Frederick W. Goldberg

ScholarGPS® ID: 56261842423118

Affiliation
AstraZeneca plc, Cambridge, United States
Affiliation History

Field
Medicine
Discipline
Oncology
Top Specialties
Medicinal Chemistry | Drug Discovery | Cancer | Chemical Synthesis
Metrics Summary
Publication Count
31
Predicted Citations
915
Predicted h-index
17
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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α‐Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping (journal article)
Seling, Nico | Atobe, Masakazu | Kasten, Kevin | Firth, James D. | Karadakov, Peter B. | Goldberg, Frederick W. | O'Brien, Peter
Angewandte Chemie, volume 136, issue 2 (2024).
10.1002/ange.202314423
Cite | Source
α‐Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping (journal article)
Seling, Nico | Atobe, Masakazu | Kasten, Kevin | Firth, James D. | Karadakov, Peter B. | Goldberg, Frederick W. | O'Brien, Peter
Angewandte Chemie International Edition, volume 63, issue 2 (2024).
10.1002/anie.202314423
Cited by (1) | Cite | Source
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit (journal article)
Kawatkar, Aarti | Clark, Roger A. | Hopcroft, Lorna | Roaquin, Debora Ann | Tomlinson, Ronald | Zuhl, Andrea M. | Lamont, Gillian M. | Kettle, Jason G. | Critchlow, Susan E. | Castaldi, M. Paola | ... | Zhang, Andrew X.
ACS Chemical Biology, volume 18, issue 2, pages 296-303 (2023).
10.1021/acschembio.2c00666
Cited by (3) | Cite | Source
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology (journal article)
Goldberg, Frederick W. | Kettle, Jason G. | Lamont, Gillian M. | Buttar, David | Ting, Attilla K. T. | McGuire, Thomas M. | Cook, Calum R. | Beattie, David | Morentin Gutierrez, Pablo | Kavanagh, Stefan L. | ... | Critchlow, Susan E.
Journal of Medicinal Chemistry, volume 66, issue 1, pages 384-397 (2023).
10.1021/acs.jmedchem.2c01342
Cited by (18) | Cite | Source
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8 H -purin-8-one Inhibitors of DNA-PK (journal article)
Goldberg, Frederick W. | Ting, Attilla K. T. | Beattie, David | Lamont, Gillian M. | Fallan, Charlene | Finlay, M. Raymond V. | Williamson, Beth | Schimpl, Marianne | Harmer, Alexander R. | Adeyemi, Oladipupo B. | ... | Davies, Barry R.
ACS Medicinal Chemistry Letters, volume 13, issue 8, pages 1295-1301 (2022).
10.1021/acsmedchemlett.2c00172
Cited by (3) | Cite | Source
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a ]pyridin-6-yl)amino]-9-(tetrahydro-2 H -pyran-4-yl)-7,9-dihydro-8 H -purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor (journal article)
Goldberg, Frederick W. | Finlay, M. Raymond V. | Ting, Attilla K. T. | Beattie, David | Lamont, Gillian M. | Fallan, Charlene | Wrigley, Gail L. | Schimpl, Marianne | Howard, Martin R. | Williamson, Beth | ... | Dean, Emma
Journal of Medicinal Chemistry, volume 63, issue 7, pages 3461-3471 (2020).
10.1021/acs.jmedchem.9b01684
Cited by (53) | Cite | Source
Evolution of Small Molecule Kinase Drugs (journal article)
Lightfoot, Helen L. | Goldberg, Frederick W. | Sedelmeier, Joerg
ACS Medicinal Chemistry Letters, volume 10, issue 2, pages 153-160 (2019).
10.1021/acsmedchemlett.8b00445
Cited by (28) | Cite | Source
Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors (journal article)
Spender, Lindsay C. | Ferguson, G. John | Hughes, Gareth D. | Davies, Barry R. | Goldberg, Frederick W. | Herrera, Blanca | Taylor, Richard G. | Strathearn, Lauren S. | Sansom, Owen J. | Barry, Simon T. | Inman, Gareth J.
Molecular Pharmacology, volume 95, issue 2, pages 222-234 (2019).
10.1124/mol.118.112946
Cited by (22) | Cite | Source
CHAPTER 1. Introduction to Kinase Drug Discovery – Modern Approaches (book chapter)
In Kinase Drug Discovery
Ward, Richard A. | Goldberg, Frederick W.
