Henry R. Maun

ScholarGPS® ID: 48781838612630

Affiliation
Genentech, Inc., South San Francisco, United States
Affiliation History

Field
Life Sciences
Discipline
Biochemistry
Top Specialties
Antibody | Active Site | Factor VII
Metrics Summary
Publication Count
26
Predicted Citations
1,326
Predicted h-index
17
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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α and β Tryptase Is Released From Mast Cells by IgE Cross-linking and Increased α/β Ratio Is Associated With Diminished PAR-2 Activity (conference)
Rathore, N. | Liu, P. | Maun, H. | Lazarus, R. | Arnott, D. | Choy, D.
American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC (2023)
10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A3041
Cite | Source
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge (journal article)
Maun, Henry R. | Vij, Rajesh | Walters, Benjamin T. | Morando, Ashley | Jackman, Janet K. | Wu, Ping | Estevez, Alberto | Chen, Xiaocheng | Franke, Yvonne | Lipari, Michael T. | ... | Koerber, James T.
Nature Communications, volume 11, issue 1 (2020).
10.1038/s41467-020-20143-x
Cited by (14) | Cite | Source
Development of a Specific Immunoassay to Selectively Measure Active Tryptase in Airway Samples (journal article)
Sperinde, Gizette | Bremer, Meire | Maun, Henry R | Baruch, Amos | Lazarus, Robert A | Koerber, James T | Vij, Rajesh | Yi, Tangsheng | Fischer, Saloumeh K | Staton, Tracy
Bioanalysis, volume 12, issue 19, pages 1377-1388 (2020).
10.4155/bio-2020-0182
Cited by (2) | Cite | Source
Anti-tryptase antibodies, compositions thereof, and uses thereof (patent)
Chen, Xiaocheng | Dennis, Mark | Jackman, Janet | Koerber, James T. | Lu, Mason | Maun, Henry R. | Rajapaksa, Kathila | Ramanujan, Saroja | Staton, Tracy | Wu, Lawren | Yi, Tangsheng
Patent Number: 10752703 (2020)
Cite | Source
Anti-tryptase antibodies, compositions thereof, and uses thereof (patent)
Chen, Xiaocheng | Dennis, Mark | Jackman, Janet | Koerber, James T. | Lu, Mason | Maun, Henry R. | Rajapaksa, Kathila | Ramanujan, Saroja | Staton, Tracy | Wu, Lawren | Yi, Tangsheng
Patent Number: 10738131 (2020)
Cite | Source
Chagasin-based scaffold compositions, methods, and uses (patent)
Lazarus, Robert A. | Maun, Henry R.
Patent Number: 10562946 (2020)
Cite | Source
Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer (journal article)
Maun, Henry R. | Liu, Peter S. | Franke, Yvonne | Eigenbrot, Charles | Forrest, William F. | Schwartz, Lawrence B. | Lazarus, Robert A.
Journal of Biological Chemistry, volume 293, issue 25, pages 9614-9628 (2018).
10.1074/jbc.M117.812016
Cited by (12) | Cite | Source
Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer (journal article)
Maun, Henry R. | Liu, Peter | Franke, Yvonne | Eigenbrot, Charles | Forrest, William F. | Schwartz, Lawrence B. | Lazarus, Robert A.
Journal of Biological Chemistry, volume 293, issue 25, pages 9614-9628 (2018).
10.2210/pdb5wi6/pdb
Cite | Source
3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix (journal article)
Ultsch, M | Braisted, A | Maun, H R | Eigenbrot, C
Protein Engineering, Design and Selection, volume 30, issue 9, pages 619-625 (2017).
10.1093/protein/gzx029
Cited by (25) | Cite | Source
An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides (journal article)
Landgraf, Kyle E | Steffek, Micah | Quan, Clifford | Tom, Jeffrey | Yu, Christine | Santell, Lydia | Maun, Henry R | Eigenbrot, Charles | Lazarus, Robert A
Nature Chemical Biology, volume 10, issue 7, pages 567-573 (2014).
10.1038/nchembio.1533
Cited by (22) | Cite | Source
