Jonathan Cheong

ScholarGPS® ID: 43517620577476

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmaceutical Sciences

Top Specialties

Drug Metabolism | Metabolism | Medicinal Chemistry

Metrics Summary

Publication Count

Predicted Citations

1,666

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human (journal article) Salphati, Laurent \| Pang, Jodie \| Alicke, Bruno \| Plise, Emile G. \| Cheong, Jonathan \| Jaochico, Allan \| Olivero, Alan G. \| Sampath, Deepak \| Wong, Susan \| Zhang, Xiaolin Xenobiotica, volume 54, issue 2, pages 64-74 (2024). 10.1080/00498254.2024.2303586 Cite \| Source
Effect of magnesium stearate surface coating method on the aerosol performance and permeability of micronized fluticasone propionate (journal article) Kumar, Virender \| Sethi, Bharti \| Yanez, Evelyn \| Leung, Dennis H. \| Ghanwatkar, Yashwardhan Y. \| Cheong, Jonathan \| Tso, Jerry \| Narang, Ajit S. \| Nagapudi, Karthik \| Mahato, Ram I. International Journal of Pharmaceutics, volume 615 (2022). 10.1016/j.ijpharm.2022.121470 Cited by (6) \| Cite \| Source
Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling (journal article) Bowman, Christine M. \| Chen, Buyun \| Cheong, Jonathan \| Liu, Liling \| Chen, Yuan \| Mao, Jialin Drug Metabolism and Disposition, volume 49, issue 7, pages 530-539 (2021). 10.1124/dmd.120.000315 Cited by (5) \| Cite \| Source
Functional similarity of modified cascade impactor to deposit drug particles on cells (journal article) Kumar, Virender \| Bariwal, Jitender \| Narang, Ajit S. \| Tso, Jerry \| Cheong, Jonathan \| Mahato, Ram I. International Journal of Pharmaceutics, volume 583 (2020). 10.1016/j.ijpharm.2020.119404 Cited by (6) \| Cite \| Source
Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats (journal article) Chang, Jae H. \| Chen, Yi-Chen \| Cheong, Jonathan \| Jones, Robert S. \| Pang, Jodie Drug Metabolism and Disposition, volume 47, issue 11, pages 1307-1313 (2019). 10.1124/dmd.119.088278 Cited by (8) \| Cite \| Source
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor (journal article) Liederer, Bianca M. \| Cheong, Jonathan \| Chou, Kang-Jye \| Dragovich, Peter S. \| Le, Hoa \| Liang, Xiaorong \| Ly, Justin \| Mukadam, Sophie \| Oeh, Jason \| Sampath, Deepak \| ... \| Wong, Susan Xenobiotica, volume 49, issue 9, pages 1063-1077 (2019). 10.1080/00498254.2018.1528407 Cited by (1) \| Cite \| Source
Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse (journal article) Chang, Jae H. \| Zhang, Xiaolin \| Messick, Kirsten \| Chen, Yi-Chen \| Chen, Eugene \| Cheong, Jonathan \| Ly, Justin Xenobiotica, volume 49, issue 5, pages 602-610 (2019). 10.1080/00498254.2018.1478167 Cited by (5) \| Cite \| Source
Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics (journal article) Pang, Jodie \| Baumgardner, Matthew \| Braun, Marie-Gabrielle \| Cheong, Jonathan \| Edgar, Kyle \| Friedman, Lori \| Hanan, Emily \| Jaochico, Allan \| Ma, Shuguang \| Plise, Emile \| ... \| Salphati, Laurent Drug Metabolism and Pharmacokinetics, volume 34, issue 1, pages S37- (2019). 10.1016/j.dmpk.2018.09.137 Cite \| Source
Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination (journal article) Chen, Eugene C. \| Broccatelli, Fabio \| Plise, Emile \| Chen, Buyun \| Liu, Liling \| Cheong, Jonathan \| Zhang, Shu \| Jorski, Jamie \| Gaffney, Katherine \| Umemoto, Kayla K. \| Salphati, Laurent Molecular Pharmaceutics, volume 15, issue 11, pages 5103-5113 (2018). 10.1021/acs.molpharmaceut.8b00688 Cited by (29) \| Cite \| Source
The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters (journal article) Cheong, Jonathan \| Halladay, Jason S. \| Plise, Emile \| Sodhi, Jasleen K. \| Salphati, Laurent Drug Metabolism Letters, volume 11, issue 2 (2018). 10.2174/1872312811666171010101248 Cited by (5) \| Cite \| Source
