Maureen Higgins

ScholarGPS® ID: 54432089012116

Affiliation

University of Dundee, Dundee, United Kingdom

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Medicinal Chemistry | Enzyme | Cancer | Chemical Synthesis

Metrics Summary

Publication Count

Predicted Citations

1,825

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1 (journal article) Moreno, Rita \| Casares, Laura \| Higgins, Maureen \| Ali, Kevin X. \| Honda, Tadashi \| Wiel, Clotilde \| Sayin, Volkan I. \| Dinkova-Kostova, Albena T. \| de la Vega, Laureano Free Radical Biology and Medicine, volume 191 (2022). 10.1016/j.freeradbiomed.2022.08.041 Cited by (9) \| Cite \| Source
Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode (journal article) Georgakopoulos, Nikolaos \| Talapatra, Sandeep \| Dikovskaya, Dina \| Dayalan Naidu, Sharadha \| Higgins, Maureen \| Gatliff, Jemma \| Ayhan, Aysel \| Nikoloudaki, Roxani \| Schaap, Marjolein \| Valko, Klara \| ... \| Wells, Geoffrey Journal of Medicinal Chemistry, volume 65, issue 10, pages 7380-7398 (2022). 10.1021/acs.jmedchem.2c00457 Cited by (14) \| Cite \| Source
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity (journal article) Casares, Laura \| Moreno, Rita \| Ali, Kevin X. \| Higgins, Maureen \| Dayalan Naidu, Sharadha \| Neill, Graham \| Cassin, Lena \| Kiib, Anders E. \| Svenningsen, Esben B. \| Minassi, Alberto \| ... \| de la Vega, Laureano Redox Biology, volume 51 (2022). 10.1016/j.redox.2022.102291 Cited by (11) \| Cite \| Source
Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors (journal article) Zhang, Ying \| Knatko, Elena V. \| Higgins, Maureen \| Dayalan Naidu, Sharadha \| Smith, Gillian \| Honda, Tadashi \| de la Vega, Laureano \| Dinkova-Kostova, Albena T. Antioxidants, volume 11, issue 2, pages 262- (2022). 10.3390/antiox11020262 Cited by (8) \| Cite \| Source
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer (journal article) Knatko, Elena V. \| Castro, Cecilia \| Higgins, Maureen \| Zhang, Ying \| Honda, Tadashi \| Henderson, Colin J. \| Wolf, C. Roland \| Griffin, Julian L. \| Dinkova-Kostova, Albena T. Communications Biology, volume 4, issue 1 (2021). 10.1038/s42003-021-02552-w Cited by (3) \| Cite \| Source
Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress (journal article) Soliman, Aiten M. \| Mekkawy, Mai H. \| Karam, Heba M. \| Higgins, Maureen \| Dinkova-Kostova, Albena T. \| Ghorab, Mostafa M. Bioorganic & Medicinal Chemistry Letters, volume 42 (2021). 10.1016/j.bmcl.2021.128002 Cited by (6) \| Cite \| Source
Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma (journal article) Roth, Kevin \| Coussement, Louis \| Knatko, Elena V. \| Higgins, Maureen \| Steyaert, Sandra \| Proby, Charlotte M. \| de Meyer, Tim \| Dinkova-Kostova, Albena T. EBioMedicine, volume 67 (2021). 10.1016/j.ebiom.2021.103383 Cited by (5) \| Cite \| Source
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production (journal article) Cvetko, Filip \| Caldwell, Stuart T. \| Higgins, Maureen \| Suzuki, Takafumi \| Yamamoto, Masayuki \| Prag, Hiran A. \| Hartley, Richard C. \| Dinkova-Kostova, Albena T. \| Murphy, Michael P. Journal of Biological Chemistry, volume 296 (2021). 10.1074/jbc.RA120.016551 Cited by (29) \| Cite \| Source
Nrf2 is a Central Regulator of the Metabolic Landscape in Macrophages and Finetunes Their Inflammatory Response (journal article) Ryan, Dylan Gerard \| Knatko, Elena V. \| Casey, Alva \| Hukelmann, Jens L. \| Brenes, Alejandro J. \| Dayalan Naidu, Sharadha \| Higgins, Maureen \| Tronci, Laura \| Nikitopoulou, Efterpi \| O’Neill, Luke A. J. \| ... \| Dinkova-Kostova, Albena SSRN Electronic Journal (2021). 10.2139/ssrn.3915010 Cite \| Source
