Elizabeth Blackwood

ScholarGPS® ID: 44108434487134

Affiliation
Genentech, Inc., South San Francisco, United States
Affiliation History

Field
Medicine
Discipline
Pathology
Top Specialties
Cancer | Medicinal Chemistry | Neoplasm | Mammal | DNA
Metrics Summary
Publication Count
44
Predicted Citations
7,195
Predicted h-index
33
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia (journal article)
Di Tullio, Alessandro | Rouault-Pierre, Kevin | Abarrategi, Ander | Mian, Syed | Grey, William | Gribben, John | Stewart, Aengus | Blackwood, Elizabeth | Bonnet, Dominique
Nature Communications, volume 8, issue 1 (2017).
10.1038/s41467-017-01834-4
Cited by (38) | Cite | Source | Open Access
Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine (gem) in patients (pts) with refractory solid tumors (journal article)
Italiano, A. | Infante, J.R. | Shapiro, G. | Moore, K.N. | Lorusso, P. | Postel-Vinay, S. | Cousin, S. | Toulmonde, M. | Lucchesi, C. | Blackwood, E. | ... | Soria, J-C.
Annals of Oncology, volume 28 (2017).
10.1093/annonc/mdx367.009
Cited by (2) | Cite | Source | Open Access
Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors (journal article)
Infante, Jeffrey R. | Hollebecque, Antoine | Postel-Vinay, Sophie | Bauer, Todd M. | Blackwood, Elizabeth M. | Evangelista, Marie | Mahrus, Sami | Peale, Franklin V. | Lu, Xuyang | Sahasranaman, Srikumar | ... | LoRusso, Patricia M.
Clinical Cancer Research, volume 23, issue 10, pages 2423-2432 (2017).
10.1158/1078-0432.CCR-16-1782
Cited by (57) | Cite | Source
Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells (journal article)
Lee, Ho-June | Cao, Yi | Pham, Victoria | Blackwood, Elizabeth | Wilson, Catherine | Evangelista, Marie | Klijn, Christiaan | Stokoe, David | Settleman, Jeff
Molecular Cancer Therapeutics, volume 16, issue 4, pages 694-704 (2017).
10.1158/1535-7163.MCT-16-0504
Cited by (17) | Cite | Source | Open Access
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window (journal article)
Rudolph, Joachim | Murray, Lesley J. | Ndubaku, Chudi O. | O’Brien, Thomas | Blackwood, Elizabeth | Wang, Weiru | Aliagas, Ignacio | Gazzard, Lewis | Crawford, James J. | Drobnick, Joy | ... | Zhong, Yu
Journal of Medicinal Chemistry, volume 59, issue 11, pages 5520-5541 (2016).
10.1021/acs.jmedchem.6b00638
Cited by (52) | Cite | Source
Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8 (journal article)
Bergeron, Philippe | Koehler, Michael F. T. | Blackwood, Elizabeth M. | Bowman, Krista | Clark, Kevin | Firestein, Ron | Kiefer, James R. | Maskos, Klaus | McCleland, Mark L. | Orren, Linda | ... | Beresini, Maureen
ACS Medicinal Chemistry Letters, volume 7, issue 6, pages 595-600 (2016).
10.1021/acsmedchemlett.6b00044
Cited by (46) | Cite | Source | Open Access
Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells (journal article)
Koehler, Michael F. T. | Bergeron, Philippe | Blackwood, Elizabeth M. | Bowman, Krista | Clark, Kevin R. | Firestein, Ron | Kiefer, James R. | Maskos, Klaus | McCleland, Mark L. | Orren, Linda | ... | Beresini, Maureen H.
ACS Medicinal Chemistry Letters, volume 7, issue 3, pages 223-228 (2016).
10.1021/acsmedchemlett.5b00278
Cited by (71) | Cite | Source | Open Access
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function (journal article)
Storm, Elaine E. | Durinck, Steffen | de Sousa e Melo, Felipe | Tremayne, Jarrod | Kljavin, Noelyn | Tan, Christine | Ye, Xiaofen | Chiu, Cecilia | Pham, Thinh | Hongo, Jo-Anne | ... | de Sauvage, Frederic J.
Nature, volume 529, issue 7584, pages 97-100 (2016).
10.1038/nature16466
Cited by (195) | Cite | Source
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p Ka Polar Moiety (journal article)
Ndubaku, Chudi O. | Crawford, James J. | Drobnick, Joy | Aliagas, Ignacio | Campbell, David | Dong, Ping | Dornan, Laura M. | Duron, Sergio | Epler, Jennifer | Gazzard, Lewis | ... | Rudolph, Joachim
ACS Medicinal Chemistry Letters, volume 6, issue 12, pages 1241-1246 (2015).
10.1021/acsmedchemlett.5b00398
Cited by (58) | Cite | Source | Open Access
Identification of Preferred Chemotherapeutics for Combining with a CHK1 Inhibitor (journal article)
Xiao, Yang | Ramiscal, Judi | Kowanetz, Kaska | Del Nagro, Christopher | Malek, Shiva | Evangelista, Marie | Blackwood, Elizabeth | Jackson, Peter K. | O'Brien, Thomas
Molecular Cancer Therapeutics, volume 12, issue 11, pages 2285-2295 (2013).
10.1158/1535-7163.MCT-13-0404
