Florent Samain

ScholarGPS® ID: 50619335435330

Affiliation

Philochem AG, Switzerland

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

DNA | Medicinal Chemistry | Neoplasm | Sensor

Metrics Summary

Publication Count

Predicted Citations

1,768

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries (journal article) Gironda-Martínez, Adrián \| Gorre, Émile M. D. \| Prati, Luca \| Gosalbes, Jean-François \| Dakhel, Sheila \| Cazzamalli, Samuele \| Samain, Florent \| Donckele, Etienne J. \| Neri, Dario Journal of Medicinal Chemistry, volume 64, issue 23, pages 17496-17510 (2021). 10.1021/acs.jmedchem.1c01693 Cited by (5) \| Cite \| Source
DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges (journal article) Gironda-Martínez, Adrián \| Donckele, Etienne J. \| Samain, Florent \| Neri, Dario ACS Pharmacology & Translational Science, volume 4, issue 4, pages 1265-1279 (2021). 10.1021/acsptsci.1c00118 Cited by (138) \| Cite \| Source
Cover Feature: Affinity Selections of DNA‐Encoded Chemical Libraries on Carbonic Anhydrase IX‐Expressing Tumor Cells Reveal a Dependence on Ligand Valence (Chem. Eur. J. 35/2021) (journal article) Oehler, Sebastian \| Catalano, Marco \| Scapozza, Ilario \| Bigatti, Martina \| Bassi, Gabriele \| Favalli, Nicholas \| Mortensen, Michael R. \| Samain, Florent \| Scheuermann, Jörg \| Neri, Dario Chemistry – A European Journal, volume 27, issue 35, pages 8888-8888 (2021). 10.1002/chem.202101855 Cite \| Source
Affinity Selections of DNA‐Encoded Chemical Libraries on Carbonic Anhydrase IX‐Expressing Tumor Cells Reveal a Dependence on Ligand Valence (journal article) Oehler, Sebastian \| Catalano, Marco \| Scapozza, Ilario \| Bigatti, Martina \| Bassi, Gabriele \| Favalli, Nicholas \| Mortensen, Michael R. \| Samain, Florent \| Scheuermann, Jörg \| Neri, Dario Chemistry – A European Journal, volume 27, issue 35, pages 8985-8993 (2021). 10.1002/chem.202100816 Cited by (20) \| Cite \| Source
An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications (journal article) Millul, Jacopo \| Bassi, Gabriele \| Mock, Jacqueline \| Elsayed, Abdullah \| Pellegrino, Christian \| Zana, Aureliano \| Dakhel Plaza, Sheila \| Nadal, Lisa \| Gloger, Andreas \| Schmidt, Eleonore \| ... \| Cazzamalli, Samuele Proceedings of the National Academy of Sciences, volume 118, issue 16 (2021). 10.1073/pnas.2101852118 Cited by (69) \| Cite \| Source
On-DNA hit validation methodologies for ligands identified from DNA-encoded chemical libraries (journal article) Prati, Luca \| Bigatti, Martina \| Donckele, Etienne J. \| Neri, Dario \| Samain, Florent Biochemical and Biophysical Research Communications, volume 533, issue 2, pages 235-240 (2020). 10.1016/j.bbrc.2020.04.030 Cited by (12) \| Cite \| Source
Critical Evaluation of Photo-cross-linking Parameters for the Implementation of Efficient DNA-Encoded Chemical Library Selections (journal article) Sannino, Alessandro \| Gironda-Martínez, Adrián \| Gorre, Émile M. D. \| Prati, Luca \| Piazzi, Jacopo \| Scheuermann, Jörg \| Neri, Dario \| Donckele, Etienne J. \| Samain, Florent ACS Combinatorial Science, volume 22, issue 4, pages 204-212 (2020). 10.1021/acscombsci.0c00023 Cited by (29) \| Cite \| Source
DNA-Compatible Diazo-Transfer Reaction in Aqueous Media Suitable for DNA-Encoded Chemical Library Synthesis (journal article) Gironda-Martínez, Adrián \| Neri, Dario \| Samain, Florent \| Donckele, Etienne J. Organic Letters, volume 21, issue 23, pages 9555-9558 (2019). 10.1021/acs.orglett.9b03726 Cited by (34) \| Cite \| Source
Quantitative Assessment of Affinity Selection Performance by Using DNA‐Encoded Chemical Libraries (journal article) Sannino, Alessandro \| Gabriele, Elena \| Bigatti, Martina \| Mulatto, Sara \| Piazzi, Jacopo \| Scheuermann, Jörg \| Neri, Dario \| Donckele, Etienne J. \| Samain, Florent ChemBioChem, volume 20, issue 7, pages 955-962 (2019). 10.1002/cbic.201800766 Cited by (38) \| Cite \| Source
Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries (journal article) Li, Yizhou \| Gabriele, Elena \| Samain, Florent \| Favalli, Nicholas \| Sladojevich, Filippo \| Scheuermann, Jörg \| Neri, Dario ACS Combinatorial Science, volume 18, issue 8, pages 438-443 (2016). 10.1021/acscombsci.6b00058 Cited by (96) \| Cite \| Source \| Open Access
“Cap-and-Catch” Purification for Enhancing the Quality of Libraries of DNA Conjugates (journal article) Franzini, Raphael M. \| Biendl, Stefan \| Mikutis, Gediminas \| Samain, Florent \| Scheuermann, Jörg \| Neri, Dario ACS Combinatorial Science, volume 17, issue 7, pages 393-398 (2015). 10.1021/acscombsci.5b00072 Cited by (25) \| Cite \| Source
Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library (journal article) Samain, Florent \| Ekblad, Torun \| Mikutis, Gediminas \| Zhong, Nan \| Zimmermann, Mauro \| Nauer, Angela \| Bajic, Davor \| Decurtins, Willy \| Scheuermann, Jörg \| Brown, Peter J. \| ... \| Franzini, Raphael M. Journal of Medicinal Chemistry, volume 58, issue 12, pages 5143-5149 (2015). 10.1021/acs.jmedchem.5b00432 Cited by (59) \| Cite \| Source
Small targeted cytotoxics from DNA-encoded chemical libraries (journal article) Samain, Florent \| Casi, Giulio Current Opinion in Chemical Biology, volume 26 (2015). 10.1016/j.cbpa.2015.02.009 Cited by (6) \| Cite \| Source
Identification of Structure–Activity Relationships from Screening a Structurally Compact DNA‐Encoded Chemical Library (journal article) Franzini, Raphael M. \| Ekblad, Torun \| Zhong, Nan \| Wichert, Moreno \| Decurtins, Willy \| Nauer, Angela \| Zimmermann, Mauro \| Samain, Florent \| Scheuermann, Jörg \| Brown, Peter J. \| ... \| Neri, Dario Angewandte Chemie International Edition, volume 54, issue 13, pages 3927-3931 (2015). 10.1002/anie.201410736 Cited by (86) \| Cite \| Source
Identification of Structure–Activity Relationships from Screening a Structurally Compact DNA‐Encoded Chemical Library (journal article) Franzini, Raphael M. \| Ekblad, Torun \| Zhong, Nan \| Wichert, Moreno \| Decurtins, Willy \| Nauer, Angela \| Zimmermann, Mauro \| Samain, Florent \| Scheuermann, Jörg \| Brown, Peter J. \| ... \| Neri, Dario Angewandte Chemie, volume 127, issue 13, pages 3999-4003 (2015). 10.1002/ange.201410736 Cited by (14) \| Cite \| Source
Systematic Evaluation and Optimization of Modification Reactions of Oligonucleotides with Amines and Carboxylic Acids for the Synthesis of DNA-Encoded Chemical Libraries (journal article) Franzini, Raphael M. \| Samain, Florent \| Abd Elrahman, Maaly \| Mikutis, Gediminas \| Nauer, Angela \| Zimmermann, Mauro \| Scheuermann, Jörg \| Hall, Jonathan \| Neri, Dario Bioconjugate Chemistry, volume 25, issue 8, pages 1453-1461 (2014). 10.1021/bc500212n Cited by (56) \| Cite \| Source
Metabolic Labeling of DNA by Purine Analogues in Vivo (journal article) Neef, Anne B. \| Samain, Florent \| Luedtke, Nathan W. ChemBioChem, volume 13, issue 12, pages 1750-1753 (2012). 10.1002/cbic.201200253 Cited by (48) \| Cite \| Source
Fluorescent DNAs printed on paper: sensing food spoilage and ripening in the vapor phase (journal article) Kwon, Hyukin \| Samain, Florent \| Kool, Eric T. Chemical Science, volume 3, issue 8, pages 2542- (2012). 10.1039/c2sc20461d Cited by (66) \| Cite \| Source
Supramolecular polymerization of oligopyrenotides – stereochemical control by single, natural nucleotides (journal article) Nussbaumer, Alina L. \| Samain, Florent \| Malinovskii, Vladimir L. \| Häner, Robert Organic & Biomolecular Chemistry, volume 10, issue 25, pages 4891- (2012). 10.1039/c2ob25320h Cited by (12) \| Cite \| Source
Differentiating a Diverse Range of Volatile Organic Compounds with Polyfluorophore Sensors Built on a DNA Scaffold (journal article) Samain, Florent \| Dai, Nan \| Kool, Eric T. Chemistry – A European Journal, volume 17, issue 1, pages 174-183 (2011). 10.1002/chem.201002836 Cited by (26) \| Cite \| Source \| Open Access