Laurent Salphati

ScholarGPS® ID: 49767113267444

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacy

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

5,656

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Absorption, metabolism, and excretion of inavolisib (GDC-0077), a PI3KA inhibitor in humans (journal article) Cho, Sungjoon \| Ma, Shuguang \| Johnson, Ryan \| Cheeti, Sravanthi \| Khojasteh, Cyrus \| Zhang, Donglu \| Salphati, Laurent Drug Metabolism and Pharmacokinetics, volume 55 (2024). 10.1016/j.dmpk.2023.100922 Cite \| Source
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human (journal article) Salphati, Laurent \| Pang, Jodie \| Alicke, Bruno \| Plise, Emile G. \| Cheong, Jonathan \| Jaochico, Allan \| Olivero, Alan G. \| Sampath, Deepak \| Wong, Susan \| Zhang, Xiaolin Xenobiotica, volume 54, issue 2, pages 64-74 (2024). 10.1080/00498254.2024.2303586 Cite \| Source
Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics (journal article) An, Le \| De Bruyn, Tom \| Pang, Jodie \| Ubhayakar, Savita \| Salphati, Laurent \| Zhang, Xing \| Liu, Liling \| Li, Ruina \| Chan, Bryan \| Dey, Anwesha \| Levy, Elizabeth S. Pharmaceuticals, volume 17, issue 2, pages 179- (2024). 10.3390/ph17020179 Cite \| Source
Mass Balance of the Indoleamine 2,3‐Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1- a ]isoindole and Species Differences in Glucuronidation (journal article) Wang, Shuai \| Ma, Shuguang \| Chen, Eugene \| Wang, Jing \| Le, Hoa \| Hanlon, Steven Paul \| Binder, Martin \| Lee, Wendy \| Khojasteh, S. Cyrus \| Salphati, Laurent Drug Metabolism and Disposition, volume 51, issue 7, pages 862-872 (2023). 10.1124/dmd.123.001289 Cited by (2) \| Cite \| Source
Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β -Sparing PI3K Inhibitor in Rats, Dogs, and Humans (journal article) Ma, Shuguang \| Cho, Sungjoon \| Sahasranaman, Srikumar \| Zhao, Weiping \| Pang, Jodie \| Ding, Xiao \| Dean, Brian \| Wang, Bin \| Hsu, Jerry Y. \| Ware, Joseph \| Salphati, Laurent Drug Metabolism and Disposition, volume 51, issue 4, pages 436-450 (2023). 10.1124/dmd.122.001096 Cited by (4) \| Cite \| Source
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors (journal article) Hu, Dennis X. \| Patel, Snahel \| Chen, Huifen \| Wang, Shumei \| Staben, Steven T. \| Dimitrova, Yoana N. \| Wallweber, Heidi Ackerly \| Lee, Joanna Y. \| Chan, Grace Ka Yan \| Sneeringer, Christopher J. \| ... \| Siu, Michael Journal of Medicinal Chemistry, volume 65, issue 17, pages 11500-11512 (2022). 10.1021/acs.jmedchem.1c01180 Cited by (13) \| Cite \| Source
Growth‐rate model predicts in vivo tumor response from in vitro data (journal article) Diegmiller, Rocky \| Salphati, Laurent \| Alicke, Bruno \| Wilson, Timothy R. \| Stout, Thomas J. \| Hafner, Marc CPT: Pharmacometrics & Systems Pharmacology, volume 11, issue 9, pages 1183-1193 (2022). 10.1002/psp4.12836 Cited by (5) \| Cite \| Source
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) (journal article) Chan, Bryan K. \| Seward, Eileen \| Lainchbury, Michael \| Brewer, Thomas F. \| An, Le \| Blench, Toby \| Cartwright, Matthew W. \| Chan, Grace Ka Yan \| Choo, Edna F. \| Drummond, Jason \| ... \| Heffron, Timothy P. ACS Medicinal Chemistry Letters, volume 13, issue 1, pages 84-91 (2022). 10.1021/acsmedchemlett.1c00473 Cited by (20) \| Cite \| Source
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy (journal article) Song, Kyung W. \| Edgar, Kyle A. \| Hanan, Emily J. \| Hafner, Marc \| Oeh, Jason \| Merchant, Mark \| Sampath, Deepak \| Nannini, Michelle A. \| Hong, Rebecca \| Phu, Lilian \| ... \| Friedman, Lori S. Cancer Discovery, volume 12, issue 1, pages 204-219 (2022). 10.1158/2159-8290.CD-21-0072 Cited by (41) \| Cite \| Source
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans (journal article) Yue, Qin \| Khojasteh, S. Cyrus \| Cho, Sungjoon \| Ma, Shuguang \| Mulder, Teresa \| Chen, John \| Pang, Jodie \| Ding, Xiao \| Deese, Alan \| Pellet, Jackson D. \| ... \| Ware, Joseph A. Xenobiotica, volume 51, issue 7, pages 796-810 (2021). 10.1080/00498254.2021.1923859 Cited by (6) \| Cite \| Source
