Chudi Ndubaku

ScholarGPS® ID: 48671758659183

Affiliation

ORIC Pharmaceuticals, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

2,550

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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CD73 Inhibition Reverses Immunosuppression and Has Potential As an Immunomodulatory Therapy in Patients with Multiple Myeloma (journal article) Junttila, Melissa R \| Ray, Arghya \| Warne, Robert \| Chen, Xi R \| Du, Ting \| Lui, Fang \| Katewa, Subhash \| Blank, Brian \| Moore, Jared \| Ndubaku, Chudi \| ... \| Friedman, Lori Blood, volume 140, issue Supplement 1, pages 9957-9958 (2022). 10.1182/blood-2022-168275 Cited by (2) \| Cite \| Source
Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I–deficient and MHC I+ tumors (journal article) Wolf, Natalie K. \| Blaj, Cristina \| Picton, Lora K. \| Snyder, Gail \| Zhang, Li \| Nicolai, Christopher J. \| Ndubaku, Chudi O. \| McWhirter, Sarah M. \| Garcia, K. Christopher \| Raulet, David H. Proceedings of the National Academy of Sciences, volume 119, issue 22 (2022). 10.1073/pnas.2200568119 Cited by (23) \| Cite \| Source
CD73 Inhibition Overcomes Immunosuppression and Triggers Autologous T-Cell Mediated Multiple Myeloma Cell Lysis in the Bone Marrow Milieu (journal article) Ray, Arghya \| Junttila, Melissa R \| DU, Ting \| Sutimantanapi, Dena \| Chen, Xi \| Warne, Bob \| Chang, Jae \| Blank, Brian \| Wu, Kejia \| Moore, Jared \| ... \| Anderson, Kenneth C. Blood, volume 138, issue Supplement 1, pages 2675-2675 (2021). 10.1182/blood-2021-148174 Cited by (1) \| Cite \| Source
584 Powerful synergistic effects of a STING agonist and the IL-2 superkine, H9, in eliciting NK and T cell responses against MHC I- and MHC I+ tumors (conference) Wolf, Natalie \| Blaj, Cristina \| Picton, Lora \| Snyder, Gail \| Zhang, Li \| Nicolai, Christopher \| Ndubaku, Chudi \| Gauthier, Kelsey Sivick \| McWhirter, Sarah \| Christopher Garcia, K \| Raulet, David SITC 36th Anniversary Annual Meeting (SITC 2021) Abstracts (2021) 10.1136/jitc-2021-SITC2021.584 Cite \| Source
Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production (journal article) Du, Xiaohui \| Moore, Jared \| Blank, Brian R. \| Eksterowicz, John \| Sutimantanapi, Dena \| Yuen, Natalie \| Metzger, Todd \| Chan, Brenda \| Huang, Tom \| Chen, Xi \| ... \| Sun, Daqing Journal of Medicinal Chemistry, volume 63, issue 18, pages 10433-10459 (2020). 10.1021/acs.jmedchem.0c01086 Cited by (24) \| Cite \| Source
Pyrazolopyrimidinone compounds and uses thereof (patent) Ndubaku, Chudi Obioma \| Katibah, George Edwin \| Roberts, Tucker Curran \| Sung, Leonard \| Ciblat, Stephane \| Raeppel, Franck \| Ly, Vu Linh \| Ramtohul, Yeeman K. \| Rybak, Taras \| Zaky, Mariam \| ... \| Ismaili, Hossein Patent Number: 10738056 (2020) Cite \| Source
NK cells mediate clearance of CD8+ T cell–resistant tumors in response to STING agonists (journal article) Nicolai, Christopher J. \| Wolf, Natalie \| Chang, I-Chang \| Kirn, Georgia \| Marcus, Assaf \| Ndubaku, Chudi O. \| McWhirter, Sarah M. \| Raulet, David H. Science Immunology, volume 5, issue 45 (2020). 10.1126/sciimmunol.aaz2738 Cited by (143) \| Cite \| Source
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity (journal article) Sivick, Kelsey E. \| Desbien, Anthony L. \| Glickman, Laura Hix \| Reiner, Gabrielle L. \| Corrales, Leticia \| Surh, Natalie H. \| Hudson, Thomas E. \| Vu, Uyen T. \| Francica, Brian J. \| Banda, Tamara \| ... \| McWhirter, Sarah M. Cell Reports, volume 29, issue 3, pages 785-789 (2019). 10.1016/j.celrep.2019.09.089 Cited by (26) \| Cite \| Source
Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol (journal article) Rovira, Alexander R. \| Müller, Nicolas \| Deng, Weiwen \| Ndubaku, Chudi \| Sarpong, Richmond Chemical Science, volume 10, issue 33, pages 7788-7791 (2019). 10.1039/C9SC02572C Cited by (6) \| Cite \| Source
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors (journal article) Bryan, Marian C. \| Drobnick, Joy \| Gobbi, Alberto \| Kolesnikov, Aleksandr \| Chen, Yongsheng \| Rajapaksa, Naomi \| Ndubaku, Chudi \| Feng, Jianwen \| Chang, Willy \| Francis, Ross \| ... \| Kiefer, James R. Journal of Medicinal Chemistry, volume 62, issue 13, pages 6223-6240 (2019). 10.1021/acs.jmedchem.9b00439 Cited by (19) \| Cite \| Source
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity (journal article) Sivick, Kelsey E. \| Desbien, Anthony L. \| Glickman, Laura Hix \| Reiner, Gabrielle L. \| Corrales, Leticia \| Surh, Natalie H. \| Hudson, Thomas E. \| Vu, Uyen T. \| Francica, Brian J. \| Banda, Tamara \| ... \| McWhirter, Sarah M. Cell Reports, volume 25, issue 11, pages 3074-3085.e5 (2018). 10.1016/j.celrep.2018.11.047 Cited by (264) \| Cite \| Source
Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer (journal article) Kinkead, Heather L. \| Hopkins, Alexander \| Lutz, Eric \| Wu, Annie A. \| Yarchoan, Mark \| Cruz, Kayla \| Woolman, Skylar \| Vithayathil, Teena \| Glickman, Laura H. \| Ndubaku, Chudi O. \| ... \| Zaidi, Neeha JCI Insight, volume 3, issue 20 (2018). 10.1172/jci.insight.122857 Cited by (120) \| Cite \| Source
Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques (journal article) Di Lello, Paola \| Pastor, Richard \| Murray, Jeremy M. \| Blake, Robert A. \| Cohen, Frederick \| Crawford, Terry D. \| Drobnick, Joy \| Drummond, Jason \| Kategaya, Lorna \| Kleinheinz, Tracy \| ... \| Tsui, Vickie Journal of Medicinal Chemistry, volume 60, issue 24, pages 10056-10070 (2017). 10.1021/acs.jmedchem.7b01293 Cited by (59) \| Cite \| Source
Benzoxazepin PI3K inhibitor compounds and methods of use (patent) Blaquiere, Nicole \| Do, Steven \| Dudley, Danette \| Folkes, Adrian \| Heald, Robert \| Heffron, Timothy \| Jones, Mark \| Kolesnikov, Aleksandr \| Ndubaku, Chudi \| Olivero, Alan G. \| ... \| Wang, Lan Patent Number: 9670228 (2017) Cited by (1) \| Cite \| Source
Aminoquinazoline and pyridopyrimidine derivatives (patent) Chen, Huifen \| Crawford, Terry \| Harris, Seth F. \| Magnuson, Steven R. \| Ndubaku, Chudi \| Wang, Lan Patent Number: 9592235 (2017) Cite \| Source
Isoquinoline and naphthyridine derivatives (patent) Chen, Huifen \| Crawford, Terry \| Magnuson, Steven R. \| Ndubaku, Chudi \| Wang, Lan Patent Number: 9586956 (2017) Cite \| Source
USP7 inhibitor compounds and methods of use (patent) Blake, Robert \| Di Lello, Paola \| Drummond, Jason \| Heideker, Christine Johanna \| Kategaya, Lorna \| Maurer, Till \| Murray, Jeremy M. \| Ndubaku, Chudi \| Pastor, Richard \| Rouge, Lionel \| ... \| Yu, Kebing Patent Number: 9573899 (2017) Cited by (1) \| Cite \| Source
Tricyclic PI3K inhibitor compounds and methods of use (patent) Dotson, Jennafer \| Heald, Robert Andrew \| Heffron, Timothy \| Jones, Graham Elgin \| Krintel, Sussie Lerche \| McLean, Neville James \| Ndubaku, Chudi \| Olivero, Alan G. \| Salphati, Laurent \| Wang, Lan \| Wei, BinQuing Patent Number: 9546182 (2017) Cite \| Source
Benzoxazepin PI3K inhibitor compounds and methods of use (patent) Blaquiere, Nicole \| Do, Steven \| Dudley, Danette \| Folkes, Adrian \| Heald, Robert \| Heffron, Timothy \| Jones, Mark \| Kolesnikov, Aleksandr \| Ndubaku, Chudi \| Olivero, Alan G. \| ... \| Wang, Lan Patent Number: 9546178 (2017) Cited by (1) \| Cite \| Source
Aminoquinazoline and pyridopyrimidine derivatives (patent) Chen, Huifen \| Crawford, Terry \| Harris, Seth F. \| Magnuson, Steven R. \| Ndubaku, Chudi \| Wang, Lan Patent Number: 9382241 (2016) Cited by (1) \| Cite \| Source