Agnese C. Pippione

ScholarGPS® ID: 51931403898634

Affiliation

University of Turin, Turin, Italy

Affiliation History

Field

Life Sciences

Discipline

Neurosciences

Top Specialties

Medicinal Chemistry | Scaffolding | Leukemia

Metrics Summary

Publication Count

Predicted Citations

1,005

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold (journal article) Pippione, Agnese Chiara \| Kilic-Kurt, Zühal \| Kovachka, Sandra \| Sainas, Stefano \| Rolando, Barbara \| Denasio, Enrica \| Pors, Klaus \| Adinolfi, Salvatore \| Zonari, Daniele \| Bagnati, Renzo \| ... \| Boschi, Donatella European Journal of Medicinal Chemistry, volume 237 (2022). 10.1016/j.ejmech.2022.114366 Cited by (10) \| Cite \| Source
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats (journal article) Rubin, Elina \| Pippione, Agnese C. \| Boyko, Matthew \| Einaudi, Giacomo \| Sainas, Stefano \| Collino, Massimo \| Cifani, Carlo \| Lolli, Marco L. \| Abu-Freha, Naim \| Kaplanski, Jacob \| ... \| Azab, Abed N. Brain Sciences, volume 12, issue 1, pages 35- (2021). 10.3390/brainsci12010035 Cited by (10) \| Cite \| Source
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Biphenyl Moiety (journal article) Sainas, Stefano \| Giorgis, Marta \| Circosta, Paola \| Gaidano, Valentina \| Bonanni, Davide \| Pippione, Agnese C. \| Bagnati, Renzo \| Passoni, Alice \| Qiu, Yaqi \| Cojocaru, Carina Florina \| ... \| Lolli, Marco L. Journal of Medicinal Chemistry, volume 64, issue 9, pages 5404-5428 (2021). 10.1021/acs.jmedchem.0c01549 Cited by (22) \| Cite \| Source
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication (journal article) Luganini, Anna \| Sibille, Giulia \| Mognetti, Barbara \| Sainas, Stefano \| Pippione, Agnese Chiara \| Giorgis, Marta \| Boschi, Donatella \| Lolli, Marco L. \| Gribaudo, Giorgio Antiviral Research, volume 189 (2021). 10.1016/j.antiviral.2021.105057 Cited by (23) \| Cite \| Source
AKR1C3 is a biomarker and druggable target for oropharyngeal tumors (journal article) Peraldo-Neia, Caterina \| Ostano, Paola \| Mello-Grand, Maurizia \| Guana, Francesca \| Gregnanin, Ilaria \| Boschi, Donatella \| Oliaro-Bosso, Simonetta \| Pippione, Agnese Chiara \| Carenzo, Andrea \| De Cecco, Loris \| ... \| Chiorino, Giovanna Cellular Oncology (2021). 10.1007/s13402-020-00571-z Cited by (8) \| Cite \| Source
The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia (journal article) Gaidano, Valentina \| Houshmand, Mohammad \| Vitale, Nicoletta \| Carrà, Giovanna \| Morotti, Alessandro \| Tenace, Valerio \| Rapelli, Stefania \| Sainas, Stefano \| Pippione, Agnese Chiara \| Giorgis, Marta \| ... \| Circosta, Paola Cancers, volume 13, issue 5, pages 1003- (2021). 10.3390/cancers13051003 Cited by (20) \| Cite \| Source
Hydroxyazoles as acid isosteres and their drug design applications—Part 1: Monocyclic systems (book chapter) In Applications of Heterocycles in the Design of Drugs and Agricultural Products Sainas, Stefano \| Pippione, Agnese C. \| Boschi, Donatella \| Lolli, Marco L. Elsevier (2021) 10.1016/bs.aihch.2020.12.001 Cited by (11) \| Cite \| Source
Hydroxyazoles as acid isosteres and their drug design applications—Part 2: Bicyclic systems (book chapter) In Applications of Heterocycles in the Design of Drugs and Agricultural Products Pippione, Agnese C. \| Sainas, Stefano \| Boschi, Donatella \| Lolli, Marco L. Elsevier (2021) 10.1016/bs.aihch.2020.12.002 Cited by (10) \| Cite \| Source
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research (journal article) Boschi, Donatella \| Pippione, Agnese Chiara \| Sainas, Stefano \| Lolli, Marco L. European Journal of Medicinal Chemistry, volume 183 (2019). 10.1016/j.ejmech.2019.111681 Cited by (58) \| Cite \| Source
Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia (journal article) Gaidano, Valentina \| Circosta, Paola \| Cignetti, Alessandro \| Houshmand, Mohammad \| Vitale, Nicoletta \| Sainas, Stefano \| Pippione, Agnese \| Marraudino, Manuela \| Bonaldo, Brigitta \| Giorgis, Marta \| ... \| Saglio, Giuseppe Blood, volume 134, issue Supplement_1, pages 3942-3942 (2019). 10.1182/blood-2019-128085 Cite \| Source
