Pamela J. Hornby

ScholarGPS® ID: 56533994772471

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Metrics Summary

Publication Count

103

Predicted Citations

4,840

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists (journal article) Patch, Raymond J. \| Zhang, Rui \| Edavettal, Suzanne \| Macielag, Mark J. \| Eckardt, Annette J. \| Li, Jiali \| Rives, Marie-Laure \| Edwards, Wilson \| Hinke, Simon A. \| Qiu, Xi \| ... \| Hornby, Pamela European Journal of Medicinal Chemistry, volume 236 (2022). 10.1016/j.ejmech.2022.114330 Cited by (2) \| Cite \| Source
Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes (journal article) Zou, Kai \| Turner, Kristen \| Zheng, Donghai \| Hinkley, J. Matthew \| Kugler, Benjamin A. \| Hornby, Pamela J. \| Lenhard, James \| Jones, Terry E. \| Pories, Walter J. \| Dohm, G. Lynis \| Houmard, Joseph A. American Journal of Physiology-Cell Physiology, volume 319, issue 6, pages C1011-C1019 (2020). 10.1152/ajpcell.00157.2020 Cited by (13) \| Cite \| Source
Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice (journal article) Albarazanji, Kamal \| Jennis, Matthew \| Cavanaugh, Cassandre R. \| Lang, Wensheng \| Singh, Bhanu \| Lanter, James C. \| Lenhard, James M. \| Hornby, Pamela J. American Journal of Physiology-Gastrointestinal and Liver Physiology, volume 316, issue 5, pages G653-G667 (2019). 10.1152/ajpgi.00404.2018 Cited by (8) \| Cite \| Source
Altered tricarboxylic acid cycle flux in primary myotubes from severely obese humans (journal article) Zou, Kai \| Hinkley, J. Matthew \| Park, Sanghee \| Zheng, Donghai \| Jones, Terry E. \| Pories, Walter J. \| Hornby, Pamela J. \| Lenhard, James \| Dohm, G. Lynis \| Houmard, Joseph A. International Journal of Obesity, volume 43, issue 4, pages 895-905 (2019). 10.1038/s41366-018-0137-7 Cited by (18) \| Cite \| Source
Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors (journal article) Kuo, Gee-Hong \| Gaul, Micheal D. \| Liang, Yin \| Xu, June Z. \| Du, Fuyong \| Hornby, Pamela \| Xu, Guozhang \| Qi, Jenson \| Wallace, Nathaniel \| Lee, Seunghun \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 28, issue 7, pages 1182-1187 (2018). 10.1016/j.bmcl.2018.02.057 Cited by (29) \| Cite \| Source
FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques (journal article) Muzammil, Salman \| Mabus, John R. \| Cooper, Philip R. \| Brezski, Randall J. \| Bement, Courtney B. \| Perkinson, Rob \| Huebert, Norman D. \| Thompson, Suzanne \| Levine, Dalia \| Kliwinski, Connie \| ... \| Hornby, Pamela J. Pharmacology Research & Perspectives, volume 4, issue 3 (2016). 10.1002/prp2.218 Cited by (9) \| Cite \| Source \| Open Access
Intestinal SGLT1 in metabolic health and disease (journal article) Lehmann, Anders \| Hornby, Pamela J. American Journal of Physiology-Gastrointestinal and Liver Physiology, volume 310, issue 11, pages G887-G898 (2016). 10.1152/ajpgi.00068.2016 Cited by (63) \| Cite \| Source \| Open Access
Deranged Glucose Oxidation in Primary Human Myotubes from Type 2 Diabetic Patients (journal article) Zou, Kai \| Hinkley, J Matthew \| Park, Sanghee \| Zheng, Donghai \| Jones, Terry E. \| Hornby, Pamela J. \| Lenhard, James \| Pories, Walter J. \| Lynis Dohm, G. \| Houmard, Joseph A. Medicine & Science in Sports & Exercise, volume 48 (2016). 10.1249/01.mss.0000487461.89727.5d Cite \| Source
Drug discovery approaches to irritable bowel syndrome (journal article) Hornby, Pamela J Expert Opinion on Drug Discovery, volume 10, issue 8, pages 809-824 (2015). 10.1517/17460441.2015.1049528 Cited by (10) \| Cite \| Source
Directed differentiation protocols for successful human intestinal organoids derived from multiple induced pluripotent stem cell lines (journal article) Kauffman, Amanda L \| Ekert, Jason E \| Gyurdieva, Alexandra V \| Rycyzyn, Michael A \| Hornby, Pamela J Stem Cell Biology and Research, volume 2, issue 1, pages 1- (2015). 10.7243/2054-717X-2-1 Cited by (8) \| Cite \| Source \| Open Access
The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups (journal article) Cooper, Philip R. \| Kliwinski, Connie M. \| Perkinson, Robert A. \| Ragwan, Edwin \| Mabus, John R. \| Powers, Gordon D. \| Dorai, Haimanti \| Giles-Komar, Jill \| Hornby, Pamela J. Frontiers in Pharmacology, volume 5 (2014). 10.3389/fphar.2014.00225 Cited by (12) \| Cite \| Source \| Open Access
Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis (journal article) Hornby, Pamela J. \| Cooper, Philip R. \| Kliwinski, Connie \| Ragwan, Edwin \| Mabus, John R. \| Harman, Benjamin \| Thompson, Suzanne \| Kauffman, Amanda L. \| Yan, Zhengyin \| Tam, Susan H. \| ... \| Giles-Komar, Jill Pharmaceutical Research, volume 31, issue 4, pages 908-922 (2014). 10.1007/s11095-013-1212-3 Cited by (65) \| Cite \| Source \| Open Access
Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn (journal article) Cooper, Philip R. \| Ciambrone, Gary J. \| Kliwinski, Connie M. \| Maze, Eva \| Johnson, Lowell \| Li, Qianqiu \| Feng, Yiqing \| Hornby, Pamela J. Brain Research, volume 1534 (2013). 10.1016/j.brainres.2013.08.035 Cited by (99) \| Cite \| Source \| Open Access
FcRn Expression and Antibody Transcytosis in Adult Human and Non‐Human Primate Intestine (journal article) Hornby, Pamela Janet \| Cooper, Philip R \| Kliwinski, Connie \| Ragwan, Edwin \| Mabus, John R \| Harman, Benjamin \| Dorai, Haimanti \| Giles‐Komar, Jill The FASEB Journal, volume 27, issue S1 (2013). 10.1096/fasebj.27.1_supplement.1093.3 Cited by (2) \| Cite \| Source
The Role of FcRn in Monoclonal Antibody Serum Uptake from the Intestine in Suckling Rat Pups (journal article) Cooper, Philip R \| Kliwinski, Connie \| Perkinson, Robert \| Mabus, John \| Giles‐Komar, Jill \| Hornby, Pamela The FASEB Journal, volume 27, issue S1 (2013). 10.1096/fasebj.27.1_supplement.1093.1 Cite \| Source
Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice (journal article) Kliwinski, C. \| Cooper, P. R. \| Perkinson, R. \| Mabus, J. R. \| Tam, S. H. \| Wilkinson, T. M. \| Giles-Komar, J. \| Scallon, B. \| Powers, G. D. \| Hornby, P. J. American Journal of Physiology-Gastrointestinal and Liver Physiology, volume 304, issue 3, pages G262-G270 (2013). 10.1152/ajpgi.00340.2012 Cited by (26) \| Cite \| Source \| Open Access
Alternative functional in vitro models of human intestinal epithelia (journal article) Kauffman, Amanda L. \| Gyurdieva, Alexandra V. \| Mabus, John R. \| Ferguson, Chrissa \| Yan, Zhengyin \| Hornby, Pamela J. Frontiers in Pharmacology, volume 4 (2013). 10.3389/fphar.2013.00079 Cited by (82) \| Cite \| Source \| Open Access
Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist (journal article) Wade, PR \| Palmer, JM \| McKenney, S \| Kenigs, V \| Chevalier, K \| Moore, BA \| Mabus, JR \| Saunders, PR \| Wallace, NH \| Schneider, CR \| ... \| Hornby, PJ British Journal of Pharmacology, volume 167, issue 5, pages 1111-1125 (2012). 10.1111/j.1476-5381.2012.02068.x Cited by (108) \| Cite \| Source \| Open Access
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d) (journal article) Breslin, Henry J. \| Diamond, Craig J. \| Kavash, Robert W. \| Cai, Chaozhong \| Dyatkin, Alexey B. \| Miskowski, Tamara A. \| Zhang, Sui-Po \| Wade, Paul R. \| Hornby, Pamela J. \| He, Wei Bioorganic & Medicinal Chemistry Letters, volume 22, issue 14, pages 4869-4872 (2012). 10.1016/j.bmcl.2012.05.042 Cited by (43) \| Cite \| Source
Modulation of Gastrointestinal Function by MuDelta, a mixed Mu Opioid Receptor Agonist/Delta Opioid Receptor Antagonist (journal article) Hornby, Pamela J The FASEB Journal, volume 26, issue S1 (2012). 10.1096/fasebj.26.1_supplement.lb766 Cite \| Source

Title	Investigators	Year	Cost	Agency
VAGAL GASTRIC MOTOR CONTROL IN MICE	Hornby, Pamela J	2001	$143,000	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	2000	$177,080	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	2000	$10,000	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1999	$171,922	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1998	$166,912	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1997	$174,187	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS/AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1995	$104,383	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS/AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1994	$99,410	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1993	$94,677	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1992	$90,169	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CNS AUTONOMIC PATHWAYS AND GASTROINTESTINAL FUNCTION	Hornby, Pamela J	1991	$97,401	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES