Roger F. Bone

ScholarGPS® ID: 43009241344407

Affiliation
Janssen Pharmaceutica
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Chemical Compound | New Class | Drug Design | Chemical Synthesis
Metrics Summary
Publication Count
45
Predicted Citations
2,269
Predicted h-index
22
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use (patent)
Klein, Brian D. | Lavreysen, Hilde | Pype, Stefan Maria Christiaan | Twyman, Roy E. | Van Osselaer, Nancy Eulalie Sylvain | White, H. Steven | Ceusters, Marc André | Cid-Núñez, José Maria | Trabanco-Suárez, Andrés Avelino | Bone, Roger Francis
Patent Number: 10537573 (2020)
Cite | Source
Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8798939 (2014)
Cite | Source
Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8753857 (2014)
Cited by (2) | Cite | Source
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article)
Subasinghe, Nalin L. | Khalil, Ehab | Travins, Jeremy M. | Ali, Farah | Ballentine, Shelley K. | Hufnagel, Heather R. | Pan, Wenxi | Leonard, Kristi | Bone, Roger F. | Soll, Richard M. | ... | Gaul, Michael D.
Bioorganic & Medicinal Chemistry Letters, volume 22, issue 16, pages 5303-5307 (2012).
10.1016/j.bmcl.2012.06.030
Cited by (12) | Cite | Source
Discovery and Clinical Evaluation of 1-{ N -[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif (journal article)
Lu, Tianbao | Markotan, Thomas | Ballentine, Shelley K. | Giardino, Edward C. | Spurlino, John | Brown, Kathryn | Maryanoff, Bruce E. | Tomczuk, Bruce E. | Damiano, Bruce P. | Shukla, Umesh | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 53, issue 4, pages 1843-1856 (2010).
10.1021/jm901802n
Cited by (30) | Cite | Source
Conjugated complement cascade inhibitors (patent)
Subasinghe, Nalin | Khalil, Ehab | Ali, Farah | Hufnagel, Heather Rae | Ballentine, Shelley | Travins, Jeremy M. | Leonard, Kristi A. | Bone, Roger F.
Patent Number: 7482376 (2009)
Cited by (4) | Cite | Source
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article)
Travins, Jeremy M. | Ali, Farah | Huang, Hui | Ballentine, Shelley K. | Khalil, Ehab | Hufnagel, Heather R. | Pan, Wenxi | Gushue, Joan | Leonard, Kristi | Bone, Roger F. | ... | Subasinghe, Nalin L.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 5, pages 1603-1606 (2008).
10.1016/j.bmcl.2008.01.064
Cited by (16) | Cite | Source
Pharmacokinetic properties of TDP4815 after single intravenous and oral administrations to rat, rabbit, monkey, dog and in vitro drug metabolism (journal article)
Chen, Yanmin | Cheng, Deping | Tio, Cesar | Kagan, Natashia | Eisennagel, Stephen | Dasgupta, Malini | Tomczuk, Bruce | Bone, Roger | Huebert, Norman
Biopharmaceutics & Drug Disposition, volume 29, issue 3, pages 127-138 (2008).
10.1002/bdd.592
Cited by (1) | Cite | Source
Cyclic oxyguanidine pyrazinones as protease inhibitors (patent)
Wang, Aihua | Tomczuk, Bruce Edward | Lu, Tianbao | Soll, Richard M. | Spurlino, John Curtis | Bone, Roger Francis
Patent Number: 7030110 (2006)
Cited by (5) | Cite | Source
A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s (journal article)
Subasinghe, Nalin L. | Travins, Jeremy M. | Ali, Farah | Huang, Hui | Ballentine, Shelley K. | Marugán, Juan José | Khalil, Ehab | Hufnagel, Heather R. | Bone, Roger F. | DesJarlais, Renee L. | ... | Tomczuk, Bruce E.
Bioorganic & Medicinal Chemistry Letters, volume 16, issue 8, pages 2200-2204 (2006).
