Susan R. Crowell

ScholarGPS® ID: 42545540211722

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Pharmacokinetics | Antibody | Metabolism

Metrics Summary

Publication Count

Predicted Citations

628

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics (journal article) Chu, Phillip Y. \| Wang, Hui \| Ross, Emily \| Stephens, Nicole \| Zhang, Hui-Min \| Andersen, Nisana \| Chan, Wayman \| Shivva, Vittal \| Crowell, Susan R. \| Spiess, Christoph \| ... \| Tran, John C. Analytical Chemistry, volume 95, issue 49, pages 17957-17961 (2023). 10.1021/acs.analchem.3c02133 Cite \| Source
Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology (journal article) Kelley, Robert F. \| Tesar, Devin B. \| Wang, Yue \| Agard, Nicholas J. \| Holder, Patrick G. \| Chan, Joyce \| Comps-Agrar, Laetitia \| Horvath, Judit \| Horvath, Joshua D. \| Crowell, Susan R. Molecular Pharmaceutics, volume 19, issue 5, pages 1540-1547 (2022). 10.1021/acs.molpharmaceut.2c00048 Cite \| Source
Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid (journal article) Sadekar, Shraddha S. \| Bowen, Mayumi \| Cai, Hao \| Jamalian, Samira \| Rafidi, Hanine \| Shatz‐Binder, Whitney \| Lafrance‐Vanasse, Julien \| Chan, Pamela \| Meilandt, William J. \| Oldendorp, Amy \| ... \| Horvath, Joshua Clinical Pharmacology & Therapeutics, volume 111, issue 4, pages 826-834 (2022). 10.1002/cpt.2531 Cited by (16) \| Cite \| Source
Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling (journal article) Pande, Paritosh \| Madeen, Erin P. \| Williams, David E. \| Crowell, Susan R. \| Ognibene, Ted J. \| Turteltaub, Ken W. \| Corley, Richard A. \| Smith, Jordan N. Toxicology and Applied Pharmacology, volume 438 (2022). 10.1016/j.taap.2021.115830 Cited by (4) \| Cite \| Source
Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes (journal article) Chan, D. \| Won, G. J. \| Read, A. T. \| Ethier, C. R. \| Thackaberry, E. \| Crowell, S. R. \| Booler, H. \| Bantseev, V. \| Sivak, J. M. Journal of The Royal Society Interface, volume 19, issue 186 (2022). 10.1098/rsif.2021.0734 Cited by (3) \| Cite \| Source
Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics (journal article) Shivva, Vittal \| Boswell, C. Andrew \| Rafidi, Hanine \| Kelley, Robert F. \| Kamath, Amrita V. \| Crowell, Susan R. Frontiers in Pharmacology, volume 12 (2021). 10.3389/fphar.2021.601569 Cited by (5) \| Cite \| Source
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy (journal article) Dere, Edward \| Crowell, Susan \| Maia, Mauricio \| Schuetz, Chris \| Lai, Phillip \| Bantseev, Vladimir \| Booler, Helen Toxicologic Pathology, volume 49, issue 3, pages 610-620 (2021). 10.1177/0192623320976095 Cited by (2) \| Cite \| Source
Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins (journal article) Laing, Steven T. \| Tassew, Nardos \| Tesar, Devin \| Wang, Yue \| Crowell, Susan R. \| Gray, Julia \| Kwong, Mandy \| Loyet, Kelly M. \| Andaya, Roxanne \| Kusi, Aija \| Kelley, Robert F. Toxicologic Pathology, volume 49, issue 3, pages 634-646 (2021). 10.1177/0192623320969124 Cited by (2) \| Cite \| Source
Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits (journal article) Tassew, Nardos G. \| Laing, Steven T. \| Shatz, Whitney \| Crowell, Susan R. \| Loyet, Kelly M. \| Schuetz, Chris \| Blanchette, Craig Toxicologic Pathology, volume 49, issue 3, pages 647-655 (2021). 10.1177/0192623320969671 Cite \| Source
Targeted IgMs agonize ocular targets with extended vitreal exposure (journal article) Chen, Yvonne \| Paluch, Maciej \| Zorn, Julie A. \| Rajan, Sharmila \| Leonard, Brandon \| Estevez, Alberto \| Brady, John \| Chiu, Henry \| Phung, Wilson \| Famili, Amin \| ... \| Agard, Nicholas J. mAbs, volume 12, issue 1 (2020). 10.1080/19420862.2020.1818436 Cited by (3) \| Cite \| Source
Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ (journal article) Meilandt, William J. \| Maloney, Janice A. \| Imperio, Jose \| Lalehzadeh, Guita \| Earr, Tim \| Crowell, Susan \| Bainbridge, Travis W. \| Lu, Yanmei \| Ernst, James A. \| Fuji, Reina N. \| Atwal, Jasvinder K. Alzheimer's Research & Therapy, volume 11, issue 1 (2019). 10.1186/s13195-019-0553-5 Cited by (25) \| Cite \| Source
Hyaluronic Acid–Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics (journal article) Famili, Amin \| Crowell, Susan R. \| Loyet, Kelly M. \| Mandikian, Danielle \| Boswell, C. Andrew \| Cain, David \| Chan, Joyce \| Comps-Agrar, Laetitia \| Kamath, Amrita \| Rajagopal, Karthikan Bioconjugate Chemistry, volume 30, issue 11, pages 2782-2789 (2019). 10.1021/acs.bioconjchem.9b00475 Cited by (13) \| Cite \| Source
Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules (journal article) Crowell, Susan R. \| Wang, Kathryn \| Famili, Amin \| Shatz, Whitney \| Loyet, Kelly M. \| Chang, Vincent \| Liu, Yanqiu \| Prabhu, Saileta \| Kamath, Amrita V. \| Kelley, Robert F. Translational Vision Science & Technology, volume 8, issue 6, pages 1- (2019). 10.1167/tvst.8.6.1 Cited by (42) \| Cite \| Source
Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye (journal article) Shatz, Whitney \| Hass, Philip E. \| Peer, Nikhil \| Paluch, Maciej T. \| Blanchette, Craig \| Han, Guanghui \| Sandoval, Wendy \| Morando, Ashley \| Loyet, Kelly M. \| Bantseev, Vladimir \| ... \| Kelley, Robert F. PLOS ONE, volume 14, issue 6, pages e0218613- (2019). 10.1371/journal.pone.0218613 Cited by (20) \| Cite \| Source
Crenezumab’s Preferential Binding Of Oligomeric Amyloid-Beta Species Underlies Its Unique Mechanism Of Action (S7.005) (journal article) Atwal, Jasvinder \| Meilandt, William \| Wetzel-Smith, Monica \| Li, Bing \| Bainbridge, Travis \| Reichelt, Mike \| Ultsch, Mark \| Ernst, James \| Wang, Weiru \| Crowell, Susan \| ... \| Ferl, Greg Neurology, volume 88, issue 16_supplement (2017). 10.1212/WNL.88.16_supplement.S7.005 Cited by (1) \| Cite \| Source
In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes (journal article) Smith, Jordan N. \| Mehinagic, Denis \| Nag, Subhasree \| Crowell, Susan R. \| Corley, Richard A. Toxicology Letters, volume 269 (2017). 10.1016/j.toxlet.2017.01.008 Cited by (17) \| Cite \| Source
Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling (journal article) Campbell, Jerry \| Franzen, Allison \| Van Landingham, Cynthia \| Lumpkin, Michael \| Crowell, Susan \| Meredith, Clive \| Loccisano, Anne \| Gentry, Robinan \| Clewell, Harvey Inhalation Toxicology, volume 28, issue 11, pages 520-535 (2016). 10.1080/08958378.2016.1214768 Cited by (9) \| Cite \| Source \| Open Access
Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab (journal article) Shatz, Whitney \| Hass, Philip E. \| Mathieu, Mary \| Kim, Hok Seon \| Leach, Kim \| Zhou, Michelle \| Crawford, Yongping \| Shen, Amy \| Wang, Kathryn \| Chang, Debby P. \| ... \| Kelley, Robert F. Molecular Pharmaceutics, volume 13, issue 9, pages 2996-3003 (2016). 10.1021/acs.molpharmaceut.6b00345 Cited by (63) \| Cite \| Source
Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation (journal article) Gong, Qian \| Hazen, Meredith \| Marshall, Brett \| Crowell, Susan R. \| Ou, Qinglin \| Wong, Athena W. \| Phung, Wilson \| Vernes, Jean-Michel \| Meng, Y. Gloria \| Tejada, Max \| ... \| Kelley, Robert F. mAbs, volume 8, issue 6, pages 1098-1106 (2016). 10.1080/19420862.2016.1189049 Cited by (18) \| Cite \| Source \| Open Access
Physiologically based pharmacokinetic modeling of ethyl acetate and ethanol in rodents and humans (journal article) Crowell, S.R. \| Smith, J.N. \| Creim, J.A. \| Faber, W. \| Teeguarden, J.G. Regulatory Toxicology and Pharmacology, volume 73, issue 1, pages 452-462 (2015). 10.1016/j.yrtph.2015.07.021 Cited by (13) \| Cite \| Source