Michael Karin | Scholar Profiles and Rankings

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NIH/NSF


Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth (journal article) De Marco, Margot \| Gauttier, Vanessa \| Pengam, Sabrina \| Mary, Caroline \| Ranieri, Bianca \| Basile, Anna \| Festa, Michela \| Falco, Antonia \| Reppucci, Francesca \| Cammarota, Anna Lisa \| ... \| Marzullo, Liberato Cell Death Discovery, volume 8, issue 1 (2022). 10.1038/s41420-022-00817-9 Cite \| Source
Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis (journal article) Hanley, Kaisa L. \| Liang, Yan \| Wang, Gaowei \| Lin, Xiaoxue \| Yang, Meixiang \| Karin, Michael \| Fu, Wenxian \| Feng, Gen-Sheng Molecular Cancer Research, volume 20, issue 3, pages 337-349 (2022). 10.1158/1541-7786.MCR-21-0479 Cite \| Source
FEN1-Generated Oxidized DNA Fragments Escape Mitochondria via mPTP- and VDAC-Dependent Channels to License NLRP3 Inflammasome and STING Activation (journal article) Xian, Hongxu \| Watari, Kosuke \| Sanchez-Lopez, Elsa \| Shadel, Gerald S. \| Karin, Michael SSRN Electronic Journal (2022). 10.2139/ssrn.4022698 Cited by (1) \| Cite \| Source
Therapeutic Blockade of ER Stress and Inflammation Prevents High Fat Diet-Induced NASH and Progression to Hepatocellular Carcinoma (journal article) Boslem, Ebru \| Riebe, Saskia \| Smeuninx, Benoit \| Egan, Casey L. \| Tegegne, Surafel \| McLennan, Emma \| Nobis, Max \| Mu, Andre \| Nowell, Cameron J. \| Horadagoda, Neil \| ... \| Febbraio, Mark Anthony SSRN Electronic Journal (2022). 10.2139/ssrn.4001943 Cite \| Source
Regulation of antitumor immunity by inflammation-induced epigenetic alterations (journal article) Karin, Michael \| Shalapour, Shabnam Cellular & Molecular Immunology, volume 19, issue 1, pages 59-66 (2022). 10.1038/s41423-021-00756-y Cited by (11) \| Cite \| Source
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis (journal article) Febbraio, Mark A. \| Karin, Michael Cell Metabolism, volume 33, issue 12, pages 2316-2328 (2021). 10.1016/j.cmet.2021.09.004 Cited by (28) \| Cite \| Source
Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice (journal article) Baglieri, Jacopo \| Zhang, Cuili \| Liang, Shuang \| Liu, Xiao \| Nishio, Takahiro \| Rosenthal, Sara B. \| Dhar, Debanjan \| Su, Hua \| Cong, Min \| Jia, Jidong \| ... \| Brenner, David A. The American Journal of Pathology, volume 191, issue 9, pages 1564-1579 (2021). 10.1016/j.ajpath.2021.05.019 Cited by (5) \| Cite \| Source
Macropinocytosis: the big drinker behind cancer cell self-consumption (journal article) Su, Hua \| Yang, Fei \| Sun, Beicheng \| Karin, Michael Autophagy, volume 17, issue 5, pages 1290-1291 (2021). 10.1080/15548627.2021.1919969 Cited by (3) \| Cite \| Source
Targeting cancer-promoting inflammation — have anti-inflammatory therapies come of age? (journal article) Hou, Jiajie \| Karin, Michael \| Sun, Beicheng Nature Reviews Clinical Oncology, volume 18, issue 5, pages 261-279 (2021). 10.1038/s41571-020-00459-9 Cited by (77) \| Cite \| Source
Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia (journal article) Trudler, Dorit \| Nazor, Kristopher L. \| Eisele, Yvonne S. \| Grabauskas, Titas \| Dolatabadi, Nima \| Parker, James \| Sultan, Abdullah \| Zhong, Zhenyu \| Goodwin, Marshall S. \| Levites, Yona \| ... \| Lipton, Stuart A. Proceedings of the National Academy of Sciences, volume 118, issue 15 (2021). 10.1073/pnas.2025847118 Cited by (43) \| Cite \| Source
From Liver Fat to Cancer: Perils of the Western Diet (journal article) Kim, Ju Youn \| He, Feng \| Karin, Michael Cancers, volume 13, issue 5, pages 1095- (2021). 10.3390/cancers13051095 Cited by (11) \| Cite \| Source
The neglected brothers come of age: B cells and cancer (journal article) Shalapour, Shabnam \| Karin, Michael Seminars in Immunology, volume 52 (2021). 10.1016/j.smim.2021.101479 Cited by (18) \| Cite \| Source
