Morgan Sheng | Scholar Profiles and Rankings

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Targeting synapse function and loss for treatment of neurodegenerative diseases (journal article) Dejanovic, Borislav \| Sheng, Morgan \| Hanson, Jesse E. Nature Reviews Drug Discovery, volume 23, issue 1, pages 23-42 (2024). 10.1038/s41573-023-00823-1 Cited by (13) \| Cite \| Source
TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice (journal article) Wang, Yuanyuan \| Wu, Tiffany \| Tsai, Ming-Chi \| Rezzonico, Mitchell G \| Abdel-Haleem, Alyaa M \| Xie, Luke \| Gandham, Vineela D \| Ngu, Hai \| Stark, Kimberly \| Glock, Caspar \| ... \| Hanson, Jesse E eLife, volume 12 (2023). 10.7554/eLife.83451 Cited by (3) \| Cite \| Source
TREM2 ‐dependent microglial function is essential for remyelination and subsequent neuroprotection (journal article) Wang, Yuanyuan \| Kyauk, Roxanne V. \| Shen, Yun‐An A. \| Xie, Luke \| Reichelt, Mike \| Lin, Han \| Jiang, Zhiyu \| Ngu, Hai \| Shen, Kimberle \| Greene, Jacob J. \| ... \| Yuen, Tracy J. Glia, volume 71, issue 5, pages 1247-1258 (2023). 10.1002/glia.24335 Cited by (13) \| Cite \| Source
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model (journal article) Aryal, Sameer \| Bonanno, Kevin \| Song, Bryan \| Mani, D.R. \| Keshishian, Hasmik \| Carr, Steven A. \| Sheng, Morgan \| Dejanovic, Borislav Cell Reports, volume 42, issue 5, pages 112497- (2023). 10.1016/j.celrep.2023.112497 Cited by (8) \| Cite \| Source
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration (journal article) Zhou, Jiechao \| Wade, Sarah D. \| Graykowski, David \| Xiao, Mei-Fang \| Zhao, Binhui \| Giannini, Lucia A. A. \| Hanson, Jesse E. \| van Swieten, John C. \| Sheng, Morgan \| Worley, Paul F. \| Dejanovic, Borislav Science Translational Medicine, volume 15, issue 689 (2023). 10.1126/scitranslmed.adf0141 Cited by (33) \| Cite \| Source
Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease (journal article) Zeng, Hu \| Huang, Jiahao \| Zhou, Haowen \| Meilandt, William J. \| Dejanovic, Borislav \| Zhou, Yiming \| Bohlen, Christopher J. \| Lee, Seung-Hye \| Ren, Jingyi \| Liu, Albert \| ... \| Wang, Xiao Nature Neuroscience (2023). 10.1038/s41593-022-01251-x Cited by (30) \| Cite \| Source
Optogenetic polymerization and assembly of electrically functional polymers for modulation of single-neuron excitability (journal article) Sessler, Chanan D. \| Zhou, Yiming \| Wang, Wenbo \| Hartley, Nolan D. \| Fu, Zhanyan \| Graykowski, David \| Sheng, Morgan \| Wang, Xiao \| Liu, Jia Science Advances, volume 8, issue 49 (2022). 10.1126/sciadv.ade1136 Cited by (11) \| Cite \| Source
NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury (journal article) Zhou, Jia \| Geng, Yang \| Su, Tonghui \| Wang, Qiuyan \| Ren, Yongfei \| Zhao, Jing \| Fu, Chaoying \| Weber, Martin \| Lin, Han \| Kaminker, Joshua S. \| ... \| Chen, Yelin Cell Reports, volume 38, issue 13, pages 110557- (2022). 10.1016/j.celrep.2022.110557 Cited by (9) \| Cite \| Source
TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease (journal article) Lee, Seung-Hye \| Rezzonico, Mitchell G. \| Friedman, Brad A. \| Huntley, Melanie H. \| Meilandt, William J. \| Pandey, Shristi \| Chen, Ying-Jiun J. \| Easton, Amy \| Modrusan, Zora \| Hansen, David V. \| ... \| Bohlen, Christopher J. Cell Reports, volume 37, issue 13, pages 110158- (2021). 10.1016/j.celrep.2021.110158 Cited by (32) \| Cite \| Source
Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination (journal article) Shen, Kimberle \| Reichelt, Mike \| Kyauk, Roxanne V. \| Ngu, Hai \| Shen, Yun-An A. \| Foreman, Oded \| Modrusan, Zora \| Friedman, Brad A. \| Sheng, Morgan \| Yuen, Tracy J. Cell Reports, volume 34, issue 10, pages 108835- (2021). 10.1016/j.celrep.2021.108835 Cited by (64) \| Cite \| Source
PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function (journal article) Wang, Yuanyuan \| Kerrisk Campbell, Meghan \| Tom, Irene \| Foreman, Oded \| Hanson, Jesse E. \| Sheng, Morgan Scientific Reports, volume 10, issue 1 (2020). 10.1038/s41598-020-67831-8 Cited by (16) \| Cite \| Source
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model (journal article) Meilandt, William J. \| Ngu, Hai \| Gogineni, Alvin \| Lalehzadeh, Guita \| Lee, Seung-Hye \| Srinivasan, Karpagam \| Imperio, Jose \| Wu, Tiffany \| Weber, Martin \| Kruse, Agatha J. \| ... \| Hansen, David V. The Journal of Neuroscience, volume 40, issue 9, pages 1956-1974 (2020). 10.1523/JNEUROSCI.1871-19.2019 Cited by (105) \| Cite \| Source
Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics (journal article) Vogl, Annette M. \| Phu, Lilian \| Becerra, Raquel \| Giusti, Sebastian A. \| Verschueren, Erik \| Hinkle, Trent B. \| Bordenave, Martín D. \| Adrian, Max \| Heidersbach, Amy \| Yankilevich, Patricio \| ... \| Sheng, Morgan Nature Structural & Molecular Biology, volume 27, issue 2, pages 210-220 (2020). 10.1038/s41594-019-0370-3 Cited by (59) \| Cite \| Source
Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes (journal article) Huntley, Melanie A. \| Srinivasan, Karpagam \| Friedman, Brad A. \| Wang, Tzu-Ming \| Yee, Ada X. \| Wang, Yuanyuan \| Kaminker, Josh S. \| Sheng, Morgan \| Hansen, David V. \| Hanson, Jesse E. The Journal of Neuroscience, volume 40, issue 5, pages 958-973 (2020). 10.1523/JNEUROSCI.1615-19.2019 Cited by (40) \| Cite \| Source
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models (journal article) Hanson, Jesse E. \| Ma, Keran \| Elstrott, Justin \| Weber, Martin \| Saillet, Sandrine \| Khan, Abdullah S. \| Simms, Jeffrey \| Liu, Benjamin \| Kim, Thomas A. \| Yu, Gui-Qiu \| ... \| Palop, Jorge J. Cell Reports, volume 30, issue 2, pages 381-396.e4 (2020). 10.1016/j.celrep.2019.12.030 Cited by (50) \| Cite \| Source
Microglia in Brain Development, Homeostasis, and Neurodegeneration (journal article) Bohlen, Christopher J. \| Friedman, Brad A. \| Dejanovic, Borislav \| Sheng, Morgan Annual Review of Genetics, volume 53, issue 1, pages 263-288 (2019). 10.1146/annurev-genet-112618-043515 Cited by (109) \| Cite \| Source
PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease (journal article) Fleck, Daniel \| Phu, Lilian \| Verschueren, Erik \| Hinkle, Trent \| Reichelt, Mike \| Bhangale, Tushar \| Haley, Benjamin \| Wang, Yuanyuan \| Graham, Robert \| Kirkpatrick, Donald S. \| ... \| Bingol, Baris The Journal of Neuroscience, volume 39, issue 24, pages 4636-4656 (2019). 10.1523/JNEUROSCI.0116-19.2019 Cited by (20) \| Cite \| Source
