Karen Wigglesworth

ScholarGPS® ID: 52093823682516

Affiliation

Jackson Laboratory, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

8,380

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Transcriptomic Diversification of Developing Cumulus and Mural Granulosa Cells in Mouse Ovarian Follicles1 (journal article) Wigglesworth, Karen \| Lee, Kyung-Bon \| Emori, Chihiro \| Sugiura, Koji \| Eppig, John J. Biology of Reproduction, volume 92, issue 1 (2015). 10.1095/biolreprod.114.121756 Cited by (74) \| Cite \| Source \| Open Access
Amino Acid 72 of Mouse and Human GDF9 Mature Domain Is Responsible for Altered Homodimer Bioactivities but Has Subtle Effects on GDF9:BMP15 Heterodimer Activities1 (journal article) Peng, Jia \| Wigglesworth, Karen \| Rangarajan, Adithya \| Eppig, John J. \| Thompson, Thomas B. \| Matzuk, Martin M. Biology of Reproduction, volume 91, issue 6 (2014). 10.1095/biolreprod.114.123158 Cited by (4) \| Cite \| Source \| Open Access
Cooperative Effects of 17β-Estradiol and Oocyte-Derived Paracrine Factors on the Transcriptome of Mouse Cumulus Cells (journal article) Emori, Chihiro \| Wigglesworth, Karen \| Fujii, Wataru \| Naito, Kunihiko \| Eppig, John J. \| Sugiura, Koji Endocrinology, volume 154, issue 12, pages 4859-4872 (2013). 10.1210/en.2013-1536 Cited by (25) \| Cite \| Source \| Open Access
Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes (journal article) Wigglesworth, Karen \| Lee, Kyung-Bon \| O’Brien, Marilyn J. \| Peng, Jia \| Matzuk, Martin M. \| Eppig, John J. Proceedings of the National Academy of Sciences, volume 110, issue 39 (2013). 10.1073/pnas.1314829110 Cited by (153) \| Cite \| Source \| Open Access
Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions (journal article) Peng, Jia \| Li, Qinglei \| Wigglesworth, Karen \| Rangarajan, Adithya \| Kattamuri, Chandramohan \| Peterson, Randall T. \| Eppig, John J. \| Thompson, Thomas B. \| Matzuk, Martin M. Proceedings of the National Academy of Sciences, volume 110, issue 8 (2013). 10.1073/pnas.1218020110 Cited by (245) \| Cite \| Source \| Open Access
Hormonal Coordination of Natriuretic Peptide Type C and Natriuretic Peptide Receptor 3 Expression in Mouse Granulosa Cells1 (journal article) Lee, Kyung-Bon \| Zhang, Meijia \| Sugiura, Koji \| Wigglesworth, Karen \| Uliasz, Tracy \| Jaffe, Laurinda A. \| Eppig, John J. Biology of Reproduction, volume 88, issue 2 (2013). 10.1095/biolreprod.112.104810 Cited by (49) \| Cite \| Source \| Open Access
Cooperative Activities of Oocyte-Derived Paracrine Factors and Estrogen on Cumulus Cell Proliferation and Metabolism. (journal article) Emori, Chihiro \| Wigglesworth, Karen \| Naito, Kunihiko \| Eppig, John \| Sugiura, Koji Biology of Reproduction, volume 87, issue Suppl_1, pages 525-525 (2012). 10.1093/biolreprod/87.s1.525 Cite \| Source
Estradiol Promotes and Maintains Cumulus Cell Expression of Natriuretic Peptide Receptor 2 (NPR2) and Meiotic Arrest in Mouse Oocytes In Vitro (journal article) Zhang, Meijia \| Su, You-Qiang \| Sugiura, Koji \| Wigglesworth, Karen \| Xia, Guoliang \| Eppig, John J. Endocrinology, volume 152, issue 11, pages 4377-4385 (2011). 10.1210/en.2011-1118 Cited by (137) \| Cite \| Source \| Open Access
Estrogen Promotes the Development of Mouse Cumulus Cells in Coordination with Oocyte-Derived GDF9 and BMP15 (journal article) Sugiura, Koji \| Su, You-Qiang \| Li, Qinglei \| Wigglesworth, Karen \| Matzuk, Martin M. \| Eppig, John J. Molecular Endocrinology, volume 24, issue 12, pages 2303-2314 (2010). 10.1210/me.2010-0260 Cited by (84) \| Cite \| Source \| Open Access
Mouse Oocytes Promote the Mechanistic Target of Rapamycin (Serine/Threonine Kinase, MTOR) Pathway in Cumulus Cells by Suppressing the Expression of DNA-damage-inducible Transcript 4-like (Ddit4l). (journal article) Su, You-Qiang \| Sugiura, Koji \| Wigglesworth, Karen \| Eppig, John J. Biology of Reproduction, volume 83, issue Suppl_1, pages 149-149 (2010). 10.1093/biolreprod/83.s1.149 Cite \| Source
