John S. Manavalan

ScholarGPS® ID: 48858635914511

Affiliation

University of Virginia, Charlottesville, United States

Affiliation History

Field

Medicine

Discipline

Hematology

Top Specialties

Antigen | Dendritic Cell | Coeliac Disease | Endothelium | Metabolism

Metrics Summary

Publication Count

Predicted Citations

5,296

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Pembrolizumab in combination with epigenetic therapy is safe and active in heavily treated patients with peripheral T‐cell lymphoma and cutaneous T‐cell lymphoma (journal article) Roberts, N. L. \| Lister, J. \| Benani, N. N. \| Jain, S. \| Battaglia, T. \| Abdelmalek, M. \| Ayers, E. C. \| Portell, C. \| Williams, M. E. \| Batchala, P. \| ... \| Marchi, E. Hematological Oncology, volume 41, issue S2, pages 269-270 (2023). 10.1002/hon.3164_181 Cite \| Source
Tolinapant, a Non-Peptidomimetic Antagonist of Inhibitors of Apoptosis Proteins, cIAP1/2 and XIAP, in Combination with the Hypomethylating Agents, Azacytidine and Decitabine Are Highly Synergistic in in Vitro Models of T Cell Lymphoma (journal article) Manavalan, John Sanil \| Pal, Ipsita \| Pursley, Aidan \| Ward, George A. \| Smyth, Tomoko \| Sims, Martin \| Taylor, Jason A. \| Feith, David J \| Loughran, Thomas P. \| O'Connor, Owen A. \| Marchi, Enrica Blood, volume 140, issue Supplement 1, pages 11552-11553 (2022). 10.1182/blood-2022-169906 Cite \| Source
The Novel Nano-Formulation of the HDAC Inhibitor, Romidepsin, for the Treatment of Relapsed, Refractory Peripheral T-Cell Lymphoma (journal article) Pal, Ipsita \| Illendula, Anuradha \| Manavalan, John Sanil \| Fox, Todd P \| O'Connor, Owen A. \| Loughran, Thomas P. \| Kester, Mark \| Feith, David J \| Marchi, Enrica Blood, volume 140, issue Supplement 1, pages 8848-8849 (2022). 10.1182/blood-2022-167628 Cite \| Source
Pembrolizumab in Combination with Epigenetic Therapy Is Safe and Active in Heavily Treated Patients with Peripheral T-Cell Lymphoma (PTCL) and Cutaneous T-Cell Lymphoma (CTCL): Preliminary Results from the Embolden Trial (journal article) Roberts, Nathan \| Lister, John \| Bennani, N. Nora \| Jain, Salvia \| Battaglia, Tammy \| Ayers, Emily C. \| Portell, Craig A. \| Williams, Michael E. \| Batchala, Prem \| Pal, Ipsita \| ... \| Marchi, Enrica Blood, volume 140, issue Supplement 1, pages 9425-9426 (2022). 10.1182/blood-2022-170181 Cited by (2) \| Cite \| Source
The combination of the IAP antagonist, tolinapant and hypomethylating agents (HMA) is highly synergistic in in vitro models of T-cell lymphoma (TCL). (journal article) Manavalan, John \| Pal, Ipsita \| Pursley, Aidan \| Ward, George \| Smyth, Tomoko \| Sims, Martin \| Feith, David \| Loughran, Thomas \| O’Connor, Owen \| Marchi, Enrica Journal of Clinical Oncology, volume 40, issue 16_suppl, pages e15088-e15088 (2022). 10.1200/JCO.2022.40.16_suppl.e15088 Cite \| Source
Novel platform for identifying multiple cancer-specific antigens. (journal article) Mor, Danielle \| Farooqui, Shakeel \| Manavalan, John \| Davis, Joseph \| Davis, Elliot Journal of Clinical Oncology, volume 40, issue 16_suppl, pages 2530-2530 (2022). 10.1200/JCO.2022.40.16_suppl.2530 Cite \| Source
