James D. Firth

ScholarGPS® ID: 51162887397222

Affiliation

University of York, Heslington, York, United Kingdom

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Chemical Synthesis

Metrics Summary

Publication Count

Predicted Citations

738

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Deciphering complexity in Pd–catalyzed cross-couplings (journal article) Clarke, George E. \| Firth, James D. \| Ledingham, Lyndsay A. \| Horbaczewskyj, Chris S. \| Bourne, Richard A. \| Bray, Joshua T. W. \| Martin, Poppy L. \| Eastwood, Jonathan B. \| Campbell, Rebecca \| Pagett, Alex \| ... \| Fairlamb, Ian J. S. Nature Communications, volume 15, issue 1 (2024). 10.1038/s41467-024-47939-5 Cited by (1) \| Cite \| Source
α‐Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping (journal article) Seling, Nico \| Atobe, Masakazu \| Kasten, Kevin \| Firth, James D. \| Karadakov, Peter B. \| Goldberg, Frederick W. \| O'Brien, Peter Angewandte Chemie, volume 136, issue 2 (2024). 10.1002/ange.202314423 Cite \| Source
α‐Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping (journal article) Seling, Nico \| Atobe, Masakazu \| Kasten, Kevin \| Firth, James D. \| Karadakov, Peter B. \| Goldberg, Frederick W. \| O'Brien, Peter Angewandte Chemie International Edition, volume 63, issue 2 (2024). 10.1002/anie.202314423 Cited by (1) \| Cite \| Source
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates (journal article) Jones, S. Paul \| Firth, James D. \| Wheldon, Mary C. \| Atobe, Masakazu \| Hubbard, Roderick E. \| Blakemore, David C. \| De Fusco, Claudia \| Lucas, Simon C. C. \| Roughley, Stephen D. \| Vidler, Lewis R. \| ... \| O'Brien, Peter RSC Medicinal Chemistry, volume 13, issue 12, pages 1614-1620 (2022). 10.1039/D2MD00239F Cite \| Source
Synthesis and functionalisation of a bifunctional normorphan 3D building block for medicinal chemistry (journal article) Gomez-Angel, Andres R. \| Donald, James R. \| Firth, James D. \| De Fusco, Claudia \| Ian Storer, R. \| Cox, Daniel J. \| O’Brien, Peter Tetrahedron, volume 83 (2021). 10.1016/j.tet.2021.131961 Cited by (4) \| Cite \| Source
Light‐ and Manganese‐Initiated Borylation of Aryl Diazonium Salts: Mechanistic Insight on the Ultrafast Time‐Scale Revealed by Time‐Resolved Spectroscopic Analysis (journal article) Firth, James D. \| Hammarback, L. Anders \| Burden, Thomas J. \| Eastwood, Jonathan B. \| Donald, James R. \| Horbaczewskyj, Chris S. \| McRobie, Matthew T. \| Tramaseur, Adam \| Clark, Ian P. \| Towrie, Michael \| ... \| Fairlamb, Ian J. S. Chemistry – A European Journal, volume 27, issue 12, pages 3979-3985 (2021). 10.1002/chem.202004568 Cited by (16) \| Cite \| Source
Rapid “high” temperature batch and flow lithiation-trapping of N-Boc pyrrolidine (journal article) Kwong, Alice \| Firth, James D. \| Farmer, Thomas J. \| O’Brien, Peter Tetrahedron, volume 81 (2021). 10.1016/j.tet.2020.131899 Cited by (7) \| Cite \| Source
Fragment-derived modulators of an industrial β-glucosidase (journal article) Makraki, Eleni \| Darby, John F. \| Carneiro, Marta G. \| Firth, James D. \| Heyam, Alex \| AB, Eiso \| O'Brien, Peter \| Siegal, Gregg \| Hubbard, Roderick E. Biochemical Journal, volume 477, issue 22, pages 4383-4395 (2020). 10.1042/BCJ20200507 Cited by (2) \| Cite \| Source
A Need for Caution in the Preparation and Application of Synthetically Versatile Aryl Diazonium Tetrafluoroborate Salts (journal article) Firth, James D. \| Fairlamb, Ian J. S. Organic Letters, volume 22, issue 18, pages 7057-7059 (2020). 10.1021/acs.orglett.0c02685 Cited by (80) \| Cite \| Source
