Petr Špaček

ScholarGPS® ID: 44739350858144

Affiliation

University of Münster, Münster, Germany

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Nucleoside | Medicinal Chemistry | Biosynthesis

Metrics Summary

Publication Count

Predicted Citations

492

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Stabilized 5′ Cap Analogue for Optochemical Activation of mRNA Translation (journal article) Weissenboeck, Florian P. \| Klöcker, Nils \| Špaček, Petr \| Hüwel, Sabine \| Rentmeister, Andrea ACS Omega (2024). 10.1021/acsomega.3c08505 Cite \| Source
MePMe-seq: antibody-free simultaneous m6A and m5C mapping in mRNA by metabolic propargyl labeling and sequencing (journal article) Hartstock, Katja \| Kueck, Nadine A. \| Spacek, Petr \| Ovcharenko, Anna \| Hüwel, Sabine \| Cornelissen, Nicolas V. \| Bollu, Amarnath \| Dieterich, Christoph \| Rentmeister, Andrea Nature Communications, volume 14, issue 1 (2023). 10.1038/s41467-023-42832-z Cited by (10) \| Cite \| Source
Licht‐aktivierte Translation verschiedener mRNAs in Zellen durch wellenlängenabhängiges Photoentschützen (journal article) Bollu, Amarnath \| Klöcker, Nils \| Špaček, Petr \| P. Weissenboeck, Florian \| Hüwel, Sabine \| Rentmeister, Andrea Angewandte Chemie, volume 135, issue 5 (2023). 10.1002/ange.202209975 Cited by (2) \| Cite \| Source
Light‐Activated Translation of Different mRNAs in Cells via Wavelength‐Dependent Photouncaging (journal article) Bollu, Amarnath \| Klöcker, Nils \| Špaček, Petr \| P. Weissenboeck, Florian \| Hüwel, Sabine \| Rentmeister, Andrea Angewandte Chemie International Edition, volume 62, issue 5 (2023). 10.1002/anie.202209975 Cited by (16) \| Cite \| Source
Photocaged 5′ cap analogues for optical control of mRNA translation in cells (journal article) Klöcker, Nils \| Weissenboeck, Florian P. \| van Dülmen, Melissa \| Špaček, Petr \| Hüwel, Sabine \| Rentmeister, Andrea Nature Chemistry, volume 14, issue 8, pages 905-913 (2022). 10.1038/s41557-022-00972-7 Cited by (38) \| Cite \| Source
Quantification of mRNA cap-modifications by means of LC-QqQ-MS (journal article) Muthmann, Nils \| Špaček, Petr \| Reichert, Dennis \| van Dülmen, Melissa \| Rentmeister, Andrea Methods, volume 203 (2022). 10.1016/j.ymeth.2021.05.018 Cited by (11) \| Cite \| Source
Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro (journal article) Doleželová, Eva \| Klejch, Tomáš \| Špaček, Petr \| Slapničková, Martina \| Guddat, Luke \| Hocková, Dana \| Zíková, Alena Scientific Reports, volume 11, issue 1 (2021). 10.1038/s41598-021-91747-6 Cited by (7) \| Cite \| Source
Helicobacter pylori Xanthine–Guanine–Hypoxanthine Phosphoribosyltransferase—A Putative Target for Drug Discovery against Gastrointestinal Tract Infections (journal article) Keough, Dianne T. \| Wun, Shun Jie \| Baszczyňski, Ondřej \| Eng, Wai Soon \| Špaček, Petr \| Panjikar, Santosh \| Naesens, Lieve \| Pohl, Radek \| Rejman, Dominik \| Hocková, Dana \| ... \| Guddat, Luke W. Journal of Medicinal Chemistry, volume 64, issue 9, pages 5710-5729 (2021). 10.1021/acs.jmedchem.0c02184 Cited by (5) \| Cite \| Source
Eine auf dem Benzophenongerüst basierende Strategie für die Photoschützung der N7‐Position des Guanosins (journal article) Anhäuser, Lea \| Klöcker, Nils \| Muttach, Fabian \| Mäsing, Florian \| Špaček, Petr \| Studer, Armido \| Rentmeister, Andrea Angewandte Chemie, volume 132, issue 8, pages 3186-3191 (2020). 10.1002/ange.201914573 Cited by (8) \| Cite \| Source
A Benzophenone‐Based Photocaging Strategy for the N7 Position of Guanosine (journal article) Anhäuser, Lea \| Klöcker, Nils \| Muttach, Fabian \| Mäsing, Florian \| Špaček, Petr \| Studer, Armido \| Rentmeister, Andrea Angewandte Chemie International Edition, volume 59, issue 8, pages 3161-3165 (2020). 10.1002/anie.201914573 Cited by (37) \| Cite \| Source
