Keren Yizhak

ScholarGPS® ID: 46165961883962

Affiliation

Technion Israel Institute of Technology, Haifa, Israel

Affiliation History

Field

Life Sciences

Discipline

Molecular and Cell Biology

Top Specialties

Cancer | Systems Biology | Metabolism

Metrics Summary

Publication Count

Predicted Citations

4,378

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Estimating tumor mutational burden from RNA-sequencing without a matched-normal sample (journal article) Katzir, Rotem \| Rudberg, Noam \| Yizhak, Keren Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-30753-2 Cited by (4) \| Cite \| Source
Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions (journal article) Hajaj, Emma \| Zisman, Elad \| Tzaban, Shay \| Merims, Sharon \| Cohen, Jonathan \| Klein, Shiri \| Frankenburg, Shoshana \| Sade-Feldman, Moshe \| Tabach, Yuval \| Yizhak, Keren \| ... \| Lotem, Michal Cancer Immunology Research, volume 9, issue 6, pages 637-650 (2021). 10.1158/2326-6066.CIR-20-0800 Cited by (8) \| Cite \| Source
Characterizing the tumor and immune landscape of melanoma patients treated with combined checkpoint blockade and MAPK targeted therapy. (journal article) Zisman, Liron \| Lawrence, Donald P. \| McDermott, David F. \| Liu, Mofei \| Buchbinder, Elizabeth Iannotti \| Gushterova, Irena \| Goyne, Anna L. K. \| Cohen, Justine Vanessa \| Miller, David Michael \| LaSalle, Thomas \| ... \| Sullivan, Ryan J. Journal of Clinical Oncology, volume 39, issue 15_suppl, pages 9522-9522 (2021). 10.1200/JCO.2021.39.15_suppl.9522 Cited by (1) \| Cite \| Source
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance (journal article) Verma, Vivek \| Shrimali, Rajeev K \| Ahmad, Shamim \| Dai, Winjie \| Wang, Hua \| Lu, Sumin \| Nandre, Rahul \| Gaur, Pankaj \| Lopez, Jose \| Sade-Feldman, Moshe \| ... \| Khleif, Samir N. Nature Immunology, volume 20, issue 9, pages 1231-1243 (2019). 10.1038/s41590-019-0441-y Cited by (216) \| Cite \| Source
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues (journal article) Yizhak, Keren \| Aguet, François \| Kim, Jaegil \| Hess, Julian M. \| Kübler, Kirsten \| Grimsby, Jonna \| Frazer, Ruslana \| Zhang, Hailei \| Haradhvala, Nicholas J. \| Rosebrock, Daniel \| ... \| Getz, Gad Science, volume 364, issue 6444 (2019). 10.1126/science.aaw0726 Cited by (320) \| Cite \| Source
A comprehensive analysis of RNA sequences reveals macroscopic somatic clonal expansion across normal tissues (journal article) Yizhak, Keren \| Aguet, François \| Kim, Jaegil \| Hess, Julian \| Kubler, Kirsten \| Grimsby, Jonna \| Frazer, Ruslana \| Zhang, Hailei \| Haradhvala, Nicholas \| Rosebrock, Daniel \| ... \| Getz, Gad bioRxiv (2018). 10.1101/416339 Cited by (6) \| Cite \| Source
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer (journal article) Puram, Sidharth V. \| Tirosh, Itay \| Parikh, Anuraag S. \| Patel, Anoop P. \| Yizhak, Keren \| Gillespie, Shawn \| Rodman, Christopher \| Luo, Christina L. \| Mroz, Edmund A. \| Emerick, Kevin S. \| ... \| Bernstein, Bradley E. Cell, volume 171, issue 7, pages 1611-1624.e24 (2017). 10.1016/j.cell.2017.10.044 Cited by (1,488) \| Cite \| Source
An integrated computational and experimental study uncovers FUT 9 as a metabolic driver of colorectal cancer (journal article) Auslander, Noam \| Cunningham, Chelsea E \| Toosi, Behzad M \| McEwen, Emily J \| Yizhak, Keren \| Vizeacoumar, Frederick S \| Parameswaran, Sreejit \| Gonen, Nir \| Freywald, Tanya \| Bhanumathy, Kalpana K \| ... \| Ruppin, Eytan Molecular Systems Biology, volume 13, issue 12 (2017). 10.15252/msb.20177739 Cited by (34) \| Cite \| Source \| Open Access