10.1016/j.bmcl.2006.01.036
Cited by (15) | Cite | Source
Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells (journal article)
Grasberger, Bruce L. | Lu, Tianbao | Schubert, Carsten | Parks, Daniel J. | Carver, Theodore E. | Koblish, Holly K. | Cummings, Maxwell D. | LaFrance, Louis V. | Milkiewicz, Karen L. | Calvo, Raul R. | ... | Bone, Roger F.
Journal of Medicinal Chemistry, volume 48, issue 4, pages 909-912 (2005).
10.1021/jm049137g
Cited by (393) | Cite | Source
Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis (journal article)
Lu, Tianbao | Markotan, Thomas | Coppo, Frank | Tomczuk, Bruce | Crysler, Carl | Eisennagel, Stephen | Spurlino, John | Gremminger, Lisa | Soll, Richard M | Giardino, Edward C | Bone, Roger
Bioorganic & Medicinal Chemistry Letters, volume 14, issue 14, pages 3727-3731 (2004).
10.1016/j.bmcl.2004.05.002
Cited by (21) | Cite | Source
A novel series of potent and selective small molecule inhibitors of the complement component C1s (journal article)
Subasinghe, Nalin L. | Ali, Farah | Illig, Carl R. | Jonathan Rudolph, M. | Klein, Scott | Khalil, Ehab | Soll, Richard M. | Bone, Roger F. | Spurlino, John C. | DesJarlais, Renee L. | ... | Sudhakara Babu, Y.
Bioorganic & Medicinal Chemistry Letters, volume 14, issue 12, pages 3043-3047 (2004).
10.1016/j.bmcl.2004.04.034
Cited by (19) | Cite | Source
Cyclic oxyguanidine protease inhibitors (patent)
Wang, Aihua | Lu, Tianbao | Tomczuk, Bruce Edward | Soll, Richard M. | Spurlino, John Curtis | Bone, Roger Francis
Patent Number: 6635637 (2003)
Cited by (4) | Cite | Source
Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors (journal article)
Tomczuk, Bruce | Lu, Tianbao | Soll, Richard M | Fedde, Cynthia | Wang, Aihua | Murphy, Larry | Crysler, Carl | Dasgupta, Malini | Eisennagel, Stephen | Spurlino, John | Bone, Roger
Bioorganic & Medicinal Chemistry Letters, volume 13, issue 8, pages 1495-1498 (2003).
10.1016/S0960-894X(03)00125-2
Cited by (27) | Cite | Source
Compounds and compositions for treating C1s-mediated diseases and conditions (patent)
Illig, Carl R. | Subasinghe, Nalin L. | Hoffman, James B. | Wilson, Kenneth J. | Rudolph, M. Jonathan | Bone, Roger F. | Klein, Scott L. | Randle, Troy L.
Patent Number: 6515002 (2003)
Cited by (6) | Cite | Source
Methods of treating C1s-mediated diseases and conditions and compositions thereof (patent)
Illig, Carl R. | Subasinghe, Nalin L. | Hoffman, James B. | Wilson, Kenneth J. | Rudolph, M. Jonathan | Bone, Roger F. | Klein, Scott L. | Randle, Troy L.
Patent Number: 6492403 (2002)
Cited by (1) | Cite | Source
Cyclic oxyguanidine pyrazinones as protease inhibitors (patent)
Wang, Aihua | Tomczuk, Bruce Edward | Lu, Tianbao | Soll, Richard M. | Spurlino, John Curtis | Bone, Roger Francis
Patent Number: 6476016 (2002)
Cited by (4) | Cite | Source
Method for the idenification of ligands (patent)
Rentzeperis, Dionisios | Askari, Hossein | Springer, Barry A. | Bone, Roger F. | Salemme, Francis R.
Patent Number: 20060024844 (2002)
Cite | Source
Method of generating chemical compounds having desired properties (patent)
Agrafiotis, Dimitris K. | Bone, Roger F. | Salemme, Francis R. | Soll, Richard M.
Patent Number: 6434490 (2002)
Cited by (16) | Cite | Source