PIDDosome-SCAP Crosstalk Controls Diet Dependent Transition from Simple Steatosis to Steatohepatitis (journal article) Kim, Ju Youn \| Wang, Lily \| Sladky, Valentina C. \| Oh, Tae Gyu \| Liu, Junlai \| Trinh, Kaitlyn \| Eichin, Felix \| Downes, Michael \| Hosseini, Mojgan \| Jacotot, Etienne D. \| ... \| Karin, Michael SSRN Electronic Journal (2021). 10.2139/ssrn.4029141 Cited by (1) \| Cite \| Source
Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease (journal article) Yueh, Mei-Fei \| He, Feng \| Chen, Chen \| Vu, Catherine \| Tripathi, Anupriya \| Knight, Rob \| Karin, Michael \| Chen, Shujuan \| Tukey, Robert H. Proceedings of the National Academy of Sciences, volume 117, issue 49, pages 31259-31266 (2020). 10.1073/pnas.2017129117 Cited by (24) \| Cite \| Source
Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer (journal article) Ryan, Stephen T. \| Zhang, Jing \| Burner, Danielle N. \| Liss, Michael \| Pittman, Emily \| Muldong, Michelle \| Shabaik, Ahmed \| Woo, Jason \| Basler, Nicole \| Cunha, Jonathan \| ... \| Jamieson, Christina A. M. Journal of Translational Medicine, volume 18, issue 1 (2020). 10.1186/s12967-020-02370-4 Cited by (16) \| Cite \| Source
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression (journal article) Kudo, Yotaro \| Sugimoto, Masayuki \| Arias, Esperanza \| Kasashima, Hiroaki \| Cordes, Thekla \| Linares, Juan F. \| Duran, Angeles \| Nakanishi, Yuki \| Nakanishi, Naoko \| L'Hermitte, Antoine \| ... \| Moscat, Jorge Cancer Cell, volume 38, issue 2, pages 247-262.e11 (2020). 10.1016/j.ccell.2020.05.018 Cited by (45) \| Cite \| Source
NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia (journal article) Sanchez-Lopez, Elsa \| Ghia, Emanuela M. \| Antonucci, Laura \| Sharma, Natasha \| Rassenti, Laura Z. \| Xu, Jinyi \| Sun, Beicheng \| Kipps, Thomas J. \| Karin, Michael Cell Death & Differentiation, volume 27, issue 7, pages 2206-2216 (2020). 10.1038/s41418-020-0496-1 Cited by (21) \| Cite \| Source
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly (journal article) He, Feng \| Antonucci, Laura \| Yamachika, Shinichiro \| Zhang, Zechuan \| Taniguchi, Koji \| Umemura, Atsushi \| Hatzivassiliou, Georgia \| Roose-Girma, Merone \| Reina-Campos, Miguel \| Duran, Angeles \| ... \| Karin, Michael Journal of Hepatology, volume 72, issue 6, pages 1182-1195 (2020). 10.1016/j.jhep.2020.01.023 Cited by (35) \| Cite \| Source
Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers (journal article) Shalapour, Shabnam \| Karin, Michael Annual Review of Immunology, volume 38, issue 1, pages 649-671 (2020). 10.1146/annurev-immunol-082019-081656 Cited by (19) \| Cite \| Source
Immunotherapy, Inflammation and Colorectal Cancer (journal article) Lichtenstern, Charles Robert \| Ngu, Rachael Katie \| Shalapour, Shabnam \| Karin, Michael Cells, volume 9, issue 3, pages 618- (2020). 10.3390/cells9030618 Cited by (103) \| Cite \| Source

Title	Investigators	Year	Cost	Agency
Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors	Karin, Michael	2020	$551,762	NATIONAL CANCER INSTITUTE
Role of p62/SQSTM1 in obesity-induced liver cancer	Karin, Michael \| Moscat, Jorge	2020	$726,246	NATIONAL CANCER INSTITUTE
Control of Lipogenesis and Hepatic Steatosis by Caspase-2	Karin, Michael	2020	$416,402	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Project 1: Control of Toxin Obesity Induced Liver Fibrosis by B Cells	Karin, Michael	2020	$298,013	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation	Karin, Michael	2020	$590,745	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors	El-Khoueiry, Anthony Boutros \| Karin, Michael \| Shalapour, Shabnam \| Tsukamoto, Hidekazu	2020	$724,384	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation	Karin, Michael	2020	$371,655	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Role of p62/SQSTM1 in obesity-induced liver cancer	Karin, Michael \| Moscat, Jorge	2019	$704,458	NATIONAL CANCER INSTITUTE
Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors	Karin, Michael	2019	$550,740	NATIONAL CANCER INSTITUTE
