Robert T. Sauer

ScholarGPS® ID: 57586442460305

Affiliation
Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
Affiliation History

Field
Life Sciences
Discipline
Biology and Biological Sciences
Top Specialties
DNA | Proteolysis | Protein Folding | Structural Biology | Biophysics | Chromosomal Translocation | Escherichia Coli | Mutation | Peptide | Bacteria | Mutagenesis | Chemical Biology | DNA Profiling | Protein | Single-molecule Experiment
Metrics Summary
Publication Count
375
Predicted Citations
44,170
Predicted h-index
112
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation (journal article)
Ghanbarpour, Alireza | Cohen, Steven E. | Fei, Xue | Kinman, Laurel F. | Bell, Tristan A. | Zhang, Jia Jia | Baker, Tania A. | Davis, Joseph H. | Sauer, Robert T.
Nature Communications, volume 14, issue 1 (2023).
10.1038/s41467-023-43145-x
Cited by (1) | Cite | Source
Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro (journal article)
Schmitz, Karl R. | Handy, Emma L. | Compton, Corey L. | Gupta, Shashank | Bishai, William R. | Sauer, Robert T. | Sello, Jason K.
ACS Chemical Biology, volume 18, issue 4, pages 724-733 (2023).
10.1021/acschembio.9b00454
Cited by (5) | Cite | Source
The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery (journal article)
Ghanbarpour, Alireza | Fei, Xue | Baker, Tania A. | Davis, Joseph H. | Sauer, Robert T.
Proceedings of the National Academy of Sciences, volume 120, issue 6 (2023).
10.1073/pnas.2219044120
Cited by (3) | Cite | Source
Lon protease degrades stable substrates slowly but with enhanced processivity, redefining the model of a strong and robust AAA+ protease (journal article)
Kasal, Meghann | Chandra Kotamarthi, Hema | Johnson, Madeline M. | Stephens, Hannah | Lang, Matthew J. | Sauer, Robert T. | Baker, Tania
Biophysical Journal, volume 122, issue 3, pages 319a-320a (2023).
10.1016/j.bpj.2022.11.1791
Cite | Source
FtsH degrades kinetically stable dimers of cyclopropane fatty acid synthase via an internal degron (journal article)
Hari, Sanjay B. | Morehouse, Juhee P. | Baker, Tania A. | Sauer, Robert T.
Molecular Microbiology, volume 119, issue 1, pages 101-111 (2023).
10.1111/mmi.15009
Cited by (1) | Cite | Source
AAA+ protease-adaptor structures reveal altered conformations and ring specialization (journal article)
Kim, Sora | Fei, Xue | Sauer, Robert T. | Baker, Tania A.
Nature Structural & Molecular Biology, volume 29, issue 11, pages 1068-1079 (2022).
10.1038/s41594-022-00850-3
Cited by (9) | Cite | Source
FtsH degrades dihydrofolate reductase by recognizing a partially folded species (journal article)
Morehouse, Juhee P. | Baker, Tania A. | Sauer, Robert T.
Protein Science, volume 31, issue 9 (2022).
10.1002/pro.4410
Cited by (2) | Cite | Source
Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis (journal article)
Sauer, Robert T. | Fei, Xue | Bell, Tristan A. | Baker, Tania A.
Critical Reviews in Biochemistry and Molecular Biology, volume 57, issue 2, pages 188-204 (2022).
10.1080/10409238.2021.1979461
Cited by (15) | Cite | Source
Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease (journal article)
Zuromski, Kristin L. | Kim, Sora | Sauer, Robert T. | Baker, Tania A.
Journal of Biological Chemistry, volume 297, issue 6, pages 101407- (2021).
10.1016/j.jbc.2021.101407
Cited by (1) | Cite | Source
ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa (journal article)
Mawla, Gina D. | Hall, Branwen M. | Cárcamo‐Oyarce, Gerardo | Grant, Robert A. | Zhang, Jia Jia | Kardon, Julia R. | Ribbeck, Katharina | Sauer, Robert T. | Baker, Tania A.
Molecular Microbiology, volume 115, issue 6, pages 1094-1109 (2021).
10.1111/mmi.14649
Cited by (14) | Cite | Source
ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP (journal article)
Kim, Sora | Zuromski, Kristin L | Bell, Tristan A | Sauer, Robert T | Baker, Tania A
eLife, volume 9 (2020).
10.7554/eLife.61451
Cited by (8) | Cite | Source
Multistep substrate binding and engagement by the AAA+ ClpXP protease (journal article)
Saunders, Reuben A. | Stinson, Benjamin M. | Baker, Tania A. | Sauer, Robert T.
Proceedings of the National Academy of Sciences, volume 117, issue 45, pages 28005-28013 (2020).
10.1073/pnas.2010804117
Cited by (16) | Cite | Source
Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates (journal article)
Fei, Xue | Bell, Tristan A | Barkow, Sarah R | Baker, Tania A | Sauer, Robert T
eLife, volume 9 (2020).
10.7554/eLife.61496
Cited by (40) | Cite | Source
Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease (journal article)
Zuromski, Kristin L. | Sauer, Robert T. | Baker, Tania A.
Proceedings of the National Academy of Sciences, volume 117, issue 41, pages 25455-25463 (2020).
10.1073/pnas.2014407117
Cited by (9) | Cite | Source
The Intrinsically Disordered N-terminal Extension of the ClpS Adaptor Reprograms Its Partner AAA + ClpAP Protease (journal article)
Torres-Delgado, Amaris | Kotamarthi, Hema Chandra | Sauer, Robert T. | Baker, Tania A.
Journal of Molecular Biology, volume 432, issue 17, pages 4908-4921 (2020).
10.1016/j.jmb.2020.07.007
Cited by (6) | Cite | Source
Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate (journal article)
Fei, Xue | Bell, Tristan A | Jenni, Simon | Stinson, Benjamin M | Baker, Tania A | Harrison, Stephen C | Sauer, Robert T
eLife, volume 9 (2020).
10.7554/eLife.52774
Cited by (35) | Cite | Source
The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation (journal article)
Kotamarthi, Hema Chandra | Sauer, Robert T. | Baker, Tania A.
Cell Reports, volume 30, issue 8, pages 2644-2654.e3 (2020).
10.1016/j.celrep.2020.01.110
Cited by (18) | Cite | Source
Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding (journal article)
Bell, Tristan A | Baker, Tania A | Sauer, Robert T
eLife, volume 8 (2019).
10.7554/eLife.46808
Cited by (12) | Cite | Source
Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation (journal article)
Amor, Alvaro J. | Schmitz, Karl R. | Baker, Tania A. | Sauer, Robert T.
Protein Science, volume 28, issue 4, pages 756-765 (2019).
10.1002/pro.3590
Cited by (22) | Cite | Source
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites (journal article)
Tang, Yong | Meister, Thomas R. | Walczak, Marta | Pulkoski-Gross, Michael J. | Hari, Sanjay B. | Sauer, Robert T. | Amberg-Johnson, Katherine | Yeh, Ellen
PLOS Biology, volume 17, issue 2, pages e3000136- (2019).
10.1371/journal.pbio.3000136
Cited by (32) | Cite | Source