Carl L. Manthey

ScholarGPS® ID: 57299788328818

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Protein Kinase Inhibitor | Macrophage | Arthritis
Metrics Summary
Publication Count
40
Predicted Citations
1,936
Predicted h-index
25
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
You must register and claim your profile to add or remove publications from it.
... publications
FILTER BY:
Year
Type
Specialty
Affiliations
Access
Co-Authors
Add
Delete
The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis (journal article)
Manthey, Carl L. | Moore, Beverley A. | Chen, Yanqing | Loza, Matthew J. | Yao, Xiang | Liu, Hao | Belkowski, Stanley M. | Raymond-Parks, Holly | Dunford, Paul J. | Leon, Francisco | ... | Plevy, Scott E.
PLOS ONE, volume 14, issue 11, pages e0223918- (2019).
10.1371/journal.pone.0223918
Cited by (13) | Cite | Source
Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy (journal article)
Genovese, Mark C. | Hsia, Elizabeth | Belkowski, Stanley M. | Chien, Caly | Masterson, Tara | Thurmond, Robin L. | Manthey, Carl L. | Yan, Xiaoyu (David) | Ge, Tingting | Franks, Carol | Greenspan, Andrew
The Journal of Rheumatology, volume 42, issue 10, pages 1752-1760 (2015).
10.3899/jrheum.141580
Cited by (47) | Cite | Source | Open Access
Targeting c-fms Kinase Attenuates Aristolochic Acid Nephropathy in Mice (journal article)
Dai, X.Y. | Huang, X.R. | Fu, P. | Zhou, L. | Manthey, C. | Nikolic-Paterson, D.J. | Lan, H.Y.
Hong Kong Journal of Nephrology, volume 17, issue 2, pages S60- (2015).
10.1016/j.hkjn.2015.09.007
Cite | Source | Open Access
Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Crysler, Carl | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | ... | Wang, Aihua
Patent Number: 8883473 (2014)
Cited by (3) | Cite | Source
THU0133 Results from A Phase 2A, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group Study of Jnj-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-Modifying Antirheumatic Drug Therapy (journal article)
Genovese, M.C. | Hsia, E. | Belkowski, S. | Chien, C. | Masterson, T. | Thurmond, R. | Manthey, C. | Yan, D. | Ge, T. | Greenspan, A.
Annals of the Rheumatic Diseases, volume 73, issue Suppl 2, pages 224.3-225 (2014).
10.1136/annrheumdis-2014-eular.2404
Cite | Source
Tu2027 Treatment with the CSF-1 Receptor kinase (CSF-1R) Inhibitor JNJ40346527 Suppresses Murine Colitis (journal article)
Moore, Beverley | Liu, Hao | Loza, Matthew | Raymond, Holly A. | Belkowski, Stanley M. | Manthey, Carl
Gastroenterology, volume 146, issue 5, pages S-900-S-901 (2014).
10.1016/S0016-5085(14)63274-1
Cited by (1) | Cite | Source
Method of inhibiting C-KIT kinase (patent)
Illig, Carl R. | Balltentine, Shelley K. | Chen, Jinsheng | Meegalla, Sanath K. | Rudolph, M. Jonathan | Wall, Mark J. | Wilson, Kenneth J. | DesJarlais, Renee L. | Manthey, Carl L. | Molloy, Christopher J.
Patent Number: 8697716 (2014)
Cite | Source
Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors (journal article)
Illig, Carl R. | Manthey, Carl L. | Meegalla, Sanath K. | Wall, Mark J. | Chen, Jinsheng | Wilson, Kenneth J. | DesJarlais, Renee L. | Ballentine, Shelley K. | Schubert, Carsten | Crysler, Carl S. | ... | Tomczuk, Bruce E.
Bioorganic & Medicinal Chemistry Letters, volume 23, issue 23, pages 6363-6369 (2013).
10.1016/j.bmcl.2013.09.061
Cited by (3) | Cite | Source
THU0085 Effect of CSF-1R Kinase Inhibitor on FDG PET, MMP Optical, and Microct Imaging in a Rat SCW Model of Rheumatoid Arthritis: Use of Functional and Structural Imaging as Translation Tools (journal article)
de Garavilla, L. | Manthey, C. | Yurkow, E. | Zhou, Z. | Cotto, C. | Meegalla, S. | Wilson, K. | Wall, M. | Chen, J. | Ballentine, S. | ... | Acton, P.
Annals of the Rheumatic Diseases, volume 72, issue Suppl 3, pages A191.4-A192 (2013).
10.1136/annrheumdis-2013-eular.613
Cite | Source
Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis (journal article)
Han, Yingjie | Ma, Frank Y. | Tesch, Greg H. | Manthey, Carl L. | Nikolic-Paterson, David J.