P1278: ACTIVATION OF THE NECROPTOSIS PATHWAY PLAYS A ROLE IN SYNERGISM WITH COMBINATION OF THE IAP ANTAGONIST, TOLINAPANT AND HYPOMETHYLATING AGENTS (HMA) IN IN VITRO MODELS OF T-CELL LYMPHOMA (TCL). (journal article) Manavalan, J. S. \| Pal, I. \| Pursley, A. \| Ward, G. \| Smyth, T. \| Sims, M. \| Feith, D. \| Loughran, T. P. \| O’Connor, O. A. \| Marchi, E. HemaSphere, volume 6 (2022). 10.1097/01.HS9.0000847976.26425.20 Cite \| Source
Tolinapant (ASTX660), a Non-Peptidomimetic Antagonist of cIAP1/2 and XIAP, and the HDAC Inhibitor Romidepsin Are Synergistic in in Vitro Models of T Cell Lymphoma (journal article) Manavalan, John S \| Pal, Ipsita \| Pursley, Aidan \| Ward, George A. \| Smyth, Tomoko \| Sims, Martin \| Feith, David J \| Loughran, Thomas P. \| O'Connor, Owen A. \| Marchi, Enrica Blood, volume 138, issue Supplement 1, pages 4356-4356 (2021). 10.1182/blood-2021-153451 Cite \| Source
Targeting MYD88-Mutant DLBCL with IRAKIMiDs: A Comparison to IRAK4 Kinase Inhibition and Evaluation of Synergy with Rational Combinations (journal article) Lue, Jennifer Kimberly \| Manavalan, John S \| Klaus, Christine \| Kanik, Rahul \| Grilo, Andre M. \| McDonald, Alice \| Gollob, Jared \| Walker, Duncan \| O'Connor, Owen A. \| Mainolfi, Nello Blood, volume 136, issue Supplement 1, pages 12-12 (2020). 10.1182/blood-2020-135898 Cited by (5) \| Cite \| Source
Abnormal Bone Acquisition With Early-Life HIV Infection: Role of Immune Activation and Senescent Osteogenic Precursors (journal article) Manavalan, John S \| Arpadi, Stephen \| Tharmarajah, Shenthuraan \| Shah, Jayesh \| Zhang, Chiyuan A \| Foca, Marc \| Neu, Natalie \| Bell, David L \| Nishiyama, Kyle K \| Kousteni, Stavroula \| Yin, Michael T Journal of Bone and Mineral Research, volume 31, issue 11, pages 1988-1996 (2016). 10.1002/jbmr.2883 Cited by (19) \| Cite \| Source \| Open Access
Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts (journal article) Krevvata, Maria \| Silva, Barbara C. \| Manavalan, John S. \| Galan-Diez, Marta \| Kode, Aruna \| Matthews, Brya Grace \| Park, David \| Zhang, Chiyuan A. \| Galili, Naomi \| Nickolas, Thomas L. \| ... \| Kousteni, Stavroula Blood, volume 124, issue 18, pages 2834-2846 (2014). 10.1182/blood-2013-07-517219 Cited by (107) \| Cite \| Source \| Open Access
Effects of Rosiglitazone vs Metformin on Circulating Osteoclast and Osteogenic Precursor Cells in Postmenopausal Women with Type 2 Diabetes Mellitus (journal article) Rubin, M. R. \| Manavalan, J. S. \| Agarwal, S. \| McMahon, D. J. \| Nino, A. \| Fitzpatrick, L. A. \| Bilezikian, J. P. The Journal of Clinical Endocrinology & Metabolism, volume 99, issue 10, pages E1933-E1942 (2014). 10.1210/jc.2013-3666 Cited by (18) \| Cite \| Source \| Open Access
Presurgical evaluation of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer. (journal article) Kalinsky, Kevin \| Sparano, Joseph A. \| Andreopoulou, Eleni \| Taback, Bret \| Wiechmann, Lisa Silvia \| Feldman, Sheldon M. \| Ananthakrishnan, Preya \| Hibshoosh, Hanina \| Manavalan, John \| Crew, Katherine D. \| ... \| Hershman, Dawn L. Journal of Clinical Oncology, volume 32, issue 15_suppl, pages 2613-2613 (2014). 10.1200/jco.2014.32.15_suppl.2613 Cited by (4) \| Cite \| Source