Cited by (49) | Cite | Source | Open Access
Combination Drug Scheduling Defines a “Window of Opportunity” for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900 (journal article)
Blackwood, Elizabeth | Epler, Jennifer | Yen, Ivana | Flagella, Michael | O'Brien, Tom | Evangelista, Marie | Schmidt, Stephen | Xiao, Yang | Choi, Jonathan | Kowanetz, Kaska | ... | Malek, Shiva
Molecular Cancer Therapeutics, volume 12, issue 10, pages 1968-1980 (2013).
10.1158/1535-7163.MCT-12-1218
Cited by (33) | Cite | Source | Open Access
P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma (journal article)
Ong, Christy C. | Jubb, Adrian M. | Jakubiak, Diana | Zhou, Wei | Rudolph, Joachim | Haverty, Peter M. | Kowanetz, Marcin | Yan, Yibing | Tremayne, Jarrod | Lisle, Richard | ... | Hoeflich, Klaus P.
JNCI: Journal of the National Cancer Institute, volume 105, issue 9, pages 606-607 (2013).
10.1093/jnci/djt054
Cited by (67) | Cite | Source | Open Access
Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases (journal article)
Zhuang, Guanglei | Yu, Kebing | Jiang, Zhaoshi | Chung, Alicia | Yao, Jenny | Ha, Connie | Toy, Karen | Soriano, Robert | Haley, Benjamin | Blackwood, Elizabeth | ... | Ferrara, Napoleone
Science Signaling, volume 6, issue 271 (2013).
10.1126/scisignal.2003572
Cited by (62) | Cite | Source
Pyrimidoaminotropanes as Potent, Selective, and Efficacious Small Molecule Kinase Inhibitors of the Mammalian Target of Rapamycin (mTOR) (journal article)
Estrada, Anthony A. | Shore, Daniel G. | Blackwood, Elizabeth | Chen, Yung-Hsiang | Deshmukh, Gauri | Ding, Xiao | DiPasquale, Antonio G. | Epler, Jennifer A. | Friedman, Lori S. | Koehler, Michael F. T. | ... | Lyssikatos, Joseph P.
Journal of Medicinal Chemistry, volume 56, issue 7, pages 3090-3101 (2013).
10.1021/jm400194n
Cited by (28) | Cite | Source
Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung Adenocarcinomas (journal article)
McCleland, Mark L. | Adler, Adam S. | Deming, Laura | Cosino, Ely | Lee, Leslie | Blackwood, Elizabeth M. | Solon, Margaret | Tao, Janet | Li, Li | Shames, David | ... | Firestein, Ron
Clinical Cancer Research, volume 19, issue 4, pages 773-784 (2013).
10.1158/1078-0432.CCR-12-2638
Cited by (97) | Cite | Source | Open Access
Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 Is Linked to TNF-α Pharmacology (journal article)
Erickson, Rebecca I. | Tarrant, Jacqueline | Cain, Gary | Lewin-Koh, Sock-Cheng | Dybdal, Noel | Wong, Harvey | Blackwood, Elizabeth | West, Kristina | Steigerwalt, Ronald | Mamounas, Michael | ... | Diaz, Dolores
Toxicological Sciences, volume 131, issue 1, pages 247-258 (2013).
10.1093/toxsci/kfs265
Cited by (30) | Cite | Source | Open Access
Potent, Selective, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin Kinase Domain Exhibiting Single Agent Antiproliferative Activity (journal article)
Koehler, Michael F. T. | Bergeron, Philippe | Blackwood, Elizabeth | Bowman, Krista K. | Chen, Yung-Hsiang | Deshmukh, Gauri | Ding, Xiao | Epler, Jennifer | Lau, Kevin | Lee, Leslie | ... | Lyssikatos, Joseph P.
Journal of Medicinal Chemistry, volume 55, issue 24, pages 10958-10971 (2012).
10.1021/jm301389h
Cited by (28) | Cite | Source
mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations (journal article)
Vijapurkar, Ulka | Robillard, Liliane | Zhou, Siqun | Degtyarev, Michael | Lin, Kui | Truong, Tom | Tremayne, Jarrod | Ross, Leanne Berry | Pei, Zhonghua | Friedman, Lori S. | ... | Belvin, Marcia
Cancer Letters, volume 326, issue 2, pages 168-175 (2012).
10.1016/j.canlet.2012.08.011
Cited by (6) | Cite | Source
An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer (journal article)
McCleland, Mark L. | Adler, Adam S. | Shang, Yonglei | Hunsaker, Thomas | Truong, Tom | Peterson, David | Torres, Eric | Li, Li | Haley, Benjamin | Stephan, Jean-Philippe | ... | Firestein, Ron
Cancer Research, volume 72, issue 22, pages 5812-5823 (2012).
10.1158/0008-5472.CAN-12-1098
Cited by (143) | Cite | Source | Open Access
Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis (journal article)
Wong, Harvey | Budha, Nageshwar R. | West, Kristina | Blackwood, Elizabeth | Ware, Joseph A. | Yu, Ron | Darbonne, Walter C. | Gould, Stephen E. | Steigerwalt, Ronald | Erickson, Rebecca | ... | Fairbrother, Wayne J.
Toxicological Sciences, volume 130, issue 1, pages 205-213 (2012).
10.1093/toxsci/kfs235
Cited by (15) | Cite | Source | Open Access