Essential Genes Embody Increased Mutational Robustness to Compensate for the Lack of Backup Genetic Redundancy (journal article) Cohen, Osher \| Oberhardt, Matthew \| Yizhak, Keren \| Ruppin, Eytan PLOS ONE, volume 11, issue 12, pages e0168444- (2016). 10.1371/journal.pone.0168444 Cited by (4) \| Cite \| Source \| Open Access
A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer (journal article) Auslander, Noam \| Yizhak, Keren \| Weinstock, Adam \| Budhu, Anuradha \| Tang, Wei \| Wang, Xin Wei \| Ambs, Stefan \| Ruppin, Eytan Scientific Reports, volume 6, issue 1 (2016). 10.1038/srep29662 Cited by (37) \| Cite \| Source \| Open Access
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis (journal article) Rabinovich, Shiran \| Adler, Lital \| Yizhak, Keren \| Sarver, Alona \| Silberman, Alon \| Agron, Shani \| Stettner, Noa \| Sun, Qin \| Brandis, Alexander \| Helbling, Daniel \| ... \| Erez, Ayelet Nature, volume 527, issue 7578, pages 379-383 (2015). 10.1038/nature15529 Cited by (256) \| Cite \| Source \| Open Access
Modeling cancer metabolism on a genome scale (journal article) Yizhak, Keren \| Chaneton, Barbara \| Gottlieb, Eyal \| Ruppin, Eytan Molecular Systems Biology, volume 11, issue 6 (2015). 10.15252/msb.20145307 Cited by (138) \| Cite \| Source \| Open Access
Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer (journal article) Yizhak, Keren \| Gaude, Edoardo \| Le Dévédec, Sylvia \| Waldman, Yedael Y \| Stein, Gideon Y \| van de Water, Bob \| Frezza, Christian \| Ruppin, Eytan eLife, volume 3 (2014). 10.7554/eLife.03641 Cited by (104) \| Cite \| Source \| Open Access
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration (journal article) Yizhak, Keren \| Le Dévédec, Sylvia E \| Rogkoti, Vasiliki Maria \| Baenke, Franziska \| de Boer, Vincent C \| Frezza, Christian \| Schulze, Almut \| van de Water, Bob \| Ruppin, Eytan Molecular Systems Biology, volume 10, issue 11 (2014). 10.15252/msb.20145746 Cited by (58) \| Cite \| Source \| Open Access
Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease (journal article) Stempler, Shiri \| Yizhak, Keren \| Ruppin, Eytan PLoS ONE, volume 9, issue 8, pages e105383- (2014). 10.1371/journal.pone.0105383 Cited by (52) \| Cite \| Source \| Open Access
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration (journal article) Yizhak, Keren \| Le Dévédec, Sylvia E \| Rogkoti, Vasiliki Maria \| Baenke, Franziska \| de Boer, Vincent C \| Frezza, Christian \| Schulze, Almut \| van de Water, Bob \| Ruppin, Eytan Molecular Systems Biology, volume 10, issue 8 (2014). 10.15252/msb.20134993 Cited by (100) \| Cite \| Source \| Open Access
Maximal Sum of Metabolic Exchange Fluxes Outperforms Biomass Yield as a Predictor of Growth Rate of Microorganisms (journal article) Zarecki, Raphy \| Oberhardt, Matthew A. \| Yizhak, Keren \| Wagner, Allon \| Shtifman Segal, Ella \| Freilich, Shiri \| Henry, Christopher S. \| Gophna, Uri \| Ruppin, Eytan PLoS ONE, volume 9, issue 5, pages e98372- (2014). 10.1371/journal.pone.0098372 Cited by (8) \| Cite \| Source \| Open Access
p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production (journal article) Goldstein, Ido \| Yizhak, Keren \| Madar, Shalom \| Goldfinger, Naomi \| Ruppin, Eytan \| Rotter, Varda Cancer & Metabolism, volume 1, issue 1 (2013). 10.1186/2049-3002-1-9 Cited by (61) \| Cite \| Source \| Open Access
Model-based identification of drug targets that revert disrupted metabolism and its application to ageing (journal article) Yizhak, Keren \| Gabay, Orshay \| Cohen, Haim \| Ruppin, Eytan Nature Communications, volume 4, issue 1 (2013). 10.1038/ncomms3632 Cited by (73) \| Cite \| Source \| Open Access
Metabolically re-modeling the drug pipeline (journal article) Oberhardt, Matthew A \| Yizhak, Keren \| Ruppin, Eytan Current Opinion in Pharmacology, volume 13, issue 5, pages 778-785 (2013). 10.1016/j.coph.2013.05.006 Cited by (28) \| Cite \| Source