sehl, P \| Tom, J Y \| Oare, D \| Lowe, D G Molecular and cellular biochemistry, volume 178, issue 1-2 (1998). Cite