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies (journal article) Dejanovic, Borislav \| Huntley, Melanie A. \| De Mazière, Ann \| Meilandt, William J. \| Wu, Tiffany \| Srinivasan, Karpagam \| Jiang, Zhiyu \| Gandham, Vineela \| Friedman, Brad A. \| Ngu, Hai \| ... \| Sheng, Morgan Neuron, volume 100, issue 6, pages 1322-1336.e7 (2018). 10.1016/j.neuron.2018.10.014 Cited by (287) \| Cite \| Source
USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-Dependent Protein Levels (journal article) Kerrisk Campbell, Meghan \| Sheng, Morgan The Journal of Neuroscience, volume 38, issue 23, pages 5289-5301 (2018). 10.1523/JNEUROSCI.3305-17.2018 Cited by (24) \| Cite \| Source
Microglia in Alzheimer’s disease (journal article) Hansen, David V. \| Hanson, Jesse E. \| Sheng, Morgan Journal of Cell Biology, volume 217, issue 2, pages 459-472 (2018). 10.1083/jcb.201709069 Cited by (1,117) \| Cite \| Source \| Open Access

Title	Investigators	Year	Cost	Agency
Molecular organization of CNS synapses	Sheng, Morgan H.	2009	$113,400	NATIONAL INSTITUTE OF MENTAL HEALTH
Project 7: Dynamics of Synapse Formation and Elimination in vivo	Sheng, Morgan H.	2008	$178,467	NATIONAL INSTITUTE OF MENTAL HEALTH
Molecular organization of CNS synapses	Sheng, Morgan H.	2008	$215,047	NATIONAL INSTITUTE OF MENTAL HEALTH
Project 7: Dynamics of Synapse Formation and Elimination in vivo	Sheng, Morgan H.	2007	$179,165	NATIONAL INSTITUTE OF MENTAL HEALTH
Molecular organization of CNS synapses	Sheng, Morgan H.	2007	$215,047	NATIONAL INSTITUTE OF MENTAL HEALTH
Project 7: Dynamics of Synapse Formation and Elimination in vivo	Sheng, Morgan H.	2006	$183,454	NATIONAL INSTITUTE OF MENTAL HEALTH
Molecular organization of CNS synapses	Sheng, Morgan H.	2006	$221,470	NATIONAL INSTITUTE OF MENTAL HEALTH
Project 7: Dynamics of Synapse Formation and Elimination in vivo	Sheng, Morgan H.	2005	$178,112	NATIONAL INSTITUTE OF MENTAL HEALTH
Molecular organization of CNS synapses	Sheng, Morgan H.	2005	$226,800	NATIONAL INSTITUTE OF MENTAL HEALTH
Project 7: Dynamics of Synapse Formation and Elimination in vivo	Sheng, Morgan H.	2004	$174,240	NATIONAL INSTITUTE OF MENTAL HEALTH
Molecular Organization of CNS Synapses	Sheng, Morgan H.	2004	$248,250	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Molecular Organization of CNS Synapses	Sheng, Morgan H.	2003	$248,250	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Molecular Organization of CNS Synapses	Sheng, Morgan H.	2002	$248,250	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Molecular Organization of CNS Synapses	Sheng, Morgan H.	2001	$248,250	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
MOLECULAR ORGANIZATION OF CNS SYNAPSES	Sheng, Morgan H.	2000	$145,040	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
MOLECULAR ORGANIZATION OF CNS SYNAPSES	Sheng, Morgan H.	1999	$139,778	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
MOLECULAR ORGANIZATION OF CNS SYNAPSES	Sheng, Morgan H.	1998	$126,441	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
MOLECULAR ORGANIZATION OF CNS SYNAPSES	Sheng, Morgan H.	1997	$121,578	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
MOLECULAR ORGANIZATION OF CNS SYNAPSES	Sheng, Morgan H.	1996	$124,147	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE