Alan G. Olivero

ScholarGPS® ID: 55883325398899

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

2,385

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human (journal article) Salphati, Laurent \| Pang, Jodie \| Alicke, Bruno \| Plise, Emile G. \| Cheong, Jonathan \| Jaochico, Allan \| Olivero, Alan G. \| Sampath, Deepak \| Wong, Susan \| Zhang, Xiaolin Xenobiotica, volume 54, issue 2, pages 64-74 (2024). 10.1080/00498254.2024.2303586 Cite \| Source
CTNI-27. MULTI-CENTER, PHASE 2 STUDY EVALUATING THE PHARMACOKINETICS, SAFETY AND PRELIMINARY EFFICACY OF PAXALISIB IN NEWLY DIAGNOSED ADULT PATIENTS WITH UNMETHYLATED GLIOBLASTOMA (GBM) (journal article) Wen, Patrick Y \| de Groot, John \| Battiste, James \| Goldlust, Samuel \| Damek, Denise \| Ellingson, Benjamin \| Garner, James \| Friend, John \| Simpson, Jeremy \| Olivero, Alan \| Cloughesy, Timothy Neuro-Oncology, volume 24, issue Supplement_7, pages vii76-vii77 (2022). 10.1093/neuonc/noac209.292 Cite \| Source
Paxalisib in patients with newly diagnosed glioblastoma with unmethylated MGMT promoter status: Final phase 2 study results. (journal article) Wen, Patrick Y. \| de Groot, John Frederick \| Battiste, James \| Goldlust, Samuel A. \| Garner, James Stuart \| Friend, John \| Simpson, Jeremy Andrew \| Damek, Denise \| Olivero, Alan \| Cloughesy, Timothy Francis Journal of Clinical Oncology, volume 40, issue 16_suppl, pages 2047-2047 (2022). 10.1200/JCO.2022.40.16_suppl.2047 Cited by (12) \| Cite \| Source
Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma (journal article) Ellingson, Benjamin M. \| Yao, Jingwen \| Raymond, Catalina \| Nathanson, David A. \| Chakhoyan, Ararat \| Simpson, Jeremy \| Garner, James S. \| Olivero, Alan G. \| Mueller, Lars U. \| Rodon, Jordi \| ... \| Wen, Patrick Y. Clinical Cancer Research, volume 26, issue 13, pages 3135-3144 (2020). 10.1158/1078-0432.CCR-19-3817 Cited by (7) \| Cite \| Source
First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma (journal article) Wen, Patrick Y. \| Cloughesy, Timothy F. \| Olivero, Alan G. \| Morrissey, Kari M. \| Wilson, Timothy R. \| Lu, Xuyang \| Mueller, Lars U. \| Coimbra, Alexandre F. \| Ellingson, Benjamin M. \| Gerstner, Elizabeth \| ... \| Rodon, Jordi Clinical Cancer Research, volume 26, issue 8, pages 1820-1828 (2020). 10.1158/1078-0432.CCR-19-2808 Cited by (53) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Olivero, Alan G. \| Patel, Snahel \| Siu, Michael \| Lyssikatos, Joseph \| Huestis, Malcolm \| Kellar, Terry Patent Number: RE47848 (2020) Cite \| Source
NIMG-34. MULTI-PARAMETRIC MR-PET IMAGING PREDICTS PHARMACOKINETICS AND CLINICAL RESPONSE TO GDC-0084 IN HUMAN RECURRENT HIGH-GRADE GLIOMA (journal article) Ellingson, Benjamin \| Yao, Jingwen \| Raymond, Catalina \| Nathanson, David \| Simpson, Jeremy \| Garner, James \| Olivero, Alan \| Mueller, Lars \| Rodon, Jordi \| Gerstner, Elizabeth \| ... \| Wen, Patrick Neuro-Oncology, volume 21, issue Supplement_6, pages vi168-vi168 (2019). 10.1093/neuonc/noz175.704 Cite \| Source
ACTR-64. PHASE 2 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS AND CLINICAL ACTIVITY OF PI3K/mTOR INHIBITOR GDC-0084 IN GBM PATIENTS WITH UNMETHYLATED O6-METHYLGUANINE-METHYLTRANSFERASE (MGMT) PROMOTER STATUS (journal article) Wen, Patrick \| DeGroot, John \| Battiste, James \| Goldlust, Samuel \| Garner, James \| Simpson, Jeremy \| Kijlstra, Jelle \| Olivero, Alan \| Cloughesy, Timothy Neuro-Oncology, volume 21, issue Supplement_6, pages vi28-vi28 (2019). 10.1093/neuonc/noz175.106 Cited by (1) \| Cite \| Source
P05.06 Phase 2 study to evaluate the safety, pharmacokinetics and clinical activity of PI3K/mTOR inhibitor GDC-0084 given to glioblastoma (GBM) patients with unmethylated O6-methylguanine-methyltransferase (MGMT) promoter status (journal article) Wen, P Y \| de Groot, J \| Battiste, J D \| Goldlust, S A \| Garner, J \| Simpson, J \| Olivero, A \| Cloughesy, T Neuro-Oncology, volume 21, issue Supplement_3, pages iii35-iii35 (2019). 10.1093/neuonc/noz126.120 Cited by (1) \| Cite \| Source
