David J. Weber

ScholarGPS® ID: 57524147820658

Affiliation
University of Maryland School of Medicine, Baltimore, United States
Affiliation History

Field
Life Sciences
Discipline
Biochemistry
Top Specialties
Peptide | Binding Protein | Calcium-binding Protein | Melanoma | Toxin | Cancer | Medicinal Chemistry | Biophysics | Spectroscopy | X-ray | X-ray Crystallography | Crystallography | Structural Biology | Structure Function | Crystal Structure
Metrics Summary
Publication Count
144
Predicted Citations
7,089
Predicted h-index
50
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Deuterium spin relaxation of fractionally deuterated ribonuclease H using paired 475 and 950 MHz NMR spectrometers (journal article)
Bhattacharya, Shibani | Varney, Kristen M. | Dahmane, Tassadite | Johnson, Bruce A. | Weber, David J. | Palmer, Arthur G.
Journal of Biomolecular NMR (2024).
10.1007/s10858-024-00443-w
Cited by (2) | Cite | Source
Deciphering S100B Allosteric Signaling: The Role of a Peptide Target, TRTK-12, as an Ensemble Modulator (journal article)
Samanta, Riya | Zhuang, Xinhao | Varney, Kristen M. | Weber, David J. | Matysiak, Silvina
Journal of Chemical Information and Modeling, volume 64, issue 8, pages 3477-3487 (2024).
10.1021/acs.jcim.4c00116
Cite | Source
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation (journal article)
Lee, Young S. | Cheng, I-Ting | Raquel, Godoy-Ruiz | Weber, David J. | Scalea, Joseph R.
Innate Immunity, volume 29, issue 7, pages 150-158 (2023).
10.1177/17534259231186239
Cite | Source
Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model (journal article)
Thankan, Retheesh S. | Thomas, Elizabeth | Purushottamachar, Puranik | Weber, David J. | Njar, Vincent C.O.
Bioorganic Chemistry, volume 139 (2023).
10.1016/j.bioorg.2023.106700
Cited by (2) | Cite | Source
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2 (journal article)
Thankan, Retheesh S. | Thomas, Elizabeth | Purushottamachar, Puranik | Weber, David J. | Ramamurthy, Vidya P. | Huang, Weiliang | Kane, Maureen A. | Njar, Vincent C. O.
Frontiers in Oncology, volume 13 (2023).
10.3389/fonc.2023.1240996
Cited by (1) | Cite | Source
Transglutaminase 2 Binds to the CD44v6 Cytoplasmic Domain to Stimulate CD44v6/ERK1/2 Signaling and Maintain an Aggressive Cancer Phenotype (journal article)
Chen, Xi | Adhikary, Gautam | Newland, John J. | Xu, Wen | Keillor, Jeffrey W. | Weber, David J. | Eckert, Richard L.
Molecular Cancer Research, volume 21, issue 9, pages 922-932 (2023).
10.1158/1541-7786.MCR-23-0051
Cited by (1) | Cite | Source
1H, 13C, and 15N assignments of the mRNA binding protein hnRNP A18 (journal article)
Coburn, Katherine M. | Roth, Braden | Varney, Kristen M. | Carrier, France | Weber, David J.
Biomolecular NMR Assignments, volume 17, issue 1, pages 37-41 (2023).
10.1007/s12104-022-10117-z
Cited by (3) | Cite | Source
Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity (journal article)
Karade, Sharanbasappa S. | Franco, Evelyn J. | Rojas, Ana C. | Hanrahan, Kaley C. | Kolesnikov, Alexander | Yu, Wenbo | MacKerell, Alexander D. | Hill, Daniel C. | Weber, David J. | Brown, Ashley N. | ... | Mariuzza, Roy A.
Journal of Medicinal Chemistry, volume 66, issue 4, pages 2744-2760 (2023).
10.1021/acs.jmedchem.2c01750
Cited by (7) | Cite | Source
Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation (journal article)
Thomas, Elizabeth | Thankan, Retheesh S. | Purushottamachar, Puranik | Weber, David J. | Njar, Vincent C. O.
Cancers, volume 15, issue 4, pages 1198- (2023).
10.3390/cancers15041198
Cited by (5) | Cite | Source
Binding and Functional Folding (BFF): A Physiological Framework for Studying Biomolecular Interactions and Allostery (journal article)
Young, Brianna D. | Cook, Mary E. | Costabile, Brianna K. | Samanta, Riya | Zhuang, Xinhao | Sevdalis, Spiridon E. | Varney, Kristen M. | Mancia, Filippo | Matysiak, Silvina | Lattman, Eaton | Weber, David J.
