Gary W. Caldwell

ScholarGPS® ID: 57550943046808

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Mass Spectrometry | Drug Discovery | Metabolism | Chromatography | Mathematical Optimization | Drug Metabolism | Pharmacokinetics | Liquid Chromatography–mass Spectrometry
Metrics Summary
Publication Count
79
Predicted Citations
2,041
Predicted h-index
26
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Simultaneously Assessing Concentration Changes in 20 Biochemical Pathways as a Result of Drug Dosing and Cytochrome P450 and Non-cytochrome P450-Mediated Metabolism: An Untargeted Metabolomics GC/MS Assay (book chapter)
In Cytochrome P450
Lin, Yanping | Li, Ying | Caldwell, Gary W.
Springer US (2021)
10.1007/978-1-0716-1542-3_20
Cite | Source
Simultaneously Assessing Concentration Changes in 17 Biochemical Pathways as a Result of Drug Dosing and Cytochrome P450 and Non-cytochrome P450-Mediated Metabolism: A Quasi-Untargeted Metabolomics LC/MS Assay (book chapter)
In Cytochrome P450
Masucci, John A. | Liang, Feng | Bingol, Kerem | Windisch, Vince | Caldwell, Gary W.
Springer US (2021)
10.1007/978-1-0716-1542-3_21
Cite | Source
Assessing Amino Acid Concentration Changes as a Result of Drug Dosing and Cytochrome P450 and Non-cytochrome P450-Mediated Metabolism (book chapter)
In Cytochrome P450
Bingol, Kerem | Masucci, John A. | Caldwell, Gary W.
Springer US (2021)
10.1007/978-1-0716-1542-3_22
Cite | Source
Inter-laboratory reproducibility of an untargeted metabolomics GC–MS assay for analysis of human plasma (journal article)
Lin, Yanping | Caldwell, Gary W. | Li, Ying | Lang, Wensheng | Masucci, John
Scientific Reports, volume 10, issue 1 (2020).
10.1038/s41598-020-67939-x
Cited by (22) | Cite | Source
An In Vivo Rat α-D-glucose Stable Isotope Homeostasis Drug Discovery Screen: A Targeted Metabolomics Approach (journal article)
Caldwell, Gary W. | Lang, Wensheng
Current Topics in Medicinal Chemistry, volume 17, issue 24 (2017).
10.2174/1568026617666170707130401
Cite | Source
Can Untargeted Metabolomics Be Utilized in Drug Discovery/Development? (journal article)
Caldwell, Gary W. | Leo, Gregory C.
Current Topics in Medicinal Chemistry, volume 17, issue 24 (2017).
10.2174/1568026617666170707130032
Cited by (16) | Cite | Source
Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo (journal article)
Qi, Jenson | Lang, Wensheng | Connelly, Margery A. | Du, Fuyong | Liang, Yin | Caldwell, Gary W. | Martin, Tonya | Hansen, Michael K. | Kuo, Gee-Hong | Gaul, Michael D. | ... | Lee, Seunghun
Analytical Biochemistry, volume 524 (2017).
10.1016/j.ab.2016.09.017
Cited by (2) | Cite | Source
Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors (journal article)
Qi, Jenson | Masucci, John A. | Lang, Wensheng | Connelly, Margery A. | Caldwell, Gary W. | Petrounia, Ioanna | Kirkpatrick, Jennifer | Barnakov, Alexander N. | Struble, Geoffrey | Miller, Robyn | ... | Lee, Seunghun
SLAS Discovery, volume 22, issue 4, pages 433-439 (2017).
10.1177/2472555217690101
Cited by (2) | Cite | Source
ADME Optimization and Toxicity Assessment in Drug Discovery (book chapter)
In Frontiers in Medicinal Chemistry
Caldwell, Gary W.
BENTHAM SCIENCE PUBLISHERS (2016)
10.2174/9781681081755116080003
Cited by (7) | Cite | Source | Open Access
In silico tools used for compound selection during target-based drug discovery and development (journal article)
Caldwell, Gary W
Expert Opinion on Drug Discovery, volume 10, issue 8, pages 901-923 (2015).
10.1517/17460441.2015.1043885
Cited by (17) | Cite | Source
Profiling Rat Brain Monoacylglycerol Lipase Activity Using an Ammonia- Adduct Enhanced Selected Ion Monitoring Liquid-Chromatography Positive Electrospray Ionization Mass Spectrometry Assay (journal article)
Caldwell, Gary W | Lang, Wensheng
Pharmaceutica Analytica Acta, volume 07, issue 03 (2015).
10.4172/2153-2435.1000470
Cite | Source | Open Access
Rapidly Distinguishing Reversible and Time-Dependent CYP450 Inhibition Using Human Liver Microsomes, Co-incubation, and Continuous Fluorometric Kinetic Analyses (book chapter)
In Optimization in Drug Discovery
Caldwell, Gary W. | Yan, Zhengyin
Humana Press (2014)
10.1007/978-1-62703-742-6_17
Cited by (5) | Cite | Source
Drug, Lipid, and Acylcarnitine Profiling Using Dried Blood Spot (DBS) Technology in Drug Discovery (book chapter)
In Optimization in Drug Discovery
Lang, Wensheng | Qi, Jenson | Caldwell, Gary W.
Humana Press (2014)
10.1007/978-1-62703-742-6_27
Cited by (3) | Cite | Source
Small Molecule Formulation Screening Strategies in Drug Discovery (book chapter)
In Optimization in Drug Discovery
Caldwell, Gary W. | Hasting, Becki | Masucci, John A. | Yan, Zhengyin
Humana Press (2014)
10.1007/978-1-62703-742-6_1
Cite | Source
Metabolic Assessment in Alamethicin-Activated Liver Microsomes: Co-activating CYPs and UGTs (book chapter)
In Optimization in Drug Discovery
Caldwell, Gary W. | Yan, Zhengyin
Humana Press (2014)
10.1007/978-1-62703-742-6_7
Cited by (2) | Cite | Source
In Vitro Trapping and Screening of Reactive Metabolites Using Liquid Chromatography-Mass Spectrometry (book chapter)
In Optimization in Drug Discovery
Yan, Zhengyin | Caldwell, Gary W.
Humana Press (2014)
10.1007/978-1-62703-742-6_28
Cited by (2) | Cite | Source
CYP Time-Dependent Inhibition (TDI) Using an IC50 Shift Assay with Stable Isotopic Labeled Substrate Probes to Facilitate Liquid Chromatography/Mass Spectrometry Analyses (book chapter)
In Optimization in Drug Discovery
Caldwell, Gary W. | Yan, Zhengyin
Humana Press (2014)
10.1007/978-1-62703-742-6_19
Cited by (1) | Cite | Source
Permeability Assessment Using 5-day Cultured Caco-2 Cell Monolayers (book chapter)
In Optimization in Drug Discovery
Caldwell, Gary W. | Ferguson, Chrissa | Buerger, Robyn | Kulp, Lovonia | Yan, Zhengyin
Humana Press (2014)
10.1007/978-1-62703-742-6_4
Cited by (2) | Cite | Source
General Guidelines for Setting Up an In Vitro LC/MS/MS Assay (book chapter)
In Optimization in Drug Discovery
Masucci, John A. | Caldwell, Gary W.
Humana Press (2014)
10.1007/978-1-62703-742-6_25
Cite | Source
In Vitro Identification of Cytochrome P450 Enzymes Responsible for Drug Metabolism (book chapter)
In Pharmacogenomics
Yan, Zhengyin | Caldwell, Gary W.
Humana Press (2013)
10.1007/978-1-62703-435-7_16
Cited by (7) | Cite | Source