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts (journal article) Kode, Aruna \| Manavalan, John S. \| Mosialou, Ioanna \| Bhagat, Govind \| Rathinam, Chozha V. \| Luo, Na \| Khiabanian, Hossein \| Lee, Albert \| Murty, Vundavalli V. \| Friedman, Richard \| ... \| Kousteni, Stavroula Nature, volume 506, issue 7487, pages 240-244 (2014). 10.1038/nature12883 Cited by (425) \| Cite \| Source \| Open Access
Circulating Osteogenic Precursor Cells in Type 2 Diabetes Mellitus (journal article) Manavalan, J. S. \| Cremers, S. \| Dempster, D. W. \| Zhou, H. \| Dworakowski, E. \| Kode, A. \| Kousteni, S. \| Rubin, M. R. The Journal of Clinical Endocrinology & Metabolism, volume 97, issue 9, pages 3240-3250 (2012). 10.1210/jc.2012-1546 Cited by (159) \| Cite \| Source \| Open Access
Parathyroid Hormone Stimulates Circulating Osteogenic Cells in Hypoparathyroidism (journal article) Rubin, M. R. \| Manavalan, J. S. \| Dempster, D. W. \| Shah, J. \| Cremers, S. \| Kousteni, S. \| Zhou, H. \| McMahon, D. J. \| Kode, A. \| Sliney, J. \| ... \| Bilezikian, J. P. The Journal of Clinical Endocrinology & Metabolism, volume 96, issue 1, pages 176-186 (2011). 10.1210/jc.2009-2682 Cited by (44) \| Cite \| Source \| Open Access
Serum cytokine elevations in celiac disease: Association with disease presentation (journal article) Manavalan, John Sanil \| Hernandez, Lincoln \| Shah, Jayesh Girish \| Konikkara, John \| Naiyer, Afzal Jamal \| Lee, Anne Roland \| Ciaccio, Edward \| Minaya, Maria Theresa \| Green, Peter H.R. \| Bhagat, Govind Human Immunology, volume 71, issue 1, pages 50-57 (2010). 10.1016/j.humimm.2009.09.351 Cited by (106) \| Cite \| Source
In vivo effects of zoledronic acid on peripheral γδ T lymphocytes in early breast cancer patients (journal article) Santini, Daniele \| Martini, Federico \| Fratto, Maria Elisabetta \| Galluzzo, Sara \| Vincenzi, Bruno \| Agrati, Chiara \| Turchi, Federica \| Piacentini, Paola \| Rocci, Laura \| Manavalan, John S. \| ... \| Poccia, Fabrizio Cancer Immunology, Immunotherapy, volume 58, issue 1, pages 31-38 (2009). 10.1007/s00262-008-0521-6 Cited by (89) \| Cite \| Source
Comparison of Commercially Available Serologic Kits for the Detection of Celiac Disease (journal article) Naiyer, Afzal J. \| Hernandez, Lincoln \| Ciaccio, Edward J. \| Papadakis, Konstantinos \| Manavalan, John S. \| Bhagat, Govind \| Green, Peter H. R. Journal of Clinical Gastroenterology, volume 43, issue 3, pages 225-232 (2009). 10.1097/MCG.0b013e31816200e5 Cited by (65) \| Cite \| Source
CD8+ suppressor and cytotoxic T cells recognize the same human leukocyte antigen-A2 restricted cytomegalovirus peptide (journal article) Qin, Haiyan \| Vlad, George \| Cortesini, Raffaello \| Suciu-Foca, Nicole \| Manavalan, John S. Human Immunology, volume 69, issue 11, pages 776-780 (2008). 10.1016/j.humimm.2008.08.287 Cited by (11) \| Cite \| Source