James R. Birtley

ScholarGPS® ID: 49828841583803

Affiliation

University of Massachusetts Medical School, Worcester, United States

Affiliation History

Field

Medicine

Discipline

Pathology

Top Specialties

Foot-and-mouth Disease | Virus | Antigen

Metrics Summary

Publication Count

Predicted Citations

1,506

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant (journal article) Meza-Segura, Mario \| Birtley, James R. \| Maldonado-Contreras, Ana \| Mueller, Christian \| Simin, Karl J. \| Stern, Lawrence J. \| McCormick, Beth A. mBio, volume 12, issue 6 (2021). 10.1128/mBio.02833-21 Cited by (8) \| Cite \| Source
The Chemical Synthesis of Knob Domain Antibody Fragments (journal article) Macpherson, Alex \| Birtley, James R. \| Broadbridge, Robert J. \| Brady, Kevin \| Schulze, Monika-Sarah E. D. \| Tang, Yalan \| Joyce, Callum \| Saunders, Kenneth \| Bogle, Gregory \| Horton, John \| ... \| Lawson, Alastair D. G. ACS Chemical Biology, volume 16, issue 9, pages 1757-1769 (2021). 10.1021/acschembio.1c00472 Cited by (11) \| Cite \| Source
The allosteric modulation of complement C5 by knob domain peptides (journal article) Macpherson, Alex \| Laabei, Maisem \| Ahdash, Zainab \| Graewert, Melissa A \| Birtley, James R \| Schulze, Monika-Sarah ED \| Crennell, Susan \| Robinson, Sarah A \| Holmes, Ben \| Oleinikovas, Vladas \| ... \| van den Elsen, Jean MH eLife, volume 10 (2021). 10.7554/eLife.63586 Cited by (20) \| Cite \| Source
Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers (journal article) Antony, Jane \| Zanini, Elisa \| Birtley, James R. \| Gabra, Hani \| Recchi, Chiara Cancer Gene Therapy, volume 28, issue 1-2, pages 18-26 (2021). 10.1038/s41417-020-0187-6 Cited by (7) \| Cite \| Source
Hemagglutinin as potential in vivo driver of DQ6-restricted clonal expansion of CD4+ T cells cross-reactive with hypocretin in narcolepsy (journal article) Jiang, Wei \| Birtley, James R. \| Hung, Shu-Chen \| Wang, Weiqi \| Chiou, Shin-Heng \| Davis, Mark M \| Stern, Lawrence J. \| Mellins, Elizabeth D The Journal of Immunology, volume 204, issue 1_Supplement, pages 224.40-224.40 (2020). 10.4049/jimmunol.204.Supp.224.40 Cite \| Source
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls (journal article) Jiang, Wei \| Birtley, James R. \| Hung, Shu-Chen \| Wang, Weiqi \| Chiou, Shin-Heng \| Macaubas, Claudia \| Kornum, Birgitte \| Tian, Lu \| Huang, Huang \| Adler, Lital \| ... \| Mellins, Elizabeth D. Nature Communications, volume 10, issue 1 (2019). 10.1038/s41467-019-13234-x Cited by (35) \| Cite \| Source
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions (journal article) Birtley, James R. \| Alomary, Mohammad \| Zanini, Elisa \| Antony, Jane \| Maben, Zachary \| Weaver, Grant C. \| Von Arx, Claudia \| Mura, Manuela \| Marinho, Aline T. \| Lu, Haonan \| ... \| Gabra, Hani Nature Communications, volume 10, issue 1 (2019). 10.1038/s41467-019-10966-8 Cited by (7) \| Cite \| Source
Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation (journal article) Maldonado-Contreras, Ana \| Birtley, James R. \| Boll, Erik \| Zhao, Yun \| Mumy, Karen L. \| Toscano, Juan \| Ayehunie, Seyoum \| Reinecker, Hans-Christian \| Stern, Lawrence J. \| McCormick, Beth A. Gut Microbes, volume 8, issue 6, pages 544-560 (2017). 10.1080/19490976.2017.1339006 Cited by (41) \| Cite \| Source
Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers (journal article) Keighren, Margaret A. \| Flockhart, Jean \| Hodson, Benjamin A. \| Shen, Guan-Yi \| Birtley, James R. \| Notarnicola-Harwood, Antonio \| West, John D. Transgenic Research, volume 24, issue 4, pages 665-691 (2015). 10.1007/s11248-015-9883-7 Cited by (3) \| Cite \| Source \| Open Access
