Carsten Schubert

ScholarGPS® ID: 59295599982142

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Life Sciences
Discipline
Biology and Biological Sciences
Top Specialties
Medicinal Chemistry | Chemical Synthesis | Colony-stimulating Factor
Metrics Summary
Publication Count
26
Predicted Citations
1,654
Predicted h-index
22
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy (journal article)
Lu, Tianbao | Schubert, Carsten | Cummings, Maxwell D. | Bignan, Gilles | Connolly, Peter J. | Smans, Karine | Ludovici, Donald | Parker, Michael H. | Meyer, Christophe | Rocaboy, Christian | ... | Meerpoel, Lieven
Bioorganic & Medicinal Chemistry Letters, volume 28, issue 12, pages 2159-2164 (2018).
10.1016/j.bmcl.2018.05.014
Cited by (27) | Cite | Source
Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors (journal article)
Illig, Carl R. | Manthey, Carl L. | Meegalla, Sanath K. | Wall, Mark J. | Chen, Jinsheng | Wilson, Kenneth J. | DesJarlais, Renee L. | Ballentine, Shelley K. | Schubert, Carsten | Crysler, Carl S. | ... | Tomczuk, Bruce E.
Bioorganic & Medicinal Chemistry Letters, volume 23, issue 23, pages 6363-6369 (2013).
10.1016/j.bmcl.2013.09.061
Cited by (3) | Cite | Source
Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano- N -[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1 H -imidazole-2-carboxamide (journal article)
Illig, Carl R. | Manthey, Carl L. | Wall, Mark J. | Meegalla, Sanath K. | Chen, Jinsheng | Wilson, Kenneth J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Schubert, Carsten | Crysler, Carl S. | ... | Tomczuk, Bruce E.
Journal of Medicinal Chemistry, volume 54, issue 22, pages 7860-7883 (2011).
10.1021/jm200900q
Cited by (32) | Cite | Source
Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors (journal article)
Wilson, Kenneth J. | Illig, Carl R. | Chen, Jinsheng | Wall, Mark J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Chen, Yanmin | Schubert, Carsten | Donatelli, Robert | Petrounia, Ioanna | ... | Meegalla, Sanath K.
Bioorganic & Medicinal Chemistry Letters, volume 20, issue 13, pages 3925-3929 (2010).
10.1016/j.bmcl.2010.05.013
Cited by (11) | Cite | Source
Combining Label‐free and Flourometric Functional Assays with Biophysical Binding Assays in Drug Discovery: A Comparison of Positives from an HTS Campaign (journal article)
Olson, Matthew Wayne | Kervinen, Jukka | Schubert, Carsten | Kirkpatrick, Jennifer | Kranz, James | Ma, Hongchung | Sun, Wenfeng | Lawson, Ed | DeCorte, Bart | Jordan, Alfonzo | ... | Todd, Matthew
The FASEB Journal, volume 23, issue S1 (2009).
10.1096/fasebj.23.1_supplement.LB303
Cite | Source
Pyrido[2,3- d ]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors (journal article)
Huang, Hui | Hutta, Daniel A. | Rinker, James M. | Hu, Huaping | Parsons, William H. | Schubert, Carsten | DesJarlais, Renee L. | Crysler, Carl S. | Chaikin, Margery A. | Donatelli, Robert R. | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 52, issue 4, pages 1081-1099 (2009).
10.1021/jm801406h
Cited by (40) | Cite | Source
Cyano-Substituted 2-Carboxyimidazoles: Synthesis of 4-Cyano-1-{[2-(tri­meth­ylsilyl)ethoxy]methyl}-1 H -imidazole-2-carboxylate Potassium Salt (journal article)
Wall, Mark | Schubert, Carsten | Illig, Carl
Synthesis, volume 2008, issue 21, pages 3377-3379 (2008).
10.1055/s-0028-1083173
Cited by (3) | Cite | Source
Structure-based optimization of a potent class of arylamide FMS inhibitors (journal article)
Meegalla, Sanath K. | Wall, Mark J. | Chen, Jinsheng | Wilson, Kenneth J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Schubert, Carsten | Crysler, Carl S. | Chen, Yanmin | Molloy, Christopher J. | ... | Illig, Carl R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 12, pages 3632-3637 (2008).
10.1016/j.bmcl.2008.04.059
Cited by (30) | Cite | Source
Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis (journal article)
Rosen, Mark D. | Hack, Michael D. | Allison, Brett D. | Phuong, Victor K. | Woods, Craig R. | Morton, Magda F. | Prendergast, Clodagh E. | Barrett, Terrance D. | Schubert, Carsten | Li, Lina
Bioorganic & Medicinal Chemistry, volume 16, issue 7, pages 3917-3925 (2008).
10.1016/j.bmc.2008.01.059
Cited by (9) | Cite | Source
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors (journal article)
Huang, Hui | Hutta, Daniel A. | Hu, Huaping | DesJarlais, Renee L. | Schubert, Carsten | Petrounia, Ioanna P. | Chaikin, Margery A. | Manthey, Carl L. | Player, Mark R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 7, pages 2355-2361 (2008).