Variant Hhip1 protein and methods and uses thereof (patent)
Bosanac, Ivan | Hymowitz, Sarah G. | Lazarus, Robert A. | Maun, Henry R. | Scales, Suzanna J. | Wen, Xiaohui
Patent Number: 8623997 (2014)
Cited by (1) | Cite | Source
Functional Consequences of the Macrophage Stimulating Protein 689C Inflammatory Bowel Disease Risk Allele (journal article)
Kauder, Steven E. | Santell, Lydia | Mai, Elaine | Wright, Lilyan Y. | Luis, Elizabeth | N'Diaye, Elsa N. | Lutman, Jeff | Ratti, Navneet | Sa, Susan M. | Maun, Henry R. | ... | Egen, Jackson G.
PLoS ONE, volume 8, issue 12, pages e83958- (2013).
10.1371/journal.pone.0083958
Cited by (18) | Cite | Source | Open Access
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent (journal article)
Merchant, Mark | Ma, Xiaolei | Maun, Henry R. | Zheng, Zhong | Peng, Jing | Romero, Mally | Huang, Arthur | Yang, Nai-ying | Nishimura, Merry | Greve, Joan | ... | Yansura, Daniel G.
Proceedings of the National Academy of Sciences, volume 110, issue 32 (2013).
10.1073/pnas.1302725110
Cited by (206) | Cite | Source | Open Access
Efficient production of antibodies against a mammalian integral membrane protein by phage display (journal article)
Hotzel, I. | Chiang, V. | Diao, J. | Pantua, H. | Maun, H. R. | Kapadia, S. B.
Protein Engineering Design and Selection, volume 24, issue 9, pages 679-689 (2011).
10.1093/protein/gzr039
Cited by (35) | Cite | Source | Open Access
Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling (journal article)
Landgraf, Kyle E. | Santell, Lydia | Billeci, Karen L. | Quan, Clifford | Young, Judy C. | Maun, Henry R. | Kirchhofer, Daniel | Lazarus, Robert A.
Journal of Biological Chemistry, volume 285, issue 51, pages 40362-40372 (2010).
10.1074/jbc.M110.179721
Cited by (17) | Cite | Source | Open Access
Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer (journal article)
Maun, Henry R. | Kirchhofer, Daniel | Lazarus, Robert A.
Biological Chemistry, volume 391, issue 8 (2010).
10.1515/bc.2010.098
Cited by (6) | Cite | Source
Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site (journal article)
Maun, Henry R. | Wen, Xiaohui | Lingel, Andreas | de Sauvage, Frederic J. | Lazarus, Robert A. | Scales, Suzie J. | Hymowitz, Sarah G.
Journal of Biological Chemistry, volume 285, issue 34, pages 26570-26580 (2010).
10.1074/jbc.M110.112284
Cited by (117) | Cite | Source | Open Access
Crystal Structure Analysis of Free and Substrate-Bound 6-Hydroxy-l-Nicotine Oxidase from Arthrobacter nicotinovorans (journal article)
Kachalova, Galina S. | Bourenkov, Gleb P. | Mengesdorf, Thorsten | Schenk, Susann | Maun, Henry R. | Burghammer, Manfred | Riekel, Christian | Decker, Karl | Bartunik, Hans D.
Journal of Molecular Biology, volume 396, issue 3, pages 785-799 (2010).
10.1016/j.jmb.2009.12.009
Cited by (32) | Cite | Source
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling (journal article)
Bosanac, Ivan | Maun, Henry R | Scales, Suzie J | Wen, Xiaohui | Lingel, Andreas | Bazan, J Fernando | de Sauvage, Frederic J | Hymowitz, Sarah G | Lazarus, Robert A
Nature Structural & Molecular Biology, volume 16, issue 7, pages 691-697 (2009).
10.1038/nsmb.1632
Cited by (122) | Cite | Source
Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist (journal article)
Kirchhofer, Daniel | Lipari, Michael T. | Santell, Lydia | Billeci, Karen L. | Maun, Henry R. | Sandoval, Wendy N. | Moran, Paul | Ridgway, John | Eigenbrot, Charles | Lazarus, Robert A.
Proceedings of the National Academy of Sciences, volume 104, issue 13, pages 5306-5311 (2007).
10.1073/pnas.0700184104
Cited by (43) | Cite | Source | Open Access