Wei Li

ScholarGPS® ID: 48044142914004

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Antibody | Gene Expression | Growth Factor

Metrics Summary

Publication Count

Predicted Citations

1,512

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region (journal article) Li, Yanjie \| Wei, Yuehua \| Ultsch, Mark \| Li, Wei \| Tang, Wanjian \| Tombling, Benjamin \| Gao, Xinxin \| Dimitrova, Yoana \| Gampe, Christian \| Fuhrmann, Jakob \| ... \| Kirchhofer, Daniel Nature Communications, volume 15, issue 1 (2024). 10.1038/s41467-024-48655-w Cite \| Source
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration (journal article) Gerhardy, Stefan \| Ultsch, Mark \| Tang, Wanjian \| Green, Evan \| Holden, Jeffrey K. \| Li, Wei \| Estevez, Alberto \| Arthur, Chris \| Tom, Irene \| Rohou, Alexis \| Kirchhofer, Daniel Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-32760-9 Cited by (6) \| Cite \| Source
Compositions and methods for treating cardiovascular disease (patent) Beresini, Maureen \| Burdick, Daniel \| Eigenbrot, Jr., Charles \| Kirchhofer, Daniel \| Lazarus, Robert \| Li, Wei \| Quinn, John \| Skelton, Nicholas \| Ultsch, Mark \| Zhang, Yingnan Patent Number: 10787484 (2020) Cite \| Source
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy (journal article) Tom, Irene \| Pham, Victoria C. \| Katschke, Kenneth J. \| Li, Wei \| Liang, Wei-Ching \| Gutierrez, Johnny \| Ah Young, Andrew \| Figueroa, Isabel \| Eshghi, Shadi Toghi \| Lee, ChingWei V. \| ... \| Lill, Jennie R. Proceedings of the National Academy of Sciences, volume 117, issue 18, pages 9952-9963 (2020). 10.1073/pnas.1917608117 Cited by (36) \| Cite \| Source
Design of Organo-Peptides As Bipartite PCSK9 Antagonists (journal article) Burdick, Daniel J. \| Skelton, Nicholas J. \| Ultsch, Mark \| Beresini, Maureen H. \| Eigenbrot, Charles \| Li, Wei \| Zhang, Yingnan \| Nguyen, Huy \| Kong-Beltran, Monica \| Quinn, John G. \| Kirchhofer, Daniel ACS Chemical Biology, volume 15, issue 2, pages 425-436 (2020). 10.1021/acschembio.9b00899 Cited by (16) \| Cite \| Source
Therapeutic compounds, compositions and methods of use thereof (patent) Cheng, Yun-Xing \| Hua, Rongbao \| Kellar, Terry \| Li, Wei \| Gibbons, Paul \| Zak, Mark Edward Patent Number: 10189836 (2019) Cite \| Source
Triazolopyridine compounds, compositions and methods of use thereof (patent) Ray, Nicholas C. \| Cheng, Yun-Xing \| Edwards, Christine \| Goodacre, Simon C. \| Li, Wei \| Patel, Snahel \| Cartwright, Matthew W. \| Sajad, Mohammed \| Yuen, Po-wai \| Zak, Mark E. Patent Number: 9873709 (2018) Cited by (1) \| Cite \| Source
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists (journal article) Zhang, Yingnan \| Ultsch, Mark \| Skelton, Nicholas J \| Burdick, Daniel J \| Beresini, Maureen H \| Li, Wei \| Kong-Beltran, Monica \| Peterson, Andrew \| Quinn, John \| Chiu, Cecilia \| ... \| Kirchhofer, Daniel Nature Structural & Molecular Biology, volume 24, issue 10, pages 848-856 (2017). 10.1038/nsmb.3453 Cited by (58) \| Cite \| Source
5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof (patent) Zak, Mark Edward \| Ray, Nicholas Charles \| Goodacre, Simon Charles \| Mendonca, Rohan \| Kellar, Terry \| Cheng, Yun-Xing \| Li, Wei \| Yuen, Po-Wei Patent Number: 9604984 (2017) Cited by (1) \| Cite \| Source
5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof (patent) Zak, Mark Edward \| Ray, Nicholas Charles \| Goodacre, Simon Charles \| Mendonca, Rohan \| Kellar, Terry \| Cheng, Yun-Xing \| Li, Wei \| Yuen, Po-Wai Patent Number: 9346815 (2016) Cited by (2) \| Cite \| Source
