Raul R. Calvo

ScholarGPS® ID: 58392175910994

Affiliation
Janssen Pharmaceutica
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Peptide | Receptor Antagonist | Receptor Modulator
Metrics Summary
Publication Count
38
Predicted Citations
2,503
Predicted h-index
22
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Characterization of NCGC1360 and NCGC1366 as Highly-Selective D2 Dopamine Receptor Antagonists and Lead Candidates for the Treatment of Neuropsychiatric Disorders (conference)
Nilson, Ashley N. | Hanson, John N. | Poudel, Tej | Dulcey, Andres E. | Rodriguiz, Ramona M. | Lee, Kuo Hao | Free, R. Benjamin | Calvo, Raul R. | Shi, Lei | Wetsel, William C. | ... | Sibley, David R.
ASPET 2024 Annual Meeting Abstract (2024)
10.1124/jpet.475.903110
Cite | Source
Substituted aza-bicyclic imidazole derivatives useful TRPM8 receptor modulators (patent)
Player, Mark R. | Calvo, Raul | Chen, Jinsheng | Meegalla, Sanath | Parks, Daniel J. | Parsons, William J. | Ballentine, Scott | Branum, Shawn
Patent Number: 9718820 (2017)
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Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators (patent)
Player, Mark R. | Calvo, Raul | Chen, Jinsheng | Meegalla, Sanath | Parks, Daniel J. | Parsons, William J. | Ballentine, Scott | Branum, Shawn
Patent Number: 9409915 (2016)
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Benzo[ d ]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans -2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1 H -benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep) (journal article)
Parsons, William H. | Calvo, Raul R. | Cheung, Wing | Lee, Yu-Kai | Patel, Sharmila | Liu, Jian | Youngman, Mark A. | Dax, Scott L. | Stone, Dennis | Qin, Ning | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 58, issue 9, pages 3859-3874 (2015).
10.1021/acs.jmedchem.5b00132
Cited by (50) | Cite | Source
Substituted AZA-bicyclic imidazole derivatives useful as TRPM8 receptor modulators (patent)
Player, Mark R | Calvo, Raul | Chen, Jinsheng | Meegalla, Sanath | Parks, Daniel J. | Parsons, William J | Ballentine, Scott | Branum, Shawn
Patent Number: 9023846 (2015)
Cite | Source
Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators (patent)
Player, Mark R. | Calvo, Raul | Chen, Jinsheng | Meegalla, Sanath | Parks, Daniel | Parsons, William | Ballentine, Scott | Branum, Shawn
Patent Number: 8680098 (2014)
Cited by (1) | Cite | Source
Benzimidazole derivatives useful as TRP M8 receptor modulators (patent)
Calvo, Raul R. | Meegalla, Sanath K. | Player, Mark R.
Patent Number: 8217060 (2012)
Cited by (1) | Cite | Source
Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia (journal article)
Calvo, Raul R. | Meegalla, Sanath K. | Parks, Daniel J. | Parsons, William H. | Ballentine, Shelley K. | Lubin, Mary Lou | Schneider, Craig | Colburn, Raymond W. | Flores, Christopher M. | Player, Mark R.
Bioorganic & Medicinal Chemistry Letters, volume 22, issue 5, pages 1903-1907 (2012).
10.1016/j.bmcl.2012.01.060
Cited by (34) | Cite | Source
Benzimidazole modulators of VR1 (patent)
Player, Mark R. | Dax, Scott L. | Parsons, William H. | Brandt, Michael Richard | Calvo, Raul R. | Patel, Sharmila | Liu, Jian | Cheung, Wing S. | Jetter, Michele C. | Lee, Yu-Kai | ... | Beauchamp, Derek A.
Patent Number: 7951829 (2011)
Cited by (5) | Cite | Source
Discovery of piperidine carboxamide TRPV1 antagonists (journal article)
Cheung, Wing S. | Calvo, Raul R. | Tounge, Brett A. | Zhang, Sui-Po | Stone, Dennis R. | Brandt, Michael R. | Hutchinson, Tasha | Flores, Christopher M. | Player, Mark R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 16, pages 4569-4572 (2008).
10.1016/j.bmcl.2008.07.035
Cited by (18) | Cite | Source
Benzimidazole modulators of vr1 (patent)
Calvo, Raul R. | Player, Mark R. | Dax, Scott L. | Parsons, William H. | Brandt, Michael R. | Patel, Sharmila | Liu, Jian | Cheung, Wing S. | Jetter, Michele | Lee, Yu-Kai | ... | Beauchamp, Derek A.
