Amy Shen

ScholarGPS® ID: 47456952207721

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Antibody | Biotechnology | Monoclonal Antibody | Chinese Hamster | Chinese Hamster Ovary Cell

Metrics Summary

Publication Count

Predicted Citations

1,624

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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SPEED‐MODE cell line development ( CLD ): Reducing Chinese hamster ovary ( CHO ) CLD timelines via earlier suspension adaptation and maximizing time spent in the exponential growth phase (journal article) Ganapathy, Kavya \| Lam, Cynthia \| Tsukuda, Joni \| Sargon, Alyssa \| Nava, Adrian \| Harms, Peter \| Shen, Amy \| Barnard, Gavin \| Misaghi, Shahram Biotechnology Progress (2024). 10.1002/btpr.3479 Cite \| Source
Gene copy number, gene configuration and LC / HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines (journal article) Lee, Zion \| Wan, Jun \| Shen, Amy \| Barnard, Gavin Biotechnology Progress, volume 40, issue 3 (2024). 10.1002/btpr.3433 Cited by (2) \| Cite \| Source
Recombinant adeno‐associated virus production evaluation in Chinese hamster ovary cells (journal article) Cao, Thu M. \| Chen, Dayue \| Barnard, Gavin C. \| Shen, Amy Biotechnology and Bioengineering, volume 121, issue 1, pages 395-402 (2024). 10.1002/bit.28578 Cited by (1) \| Cite \| Source
Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies (journal article) Barnard, Gavin C. \| Zhou, Michelle \| Shen, Amy \| Yuk, Inn H. \| Laird, Michael W. Biotechnology Progress, volume 40, issue 1 (2024). 10.1002/btpr.3399 Cited by (2) \| Cite \| Source
Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growth (journal article) Lam, Cynthia \| Carver, Joseph \| Ng, Domingos \| Zhan, Dejin \| Tang, Danming \| Kandamkalam, Thara \| Snedecor, Brad \| Barnard, Gavin \| Shen, Amy \| Misaghi, Shahram Biotechnology Progress, volume 39, issue 3 (2023). 10.1002/btpr.3337 Cited by (1) \| Cite \| Source
C-Terminal Lysine Processing of IgG in Human Suction Blister Fluid: Implications for Subcutaneous Administration (journal article) Ayalew, Luladey \| Chan, Phyllis \| Hu, Zhilan \| Shen, Amy \| Duenas, Eileen \| Kirschbrown, Whitney \| Schick, Arthur J. \| Chen, Yan \| Kim, Michael T. Molecular Pharmaceutics, volume 19, issue 11, pages 4043-4054 (2022). 10.1021/acs.molpharmaceut.2c00506 Cited by (7) \| Cite \| Source
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study (journal article) Tang, Danming \| Gunson, Jane \| Tran, Eric \| Lam, Cynthia \| Shen, Amy \| Snedecor, Brad \| Barnard, Gavin \| Misaghi, Shahram Biotechnology Progress, volume 38, issue 6 (2022). 10.1002/btpr.3290 Cited by (2) \| Cite \| Source
Versatile LC–MS-Based Workflow with Robust 0.1 ppm Sensitivity for Identifying Residual HCPs in Biotherapeutic Products (journal article) Yang, Feng \| Li, Delia \| Kufer, Regina \| Cadang, Lance \| Zhang, Jennifer \| Dai, Lu \| Guo, Jia \| Wohlrab, Stefanie \| Greenwood-Goodwin, Midori \| Shen, Amy \| ... \| Yuk, Inn H. Analytical Chemistry, volume 94, issue 2, pages 723-731 (2022). 10.1021/acs.analchem.1c03095 Cited by (11) \| Cite \| Source
A ribonucleoprotein‐based decaplex CRISPR /Cas9 knockout strategy for CHO host engineering (journal article) Carver, Joseph \| Kern, Marie \| Ko, Peggy \| Greenwood‐Goodwin, Midori \| Yu, X. Christopher \| Duan, Dana \| Tang, Danming \| Misaghi, Shahram \| Auslaender, Simon \| Haley, Ben \| ... \| Shen, Amy Biotechnology Progress, volume 38, issue 1 (2022). 10.1002/btpr.3212 Cited by (3) \| Cite \| Source
Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation (journal article) Graf, Tobias \| Tomlinson, Anthony \| Yuk, Inn H. \| Kufer, Regina \| Spensberger, Bernhard \| Falkenstein, Roberto \| Shen, Amy \| Li, Hong \| Duan, Dana \| Liu, Wenqiang \| ... \| Leiss, Michael Journal of Pharmaceutical Sciences, volume 110, issue 11, pages 3558-3567 (2021). 10.1016/j.xphs.2021.06.033 Cited by (39) \| Cite \| Source