Project 1: Control of Toxin Obesity Induced Liver Fibrosis by B Cells	Karin, Michael	2019	$312,375	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation	Karin, Michael	2019	$590,745	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Control of Lipogenesis and Hepatic Steatosis by Caspase-2	Karin, Michael	2019	$415,961	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors	El-Khoueiry, Anthony Boutros \| Karin, Michael \| Shalapour, Shabnam \| Tsukamoto, Hidekazu	2019	$724,197	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
Role of p62/SQSTM1 in obesity-induced liver cancer	Karin, Michael \| Moscat, Jorge	2018	$726,246	NATIONAL CANCER INSTITUTE
Project 1: Control of Toxin Obesity Induced Liver Fibrosis by B Cells	Karin, Michael	2018	$347,390	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
The Role of IL-17 in Alcoholic Liver Disease and Cancer	Karin, Michael \| Kisseleva, Tatiana	2018	$353,250	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation	Karin, Michael	2018	$590,745	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Project 1: Control of Toxin Obesity Induced Liver Fibrosis by B Cells	Karin, Michael	2018	$50,000	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors	El-Khoueiry, Anthony Boutros \| Karin, Michael \| Shalapour, Shabnam \| Tsukamoto, Hidekazu	2018	$737,531	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
Role of p62/SQSTM1 in obesity-induced liver cancer	Karin, Michael \| Moscat, Jorge	2017	$739,996	NATIONAL CANCER INSTITUTE
IKK and the Control of Prostate Cancer Metastasis	Karin, Michael	2017	$257,099	NATIONAL CANCER INSTITUTE
Project 1: Control of Toxin Obesity Induced Liver Fibrosis by B Cells	Karin, Michael	2017	$299,658	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Regulation of NF-kappaB and IKK by proinflammatory stimuli	Karin, Michael	2017	$492,288	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
The Role of IL-17 in Alcoholic Liver Disease and Cancer	Karin, Michael \| Kisseleva, Tatiana	2017	$353,250	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
IKK and the Control of Prostate Cancer Metastasis	Karin, Michael	2016	$257,099	NATIONAL CANCER INSTITUTE
Role of Inflammation in tumor promotion and progression	Karin, Michael	2016	$446,701	NATIONAL CANCER INSTITUTE
Project 1: Effects of Superfund Toxicants on Liver Cancer Progenitors	Karin, Michael	2016	$290,389	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Regulation of NF-kappaB and IKK by proinflammatory stimuli	Karin, Michael	2016	$492,288	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
The Role of IL-17 in Alcoholic Liver Disease and Cancer	Karin, Michael \| Kisseleva, TATIANA (contact)	2016	$353,250	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer	Karin, Michael	2016	$382,893	NATIONAL CANCER INSTITUTE
IKK and the Control of Prostate Cancer Metastasis	Karin, Michael	2015	$257,099	NATIONAL CANCER INSTITUTE
IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer	Karin, Michael	2015	$382,893	NATIONAL CANCER INSTITUTE
Project 1: Effects of Superfund Toxicants on Liver Cancer Progenitors	Karin, Michael	2015	$299,044	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Role of Inflammation in tumor promotion and progression	Karin, Michael	2015	$446,701	NATIONAL CANCER INSTITUTE
TOR signaling and autophagy in obesity-promoted liver tumorigenesis	Karin, Michael	2015	$351,277	NATIONAL CANCER INSTITUTE
Regulation of NF-kappaB and IKK by proinflammatory stimuli	Karin, Michael	2015	$492,288	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
The Role of IL-17 in Alcoholic Liver Disease and Cancer	Karin, Michael \| Kisseleva, TATIANA (contact)	2015	$342,652	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
IKK and the Control of Prostate Cancer Metastasis	Karin, Michael	2014	$249,386	NATIONAL CANCER INSTITUTE
Role of Inflammation in tumor promotion and progression	Karin, Michael	2014	$433,300	NATIONAL CANCER INSTITUTE
IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer	Karin, Michael	2014	$371,406	NATIONAL CANCER INSTITUTE