Cynthia M. Milligan

ScholarGPS® ID: 56358367623761

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Covalent Bond | Crystal Structure
Metrics Summary
Publication Count
23
Predicted Citations
313
Predicted h-index
8
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions (journal article)
McCarver, Stefan | Hanna, Luke | Samant, Andrew | Thompson, Aaron A. | Seierstad, Mark | Saha, Arjun | Wu, Dongpei | Lord, Brian | Sutton, Steven W. | Shah, Vishal | ... | Shireman, Brock T.
ACS Medicinal Chemistry Letters, volume 15, issue 4, pages 486-492 (2024).
10.1021/acsmedchemlett.3c00523
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Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor (journal article)
Xu, Guozhang | Gaul, Michael D. | Liu, Zhijie | DesJarlais, Renee L. | Qi, Jenson | Wang, Weixue | Krosky, Daniel | Petrounia, Ioanna | Milligan, Cynthia M. | Hermans, An | ... | Spurlino, John C.
Bioorganic & Medicinal Chemistry Letters, volume 30, issue 23, pages 127602- (2020).
10.1016/j.bmcl.2020.127602
Cited by (4) | Cite | Source
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors (journal article)
Zhu, Bin | Connolly, Peter J. | Zhang, Yue-Mei | McDonnell, Mark E. | Bian, Haiyan | Lin, Shu-Chen | Liu, Li | Zhang, Sui-Po | Chevalier, Kristen M. | Brandt, Michael R. | ... | Macielag, Mark J.
Bioorganic & Medicinal Chemistry Letters, volume 30, issue 14, pages 127243- (2020).
10.1016/j.bmcl.2020.127243
Cited by (12) | Cite | Source
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt (journal article)
Gege, Christian | Albers, Michael | Kinzel, Olaf | Kleymann, Gerald | Schlüter, Thomas | Steeneck, Christoph | Hoffmann, Thomas | Xue, Xiaohua | Cummings, Maxwell D. | Spurlino, John | ... | Goldberg, Steven D.
Bioorganic & Medicinal Chemistry Letters, volume 30, issue 12, pages 127205- (2020).
10.1016/j.bmcl.2020.127205
Cited by (12) | Cite | Source
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL) (journal article)
Zhu, Bin | Connolly, Peter J. | Zhang, Sui-Po | Chevalier, Kristen M. | Milligan, Cynthia M. | Flores, Christopher M. | Macielag, Mark J.
Bioorganic & Medicinal Chemistry Letters, volume 30, issue 12, pages 127198- (2020).
10.1016/j.bmcl.2020.127198
Cited by (7) | Cite | Source
6-Substituted quinolines as RORγt inverse agonists (journal article)
Barbay, J. Kent | Cummings, Maxwell D. | Abad, Marta | Castro, Glenda | Kreutter, Kevin D. | Kummer, David A. | Maharoof, Umar | Milligan, Cynthia | Nishimura, Rachel | Pierce, Joan | ... | Leonard, Kristi
Bioorganic & Medicinal Chemistry Letters, volume 27, issue 23, pages 5277-5283 (2017).
10.1016/j.bmcl.2017.10.027
Cited by (23) | Cite | Source
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt (journal article)
Kummer, David A. | Cummings, Maxwell D. | Abad, Marta | Barbay, Joseph | Castro, Glenda | Wolin, Ronald | Kreutter, Kevin D. | Maharoof, Umar | Milligan, Cynthia | Nishimura, Rachel | ... | Leonard, Kristi
Bioorganic & Medicinal Chemistry Letters, volume 27, issue 9, pages 2047-2057 (2017).
10.1016/j.bmcl.2017.02.044
Cited by (25) | Cite | Source
Methods to measure dissociation rates for ligands that form reversible covalent bonds (patent)
Rentzeperis, Dionisios | Abad, Marta Cristina | Barnakova, Ludmila A. | Lewandowski, Frank A. | Milligan, Cynthia M.
Patent Number: 8927297 (2015)
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Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Crysler, Carl | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | ... | Wang, Aihua
Patent Number: 8883473 (2014)
Cited by (3) | Cite | Source
Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8798939 (2014)
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Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8753857 (2014)
Cited by (2) | Cite | Source
Co-crystallization of ERR-α with a ligand that forms a reversible covalent bond (patent)
Milligan, Cynthia M. | Rentzeperis, Dionisios | Lewandowski, Frank A. | Barnakova, Ludmila A. | Abad, Marta Cristina
Patent Number: 8455244 (2013)
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Protein engineering of monoacylglycerol lipase (MGLL) (patent)
Grasberger, Bruce L. | Schalk-Hihi, Celine | Maguire, Diane M. | Lewandowski, Frank A. | Milligan, Cynthia M. | Alexander, Richard S.
Patent Number: 8257698 (2012)
Cited by (2) | Cite | Source
Co-crystallization of ERR-α with a ligand that forms a reversible covalent bond (patent)
Rentzeperis, Dionisios | Abad, Marta Cristina | Barnakova, Ludmila A. | Lewandowski, Frank A. | Milligan, Cynthia M.
Patent Number: 8187871 (2012)
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Crystal structure of monoacylglycerol lipase (MGLL) (patent)
Schubert, Carsten | Grasberger, Bruce L. | Schalk-Hihi, Celine | Maguire, Diane M. | Lewandowski, Frank A. | Milligan, Cynthia M. | Alexander, Richard S.
Patent Number: 8080400 (2011)
Cited by (6) | Cite | Source
Alternative crystal form of monoacylglycerol lipase (MGLL) (patent)
Schubert, Carsten | Grasberger, Bruce L. | Schalk-Hihi, Celine | Maguire, Diane M. | Lewandowski, Frank A. | Milligan, Cynthia M. | Alexander, Richard S.
Patent Number: 8067220 (2011)
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Co-crystallization of ERR-α with a ligand that forms a reversible covalent bond (patent)
Rentzeperis, Dionisios | Abad, Marta Cristina | Barnakova, Ludmila A. | Lewandowski, Frank A. | Milligan, Cynthia M.
Patent Number: 20110046891 (2010)
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Crystallized structure of estrogen related receptor gamma in complex with bisphenol A (patent)
Abad, Marta C. | Rentzeperis, Dionisios | O\'Neill, John | Askari, Hossein B. | Milligan, Cynthia M. | Lewandowski, Frank A.
Patent Number: 7655756 (2010)
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CRYSTAL STRUCTURE OF THE CARBOXYL TRANSFERASE DOMAIN OF HUMAN ACETYL-COA CARBOXYLASE 2 PROTEIN (ACC2 CT) AND USES THEREOF (patent)
Grasberger, Bruce L. | Milligan, Cynthia M. | Spurlino, John | Steele, Ruth A. | Singleton, Kenneth R. | Gibbs, Alan C. | Lewandowski, Francis A.
Patent Number: 20090155815 (2008)
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Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase. 2. Investigation of the Carboxamide Portion of Spirocyclic Piperidine Amides (journal article)
Costanzo, Michael | Yabut, Stephen | Zhang, Han-Cheng | White, Kimberley | Wang, Yuanping | Minor, Lisa | Tounge, Brett | Barnakov, Alexander | Lewandowski, Frank | Milligan, Cynthia | ... | Maryanoff, Bruce
Letters in Drug Design & Discovery, volume 5, issue 2, pages 116-121 (2008).
10.2174/157018008783928418
Cited by (3) | Cite | Source