Saroja Ramanujan

ScholarGPS® ID: 52158470409922

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacology and Toxicology

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

3,592

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule (journal article) Hosseini, Iraj \| Fleisher, Brett \| Getz, Jennifer \| Decalf, Jérémie \| Kwong, Mandy \| Ovacik, Meric \| Bainbridge, Travis W. \| Moussion, Christine \| Rao, Gautham K. \| Gadkar, Kapil \| ... \| Ramanujan, Saroja Pharmaceutics, volume 16, issue 5, pages 660- (2024). 10.3390/pharmaceutics16050660 Cite \| Source
Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy (journal article) Joslyn, Louis R. \| Huang, Weize \| Miles, Dale \| Hosseini, Iraj \| Ramanujan, Saroja npj Systems Biology and Applications, volume 10, issue 1 (2024). 10.1038/s41540-024-00335-7 Cited by (1) \| Cite \| Source
Systems‐based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL (journal article) Susilo, Monica E. \| Li, Chi‐Chung \| Gadkar, Kapil \| Hernandez, Genevive \| Huw, Ling‐Yuh \| Jin, Jin Y. \| Yin, Shen \| Wei, Michael C. \| Ramanujan, Saroja \| Hosseini, Iraj Clinical and Translational Science, volume 16, issue 7, pages 1134-1148 (2023). 10.1111/cts.13501 Cited by (16) \| Cite \| Source
Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics (journal article) Lu, Dan \| Yadav, Rajbharan \| Holder, Patrick \| Chiang, Eugene \| Sanjabi, Shomyseh \| Poon, Victor \| Bernett, Matthew \| Varma, Rajat \| Liu, Ke \| Leung, Irene \| ... \| Ramanujan, Saroja European Journal of Pharmaceutical Sciences, volume 186 (2023). 10.1016/j.ejps.2023.106450 Cited by (6) \| Cite \| Source
A mechanistic PK / PD model to enable dose selection of the potent anti‐tryptase antibody ( MTPS9579A ) in patients with moderate‐to‐severe asthma (journal article) Rymut, Sharon M. \| Henderson, Lindsay M. \| Poon, Victor \| Staton, Tracy L. \| Cai, Fang \| Sukumaran, Siddharth \| Rhee, Horace \| Owen, Ryan \| Ramanujan, Saroja \| Yoshida, Kenta Clinical and Translational Science, volume 16, issue 4, pages 694-703 (2023). 10.1111/cts.13483 Cite \| Source
The convergence of pharmacometrics and quantitative systems pharmacology in pharmaceutical research and development (journal article) Joshi, Amita \| Ramanujan, Saroja \| Jin, Jin Y. European Journal of Pharmaceutical Sciences, volume 182 (2023). 10.1016/j.ejps.2023.106380 Cited by (2) \| Cite \| Source
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates (journal article) Ramakrishnan, Vidya \| Friedrich, Christina \| Witt, Colleen \| Sheehan, Robert \| Pryor, Meghan \| Atwal, Jasvinder K. \| Wildsmith, Kristin \| Kudrycki, Katherine \| Lee, Seung‐Hye \| Mazer, Norman \| ... \| Quartino, Angelica CPT: Pharmacometrics & Systems Pharmacology, volume 12, issue 1, pages 62-73 (2023). 10.1002/psp4.12876 Cited by (5) \| Cite \| Source
Integrated systems modeling of severe asthma: Exploration of IL ‐33/ ST2 antagonism (journal article) Gadkar, Kapil \| Feigelman, Justin \| Sukumaran, Siddharth \| Rodrigo, Manoj C. \| Staton, Tracy \| Cai, Fang \| Bauer, Rebecca N. \| Choy, David F. \| Stokes, Cynthia L. \| Scheerens, Heleen \| Ramanujan, Saroja CPT: Pharmacometrics & Systems Pharmacology, volume 11, issue 9, pages 1268-1277 (2022). 10.1002/psp4.12842 Cited by (4) \| Cite \| Source
Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors (journal article) Gadkar, Kapil \| Friedrich, Christina \| Hurez, Vincent \| Ruiz, Maria‐Luisa \| Dickmann, Leslie \| Kumar Jolly, Mohit \| Schutt, Leah \| Jin, Jin \| Ware, Joseph A. \| Ramanujan, Saroja CPT: Pharmacometrics & Systems Pharmacology, volume 11, issue 5, pages 616-627 (2022). 10.1002/psp4.12749 Cited by (4) \| Cite \| Source
Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making (journal article) Kondic, Anna \| Bottino, Dean \| Harrold, John \| Kearns, Jeffrey D. \| Musante, CJ \| Odinecs, Aleksandrs \| Ramanujan, Saroja \| Selimkhanov, Jangir \| Schoeberl, Birgit Frontiers in Pharmacology, volume 13 (2022). 10.3389/fphar.2022.860881 Cited by (6) \| Cite \| Source
Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling (journal article) Hosseini, Iraj \| Gadkar, Kapil \| Stefanich, Eric \| Li, Chi-Chung \| Sun, Liping L. \| Chu, Yu-Waye \| Ramanujan, Saroja npj Systems Biology and Applications, volume 6, issue 1 (2020). 10.1038/s41540-020-00145-7 Cited by (68) \| Cite \| Source
Anti-tryptase antibodies, compositions thereof, and uses thereof (patent) Chen, Xiaocheng \| Dennis, Mark \| Jackman, Janet \| Koerber, James T. \| Lu, Mason \| Maun, Henry R. \| Rajapaksa, Kathila \| Ramanujan, Saroja \| Staton, Tracy \| Wu, Lawren \| Yi, Tangsheng Patent Number: 10752703 (2020) Cite \| Source
Anti-tryptase antibodies, compositions thereof, and uses thereof (patent) Chen, Xiaocheng \| Dennis, Mark \| Jackman, Janet \| Koerber, James T. \| Lu, Mason \| Maun, Henry R. \| Rajapaksa, Kathila \| Ramanujan, Saroja \| Staton, Tracy \| Wu, Lawren \| Yi, Tangsheng Patent Number: 10738131 (2020) Cite \| Source
Mechanistic Modeling of Soluble Aβ Dynamics and Target Engagement in the Brain by Anti-Aβ mAbs in Alzheimer’s Disease (journal article) Ferl, Gregory Z. \| Fuji, Reina N. \| Atwal, Jasvinder K. \| Sun, Tony \| Ramanujan, Saroja \| Quartino, Angelica L. Current Alzheimer Research, volume 17, issue 4, pages 393-406 (2020). 10.2174/1567205017666200302122307 Cited by (7) \| Cite \| Source
gQSPSim: A SimBiology‐Based GUI for Standardized QSP Model Development and Application (journal article) Hosseini, Iraj \| Feigelman, Justin \| Gajjala, Anita \| Susilo, Monica \| Ramakrishnan, Vidya \| Ramanujan, Saroja \| Gadkar, Kapil CPT: Pharmacometrics & Systems Pharmacology, volume 9, issue 3, pages 165-176 (2020). 10.1002/psp4.12494 Cited by (13) \| Cite \| Source
Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus (journal article) Deng, Rong \| Zhou, Chenguang \| Li, Dongwei \| Cai, Hao \| Sukumaran, Siddharth \| Carrasco-Triguero, Montserrat \| Saad, Ola \| Nazzal, Denise \| Lowe, Christopher \| Ramanujan, Saroja \| Kamath, Amrita V. mAbs, volume 11, issue 6, pages 1162-1174 (2019). 10.1080/19420862.2019.1627152 Cited by (26) \| Cite \| Source
A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models (journal article) Ramanujan, Saroja \| Chan, Jason R. \| Friedrich, Christina M. \| Thalhauser, Craig J. CPT: Pharmacometrics & Systems Pharmacology, volume 8, issue 6, pages 340-343 (2019). 10.1002/psp4.12409 Cited by (13) \| Cite \| Source
A Preclinical Population Pharmacokinetic Model for Anti‐CD20/CD3 T‐Cell‐Dependent Bispecific Antibodies (journal article) Ferl, Gregory Z. \| Reyes, Arthur \| Sun, Liping L. \| Cheu, Melissa \| Oldendorp, Amy \| Ramanujan, Saroja \| Stefanich, Eric G. Clinical and Translational Science, volume 11, issue 3, pages 296-304 (2018). 10.1111/cts.12535 Cited by (22) \| Cite \| Source \| Open Access
gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development (journal article) Hosseini, Iraj \| Gajjala, Anita \| Bumbaca Yadav, Daniela \| Sukumaran, Siddharth \| Ramanujan, Saroja \| Paxson, Ricardo \| Gadkar, Kapil Journal of Pharmacokinetics and Pharmacodynamics, volume 45, issue 2, pages 259-275 (2018). 10.1007/s10928-017-9562-9 Cited by (21) \| Cite \| Source \| Open Access
A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types (journal article) Wagle, Marie-Claire \| Kirouac, Daniel \| Klijn, Christiaan \| Liu, Bonnie \| Mahajan, Shilpi \| Junttila, Melissa \| Moffat, John \| Merchant, Mark \| Huw, Ling \| Wongchenko, Matthew \| ... \| Huang, Shih-Min A. npj Precision Oncology, volume 2, issue 1 (2018). 10.1038/s41698-018-0051-4 Cited by (98) \| Cite \| Source \| Open Access

Title	Investigators	Year	Cost	Agency
TRANSPORT OF GENES VECTORS IN TUMORS	Ramanujan, Saroja	2000	$11,334	NATIONAL CANCER INSTITUTE
TRANSPORT OF GENES VECTORS IN TUMORS	Ramanujan, Saroja	1999	$31,720	NATIONAL CANCER INSTITUTE