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3 (journal article) Lolli, Marco L. \| Carnovale, Irene M. \| Pippione, Agnese C. \| Wahlgren, Weixiao Y. \| Bonanni, Davide \| Marini, Elisabetta \| Zonari, Daniele \| Gallicchio, Margherita \| Boscaro, Valentina \| Goyal, Parveen \| ... \| Boschi, Donatella ACS Medicinal Chemistry Letters, volume 10, issue 4, pages 437-443 (2019). 10.1021/acsmedchemlett.8b00484 Cited by (33) \| Cite \| Source
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies (journal article) Pippione, Agnese C. \| Sainas, Stefano \| Goyal, Parveen \| Fritzson, Ingela \| Cassiano, Gustavo C. \| Giraudo, Alessandro \| Giorgis, Marta \| Tavella, Tatyana A. \| Bagnati, Renzo \| Rolando, Barbara \| ... \| Lolli, Marco L. European Journal of Medicinal Chemistry, volume 163 (2019). 10.1016/j.ejmech.2018.11.044 Cited by (23) \| Cite \| Source
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors (journal article) Sainas, Stefano \| Pippione, Agnese C. \| Lupino, Elisa \| Giorgis, Marta \| Circosta, Paola \| Gaidano, Valentina \| Goyal, Parveen \| Bonanni, Davide \| Rolando, Barbara \| Cignetti, Alessandro \| ... \| Lolli, Marco L. Journal of Medicinal Chemistry, volume 61, issue 14, pages 6034-6055 (2018). 10.1021/acs.jmedchem.8b00373 Cited by (57) \| Cite \| Source
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors (journal article) Sainas, Stefano \| Pippione, Agnese Chiara \| Lupino, Elisa \| Giorgis, Marta \| Circosta, Paola \| Gaidano, Valentina \| Goyal, Parveen \| bonanni, davide \| Rolando, Barbara \| Cignetti, Alessandro \| ... \| Lolli, Marco L. Journal of Medicinal Chemistry, volume 61, issue 14, pages 6034-6055 (2018). 10.2210/pdb6fmd/pdb Cited by (3) \| Cite \| Source
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. (journal article) Pippione, Agnese Chiara \| Carnovale, Irene Maria \| Bonanni, Davide \| Sini, Marcella \| Goyal, Parveen \| Marini, Elisabetta \| Pors, Klaus \| Adinolfi, Salvatore \| Zonari, Daniele \| Festuccia, Claudio \| ... \| Lolli, Marco L. European Journal of Medicinal Chemistry, volume 150 (2018). 10.2210/pdb6f2u/pdb Cited by (3) \| Cite \| Source \| Open Access
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid (journal article) Pippione, Agnese Chiara \| Carnovale, Irene Maria \| Bonanni, Davide \| Sini, Marcella \| Goyal, Parveen \| Marini, Elisabetta \| Pors, Klaus \| Adinolfi, Salvatore \| Zonari, Daniele \| Festuccia, Claudio \| ... \| Lolli, Marco Lucio European Journal of Medicinal Chemistry, volume 150 (2018). 10.1016/j.ejmech.2018.03.040 Cited by (41) \| Cite \| Source \| Open Access
Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy (journal article) Lolli, Marco L. \| Sainas, Stefano \| Pippione, Agnese C. \| Giorgis, Marta \| Boschi, Donatella \| Dosio, Franco Recent Patents on Anti-Cancer Drug Discovery, volume 13, issue 1 (2018). 10.2174/1574892812666171108124218 Cited by (60) \| Cite \| Source
N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK (journal article) Pippione, Agnese C. \| Sainas, Stefano \| Federico, Antonella \| Lupino, Elisa \| Piccinini, Marco \| Kubbutat, Michael \| Contreras, Jean-Marie \| Morice, Christophe \| Barge, Alessandro \| Ducime, Alex \| ... \| Lolli, Marco L. MedChemComm, volume 9, issue 6, pages 963-968 (2018). 10.1039/C8MD00068A Cited by (25) \| Cite \| Source
DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents (journal article) Sainas, S. \| Pippione, A.C. \| Boschi, D., \| Gaidano, V. \| Circosta, P. \| Cignetti, A. \| Dosio, F., \| Lolli, M.L., Drugs of the Future , volume 43, issue 11, pages 0823- (2018). 10.1358/dof.2018.043.11.2856492 Cited by (8) \| Cite \| Source
Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention (journal article) Pippione, Agnese C. \| Boschi, Donatella \| Pors, Klaus \| Oliaro-Bosso, Simonetta \| Lolli, Marco L. Journal of Cancer Metastasis and Treatment, volume 3, issue 12, pages 328- (2017). 10.20517/2394-4722.2017.44 Cited by (22) \| Cite \| Source \| Open Access