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses (journal article) Zervoudi, Efthalia \| Saridakis, Emmanuel \| Birtley, James R. \| Seregin, Sergey S. \| Reeves, Emma \| Kokkala, Paraskevi \| Aldhamen, Yasser A. \| Amalfitano, Andrea \| Mavridis, Irene M. \| James, Edward \| ... \| Stratikos, Efstratios Proceedings of the National Academy of Sciences, volume 110, issue 49, pages 19890-19895 (2013). 10.1073/pnas.1309781110 Cited by (107) \| Cite \| Source \| Open Access
Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions (journal article) Bozoky, Zoltan \| Krzeminski, Mickael \| Muhandiram, Ranjith \| Birtley, James R. \| Al-Zahrani, Ateeq \| Thomas, Philip J. \| Frizzell, Raymond A. \| Ford, Robert C. \| Forman-Kay, Julie D. Proceedings of the National Academy of Sciences, volume 110, issue 47 (2013). 10.1073/pnas.1315104110 Cited by (135) \| Cite \| Source \| Open Access
Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins (journal article) Leen, Eoin N. \| Kwok, K. Y. Rex \| Birtley, James R. \| Simpson, Peter J. \| Subba-Reddy, Chennareddy V. \| Chaudhry, Yasmin \| Sosnovtsev, Stanislav V. \| Green, Kim Y. \| Prater, Sean N. \| Tong, Michael \| ... \| Curry, Stephen Journal of Virology, volume 87, issue 10, pages 5318-5330 (2013). 10.1128/JVI.03151-12 Cited by (37) \| Cite \| Source \| Open Access
A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing (journal article) Evnouchidou, Irini \| Birtley, James \| Seregin, Sergey \| Papakyriakou, Athanasios \| Zervoudi, Efthalia \| Samiotaki, Martina \| Panayotou, George \| Giastas, Petros \| Petrakis, Olivia \| Georgiadis, Dimitris \| ... \| Stratikos, Efstratios The Journal of Immunology, volume 189, issue 5, pages 2383-2392 (2012). 10.4049/jimmunol.1200918 Cited by (86) \| Cite \| Source \| Open Access
A common polymorphism in ER aminopeptidase 2 acts as a specificity switch and can influence antigenic peptide processing (journal article) Evnouchidou, Irini \| Seregin, Sergey \| Birtley, James \| Saridakis, Emmanuel \| Mavridis, Irini \| Amalfitano, Andrea \| Stratikos, Efstratios Molecular Immunology, volume 51, issue 1, pages 32- (2012). 10.1016/j.molimm.2012.02.090 Cite \| Source
The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing (journal article) Birtley, James R. \| Saridakis, Emmanuel \| Stratikos, Efstratios \| Mavridis, Irene M. Biochemistry, volume 51, issue 1, pages 286-295 (2012). 10.1021/bi201230p Cited by (82) \| Cite \| Source
CFTR Three-Dimensional Structure (book chapter) In Cystic Fibrosis Ford, Robert C. \| Birtley, James \| Rosenberg, Mark F. \| Zhang, Liang Humana Press (2011) 10.1007/978-1-61779-117-8_22 Cited by (9) \| Cite \| Source
Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding (journal article) Zhang, Liang \| Aleksandrov, Luba A. \| Zhao, Zhefeng \| Birtley, James R. \| Riordan, John R. \| Ford, Robert C. Journal of Structural Biology, volume 167, issue 3, pages 242-251 (2009). 10.1016/j.jsb.2009.06.004 Cited by (52) \| Cite \| Source
Structural insights into the transcriptional and translational roles of Ebp1 (journal article) Monie, Tom P \| Perrin, Andrew J \| Birtley, James R \| Sweeney, Trevor R \| Karakasiliotis, Ioannis \| Chaudhry, Yasmin \| Roberts, Lisa O \| Matthews, Stephen \| Goodfellow, Ian G \| Curry, Stephen The EMBO Journal, volume 26, issue 17, pages 3936-3944 (2007). 10.1038/sj.emboj.7601817 Cited by (85) \| Cite \| Source \| Open Access
A continuous assay for foot-and-mouth disease virus 3C protease activity (journal article) Jaulent, Agnès M. \| Fahy, Aodhnait S. \| Knox, Stephen R. \| Birtley, James R. \| Roqué-Rosell, Núria \| Curry, Stephen \| Leatherbarrow, Robin J. Analytical Biochemistry, volume 368, issue 2, pages 130-137 (2007). 10.1016/j.ab.2007.05.026 Cited by (15) \| Cite \| Source
Structural and Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the β-Ribbon in Proteolysis (journal article) Sweeney, Trevor R. \| Roqué-Rosell, Núria \| Birtley, James R. \| Leatherbarrow, Robin J. \| Curry, Stephen Journal of Virology, volume 81, issue 1, pages 115-124 (2007). 10.1128/JVI.01587-06 Cited by (84) \| Cite \| Source \| Open Access