Christopher Stubbs

ScholarGPS® ID: 58018227736465

Affiliation

AstraZeneca plc, Cambridge, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Polymer | Biomimetics | Chemical Synthesis | Cryopreservation

Metrics Summary

Publication Count

Predicted Citations

1,356

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Combining structural and coevolution information to unveil allosteric sites (journal article) La Sala, Giuseppina \| Pfleger, Christopher \| Käck, Helena \| Wissler, Lisa \| Nevin, Philip \| Böhm, Kerstin \| Janet, Jon Paul \| Schimpl, Marianne \| Stubbs, Christopher J. \| De Vivo, Marco \| ... \| Frolov, Andrey I. Chemical Science, volume 14, issue 25, pages 7057-7067 (2023). 10.1039/D2SC06272K Cited by (3) \| Cite \| Source
Ice nucleation in aqueous solutions of short- and long-chain poly(vinyl alcohol) studied with a droplet microfluidics setup (journal article) Eickhoff, Lukas \| Keßler, Mira \| Stubbs, Christopher \| Derksen, Jakob \| Viefhues, Martina \| Anselmetti, Dario \| Gibson, Matthew I. \| Hoge, Berthold \| Koop, Thomas The Journal of Chemical Physics, volume 158, issue 15, pages 154504- (2023). 10.1063/5.0136192 Cited by (6) \| Cite \| Source
Discovery of a selective c-MET inhibitor with a novel binding mode (journal article) Collie, Gavin W. \| Barlind, Louise \| Bazzaz, Sana \| Börjesson, Ulf \| Dale, Ian L. \| Disch, Jeremy S. \| Habeshian, Sevan \| Jetson, Rachael \| Khurana, Puneet \| Madin, Andrew \| ... \| Stubbs, Christopher J. Bioorganic & Medicinal Chemistry Letters, volume 75 (2022). 10.1016/j.bmcl.2022.128948 Cited by (5) \| Cite \| Source
Fragment screening at AstraZeneca: developing the next generation biophysics fragment set (journal article) Lucas, Simon C. C. \| Börjesson, Ulf \| Bostock, Mark J. \| Cuff, John \| Edfeldt, Fredrik \| Embrey, Kevin J. \| Eriksson, Per-Olof \| Gohlke, Andrea \| Gunnarson, Anders \| Lainchbury, Michael \| ... \| Storer, R. Ian RSC Medicinal Chemistry, volume 13, issue 9, pages 1052-1057 (2022). 10.1039/D2MD00154C Cited by (7) \| Cite \| Source
Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins (journal article) Malvezzi, Francesca \| Stubbs, Christopher J. \| Jowitt, Thomas A. \| Dale, Ian L. \| Guo, Xieyang \| DeGnore, Jon P. \| Degliesposti, Gianluca \| Skehel, J. Mark \| Bannister, Andrew J. \| McAlister, Mark S. Communications Biology, volume 4, issue 1 (2021). 10.1038/s42003-021-02750-6 Cited by (11) \| Cite \| Source
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR (journal article) Gunnarsson, Anders \| Stubbs, Christopher J. \| Rawlins, Philip B. \| Taylor-Newman, Eleanor \| Lee, Wei-chao \| Geschwindner, Stefan \| Hytönen, Vesa \| Holdgate, Geoffrey \| Jha, Rupam \| Dahl, Göran SLAS Discovery, volume 26, issue 5, pages 730-739 (2021). 10.1177/2472555220975358 Cited by (7) \| Cite \| Source
The atomistic details of the ice recrystallisation inhibition activity of PVA (journal article) Bachtiger, Fabienne \| Congdon, Thomas R. \| Stubbs, Christopher \| Gibson, Matthew I. \| Sosso, Gabriele C. Nature Communications, volume 12, issue 1 (2021). 10.1038/s41467-021-21717-z Cited by (75) \| Cite \| Source
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET (journal article) Collie, Gavin W. \| Michaelides, Iacovos N. \| Embrey, Kevin \| Stubbs, Christopher J. \| Börjesson, Ulf \| Dale, Ian L. \| Snijder, Arjan \| Barlind, Louise \| Song, Kun \| Khurana, Puneet \| ... \| Storer, R. Ian ACS Medicinal Chemistry Letters, volume 12, issue 1, pages 162-167 (2021). 10.1021/acsmedchemlett.0c00392 Cited by (14) \| Cite \| Source
Indirect Detection of Ligand Binding by Thermal Melt Analysis (book chapter) In Protein-Ligand Interactions Shaw, Joseph \| Stubbs, Christopher Springer US (2021) 10.1007/978-1-0716-1197-5_8 Cited by (1) \| Cite \| Source