Patent Number: 20110190344 (2007)
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Substituted 1,4-diazepines and uses thereof (patent)
Lu, Tianbao | Milkiewicz, Karen L. | Raboisson, Pierre | Cummings, Maxwell David | Calvo, Raul R. | Parks, Daniel J.
Patent Number: 7115598 (2006)
Cited by (2) | Cite | Source
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity (journal article)
Leonard, Kristi | Marugan, Juan Jose | Raboisson, Pierre | Calvo, Raul | Gushue, Joan M. | Koblish, Holly K. | Lattanze, Jennifer | Zhao, Shuyuan | Cummings, Maxwell D. | Player, Mark R. | ... | Lu, Tianbao
Bioorganic & Medicinal Chemistry Letters, volume 16, issue 13, pages 3463-3468 (2006).
10.1016/j.bmcl.2006.04.009
Cited by (57) | Cite | Source
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists (journal article)
Marugan, Juan Jose | Leonard, Kristi | Raboisson, Pierre | Gushue, Joan M. | Calvo, Raul | Koblish, Holly K. | Lattanze, Jennifer | Zhao, Shuyuan | Cummings, Maxwell D. | Player, Mark R. | ... | Lu, Tianbao
Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3115-3120 (2006).
10.1016/j.bmcl.2006.03.067
Cited by (33) | Cite | Source
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design (journal article)
Parks, Daniel J. | LaFrance, Louis V. | Calvo, Raul R. | Milkiewicz, Karen L. | José Marugán, Juan | Raboisson, Pierre | Schubert, Carsten | Koblish, Holly K. | Zhao, Shuyuan | Franks, Carol F. | ... | Lu, Tianbao
Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3310-3314 (2006).
10.1016/j.bmcl.2006.03.055
Cited by (70) | Cite | Source
Substituted 1,4‐Benzodiazepine‐2,5‐diones as α ‐Helix Mimetic Antagonists of the HDM2‐p53 Protein–Protein Interaction (journal article)
Cummings, Maxwell D. | Schubert, Carsten | Parks, Daniel J. | Calvo, Raul R. | LaFrance, Louis V. | Lattanze, Jennifer | Milkiewicz, Karen L. | Lu, Tianbao
Chemical Biology & Drug Design, volume 67, issue 3, pages 201-205 (2006).
10.1111/j.1747-0285.2006.00365.x
Cited by (43) | Cite | Source | Open Access
Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo (journal article)
Koblish, Holly K. | Zhao, Shuyuan | Franks, Carol F. | Donatelli, Robert R. | Tominovich, Rose M. | LaFrance, Louis V. | Leonard, Kristi A. | Gushue, Joan M. | Parks, Daniel J. | Calvo, Raul R. | ... | Maroney, Anna C.
Molecular Cancer Therapeutics, volume 5, issue 1, pages 160-169 (2006).
10.1158/1535-7163.MCT-05-0199
Cited by (145) | Cite | Source | Open Access
4-Piperidinecarboxamide modulators of vanilloid VR1 receptor (patent)
Calvo, Raul R. | Cheung, Wing | Player, Mark R.
Patent Number: 20060116368 (2005)
Cite | Source
1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR (journal article)
Parks, Daniel J. | LaFrance, Louis V. | Calvo, Raul R. | Milkiewicz, Karen L. | Gupta, Varsha | Lattanze, Jennifer | Ramachandren, Kannan | Carver, Theodore E. | Petrella, Eugene C. | Cummings, Maxwell D. | ... | Lu, Tianbao
Bioorganic & Medicinal Chemistry Letters, volume 15, issue 3, pages 765-770 (2005).
10.1016/j.bmcl.2004.11.009
Cited by (156) | Cite | Source
Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells (journal article)
Grasberger, Bruce L. | Lu, Tianbao | Schubert, Carsten | Parks, Daniel J. | Carver, Theodore E. | Koblish, Holly K. | Cummings, Maxwell D. | LaFrance, Louis V. | Milkiewicz, Karen L. | Calvo, Raul R. | ... | Bone, Roger F.
Journal of Medicinal Chemistry, volume 48, issue 4, pages 909-912 (2005).
10.1021/jm049137g
Cited by (393) | Cite | Source