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach (journal article) Kumar, Vineet \| Yin, Mengyue \| Ishida, Kazuya \| Salphati, Laurent \| Hop, Cornelis E.C.A. \| Rowbottom, Christopher \| Xiao, Guangqing \| Lai, Yurong \| Mathias, Anita \| Chu, Xiaoyan \| ... \| Unadkat, Jashvant D. Drug Metabolism and Disposition, volume 49, issue 2, pages 159-168 (2021). 10.1124/dmd.120.000204 Cited by (25) \| Cite \| Source
P129 - In-vivo transporter-mediated hepatic clearance of rosuvastatin in humans could be better predicted using transporter-expressing cells than hepatocytes (journal article) Kumar, Vineet \| Ishida, Kazuya \| Salphati, Laurent \| Hop, Cornelis E.C. A. \| Rowbottom, Christopher \| Xiao, Guangqing \| Lai, Yurong \| Mathias, Anita \| Chu, Xiaoyan \| Humphreys, W. Griffith \| ... \| Unadkat, Jashvant D. Drug Metabolism and Pharmacokinetics, volume 35, issue 1, pages S61-S62 (2020). 10.1016/j.dmpk.2020.04.130 Cite \| Source
Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI (journal article) Jones, Nicholas S. \| Yoshida, Kenta \| Salphati, Laurent \| Kenny, Jane R. \| Durk, Matthew R. \| Chinn, Leslie W. Clinical Pharmacology & Therapeutics, volume 107, issue 1, pages 269-277 (2020). 10.1002/cpt.1599 Cited by (53) \| Cite \| Source
Positron Emission Tomography Imaging of [11 C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A (journal article) Billington, Sarah \| Shoner, Steven \| Lee, Scott \| Clark‐Snustad, Kindra \| Pennington, Matthew \| Lewis, David \| Muzi, Mark \| Rene, Shirley \| Lee, Jean \| Nguyen, Tot Bui \| ... \| Unadkat, Jashvant D. Clinical Pharmacology & Therapeutics, volume 106, issue 5, pages 1056-1066 (2019). 10.1002/cpt.1506 Cited by (51) \| Cite \| Source
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor (journal article) Ma, Shuguang \| Suchomel, Julia \| Yanez, Evelyn \| Yost, Edward \| Liang, Xiaorong \| Zhu, Rui \| Le, Hoa \| Siebers, Nicholas \| Joas, Lori \| Morley, Roland \| ... \| Morrissey, Kari M. British Journal of Clinical Pharmacology, volume 85, issue 8, pages 1751-1760 (2019). 10.1111/bcp.13961 Cited by (14) \| Cite \| Source
Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics (journal article) Billington, Sarah \| Salphati, Laurent \| Hop, Cornelis E. C. A. \| Chu, Xiaoyan \| Evers, Raymond \| Burdette, Doug \| Rowbottom, Christopher \| Lai, Yurong \| Xiao, Guangqing \| Humphreys, W. Griffith \| ... \| Unadkat, Jashvant D. Clinical Pharmacology & Therapeutics, volume 106, issue 1, pages 228-237 (2019). 10.1002/cpt.1373 Cited by (63) \| Cite \| Source
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation (journal article) Kumar, Vineet \| Salphati, Laurent \| Hop, Cornelis E. C. A. \| Xiao, Guangqing \| Lai, Yurong \| Mathias, Anita \| Chu, Xiaoyan \| Humphreys, W. Griffith \| Liao, Mingxiang \| Heyward, Scott \| Unadkat, Jashvant D. Drug Metabolism and Disposition, volume 47, issue 4, pages 350-357 (2019). 10.1124/dmd.118.084988 Cited by (38) \| Cite \| Source
Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics (journal article) Pang, Jodie \| Baumgardner, Matthew \| Braun, Marie-Gabrielle \| Cheong, Jonathan \| Edgar, Kyle \| Friedman, Lori \| Hanan, Emily \| Jaochico, Allan \| Ma, Shuguang \| Plise, Emile \| ... \| Salphati, Laurent Drug Metabolism and Pharmacokinetics, volume 34, issue 1, pages S37- (2019). 10.1016/j.dmpk.2018.09.137 Cite \| Source
Can transporter-expressing cells predict rosuvastatin uptake clearance in suspended or plated human hepatocytes? (journal article) Kumar, Vineet \| Salphati, Laurent \| Hop, Cornelis E.C.A. \| Rowbottom, Christopher \| Xiao, Guangqing \| Lai, Yurong \| Mathias, Anita \| Chu, Xiaoyan \| Humphreys, W. Griffith \| Liao, Mingxiang \| ... \| Unadkat, Jashvant Drug Metabolism and Pharmacokinetics, volume 34, issue 1, pages S22-S23 (2019). 10.1016/j.dmpk.2018.09.094 Cite \| Source
Does plasma membrane and total transporter abundance differ between suspended, plated, sandwich culture hepatocytes and human liver tissue? (journal article) Kumar, Vineet \| Salphati, Laurent \| Hop, Cornelis E.C.A. \| Rowbottom, Christopher \| Xiao, Guangqing \| Lai, Yurong \| Mathias, Anita \| Chu, Xiaoyan \| Humphreys, W.Griffith \| Liao, Mingxiang \| ... \| Unadkat, Jashvant Drug Metabolism and Pharmacokinetics, volume 34, issue 1, pages S17- (2019). 10.1016/j.dmpk.2018.09.078 Cite \| Source