Development of a Targeted Integration Chinese Hamster Ovary ( ) Host Directly Targeting Either One or Two Vectors Simultaneously to a Single Locus Using the Cre/Lox System (journal article) Ng, Domingos \| Zhou, Meixia \| Zhan, Dejin \| Yip, Shirley \| Ko, Peggy \| Yim, Mandy \| Modrusan, Zora \| Joly, John \| Snedecor, Brad \| Laird, Michael W. \| Shen, Amy Biotechnology Progress (2021). 10.1002/btpr.3140 Cited by (21) \| Cite \| Source
Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions (journal article) Sun, Yue \| Cai, Hao \| Hu, Zhilan \| Boswell, C. Andrew \| Diao, Jinpian \| Li, Charlene \| Zhang, Liangyi \| Shen, Amy \| Teske, Christopher A. \| Zhang, Boyan \| ... \| Jiang, Guoying Journal of Pharmaceutical Sciences, volume 109, issue 12, pages 3690-3696 (2020). 10.1016/j.xphs.2020.09.003 Cited by (5) \| Cite \| Source
Decreasing lactate level and increasing polypeptide production by down regulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase (patent) Zhou, Meixia \| Snedecor, Bradley Richard \| Ng, Chi Kin Domingos \| Shen, Amy Patent Number: 10704071 (2020) Cite \| Source
Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position (journal article) Carver, Joe \| Ng, Domingos \| Zhou, Michelle \| Ko, Peggy \| Zhan, Dejin \| Yim, Mandy \| Shaw, David \| Snedecor, Brad \| Laird, Michael W. \| Lang, Steven \| ... \| Hu, Zhilan Biotechnology Progress, volume 36, issue 4 (2020). 10.1002/btpr.2967 Cited by (47) \| Cite \| Source
High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry (journal article) Sawyer, William S. \| Srikumar, Neha \| Carver, Joseph \| Chu, Phillip Y. \| Shen, Amy \| Xu, Ankai \| Williams, Ambrose J. \| Spiess, Christoph \| Wu, Cong \| Liu, Yichin \| Tran, John C. Proceedings of the National Academy of Sciences, volume 117, issue 18, pages 9851-9856 (2020). 10.1073/pnas.1917383117 Cited by (40) \| Cite \| Source
High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells (journal article) Tung, Meg \| Tang, Danming \| Wang, Szu‐Han \| Zhan, Dejin \| Kiplinger, Karen \| Pan, Shu \| Jing, Yifeng \| Shen, Amy \| Ahyow, Patrick \| Snedecor, Brad \| ... \| Misaghi, Shahram Biotechnology Journal, volume 13, issue 10 (2018). 10.1002/biot.201700746 Cited by (5) \| Cite \| Source
Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase (patent) Zhou, Meixia \| Snedecor, Bradley Richard \| Ng, Chi Kin Domingos \| Shen, Amy Patent Number: 10011856 (2018) Cited by (2) \| Cite \| Source
Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality (journal article) Ko, Peggy \| Misaghi, Shahram \| Hu, Zhilan \| Zhan, Dejin \| Tsukuda, Joni \| Yim, Mandy \| Sanford, Mark \| Shaw, David \| Shiratori, Masaru \| Snedecor, Brad \| ... \| Shen, Amy Biotechnology Progress, volume 34, issue 3, pages 624-634 (2018). 10.1002/btpr.2594 Cited by (41) \| Cite \| Source
A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies (journal article) Hu, Zhilan \| Hsu, Wendy \| Pynn, Abby \| Ng, Domingos \| Quicho, Donna \| Adem, Yilma \| Kwong, Zephie \| Mauger, Brad \| Joly, John \| Snedecor, Bradley \| ... \| Shen, Amy Biotechnology Progress, volume 33, issue 6, pages 1449-1455 (2017). 10.1002/btpr.2467 Cited by (26) \| Cite \| Source
Evaluation of heavy chain C‐terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells (journal article) Hu, Zhilan \| Tang, Danming \| Misaghi, Shahram \| Jiang, Guoying \| Yu, Christopher \| Yim, Mandy \| Shaw, David \| Snedecor, Brad \| Laird, Michael W. \| Shen, Amy Biotechnology Progress, volume 33, issue 3, pages 786-794 (2017). 10.1002/btpr.2444 Cited by (16) \| Cite \| Source