The Isoquinoline PRL-295 Increases the Thermostability of Keap1 and Disrupts Its Interaction with Nrf2 (journal article) Dayalan Naidu, Sharadha \| Suzuki, Takafumi \| Dikovskaya, Dina \| Knatko, Elena V. \| Higgins, Maureen \| Sato, Miu \| Novak, Miroslav \| Moore, Terry W. \| Yamamoto, Masayuki \| Dinkova-Kostova, Albena SSRN Electronic Journal (2021). 10.2139/ssrn.3903550 Cite \| Source
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity (journal article) Casares, Laura \| Unciti-Broceta, Juan Diego \| Prados, Maria Eugenia \| Caprioglio, Diego \| Mattoteia, Daiana \| Higgins, Maureen \| Apendino, Giovanni \| Dinkova-Kostova, Albena T. \| Muñoz, Eduardo \| de la Vega, Laureano Redox Biology, volume 37 (2020). 10.1016/j.redox.2020.101689 Cited by (23) \| Cite \| Source
Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety (journal article) Soliman, Aiten M. \| Karam, Heba M. \| Mekkawy, Mai H. \| Higgins, Maureen \| Dinkova-Kostova, Albena T. \| Ghorab, Mostafa M. European Journal of Medicinal Chemistry, volume 200 (2020). 10.1016/j.ejmech.2020.112467 Cited by (12) \| Cite \| Source
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy (journal article) Shekh-Ahmad, Tawfeeq \| Eckel, Ramona \| Dayalan Naidu, Sharadha \| Higgins, Maureen \| Yamamoto, Masayuki \| Dinkova-Kostova, Albena T \| Kovac, Stjepana \| Abramov, Andrey Y \| Walker, Matthew C Brain, volume 141, issue 5, pages 1390-1403 (2018). 10.1093/brain/awy071 Cited by (100) \| Cite \| Source \| Open Access
Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma (journal article) Knatko, Elena V. \| Praslicka, Brandon \| Higgins, Maureen \| Evans, Alan \| Purdie, Karin J. \| Harwood, Catherine A. \| Proby, Charlotte M. \| Ooi, Aikseng \| Dinkova-Kostova, Albena T. Cancer Prevention Research, volume 10, issue 1, pages 67-75 (2017). 10.1158/1940-6207.CAPR-16-0218 Cited by (18) \| Cite \| Source \| Open Access
NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives (journal article) Ghorab, Mostafa M. \| Alsaid, Mansour S. \| El-Gazzar, Marwa G. \| Higgins, Maureen \| Dinkova-Kostova, Albena T. \| Shahat, Abdelaaty A. Journal of Enzyme Inhibition and Medicinal Chemistry, volume 31, issue 6, pages 1369-1374 (2016). 10.3109/14756366.2015.1135913 Cited by (3) \| Cite \| Source \| Open Access
Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives (journal article) Ghorab, Mostafa M. \| Alsaid, Mansour S. \| Higgins, Maureen \| Dinkova-Kostova, Albena T. \| Shahat, Abdelaaty A. \| Elghazawy, Nehal H. \| Arafa, Reem K. Journal of Enzyme Inhibition and Medicinal Chemistry, volume 31, issue 6, pages 1612-1618 (2016). 10.3109/14756366.2016.1158714 Cited by (4) \| Cite \| Source \| Open Access
Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1 (journal article) Ghorab, Mostafa M. \| Alsaid, Mansour S. \| El-Gazzar, Marwa G. \| Higgins, Maureen \| Dinkova-Kostova, Albena T. \| Shahat, Abdelaaty A. Journal of Enzyme Inhibition and Medicinal Chemistry, volume 31, issue sup1, pages 34-39 (2016). 10.3109/14756366.2016.1163343 Cited by (4) \| Cite \| Source \| Open Access
Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1 (journal article) Hamed, Ahmed R. \| Hegazy, Mohamed-Elamir F. \| Higgins, Maureen \| Mohamed, Tarik A. \| Abdel-Azim, Nahla S. \| Pare, Paul W. \| Dinkova-Kostova, Albena T. Journal of Natural Medicines, volume 70, issue 3, pages 683-688 (2016). 10.1007/s11418-016-0994-0 Cited by (10) \| Cite \| Source \| Open Access
Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma (journal article) Knatko, Elena V. \| Higgins, Maureen \| Fahey, Jed W. \| Dinkova-Kostova, Albena T. Scientific Reports, volume 6, issue 1 (2016). 10.1038/srep25804 Cited by (26) \| Cite \| Source \| Open Access
NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives (journal article) Arafa, Reem \| Ghorab, Mostafa \| Alsaid, Mansour \| Higgins, Maureen \| Dinkova-Kostova, Albena \| Shahat, Abdelaaty \| Elghazawy, Nehal Drug Design, Development and Therapy, volume Volume 10 (2016). 10.2147/DDDT.S105423 Cited by (5) \| Cite \| Source \| Open Access