Anti-PCSK9 antibodies, formulations, dosing, and methods of use (patent) Wu, Yan \| Chiu, Cecilia Pui Chi \| Kirchhofer, Daniel K. \| Peterson, Andrew \| Kolumam, Ganesh A. \| Beltran, Monica Kong \| Moran, Paul \| Li, Wei \| Lam, Xanthe M. \| Luis, Lin \| Hui, Ada Patent Number: 9266961 (2016) Cited by (1) \| Cite \| Source
Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor (journal article) Zhang, Yingnan \| Eigenbrot, Charles \| Zhou, Lijuan \| Shia, Steven \| Li, Wei \| Quan, Clifford \| Tom, Jeffrey \| Moran, Paul \| Di Lello, Paola \| Skelton, Nicholas J. \| ... \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 289, issue 2, pages 942-955 (2014). 10.1074/jbc.M113.514067 Cited by (138) \| Cite \| Source \| Open Access
ANTI-PCSK9 ANTIBODIES, FORMULATIONS, DOSING, AND METHODS OF USE (patent) Wu, Yan \| Chiu, Cecilia Pui Chi \| Kirchhofer, Daniel \| Peterson, Andrew S. \| Kolumam, Ganesh \| Beltran, Monica Kong \| Moran, Paul \| Li, Wei \| Lam, Xanthe M. \| Luis, Lin \| Hui, Ada Patent Number: 20130344085 (2013) Cite \| Source
Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels (journal article) Lipari, Michael T. \| Li, Wei \| Moran, Paul \| Kong-Beltran, Monica \| Sai, Tao \| Lai, Joyce \| Lin, S. Jack \| Kolumam, Ganesh \| Zavala-Solorio, Jose \| Izrael-Tomasevic, Anita \| ... \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 287, issue 52, pages 43482-43491 (2012). 10.1074/jbc.M112.380618 Cited by (105) \| Cite \| Source \| Open Access
Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain (journal article) Zhang, Yingnan \| Zhou, Lijuan \| Kong-Beltran, Monica \| Li, Wei \| Moran, Paul \| Wang, Jianyong \| Quan, Clifford \| Tom, Jeffrey \| Kolumam, Ganesh \| Elliott, J. Michael \| ... \| Kirchhofer, Daniel Journal of Molecular Biology, volume 422, issue 5, pages 685-696 (2012). 10.1016/j.jmb.2012.06.018 Cited by (34) \| Cite \| Source
Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis (journal article) Li, Wei \| Wang, Bu-Er \| Moran, Paul \| Lipari, Terry \| Ganesan, Rajkumar \| Corpuz, Racquel \| Ludlam, Mary J.C. \| Gogineni, Alvin \| Koeppen, Hartmut \| Bunting, Stuart \| ... \| Kirchhofer, Daniel Cancer Research, volume 69, issue 21, pages 8395-8402 (2009). 10.1158/0008-5472.CAN-09-1995 Cited by (49) \| Cite \| Source
The Serine Protease Marapsin Is Expressed in Stratified Squamous Epithelia and Is Up-regulated in the Hyperproliferative Epidermis of Psoriasis and Regenerating Wounds (journal article) Li, Wei \| Danilenko, Dimitry M. \| Bunting, Stuart \| Ganesan, Rajkumar \| Sa, Susan \| Ferrando, Ronald \| Wu, Thomas D. \| Kolumam, Ganesh A. \| Ouyang, Wenjun \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 284, issue 1, pages 218-228 (2009). 10.1074/jbc.M806267200 Cited by (36) \| Cite \| Source \| Open Access
Pro-urokinase-type Plasminogen Activator Is a Substrate for Hepsin (journal article) Moran, Paul \| Li, Wei \| Fan, Bin \| Vij, Rajesh \| Eigenbrot, Charles \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 281, issue 41, pages 30439-30446 (2006). 10.1074/jbc.M605440200 Cited by (73) \| Cite \| Source \| Open Access
Identification of Hepatocyte Growth Factor Activator Inhibitor-1B as a Potential Physiological Inhibitor of Prostasin (journal article) Fan, Bin \| Wu, Thomas D. \| Li, Wei \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 280, issue 41, pages 34513-34520 (2005). 10.1074/jbc.M502119200 Cited by (73) \| Cite \| Source \| Open Access
Inhibitory effects of interferon-γ on myocardial hypertrophy (journal article) Jin, Hongkui \| Li, Wei \| Yang, Renhui \| Ogasawara, Annie \| Lu, Hsienwie \| Paoni, Nicholas F. Cytokine, volume 31, issue 6, pages 405-414 (2005). 10.1016/j.cyto.2005.06.013 Cited by (14) \| Cite \| Source