Characterization of the Kinetic Mechanism of Human Protein Arginine Methyltransferase 5 (journal article) Eddershaw, Alice R. \| Stubbs, Christopher J. \| Edwardes, Lucy V. \| Underwood, Elizabeth \| Hamm, Gregory R. \| Davey, Paul R. J. \| Clarkson, Paul N. \| Syson, Karl Biochemistry, volume 59, issue 50, pages 4775-4786 (2020). 10.1021/acs.biochem.0c00554 Cited by (6) \| Cite \| Source
Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies (journal article) Lawson, Nicola L. \| Dix, Carly I. \| Scorer, Paul W. \| Stubbs, Christopher J. \| Wong, Edmond \| Hutchinson, Liam \| McCall, Eileen J. \| Schimpl, Marianne \| DeVries, Emma \| Walker, Jill \| ... \| Barker, Craig Modern Pathology, volume 33, issue 4, pages 518-530 (2020). 10.1038/s41379-019-0372-z Cited by (59) \| Cite \| Source
Combinatorial Biomaterials Discovery Strategy to Identify New Macromolecular Cryoprotectants (journal article) Stubbs, Christopher \| Murray, Kathryn A. \| Ishibe, Toru \| Mathers, Robert T. \| Gibson, Matthew I. ACS Macro Letters, volume 9, issue 2, pages 290-294 (2020). 10.1021/acsmacrolett.0c00044 Cited by (33) \| Cite \| Source
PCR-RAFT: rapid high throughput oxygen tolerant RAFT polymer synthesis in a biology laboratory (journal article) Gurnani, Pratik \| Floyd, Thomas \| Tanaka, Joji \| Stubbs, Christopher \| Lester, Daniel \| Sanchez-Cano, Carlos \| Perrier, Sébastien Polymer Chemistry, volume 11, issue 6, pages 1230-1236 (2020). 10.1039/C9PY01521C Cited by (21) \| Cite \| Source
Polyampholytes as Emerging Macromolecular Cryoprotectants (journal article) Stubbs, Christopher \| Bailey, Trisha L. \| Murray, Kathryn \| Gibson, Matthew I. Biomacromolecules, volume 21, issue 1, pages 7-17 (2020). 10.1021/acs.biomac.9b01053 Cited by (69) \| Cite \| Source
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes (journal article) Liu, Yang \| Bunney, Tom D. \| Khosa, Sakshi \| Macé, Kévin \| Beckenbauer, Katharina \| Askwith, Trevor \| Maslen, Sarah \| Stubbs, Christopher \| de Oliveira, Taiana M. \| Sader, Kasim \| ... \| Katan, Matilda EBioMedicine, volume 51 (2020). 10.1016/j.ebiom.2019.102607 Cited by (29) \| Cite \| Source
Cell Cryopreservation Using Bio-Inspired Polyampholytes (journal article) Murray, Kathryn \| Bailey, Trisha \| Stubbs, Christopher \| Gibson, Matthew Cryobiology, volume 91 (2019). 10.1016/j.cryobiol.2019.10.106 Cite \| Source
High-Throughput Tertiary Amine Deoxygenated Photopolymerizations for Synthesizing Polymer Libraries (journal article) Stubbs, Christopher \| Congdon, Thomas \| Davis, Jessica \| Lester, Daniel \| Richards, Sarah-Jane \| Gibson, Matthew I. Macromolecules, volume 52, issue 20, pages 7603-7612 (2019). 10.1021/acs.macromol.9b01714 Cited by (33) \| Cite \| Source
Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors (journal article) Collie, Gavin W. \| Koh, Cheryl M. \| O’Neill, Daniel J. \| Stubbs, Christopher J. \| Khurana, Puneet \| Eddershaw, Alice \| Snijder, Arjan \| Mauritzson, Fredrik \| Barlind, Louise \| Dale, Ian L. \| ... \| Narvaez, Ana J. ACS Medicinal Chemistry Letters, volume 10, issue 9, pages 1322-1327 (2019). 10.1021/acsmedchemlett.9b00276 Cited by (34) \| Cite \| Source
Enhancement of Macromolecular Ice Recrystallization Inhibition Activity by Exploiting Depletion Forces (journal article) Ishibe, Toru \| Congdon, Thomas \| Stubbs, Christopher \| Hasan, Muhammad \| Sosso, Gabriele C. \| Gibson, Matthew I. ACS Macro Letters, volume 8, issue 8, pages 1063-1067 (2019). 10.1021/acsmacrolett.9b00386 Cited by (18) \| Cite \| Source
Synthetically Scalable Poly(ampholyte) Which Dramatically Enhances Cellular Cryopreservation (journal article) Bailey, Trisha L. \| Stubbs, Christopher \| Murray, Kathryn \| Tomás, Ruben M. F. \| Otten, Lucienne \| Gibson, Matthew I. Biomacromolecules, volume 20, issue 8, pages 3104-3114 (2019). 10.1021/acs.biomac.9b00681 Cited by (41) \| Cite \| Source