Predicting Passive Permeability of Drug-like Molecules from Chemical Structure: Where Are We? (journal article) Broccatelli, F. \| Salphati, L. \| Plise, E. \| Cheong, J. \| Gobbi, A. \| Lee, M.-L. \| Aliagas, I. Molecular Pharmaceutics, volume 13, issue 12, pages 4199-4208 (2016). 10.1021/acs.molpharmaceut.6b00836 Cited by (32) \| Cite \| Source
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma (journal article) Salphati, Laurent \| Alicke, Bruno \| Heffron, Timothy P. \| Shahidi-Latham, Sheerin \| Nishimura, Merry \| Cao, Tim \| Carano, Richard A. \| Cheong, Jonathan \| Greve, Joan \| Koeppen, Hartmut \| ... \| Olivero, Alan G. Drug Metabolism and Disposition, volume 44, issue 12, pages 1881-1889 (2016). 10.1124/dmd.116.071423 Cited by (40) \| Cite \| Source
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR (journal article) Heffron, Timothy P. \| Ndubaku, Chudi O. \| Salphati, Laurent \| Alicke, Bruno \| Cheong, Jonathan \| Drobnick, Joy \| Edgar, Kyle \| Gould, Stephen E. \| Lee, Leslie B. \| Lesnick, John D. \| ... \| Olivero, Alan G. ACS Medicinal Chemistry Letters, volume 7, issue 4, pages 351-356 (2016). 10.1021/acsmedchemlett.6b00005 Cited by (77) \| Cite \| Source \| Open Access
Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors (journal article) Crawford, James J. \| Lee, Wendy \| Aliagas, Ignacio \| Mathieu, Simon \| Hoeflich, Klaus P. \| Zhou, Wei \| Wang, Weiru \| Rouge, Lionel \| Murray, Lesley \| La, Hank \| ... \| Rudolph, Joachim Journal of Medicinal Chemistry, volume 58, issue 12, pages 5121-5136 (2015). 10.1021/acs.jmedchem.5b00572 Cited by (31) \| Cite \| Source
Practical Permeability-Based Hepatic Clearance Classification System (Hepccs) in Drug Discovery (journal article) Fan, Peter W \| Song, Yang \| Berezhkovskiy, Leonid M \| Cheong, Jonathan \| Plise, Emile G \| Khojasteh, S Cyrus Future Medicinal Chemistry, volume 6, issue 18, pages 1995-2012 (2014). 10.4155/fmc.14.141 Cited by (7) \| Cite \| Source
Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice (journal article) Chang, Jae H. \| Ly, Justin \| Plise, Emile \| Zhang, Xiaolin \| Messick, Kirsten \| Wright, Matthew \| Cheong, Jonathan Drug Metabolism and Disposition, volume 42, issue 6, pages 1067-1073 (2014). 10.1124/dmd.114.057968 Cited by (22) \| Cite \| Source \| Open Access
Use of Cassette Dosing Approach to Examine the Effects of P-Glycoprotein on the Brain and Cerebrospinal Fluid Concentrations in Wild-Type and P-Glycoprotein Knockout Rats (journal article) Liu, Xingrong \| Cheong, Jonathan \| Ding, Xiao \| Deshmukh, Gauri Drug Metabolism and Disposition, volume 42, issue 4, pages 482-491 (2014). 10.1124/dmd.113.055590 Cited by (24) \| Cite \| Source \| Open Access
Evaluating the In Vitro Inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in Predicting Drug-Induced Hyperbilirubinemia (journal article) Chang, Jae H. \| Plise, Emile \| Cheong, Jonathan \| Ho, Quynh \| Lin, Molly Molecular Pharmaceutics, volume 10, issue 8, pages 3067-3075 (2013). 10.1021/mp4001348 Cited by (66) \| Cite \| Source
The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α (journal article) Heffron, Timothy P. \| Salphati, Laurent \| Alicke, Bruno \| Cheong, Jonathan \| Dotson, Jennafer \| Edgar, Kyle \| Goldsmith, Richard \| Gould, Stephen E. \| Lee, Leslie B. \| Lesnick, John D. \| ... \| Zhang, Xiaolin Journal of Medicinal Chemistry, volume 55, issue 18, pages 8007-8020 (2012). 10.1021/jm300867c Cited by (46) \| Cite \| Source
A Convenient Method to Measure Blood–Plasma Concentration Ratio Using Routine Plasma Collection in In Vivo Pharmacokinetic Studies (journal article) Berezhkovskiy, Leonid M. \| Zhang, Xiaolin \| Cheong, Jonathan Journal of Pharmaceutical Sciences, volume 100, issue 12, pages 5293-5298 (2011). 10.1002/jps.22709 Cited by (13) \| Cite \| Source