Anthony J. O'Donoghue

ScholarGPS® ID: 48068327177315

Affiliation

University of California, San Diego, San Diego, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmaceutical Sciences

Top Specialties

Peptide | Severe Acute Respiratory Syndrome | Severe Acute Respiratory Syndrome Coronavirus 2 | Severe Acute Respiratory Syndrome-related Coronavirus

Metrics Summary

Publication Count

Predicted Citations

1,146

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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An approach to zwitterionic peptide design for colorimetric detection of the Southampton norovirus SV3CP protease (journal article) Yeung, Justin \| Jin, Zhicheng \| Ling, Chuxuan \| Retout, Maurice \| Barbosa da Silva, Elany \| Damani, Manan \| Chang, Yu-Ci \| Yim, Wonjun \| O'Donoghue, Anthony J. \| Jokerst, Jesse V. The Analyst, volume 148, issue 18, pages 4504-4512 (2023). 10.1039/D3AN00873H Cited by (2) \| Cite \| Source
Enteral protease inhibition reduces systemic enzymatic activity and proteolysis after experimental trauma-hemorrhagic shock (journal article) Dos Santos, Fernando \| LI, Joyce \| O'Donoghue, Anthony \| Kistler, Erik Physiology, volume 38, issue S1 (2023). 10.1152/physiol.2023.38.S1.5731285 Cite \| Source
Development of Potent and Highly Selective Epoxyketone‐Based Plasmodium Proteasome Inhibitors (journal article) Almaliti, Jehad \| Fajtová, Pavla \| Calla, Jaeson \| LaMonte, Gregory M. \| Feng, Mudong \| Rocamora, Frances \| Ottilie, Sabine \| Glukhov, Evgenia \| Boura, Evzen \| Suhandynata, Raymond T. \| ... \| O'Donoghue, Anthony J. Chemistry – A European Journal, volume 29, issue 20 (2023). 10.1002/chem.202203958 Cited by (3) \| Cite \| Source
Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing (journal article) Jin, Zhicheng \| Li, Yi \| Li, Ke \| Zhou, Jiajing \| Yeung, Justin \| Ling, Chuxuan \| Yim, Wonjun \| He, Tengyu \| Cheng, Yong \| Xu, Ming \| ... \| Jokerst, Jesse V. Angewandte Chemie International Edition, volume 62, issue 4 (2023). 10.1002/anie.202214394 Cited by (7) \| Cite \| Source
Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing (journal article) Jin, Zhicheng \| Li, Yi \| Li, Ke \| Zhou, Jiajing \| Yeung, Justin \| Ling, Chuxuan \| Yim, Wonjun \| He, Tengyu \| Cheng, Yong \| Xu, Ming \| ... \| Jokerst, Jesse V. Angewandte Chemie, volume 135, issue 4 (2023). 10.1002/ange.202214394 Cited by (5) \| Cite \| Source
Allergen Content and Protease Activity in Milk Feeds from Mothers of Preterm Infants (journal article) Luskin, Kathleen \| Mortazavi, Diba \| Bai-Tong, Sherry \| Bertrand, Kerri \| Chambers, Christina \| Schulkers-Escalante, Keriann \| Ahmad, Alla \| Luedtke, Stephanie \| O'Donoghue, Anthony J. \| Ghassemian, Majid \| ... \| Leibel, Sydney A. Breastfeeding Medicine, volume 17, issue 11, pages 947-957 (2022). 10.1089/bfm.2022.0115 Cited by (1) \| Cite \| Source
A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening (journal article) Cheng, Yong \| Borum, Raina M. \| Clark, Alex E. \| Jin, Zhicheng \| Moore, Colman \| Fajtová, Pavla \| O'Donoghue, Anthony J. \| Carlin, Aaron F. \| Jokerst, Jesse V. Angewandte Chemie International Edition, volume 61, issue 9 (2022). 10.1002/anie.202113617 Cited by (26) \| Cite \| Source
A Charge‐Switchable Zwitterionic Peptide for Rapid Detection of SARS‐CoV‐2 Main Protease (journal article) Jin, Zhicheng \| Mantri, Yash \| Retout, Maurice \| Cheng, Yong \| Zhou, Jiajing \| Jorns, Alec \| Fajtova, Pavla \| Yim, Wonjun \| Moore, Colman \| Xu, Ming \| ... \| Jokerst, Jesse V. Angewandte Chemie, volume 134, issue 9 (2022). 10.1002/ange.202112995 Cited by (2) \| Cite \| Source
A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening (journal article) Cheng, Yong \| Borum, Raina M. \| Clark, Alex E. \| Jin, Zhicheng \| Moore, Colman \| Fajtová, Pavla \| O'Donoghue, Anthony J. \| Carlin, Aaron F. \| Jokerst, Jesse V. Angewandte Chemie, volume 134, issue 9 (2022). 10.1002/ange.202113617 Cited by (6) \| Cite \| Source
A Charge‐Switchable Zwitterionic Peptide for Rapid Detection of SARS‐CoV‐2 Main Protease (journal article) Jin, Zhicheng \| Mantri, Yash \| Retout, Maurice \| Cheng, Yong \| Zhou, Jiajing \| Jorns, Alec \| Fajtova, Pavla \| Yim, Wonjun \| Moore, Colman \| Xu, Ming \| ... \| Jokerst, Jesse V. Angewandte Chemie International Edition, volume 61, issue 9 (2022). 10.1002/anie.202112995 Cited by (54) \| Cite \| Source
Improved Scalable Synthesis of Clinical Candidate KZR‐616, a Selective Immunoproteasome Inhibitor (journal article) Almaliti, Jehad \| Fajtová, Pavla \| O'Donoghue, Anthony J. \| AlHindy, Momen \| Gerwick, William H. ChemistrySelect, volume 6, issue 44, pages 12461-12465 (2021). 10.1002/slct.202103455 Cited by (1) \| Cite \| Source
Drug Discovery and Development for Kinetoplastid Diseases (book chapter) In Burger's Medicinal Chemistry and Drug Discovery Caffrey, Conor R. \| Steverding, Dietmar \| Ferreira, Rafaela S. \| de Oliveira, Renata B. \| O'Donoghue, Anthony J. \| Monti, Ludovica \| Ballatore, Carlo \| Bachovchin, Kelly A. \| Ferrins, Lori \| Pollastri, Michael P. \| ... \| Ekins, Sean Wiley (2021) 10.1002/0471266949.bmc235.pub2 Cited by (4) \| Cite \| Source
The Pseudomonas aeruginosa protease LasB directly activates IL-1β (journal article) Sun, Josh \| LaRock, Doris L. \| Skowronski, Elaine A. \| Kimmey, Jacqueline M. \| Olson, Joshua \| Jiang, Zhenze \| O'Donoghue, Anthony J. \| Nizet, Victor \| LaRock, Christopher N. EBioMedicine, volume 60 (2020). 10.1016/j.ebiom.2020.102984 Cited by (28) \| Cite \| Source
Engineering of multiple trypsin/chymotrypsin sites in Cry3A to enhance its activity against Monochamus alternatus Hope larvae (journal article) Guo, Yajie \| Wang, Yafang \| O'Donoghue, Anthony J \| Jiang, Zhenze \| Carballar‐Lejarazú, Rebeca \| Liang, Guanghong \| Hu, Xia \| Wang, Rong \| Xu, Lei \| Guan, Xiong \| ... \| Wu, Songqing Pest Management Science, volume 76, issue 9, pages 3117-3126 (2020). 10.1002/ps.5866 Cited by (11) \| Cite \| Source
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders (journal article) Hook, Vivian \| Yoon, Michael \| Mosier, Charles \| Ito, Gen \| Podvin, Sonia \| Head, Brian P. \| Rissman, Robert \| O'Donoghue, Anthony J. \| Hook, Gregory Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, volume 1868, issue 8, pages 140428- (2020). 10.1016/j.bbapap.2020.140428 Cited by (91) \| Cite \| Source
Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses (journal article) Podvin, Sonia \| Jones, Alexander \| Liu, Qing \| Aulston, Brent \| Ransom, Linnea \| Ames, Janneca \| Shen, Gloria \| Lietz, Christopher B. \| Jiang, Zhenze \| O'Donoghue, Anthony J. \| ... \| Hook, Vivian Molecular & Cellular Proteomics, volume 19, issue 6, pages 1017-1034 (2020). 10.1074/mcp.RA120.002079 Cited by (30) \| Cite \| Source
Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin (journal article) Dvořáková, Hana \| Leontovyč, Roman \| Macháček, Tomáš \| O'Donoghue, Anthony J. \| Šedo, Ondřej \| Zdráhal, Zbyněk \| Craik, Charles S. \| Caffrey, Conor R. \| Horák, Petr \| Mikeš, Libor Frontiers in Cellular and Infection Microbiology, volume 10 (2020). 10.3389/fcimb.2020.00066 Cited by (2) \| Cite \| Source
Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry (journal article) Lapek, John D. \| Jiang, Zhenze \| Wozniak, Jacob M. \| Arutyunova, Elena \| Wang, Steven C \| Lemieux, M. Joanne \| Gonzalez, David J. \| O'Donoghue, Anthony J. Molecular & Cellular Proteomics, volume 18, issue 5, pages 968a-981 (2019). 10.1074/mcp.TIR118.001099 Cited by (22) \| Cite \| Source
Validation of Babesia proteasome as a drug target (journal article) Jalovecka, Marie \| Hartmann, David \| Miyamoto, Yukiko \| Eckmann, Lars \| Hajdusek, Ondrej \| O'Donoghue, Anthony J. \| Sojka, Daniel International Journal for Parasitology: Drugs and Drug Resistance, volume 8, issue 3, pages 394-402 (2018). 10.1016/j.ijpddr.2018.08.001 Cited by (13) \| Cite \| Source \| Open Access
Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L (journal article) Corvo, Ileana \| Ferraro, Florencia \| Merlino, Alicia \| Zuberbühler, Kathrin \| O'Donoghue, Anthony J. \| Pastro, Lucía \| Pi-Denis, Natalia \| Basika, Tatiana \| Roche, Leda \| McKerrow, James H. \| ... \| Tort, José F. Frontiers in Molecular Biosciences, volume 5 (2018). 10.3389/fmolb.2018.00040 Cited by (12) \| Cite \| Source \| Open Access

Title	Investigators	Year	Cost	Agency
Point-of-Care Quantitation of Sputum Neutrophil Elastase Activity in Chronic Airway Disease	Hall, Drew Alexander \| O'DONOGHUE, Anthony John	2020	$196,875	NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
Selective proteasome inhibitors for trichomoniasis	Eckmann, Lars \| O'DONOGHUE, Anthony John	2020	$196,875	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Selective proteasome inhibitors for trichomoniasis	Eckmann, Lars \| O'DONOGHUE, Anthony John	2019	$236,250	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Point-of-Care Quantitation of Sputum Neutrophil Elastase Activity in Chronic Airway Disease	Hall, Drew Alexander \| O'DONOGHUE, Anthony John	2019	$236,250	NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
Exploring the proteasome as a new drug target to treat schistosomiasis	O'DONOGHUE, Anthony John	2018	$193,750	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Exploring the proteasome as a new drug target to treat schistosomiasis	O'DONOGHUE, Anthony John	2017	$232,500	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES