Shuyuan Zhao

ScholarGPS® ID: 45030694832094

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Medicinal Chemistry

Metrics Summary

Publication Count

Predicted Citations

1,248

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination (journal article) Huang, Hui \| Meegalla, Sanath K. \| Lanter, James C. \| Winters, Michael P. \| Zhao, Shuyuan \| Littrell, James \| Qi, Jenson \| Rady, Brian \| Lee, Paul S. \| Liu, Jianying \| ... \| Player, Mark R. ACS Medicinal Chemistry Letters, volume 10, issue 1, pages 16-21 (2019). 10.1021/acsmedchemlett.8b00444 Cited by (19) \| Cite \| Source
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1 ) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity (journal article) Zhang, Yue-Mei \| Greco, Michael N. \| Macielag, Mark J. \| Teleha, Christopher A. \| DesJarlais, Renee L. \| Tang, Yuting \| Ho, George \| Hou, Cuifen \| Chen, Cailin \| Zhao, Shuyuan \| ... \| Leonard, James Journal of Medicinal Chemistry, volume 61, issue 22, pages 10276-10298 (2018). 10.1021/acs.jmedchem.8b01467 Cited by (13) \| Cite \| Source
GPR40-Mediated G α 12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets (journal article) Rives, Marie-Laure \| Rady, Brian \| Swanson, Nadia \| Zhao, Shuyuan \| Qi, Jenson \| Arnoult, Eric \| Bakaj, Ivona \| Mancini, Arturo \| Breton, Billy \| Lee, S. Paul \| ... \| Pocai, Alessandro Molecular Pharmacology, volume 93, issue 6, pages 581-591 (2018). 10.1124/mol.117.111369 Cited by (22) \| Cite \| Source
Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists (journal article) Huang, Hui \| Winters, Michael P. \| Meegalla, Sanath K. \| Arnoult, Eric \| Paul Lee, S. \| Zhao, Shuyuan \| Martin, Tonya \| Rady, Brian \| Liu, Jianying \| Towers, Meghan \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 28, issue 3, pages 429-436 (2018). 10.1016/j.bmcl.2017.12.022 Cited by (12) \| Cite \| Source
Discovery of a novel potent GPR40 full agonist (journal article) Meegalla, Sanath K. \| Huang, Hui \| Martin, Tonya \| Xu, June \| Zhao, Shuyuan \| Liu, Jianying \| Hall, Meghan \| Gunnet, Joe \| Wang, Yuanping \| Rady, Brian \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 28, issue 4, pages 720-726 (2018). 10.1016/j.bmcl.2018.01.013 Cited by (8) \| Cite \| Source
Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor (journal article) Winters, Michael P. \| Crysler, Carl \| Subasinghe, Nalin \| Ryan, Declan \| Leong, Lynette \| Zhao, Shuyuan \| Donatelli, Robert \| Yurkow, Edward \| Mazzulla, Marie \| Boczon, Lisa \| ... \| Tomczuk, Bruce Bioorganic & Medicinal Chemistry Letters, volume 18, issue 6, pages 1926-1930 (2008). 10.1016/j.bmcl.2008.01.127 Cited by (27) \| Cite \| Source
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity (journal article) Leonard, Kristi \| Marugan, Juan Jose \| Raboisson, Pierre \| Calvo, Raul \| Gushue, Joan M. \| Koblish, Holly K. \| Lattanze, Jennifer \| Zhao, Shuyuan \| Cummings, Maxwell D. \| Player, Mark R. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 13, pages 3463-3468 (2006). 10.1016/j.bmcl.2006.04.009 Cited by (57) \| Cite \| Source
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design (journal article) Parks, Daniel J. \| LaFrance, Louis V. \| Calvo, Raul R. \| Milkiewicz, Karen L. \| José Marugán, Juan \| Raboisson, Pierre \| Schubert, Carsten \| Koblish, Holly K. \| Zhao, Shuyuan \| Franks, Carol F. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3310-3314 (2006). 10.1016/j.bmcl.2006.03.055 Cited by (70) \| Cite \| Source
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists (journal article) Marugan, Juan Jose \| Leonard, Kristi \| Raboisson, Pierre \| Gushue, Joan M. \| Calvo, Raul \| Koblish, Holly K. \| Lattanze, Jennifer \| Zhao, Shuyuan \| Cummings, Maxwell D. \| Player, Mark R. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3115-3120 (2006). 10.1016/j.bmcl.2006.03.067 Cited by (33) \| Cite \| Source
Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo (journal article) Koblish, Holly K. \| Zhao, Shuyuan \| Franks, Carol F. \| Donatelli, Robert R. \| Tominovich, Rose M. \| LaFrance, Louis V. \| Leonard, Kristi A. \| Gushue, Joan M. \| Parks, Daniel J. \| Calvo, Raul R. \| ... \| Maroney, Anna C. Molecular Cancer Therapeutics, volume 5, issue 1, pages 160-169 (2006). 10.1158/1535-7163.MCT-05-0199 Cited by (145) \| Cite \| Source \| Open Access
Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists (journal article) Raboisson, Pierre \| Marugán, Juan José \| Schubert, Carsten \| Koblish, Holly K. \| Lu, Tianbao \| Zhao, Shuyuan \| Player, Mark R. \| Maroney, Anna C. \| Reed, Rolanda L. \| Huebert, Norman D. \| ... \| Cummings, Maxwell D. Bioorganic & Medicinal Chemistry Letters, volume 15, issue 7, pages 1857-1861 (2005). 10.1016/j.bmcl.2005.02.018 Cited by (49) \| Cite \| Source
Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells (journal article) Grasberger, Bruce L. \| Lu, Tianbao \| Schubert, Carsten \| Parks, Daniel J. \| Carver, Theodore E. \| Koblish, Holly K. \| Cummings, Maxwell D. \| LaFrance, Louis V. \| Milkiewicz, Karen L. \| Calvo, Raul R. \| ... \| Bone, Roger F. Journal of Medicinal Chemistry, volume 48, issue 4, pages 909-912 (2005). 10.1021/jm049137g Cited by (393) \| Cite \| Source