ACTR-51. PHASE 2 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS AND CLINICAL ACTIVITY OF PI3K/MTOR INHIBITOR GDC-0084 GIVEN TO GLIOBLASTOMA (GBM) PATIENTS WITH UNMETHYLATED O6-METHYLGUANINE-METHYLTRANSFERASE PROMOTER STATUS (journal article) Wen, Patrick \| Cloughesy, Timothy \| de Groot, John \| Battiste, James \| Garner, James \| Simpson, Jeremy \| Olivero, Alan \| Gerstner, Elizabeth Neuro-Oncology, volume 20, issue suppl_6, pages vi23-vi23 (2018). 10.1093/neuonc/noy148.083 Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Olivero, Alan G \| Patel, Snahel \| Siu, Michael \| Lyssikatos, Joseph Patent Number: 10028954 (2018) Cited by (1) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Dong, Liting \| Chen, Kevin X. \| Gibbons, Paul \| Huestis, Malcolm \| Kellar, Terry \| Liu, Wen \| Ma, Changyou \| Lyssikatos, Joseph \| Olivero, Alan \| ... \| Siu, Michael Patent Number: 10010549 (2018) Cited by (1) \| Cite \| Source
Pharmaceutical compounds (patent) Folkes, Adrian \| Shuttleworth, Stephen \| Chuckowree, Irina \| Oxenford, Sally \| Wan, Nan Chi \| Castanedo, Georgette \| Goldsmith, Richard \| Gunzer-Toste, Janet \| Heffron, Tim \| Mathieu, Simon \| ... \| Zhu, Bing-Yan Patent Number: 9943519 (2018) Cite \| Source
Benzoxazepin PI3K inhibitor compounds and methods of use (patent) Blaquiere, Nicole \| Do, Steven \| Dudley, Danette \| Folkes, Adrian \| Heald, Robert \| Heffron, Timothy \| Jones, Mark \| Kolesnikov, Aleksandr \| Ndubaku, Chudi \| Olivero, Alan G. \| ... \| Wang, Lan Patent Number: 9670228 (2017) Cited by (1) \| Cite \| Source
Benzoxazepin PI3K inhibitor compounds and methods of use (patent) Blaquiere, Nicole \| Do, Steven \| Dudley, Danette \| Folkes, Adrian \| Heald, Robert \| Heffron, Timothy \| Jones, Mark \| Kolesnikov, Aleksandr \| Ndubaku, Chudi \| Olivero, Alan G. \| ... \| Wang, Lan Patent Number: 9546178 (2017) Cited by (1) \| Cite \| Source
Tricyclic PI3K inhibitor compounds and methods of use (patent) Dotson, Jennafer \| Heald, Robert Andrew \| Heffron, Timothy \| Jones, Graham Elgin \| Krintel, Sussie Lerche \| McLean, Neville James \| Ndubaku, Chudi \| Olivero, Alan G. \| Salphati, Laurent \| Wang, Lan \| Wei, BinQuing Patent Number: 9546182 (2017) Cite \| Source
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma (journal article) Salphati, Laurent \| Alicke, Bruno \| Heffron, Timothy P. \| Shahidi-Latham, Sheerin \| Nishimura, Merry \| Cao, Tim \| Carano, Richard A. \| Cheong, Jonathan \| Greve, Joan \| Koeppen, Hartmut \| ... \| Olivero, Alan G. Drug Metabolism and Disposition, volume 44, issue 12, pages 1881-1889 (2016). 10.1124/dmd.116.071423 Cited by (40) \| Cite \| Source
Phosphoinositide 3-kinase inhibitor compounds and methods of use (patent) Castanedo, Georgette \| Dotson, Jennafer \| Goldsmith, Richard \| Gunzner, Janet \| Heffron, Tim \| Mathieu, Simon \| Olivero, Alan \| Sutherlin, Daniel P. \| Wang, Shumei \| Zhu, Bing-Yan \| ... \| Wan, Nan Chi Patent Number: 9487533 (2016) Cite \| Source
A first-in-human phase 1 study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma. (journal article) Wen, Patrick Y. \| Cloughesy, Timothy Francis \| Olivero, Alan \| Lu, Xuyang \| Mueller, Lars \| Fernandez Coimbra, Alexandre \| Gerstner, Elizabeth Robins \| Rodon Ahnert, Jordi Journal of Clinical Oncology, volume 34, issue 15_suppl, pages 2012-2012 (2016). 10.1200/JCO.2016.34.15_suppl.2012 Cited by (12) \| Cite \| Source
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR (journal article) Heffron, Timothy P. \| Ndubaku, Chudi O. \| Salphati, Laurent \| Alicke, Bruno \| Cheong, Jonathan \| Drobnick, Joy \| Edgar, Kyle \| Gould, Stephen E. \| Lee, Leslie B. \| Lesnick, John D. \| ... \| Olivero, Alan G. ACS Medicinal Chemistry Letters, volume 7, issue 4, pages 351-356 (2016). 10.1021/acsmedchemlett.6b00005 Cited by (77) \| Cite \| Source \| Open Access