Journal of Molecular Biology, volume 434, issue 23, pages 167872- (2022).
10.1016/j.jmb.2022.167872
Cited by (3) | Cite | Source
Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models (journal article)
Thomas, Elizabeth | Thankan, Retheesh S. | Purushottamachar, Puranik | Huang, Weiliang | Kane, Maureen A. | Zhang, Yuji | Ambulos, Nicholas P. | Weber, David J. | Njar, Vincent C. O.
Cells, volume 11, issue 17, pages 2699- (2022).
10.3390/cells11172699
Cited by (8) | Cite | Source
Transcriptome profiling reveals that VNPP433‐3β, the lead next‐generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial–mesenchymal transition and stem cell markers (journal article)
Thomas, Elizabeth | Thankan, Retheesh S. | Purushottamachar, Puranik | Huang, Weiliang | Kane, Maureen A. | Zhang, Yuji | Ambulos, Nicholas | Weber, David J. | Njar, Vincent C. O.
Molecular Carcinogenesis, volume 61, issue 7, pages 643-654 (2022).
10.1002/mc.23406
Cited by (25) | Cite | Source
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity (journal article)
Rorke, Ellen A. | Adhikary, Gautam | Szmacinski, Henryk | Lakowicz, Joseph R. | Weber, David J. | Godoy‐Ruiz, Raquel | Puranik, Purushottamachar | Keillor, Jeffrey W. | Gates, Eric W. J. | Eckert, Richard L.
Molecular Carcinogenesis, volume 61, issue 1, pages 19-32 (2022).
10.1002/mc.23356
Cited by (12) | Cite | Source
Nano-Assembly of Quisinostat and Biodegradable Macromolecular Carrier Results in Supramolecular Complexes with Slow-Release Capabilities (journal article)
Chowdhury, Ananda | Marin, Alexander | Weber, David J. | Andrianov, Alexander K.
Pharmaceutics, volume 13, issue 11, pages 1834- (2021).
10.3390/pharmaceutics13111834
Cited by (3) | Cite | Source
Physiologically Relevant Free Ca2+ Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6 (journal article)
Young, Brianna D. | Varney, Kristen M. | Wilder, Paul T. | Costabile, Brianna K. | Pozharski, Edwin | Cook, Mary E. | Godoy-Ruiz, Raquel | Clarke, Oliver B. | Mancia, Filippo | Weber, David J.
Journal of Molecular Biology, volume 433, issue 22, pages 167272- (2021).
10.1016/j.jmb.2021.167272
Cited by (4) | Cite | Source
1HN, 13C, and 15N backbone resonance assignments of the SET/TAF-1β/I2PP2A oncoprotein (residues 23–225) (journal article)
Roth, Braden M. | DePalma, Ryan M. | Cook, Mary E. | Varney, Kristen M. | Weber, David J. | Ogretmen, Besim
Biomolecular NMR Assignments, volume 15, issue 2, pages 383-387 (2021).
10.1007/s12104-021-10034-7
Cited by (1) | Cite | Source
The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling (journal article)
Alasady, Milad J. | Terry, Alexander R. | Pierce, Adam D. | Cavalier, Michael C. | Blaha, Catherine S. | Adipietro, Kaylin A. | Wilder, Paul T. | Weber, David J. | Hay, Nissim
PLOS ONE, volume 16, issue 8, pages e0256238- (2021).
10.1371/journal.pone.0256238
Cited by (2) | Cite | Source
Structural Fine‐Tuning of Binary Toxin Components for Therapeutic Applications (journal article)
Abeyawardhane, Dinendra | Adipietro, Kaylin | Godoy‐Ruiz, Raquel | Varney, Kristen | Pozharski, Edwin | Weber, David
The FASEB Journal, volume 35, issue S1 (2021).
10.1096/fasebj.2021.35.S1.04607
Cite | Source
1HN, 13C, and 15N resonance assignments of the Clostridioides difficile receptor binding domain 2 (CDTb, residues 757–876) (journal article)
Cook, Mary E. | Varney, Kristen M. | Godoy-Ruiz, Raquel | Weber, David J.
Biomolecular NMR Assignments, volume 15, issue 1, pages 35-39 (2021).
10.1007/s12104-020-09979-y
Cite | Source
Engineering subtilisin proteases that specifically degrade active RAS (journal article)
Chen, Yingwei | Toth, Eric A. | Ruan, Biao | Choi, Eun Jung | Simmerman, Richard | Chen, Yihong | He, Yanan | Wang, Ruixue | Godoy-Ruiz, Raquel | King, Harlan | ... | Bryan, Philip N.
Communications Biology, volume 4, issue 1 (2021).
10.1038/s42003-021-01818-7
Cited by (10) | Cite | Source