Royal Society of Chemistry (2018)
10.1039/9781788013093-00001
Cited by (1) | Cite | Source
CHAPTER 11. The Importance of Kinase Mutations in Cancer Drug Discovery (book chapter)
In Kinase Drug Discovery
Ward, Richard A. | Goldberg, Frederick W.
Royal Society of Chemistry (2018)
10.1039/9781788013093-00281
Cite | Source
Selective Kinase Inhibitors in Cancer (book chapter)
In Comprehensive Medicinal Chemistry III
Mortlock, A.A. | Wilson, D.M. | Kettle, J.G. | Goldberg, F.W. | Foote, K.M.
Elsevier (2017)
10.1016/B978-0-12-409547-2.12391-1
Cited by (4) | Cite | Source
Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors (journal article)
McCoull, William | Hennessy, Edward J. | Blades, Kevin | Chuaqui, Claudio | Dowling, James E. | Ferguson, Andrew D. | Goldberg, Frederick W. | Howe, Nicholas | Jones, Christopher R. | Kemmitt, Paul D. | ... | Yang, Bin
ACS Medicinal Chemistry Letters, volume 7, issue 12, pages 1118-1123 (2016).
10.1021/acsmedchemlett.6b00322
Cited by (17) | Cite | Source | Open Access
Identification and optimisation of a series of N-(4-anilino-2-pyridyl)acetamide activin receptor-like kinase 1 (ALK1) inhibitors (journal article)
Goldberg, Frederick W. | Daunt, Paula | Pearson, Stuart E. | Greenwood, Ryan | Grist, Matthew | Debreczeni, Judit É.
MedChemComm, volume 7, issue 6, pages 1204-1208 (2016).
10.1039/C6MD00039H
Cited by (5) | Cite | Source
ChemInform Abstract: Synthesis of Enantiomerically Pure 2‐Heteroaromatic‐Substituted 1,2‐Amino Alcohols from Chiral tert‐Butanesulfinyl Aldimines. (journal article)
Chen, Yantao | Goldberg, Frederick W. | Xiong, Jian | Wang, Shujun
ChemInform, volume 46, issue 28 (2015).
10.1002/chin.201528070
Cite | Source
Design of pyrazolo-pyrimidines as 11β-HSD1 inhibitors through optimisation of molecular electrostatic potential (journal article)
Robb, Graeme R. | Boyd, Scott | Davies, Christopher D. | Dossetter, Alexander G. | Goldberg, Frederick W. | Kemmitt, Paul D. | Scott, James S. | Swales, John G.
MedChemComm, volume 6, issue 5, pages 926-934 (2015).
10.1039/C5MD00043B
Cited by (5) | Cite | Source
Designing novel building blocks is an overlooked strategy to improve compound quality (journal article)
Goldberg, Frederick W. | Kettle, Jason G. | Kogej, Thierry | Perry, Matthew W.D. | Tomkinson, Nick P.
Drug Discovery Today, volume 20, issue 1, pages 11-17 (2015).
10.1016/j.drudis.2014.09.023
Cited by (166) | Cite | Source
Synthesis of Enantiomerically Pure 2-Heteroaromatic-Substituted 1,2-Amino Alcohols from Chiral tert-Butanesulfinyl Aldimines (journal article)
Chen, Yantao | Goldberg, Frederick | Xiong, Jian | Wang, Shujun
Synthesis, volume 47, issue 05, pages 679-691 (2014).
10.1055/s-0034-1378943
Cited by (6) | Cite | Source
General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor (journal article)
Goldberg, Frederick W. | Kettle, Jason G. | Xiong, Jian | Lin, Daoguang
Tetrahedron, volume 70, issue 37, pages 6613-6622 (2014).
10.1016/j.tet.2014.06.120
Cited by (60) | Cite | Source
Medicinal Chemistry of Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) (journal article)
Scott, James S. | Goldberg, Frederick W. | Turnbull, Andrew V.
Journal of Medicinal Chemistry, volume 57, issue 11, pages 4466-4486 (2014).
10.1021/jm4014746
Cited by (79) | Cite | Source
Optimization of Brain Penetrant 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice (journal article)
Goldberg, Frederick W. | Dossetter, Alexander G. | Scott, James S. | Robb, Graeme R. | Boyd, Scott | Groombridge, Sam D. | Kemmitt, Paul D. | Sjögren, Tove | Gutierrez, Pablo Morentin | deSchoolmeester, Joanne | ... | Wild, Martin J.
Journal of Medicinal Chemistry, volume 57, issue 3, pages 970-986 (2014).
10.1021/jm4016729
Cited by (21) | Cite | Source