Design and Synthesis of 56 Shape‐Diverse 3D Fragments (journal article) Downes, Thomas D. \| Jones, S. Paul \| Klein, Hanna F. \| Wheldon, Mary C. \| Atobe, Masakazu \| Bond, Paul S. \| Firth, James D. \| Chan, Ngai S. \| Waddelove, Laura \| Hubbard, Roderick E. \| ... \| O'Brien, Peter Chemistry – A European Journal, volume 26, issue 41, pages 8969-8975 (2020). 10.1002/chem.202001123 Cited by (36) \| Cite \| Source
Gram‐Scale Synthesis of the (−)‐Sparteine Surrogate and (−)‐Sparteine (journal article) Firth, James D. \| Canipa, Steven J. \| Ferris, Leigh \| O'Brien, Peter Angewandte Chemie, volume 130, issue 1, pages 229-232 (2018). 10.1002/ange.201710261 Cited by (10) \| Cite \| Source \| Open Access
Gram‐Scale Synthesis of the (−)‐Sparteine Surrogate and (−)‐Sparteine (journal article) Firth, James D. \| Canipa, Steven J. \| Ferris, Leigh \| O'Brien, Peter Angewandte Chemie International Edition, volume 57, issue 1, pages 223-226 (2018). 10.1002/anie.201710261 Cited by (30) \| Cite \| Source
Chapter 4. Lead- and Fragment-oriented Synthesis (book chapter) In Chemical and Biological Synthesis Firth, James D. \| O'Brien, Peter Royal Society of Chemistry (2018) 10.1039/9781788012805-00074 Cited by (4) \| Cite \| Source
General Procedures for the Lithiation/Trapping of N -Boc Piperazines (journal article) Firth, James D. \| O’Brien, Peter \| Ferris, Leigh The Journal of Organic Chemistry, volume 82, issue 13, pages 7023-7031 (2017). 10.1021/acs.joc.7b00913 Cited by (10) \| Cite \| Source \| Open Access
Increase of enzyme activity through specific covalent modification with fragments (journal article) Darby, John F. \| Atobe, Masakazu \| Firth, James D. \| Bond, Paul \| Davies, Gideon J. \| O'Brien, Peter \| Hubbard, Roderick E. Chem. Sci., volume 8, issue 11, pages 7772-7779 (2017). 10.1039/C7SC01966A Cited by (35) \| Cite \| Source \| Open Access
ChemInform Abstract: Synthesis of Enantiopure Piperazines via Asymmetric Lithiation—Trapping of N‐Boc Piperazines: Unexpected Role of the Electrophile and Distal N‐Substituent. (journal article) Firth, James D. \| O'Brien, Peter \| Ferris, Leigh ChemInform, volume 47, issue 30 (2016). 10.1002/chin.201630204 Cite \| Source
Synthesis of Enantiopure Piperazines via Asymmetric Lithiation–Trapping of N -Boc Piperazines: Unexpected Role of the Electrophile and Distal N -Substituent (journal article) Firth, James D. \| O’Brien, Peter \| Ferris, Leigh Journal of the American Chemical Society, volume 138, issue 2, pages 651-659 (2016). 10.1021/jacs.5b11288 Cited by (50) \| Cite \| Source
A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds (journal article) Firth, James D. \| Craven, Philip G. E. \| Lilburn, Matthew \| Pahl, Axel \| Marsden, Stephen P. \| Nelson, Adam Chemical Communications, volume 52, issue 63, pages 9837-9840 (2016). 10.1039/C6CC04662B Cited by (26) \| Cite \| Source \| Open Access
ChemInform Abstract: Exploitation of the Ugi—Joullie Reaction in the Synthesis of Libraries of Drug‐Like Bicyclic Hydantoins. (journal article) Firth, James D. \| Zhang, Rong \| Morgentin, Remy \| Guilleux, Rachel \| Kalliokoski, Tuomo \| Warriner, Stuart \| Foster, Richard \| Marsden, Stephen P. \| Nelson, Adam ChemInform, volume 47, issue 1 (2016). 10.1002/chin.201601036 Cite \| Source \| Open Access
Exploitation of the Ugi–Joullié Reaction in the Synthesis of Libraries of Drug-Like Bicyclic Hydantoins (journal article) Firth, James \| Zhang, Rong \| Morgentin, Rémy \| Guilleux, Rachel \| Kalliokoski, Tuomo \| Warriner, Stuart \| Foster, Richard \| Marsden, Stephen \| Nelson, Adam Synthesis, volume 47, issue 16, pages 2391-2406 (2015). 10.1055/s-0034-1378704 Cited by (20) \| Cite \| Source \| Open Access