American Journal of Physiology-Renal Physiology, volume 304, issue 8, pages F1043-F1053 (2013).
10.1152/ajprenal.00389.2012
Cited by (63) | Cite | Source | Open Access
METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION (patent)
Jackson, Paul Francis | Manthey, Carl | Rhodes, Kenneth | Scannevin, Robert | Leonard, Kristi Anne | Barbay, Joseph Kent | Todd, Matthew | Springer, Barry A.
Patent Number: 20120302573 (2012)
Cite | Source
Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano- N -[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1 H -imidazole-2-carboxamide (journal article)
Illig, Carl R. | Manthey, Carl L. | Wall, Mark J. | Meegalla, Sanath K. | Chen, Jinsheng | Wilson, Kenneth J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Schubert, Carsten | Crysler, Carl S. | ... | Tomczuk, Bruce E.
Journal of Medicinal Chemistry, volume 54, issue 22, pages 7860-7883 (2011).
10.1021/jm200900q
Cited by (32) | Cite | Source
Matrix Metalloproteinase-9 Inhibition Reduces Inflammation and Improves Motility in Murine Models of Postoperative Ileus (journal article)
Moore, Beverley A. | Manthey, Carl L. | Johnson, Dana L. | Bauer, Anthony J.
Gastroenterology, volume 141, issue 4, pages 1283-1292.e4 (2011).
10.1053/j.gastro.2011.06.035
Cited by (46) | Cite | Source | Open Access
c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat (journal article)
Han, Yingjie | Ma, Frank Y | Tesch, Greg H | Manthey, Carl L | Nikolic-Paterson, David J
Laboratory Investigation, volume 91, issue 7, pages 978-991 (2011).
10.1038/labinvest.2011.61
Cited by (56) | Cite | Source | Open Access
Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors (journal article)
Wilson, Kenneth J. | Illig, Carl R. | Chen, Jinsheng | Wall, Mark J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Chen, Yanmin | Schubert, Carsten | Donatelli, Robert | Petrounia, Ioanna | ... | Meegalla, Sanath K.
Bioorganic & Medicinal Chemistry Letters, volume 20, issue 13, pages 3925-3929 (2010).
10.1016/j.bmcl.2010.05.013
Cited by (11) | Cite | Source
Class of arylamide compounds useful as inhibitors of c-fms kinase (patent)
Illig, Carl R. | Ballentine, Shelley K. | Chen, Jinsheng | Meegalla, Sanath | Rudolph, Jonathan | Wall, Mark J. | Wilson, Kenneth J. | DesJarlais, Renee | Manthey, Carl L. | Flores, Christopher M. | Molloy, Christopher J.
Patent Number: 7705042 (2010)
Cited by (4) | Cite | Source
Inhibitors of c-fms kinase (patent)
Illig, Carl R. | Ballentine, Shelley K. | Chen, Jinsheng | Meegalla, Sanath K. | Rudolph, M. Jonathan | Wall, Mark J. | Wilson, Kenneth J. | Desjarlais, Renee L. | Manthey, Carl L. | Flores, Christopher | Molloy, Christopher J.
Patent Number: 7662837 (2010)
Cited by (19) | Cite | Source
Inhibitors of c-fms kinase (patent)
Illig, Carl R. | Ballentine, Shelley K. | Chen, Jinsheng | Meegalla, Sanath K. | Rudolph, M. Jonathan | Wall, Mark J. | Wilson, Kenneth J. | Desjarlais, Renee L. | Manthey, Carl L. | Flores, Christopher | Molloy, Christopher J.
Patent Number: 7645755 (2010)
Cited by (23) | Cite | Source
JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia (journal article)
Manthey, Carl L. | Johnson, Dana L. | Illig, Carl R. | Tuman, Robert W. | Zhou, Zhao | Baker, Judith F. | Chaikin, Margery A. | Donatelli, Robert R. | Franks, Carol F. | Zeng, Lee | ... | Molloy, Christopher J.
Molecular Cancer Therapeutics, volume 8, issue 11, pages 3151-3161 (2009).
10.1158/1535-7163.MCT-09-0255
Cited by (96) | Cite | Source | Open Access
Pyrido[2,3- d ]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors (journal article)
Huang, Hui | Hutta, Daniel A. | Rinker, James M. | Hu, Huaping | Parsons, William H. | Schubert, Carsten | DesJarlais, Renee L. | Crysler, Carl S. | Chaikin, Margery A. | Donatelli, Robert R. | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 52, issue 4, pages 1081-1099 (2009).
10.1021/jm801406h
Cited by (40) | Cite | Source