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. (journal article) Dolezelova, Eva \| Terán, David \| Gahura, Ondřej \| Kotrbova, Z \| Prochazkova, M \| Keough, Dianne T. \| Špaček, Petr \| Hocková, Dana \| Guddat, Luke W. \| Zíková, Alena PLOS Neglected Tropical Diseases, volume 12, issue 2, pages 1-28 (2018). 10.2210/pdb6apv/pdb Cited by (3) \| Cite \| Source
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery (journal article) Doleželová, Eva \| Terán, David \| Gahura, Ondřej \| Kotrbová, Zuzana \| Procházková, Michaela \| Keough, Dianne \| Špaček, Petr \| Hocková, Dana \| Guddat, Luke \| Zíková, Alena PLOS Neglected Tropical Diseases, volume 12, issue 2, pages e0006301- (2018). 10.1371/journal.pntd.0006301 Cited by (33) \| Cite \| Source \| Open Access
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine–Guanine–(Xanthine) Phosphoribosyltransferase (journal article) Špaček, Petr \| Keough, Dianne T. \| Chavchich, Marina \| Dračínský, Martin \| Janeba, Zlatko \| Naesens, Lieve \| Edstein, Michael D. \| Guddat, Luke W. \| Hocková, Dana Journal of Medicinal Chemistry, volume 60, issue 17, pages 7539-7554 (2017). 10.1021/acs.jmedchem.7b00926 Cited by (17) \| Cite \| Source
Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs (journal article) Špaček, Petr \| Keough, Dianne T. \| Chavchich, Marina \| Dračínský, Martin \| Janeba, Zlatko \| Naesens, Lieve \| Edstein, Michael D. \| Guddat, Luke W. \| Hocková, Dana Bioorganic & Medicinal Chemistry, volume 25, issue 15, pages 4008-4030 (2017). 10.1016/j.bmc.2017.05.048 Cited by (20) \| Cite \| Source
Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase (journal article) Eng, Wai Soon \| Hocková, Dana \| Špaček, Petr \| Baszczyňski, Ondřej \| Janeba, Zlatko \| Naesens, Lieve \| Keough, Dianne T. \| Guddat, Luke W. ChemistrySelect, volume 1, issue 19, pages 6267-6276 (2016). 10.1002/slct.201601679 Cited by (10) \| Cite \| Source
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity (journal article) Eng, Wai Soon \| Hocková, Dana \| Špaček, Petr \| Janeba, Zlatko \| West, Nicholas P. \| Woods, Kyra \| Naesens, Lieve M. J. \| Keough, Dianne T. \| Guddat, Luke W. Journal of Medicinal Chemistry, volume 58, issue 11, pages 4822-4838 (2015). 10.1021/acs.jmedchem.5b00611 Cited by (37) \| Cite \| Source
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity (journal article) Keough, Dianne \| Špaček, Petr \| Hocková, Dana \| Tichý, Tomáš \| Vrbková, Silvie \| Slavětínská, Lenka \| Janeba, Zlatko \| Naesens, Lieve \| Edstein, Michael \| Chavchich, Marina \| ... \| Guddat, Luke Malaria Journal, volume 13, issue S1 (2014). 10.1186/1475-2875-13-S1-P91 Cite \| Source \| Open Access
Acyclic nucleoside bis-phosphonates as potent inhibitors of 6-oxopurine phosphoribosyltransferases (conference) Špaček, Petr \| Keough, Dianne T. \| Vrbková, Silvie \| Slavětínská, Lenka \| Janeba, Zlatko \| Naesens, Lieve \| Edstein, Michael D. \| Chavchich, Marina \| Wang, Tzu-Hsuan \| de Jersey, John \| ... \| Hocková, Dana XVIth Symposium on Chemistry of Nucleic Acid Components (2014) Český Krumlov 10.1135/css201414375 Cite \| Source
Acyclic nucleoside bisphosphonates as inhibitors of 6-oxopurine phosphoribosyltransferases: potential antimalarial and antibacterial agents (conference) Hocková, Dana \| Keough, Dianne T. \| Špaček, Petr \| Janeba, Zlatko \| Edstein, Michael D. \| Chavchich, Marina \| Wang, Tzu-Hsuan \| Eng, Wai Soon \| West, Nicholas P. \| de Jersey, John \| Guddat, Luke W. XVIth Symposium on Chemistry of Nucleic Acid Components (2014) Český Krumlov 10.1135/css201414107 Cite \| Source
Inhibition of the Escherichia coli 6-Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents (journal article) Keough, Dianne T. \| Hocková, Dana \| Rejman, Dominik \| Špaček, Petr \| Vrbková, Silvie \| Krečmerová, Marcela \| Eng, Wai Soon \| Jans, Harmen \| West, Nicholas P. \| Naesens, Lieve M. J. \| ... \| Guddat, Luke W. Journal of Medicinal Chemistry, volume 56, issue 17, pages 6967-6984 (2013). 10.1021/jm400779n Cited by (41) \| Cite \| Source