Tianbao Lu

ScholarGPS® ID: 53250375529751

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

2,467

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease (journal article) Lu, Tianbao \| Connolly, Peter J. \| Philippar, Ulrike \| Sun, Weimei \| Cummings, Maxwell D. \| Barbay, Kent \| Gys, Luc \| Van Nuffel, Luc \| Austin, Nigel \| Bekkers, Mariette \| ... \| Edwards, James Bioorganic & Medicinal Chemistry Letters, volume 29, issue 23, pages 126743- (2019). 10.1016/j.bmcl.2019.126743 Cited by (10) \| Cite \| Source
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists (journal article) Song, Fengbin \| Xu, Guozhang \| Gaul, Michael D. \| Zhao, Baoping \| Lu, Tianbao \| Zhang, Rui \| DesJarlais, Renee L. \| DiLoreto, Karen \| Huebert, Norman \| Shook, Brian \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 15, pages 1974-1980 (2019). 10.1016/j.bmcl.2019.05.036 Cited by (15) \| Cite \| Source
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy (journal article) Lu, Tianbao \| Schubert, Carsten \| Cummings, Maxwell D. \| Bignan, Gilles \| Connolly, Peter J. \| Smans, Karine \| Ludovici, Donald \| Parker, Michael H. \| Meyer, Christophe \| Rocaboy, Christian \| ... \| Meerpoel, Lieven Bioorganic & Medicinal Chemistry Letters, volume 28, issue 12, pages 2159-2164 (2018). 10.1016/j.bmcl.2018.05.014 Cited by (27) \| Cite \| Source
Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors (journal article) Meegalla, Sanath K. \| Huang, Hui \| Illig, Carl R. \| Parks, Daniel J. \| Chen, Jinsheng \| Lee, Yu-Kai \| Wilson, Kenneth J. \| Patel, Sharmila K. \| Cheung, Wing S. \| Lu, Tianbao \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 17, pages 4216-4222 (2016). 10.1016/j.bmcl.2016.07.054 Cited by (12) \| Cite \| Source
Discovery and Clinical Evaluation of 1-{ N -[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif (journal article) Lu, Tianbao \| Markotan, Thomas \| Ballentine, Shelley K. \| Giardino, Edward C. \| Spurlino, John \| Brown, Kathryn \| Maryanoff, Bruce E. \| Tomczuk, Bruce E. \| Damiano, Bruce P. \| Shukla, Umesh \| ... \| Player, Mark R. Journal of Medicinal Chemistry, volume 53, issue 4, pages 1843-1856 (2010). 10.1021/jm901802n Cited by (30) \| Cite \| Source
Substituted phenyl acetamides and their use as protease inhibitors (patent) Kreutter, Kevin D. \| Lee, Lily \| Lu, Tianbao \| Mohan, Venkatraman \| Patel, Sharmila \| Huang, Hui \| Xu, Guozhang \| Fitzgerald, Mark Patent Number: 7550474 (2009) Cite \| Source
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif (journal article) Kreutter, Kevin D. \| Lu, Tianbao \| Lee, Lily \| Giardino, Edward C. \| Patel, Sharmila \| Huang, Hui \| Xu, Guozhang \| Fitzgerald, Mark \| Haertlein, Barbara J. \| Mohan, Venkatraman \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 9, pages 2865-2870 (2008). 10.1016/j.bmcl.2008.03.087 Cited by (29) \| Cite \| Source
7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa (journal article) Lee, Yu-Kai \| Parks, Daniel J. \| Lu, Tianbao \| Thieu, Tho V. \| Markotan, Thomas \| Pan, Wenxi \| McComsey, David F. \| Milkiewicz, Karen L. \| Crysler, Carl S. \| Ninan, Nisha \| ... \| Player, Mark R. Journal of Medicinal Chemistry, volume 51, issue 2, pages 282-297 (2008). 10.1021/jm701217r Cited by (52) \| Cite \| Source
2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors (journal article) Lee, Lily \| Kreutter, Kevin D. \| Pan, Wenxi \| Crysler, Carl \| Spurlino, John \| Player, Mark R. \| Tomczuk, Bruce \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 17, issue 22, pages 6266-6269 (2007). 10.1016/j.bmcl.2007.09.013 Cited by (41) \| Cite \| Source
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity (journal article) Leonard, Kristi \| Marugan, Juan Jose \| Raboisson, Pierre \| Calvo, Raul \| Gushue, Joan M. \| Koblish, Holly K. \| Lattanze, Jennifer \| Zhao, Shuyuan \| Cummings, Maxwell D. \| Player, Mark R. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 13, pages 3463-3468 (2006). 10.1016/j.bmcl.2006.04.009 Cited by (57) \| Cite \| Source
Exploration of Potential Prodrugs of RWJ‐445167, an Oxyguanidine‐based Dual Inhibitor of Thrombin and Factor Xa (journal article) Maryanoff, Bruce E. \| McComsey, David F. \| Costanzo, Michael J. \| Yabut, Stephen C. \| Lu, Tianbao \| Player, Mark R. \| Giardino, Edward C. \| Damiano, Bruce P. Chemical Biology & Drug Design, volume 68, issue 1, pages 29-36 (2006). 10.1111/j.1747-0285.2006.00408.x Cited by (22) \| Cite \| Source \| Open Access
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists (journal article) Marugan, Juan Jose \| Leonard, Kristi \| Raboisson, Pierre \| Gushue, Joan M. \| Calvo, Raul \| Koblish, Holly K. \| Lattanze, Jennifer \| Zhao, Shuyuan \| Cummings, Maxwell D. \| Player, Mark R. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3115-3120 (2006). 10.1016/j.bmcl.2006.03.067 Cited by (33) \| Cite \| Source
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design (journal article) Parks, Daniel J. \| LaFrance, Louis V. \| Calvo, Raul R. \| Milkiewicz, Karen L. \| José Marugán, Juan \| Raboisson, Pierre \| Schubert, Carsten \| Koblish, Holly K. \| Zhao, Shuyuan \| Franks, Carol F. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3310-3314 (2006). 10.1016/j.bmcl.2006.03.055 Cited by (70) \| Cite \| Source
Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors (patent) Lu, Tianbao \| Tomczuk, Bruce E. \| Markotan, Thomas P. \| Siedem, Colleen Patent Number: 7029654 (2006) Cited by (5) \| Cite \| Source
Cyclic oxyguanidine pyrazinones as protease inhibitors (patent) Wang, Aihua \| Tomczuk, Bruce Edward \| Lu, Tianbao \| Soll, Richard M. \| Spurlino, John Curtis \| Bone, Roger Francis Patent Number: 7030110 (2006) Cited by (5) \| Cite \| Source
Substituted 1,4‐Benzodiazepine‐2,5‐diones as α ‐Helix Mimetic Antagonists of the HDM2‐p53 Protein–Protein Interaction (journal article) Cummings, Maxwell D. \| Schubert, Carsten \| Parks, Daniel J. \| Calvo, Raul R. \| LaFrance, Louis V. \| Lattanze, Jennifer \| Milkiewicz, Karen L. \| Lu, Tianbao Chemical Biology & Drug Design, volume 67, issue 3, pages 201-205 (2006). 10.1111/j.1747-0285.2006.00365.x Cited by (43) \| Cite \| Source \| Open Access
Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo (journal article) Koblish, Holly K. \| Zhao, Shuyuan \| Franks, Carol F. \| Donatelli, Robert R. \| Tominovich, Rose M. \| LaFrance, Louis V. \| Leonard, Kristi A. \| Gushue, Joan M. \| Parks, Daniel J. \| Calvo, Raul R. \| ... \| Maroney, Anna C. Molecular Cancer Therapeutics, volume 5, issue 1, pages 160-169 (2006). 10.1158/1535-7163.MCT-05-0199 Cited by (145) \| Cite \| Source \| Open Access
1,4‐Benzodiazepine‐2,5‐diones as Small Molecule Antagonists of the HDM2—p53 Interaction: Discovery and SAR. (journal article) Lu, Tianbao ChemInform, volume 36, issue 25 (2005). 10.1002/chin.200525165 Cite \| Source
Aminopyridyl-substituted phenyl acetamides as protease inhibitors (patent) Pan, Wenxi \| Lu, Tianbao \| Markotan, Thomas P. \| Tomczuk, Bruce E. Patent Number: 6900231 (2005) Cited by (8) \| Cite \| Source
Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists (journal article) Raboisson, Pierre \| Marugán, Juan José \| Schubert, Carsten \| Koblish, Holly K. \| Lu, Tianbao \| Zhao, Shuyuan \| Player, Mark R. \| Maroney, Anna C. \| Reed, Rolanda L. \| Huebert, Norman D. \| ... \| Cummings, Maxwell D. Bioorganic & Medicinal Chemistry Letters, volume 15, issue 7, pages 1857-1861 (2005). 10.1016/j.bmcl.2005.02.018 Cited by (49) \| Cite \| Source