Mouse Oocytes Enable LH-Induced Maturation of the Cumulus-Oocyte Complex via Promoting EGF Receptor-Dependent Signaling (journal article) Su, You-Qiang \| Sugiura, Koji \| Li, Qinglei \| Wigglesworth, Karen \| Matzuk, Martin M. \| Eppig, John J. Molecular Endocrinology, volume 24, issue 6, pages 1230-1239 (2010). 10.1210/me.2009-0497 Cited by (99) \| Cite \| Source \| Open Access
Fibroblast Growth Factors and Epidermal Growth Factor Cooperate with Oocyte-Derived Members of the TGFbeta Superfamily to Regulate Spry2 mRNA Levels in Mouse Cumulus Cells1 (journal article) Sugiura, Koji \| Su, You-Qiang \| Li, Qinglei \| Wigglesworth, Karen \| Matzuk, Martin M. \| Eppig, John J. Biology of Reproduction, volume 81, issue 5, pages 833-841 (2009). 10.1095/biolreprod.109.078485 Cited by (52) \| Cite \| Source \| Open Access
Probe-Level Analysis of Expression Microarrays Characterizes Isoform-Specific Degradation during Mouse Oocyte Maturation (journal article) Salisbury, Jesse \| Hutchison, Keith W. \| Wigglesworth, Karen \| Eppig, John J. \| Graber, Joel H. PLoS ONE, volume 4, issue 10, pages e7479- (2009). 10.1371/journal.pone.0007479 Cited by (28) \| Cite \| Source \| Open Access
Oocyte-Maturation Defective 1 (omd1): An ENU-Induced Mutation in Mouse Affecting the Oocyte-to-Embryo Transition. (journal article) Su, You-Qiang \| Wigglesworth, Karen \| Handel, Mary Ann \| Schimenti, John \| Eppig, John Biology of Reproduction, volume 81, issue Suppl_1, pages 287-287 (2009). 10.1093/biolreprod/81.s1.287 Cite \| Source
Effect of in vitro maturation of mouse oocytes on the health and lifespan of adult offspring (journal article) Eppig, J.J. \| O'Brien, M.J. \| Wigglesworth, K. \| Nicholson, A. \| Zhang, W. \| King, B.A. Human Reproduction, volume 24, issue 4, pages 922-928 (2008). 10.1093/humrep/den466 Cited by (53) \| Cite \| Source \| Open Access
The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte–embryo transition (journal article) Philipps, Dana L. \| Wigglesworth, Karen \| Hartford, Suzanne A. \| Sun, Fengyun \| Pattabiraman, Shrivatsav \| Schimenti, Kerry \| Handel, MaryAnn \| Eppig, John J. \| Schimenti, John C. Developmental Biology, volume 317, issue 1, pages 72-82 (2008). 10.1016/j.ydbio.2008.02.018 Cited by (59) \| Cite \| Source \| Open Access
Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells (journal article) Sugiura, Koji \| Su, You-Qiang \| Diaz, Francisco J. \| Pangas, Stephanie A. \| Sharma, Shweta \| Wigglesworth, Karen \| O'Brien, Marilyn J. \| Matzuk, Martin M. \| Shimasaki, Shunichi \| Eppig, John J. Development, volume 135, issue 4, pages 786-786 (2008). 10.1242/dev.020024 Cited by (6) \| Cite \| Source \| Open Access
Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells (journal article) Su, You-Qiang \| Sugiura, Koji \| Wigglesworth, Karen \| O'Brien, Marilyn J. \| Affourtit, Jason P. \| Pangas, Stephanie A. \| Matzuk, Martin M. \| Eppig, John J. Development, volume 135, issue 1, pages 111-121 (2008). 10.1242/dev.009068 Cited by (316) \| Cite \| Source \| Open Access
Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells (journal article) Sugiura, Koji \| Su, You-Qiang \| Diaz, Francisco J. \| Pangas, Stephanie A. \| Sharma, Shweta \| Wigglesworth, Karen \| O'Brien, Marilyn J. \| Matzuk, Martin M. \| Shimasaki, Shunichi \| Eppig, John J. Development, volume 134, issue 14, pages 2593-2603 (2007). 10.1242/dev.006882 Cited by (265) \| Cite \| Source \| Open Access
MOUSE OOCYTES PROMOTE STEROL BIOSYNTHESIS IN CUMULUS CELLS: MORE EVIDENCE FOR OOCYTEREGULATION OF METABOLIC COOPERATIVITY BETWEEN GRANULOSA CELLS AND OOCYTES (journal article) Su, You-Qiang \| Sugiura, Koji \| Wigglesworth, Karen \| Pangas, Stephanie \| Matzuk, Martin \| Eppig, John Biology of Reproduction, volume 77, issue Suppl_1, pages 189-189 (2007). 10.1093/biolreprod/77.s1.189c Cite \| Source