10.1016/j.bmcl.2008.02.070
Cited by (46) | Cite | Source
Suzuki−Miyaura Approach to JNJ-26076713, an Orally Active Tetrahydroquinoline-Containing αV β3 /αV β5 Integrin Antagonist. Enantioselective Synthesis and Stereochemical Studies (journal article)
Kinney, William A. | Teleha, Christopher A. | Thompson, Andrew S. | Newport, Maria | Hansen, Ryan | Ballentine, Scott | Ghosh, Shyamali | Mahan, Andrew | Grasa, Gabriela | Zanotti-Gerosa, Antonio | ... | Maryanoff, Bruce E.
The Journal of Organic Chemistry, volume 73, issue 6, pages 2302-2310 (2008).
10.1021/jo702551t
Cited by (25) | Cite | Source
Discovery of novel FMS kinase inhibitors as anti-inflammatory agents (journal article)
Illig, Carl R. | Chen, Jinsheng | Wall, Mark J. | Wilson, Kenneth J. | Ballentine, Shelley K. | Rudolph, M. Jonathan | DesJarlais, Renee L. | Chen, Yanmin | Schubert, Carsten | Petrounia, Ioanna | ... | Meegalla, Sanath K.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 5, pages 1642-1648 (2008).
10.1016/j.bmcl.2008.01.059
Cited by (44) | Cite | Source
Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors (journal article)
Wall, Mark J. | Chen, Jinsheng | Meegalla, Sanath | Ballentine, Shelley K. | Wilson, Kenneth J. | DesJarlais, Renee L. | Schubert, Carsten | Chaikin, Margery A. | Crysler, Carl | Petrounia, Ioanna P. | ... | Illig, Carl R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 6, pages 2097-2102 (2008).
10.1016/j.bmcl.2008.01.088
Cited by (47) | Cite | Source
A Practical Synthesis of Enantiopure 7-Alkoxy-4-aryl-tetrahydroisoquinoline, a Dual Serotonin Reuptake Inhibitor/Histamine H3 Antagonist (journal article)
Deng, Xiaohu | Liang, Jimmy T. | Liu, Jing | McAllister, Heather | Schubert, Carsten | Mani, Neelakandha S.
Organic Process Research & Development, volume 11, issue 6, pages 1043-1050 (2007).
10.1021/op700183q
Cited by (20) | Cite | Source
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors (journal article)
Letavic, Michael A. | Keith, John M. | Jablonowski, Jill A. | Stocking, Emily M. | Gomez, Leslie A. | Ly, Kiev S. | Miller, Jennifer M. | Barbier, Ann J. | Bonaventure, Pascal | Boggs, Jamin D. | ... | Carruthers, Nicholas I.
Bioorganic & Medicinal Chemistry Letters, volume 17, issue 4, pages 1047-1051 (2007).
10.1016/j.bmcl.2006.11.036
Cited by (29) | Cite | Source
Protein Engineering of the Colony-stimulating Factor-1 Receptor Kinase Domain for Structural Studies (journal article)
Schalk-Hihi, Céline | Ma, Hong-Chang | Struble, Geoffrey T. | Bayoumy, Shariff | Williams, Robyn | Devine, Eric | Petrounia, Ioanna P. | Mezzasalma, Tara | Zeng, Lee | Schubert, Carsten | ... | Deckman, Ingrid C.
Journal of Biological Chemistry, volume 282, issue 6, pages 4085-4093 (2007).
10.1074/jbc.M608182200
Cited by (11) | Cite | Source | Open Access
Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors (journal article)
Schubert, Carsten | Schalk-Hihi, Céline | Struble, Geoffrey T. | Ma, Hong-Chang | Petrounia, Ioanna P. | Brandt, Benjamin | Deckman, Ingrid C. | Patch, Raymond J. | Player, Mark R. | Spurlino, John C. | Springer, Barry A.
Journal of Biological Chemistry, volume 282, issue 6, pages 4094-4101 (2007).
10.1074/jbc.M608183200
Cited by (57) | Cite | Source | Open Access
Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2 (journal article)
Sakurai, Kaori | Schubert, Carsten | Kahne, Daniel
Journal of the American Chemical Society, volume 128, issue 34, pages 11000-11001 (2006).
10.1021/ja063102j
Cited by (51) | Cite | Source
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists (journal article)
Marugan, Juan Jose | Leonard, Kristi | Raboisson, Pierre | Gushue, Joan M. | Calvo, Raul | Koblish, Holly K. | Lattanze, Jennifer | Zhao, Shuyuan | Cummings, Maxwell D. | Player, Mark R. | ... | Lu, Tianbao
Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3115-3120 (2006).
10.1016/j.bmcl.2006.03.067
Cited by (33) | Cite | Source
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design (journal article)
Parks, Daniel J. | LaFrance, Louis V. | Calvo, Raul R. | Milkiewicz, Karen L. | José Marugán, Juan | Raboisson, Pierre | Schubert, Carsten | Koblish, Holly K. | Zhao, Shuyuan | Franks, Carol F. | ... | Lu, Tianbao
Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3310-3314 (2006).
10.1016/j.bmcl.2006.03.055
Cited by (70) | Cite | Source