Christopher P. Arthur

ScholarGPS® ID: 42433481500484

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Microscopy | Transmission Electron Cryomicroscopy | Electron Microscope | Toxin

Metrics Summary

Publication Count

Predicted Citations

2,194

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors (journal article) Kschonsak, Marc \| Jao, Christine C \| Arthur, Christopher P \| Rohou, Alexis L \| Bergeron, Philippe \| Ortwine, Daniel F \| McKerrall, Steven J \| Hackos, David H \| Deng, Lunbin \| Chen, Jun \| ... \| Tellis, John C eLife, volume 12 (2023). 10.7554/eLife.84151 Cited by (7) \| Cite \| Source
Structure of the core human NADPH oxidase NOX2 (journal article) Noreng, Sigrid \| Ota, Naruhisa \| Sun, Yonglian \| Ho, Hoangdung \| Johnson, Matthew \| Arthur, Christopher P. \| Schneider, Kellen \| Lehoux, Isabelle \| Davies, Christopher W. \| Mortara, Kyle \| ... \| Koerber, James T. Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-33711-0 Cited by (30) \| Cite \| Source
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration (journal article) Gerhardy, Stefan \| Ultsch, Mark \| Tang, Wanjian \| Green, Evan \| Holden, Jeffrey K. \| Li, Wei \| Estevez, Alberto \| Arthur, Chris \| Tom, Irene \| Rohou, Alexis \| Kirchhofer, Daniel Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-32760-9 Cited by (6) \| Cite \| Source
Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel (journal article) Noland, Cameron L. \| Chua, Han Chow \| Kschonsak, Marc \| Heusser, Stephanie Andrea \| Braun, Nina \| Chang, Timothy \| Tam, Christine \| Tang, Jia \| Arthur, Christopher P. \| Ciferri, Claudio \| ... \| Payandeh, Jian Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-28984-4 Cited by (10) \| Cite \| Source
Structural basis for HCMV Pentamer receptor recognition and antibody neutralization (journal article) Kschonsak, Marc \| Johnson, Matthew C. \| Schelling, Rachel \| Green, Evan M. \| Rougé, Lionel \| Ho, Hoangdung \| Patel, Nidhi \| Kilic, Cem \| Kraft, Edward \| Arthur, Christopher P. \| ... \| Ciferri, Claudio Science Advances, volume 8, issue 10 (2022). 10.1126/sciadv.abm2536 Cited by (13) \| Cite \| Source
Structural architecture of the human NALCN channelosome (journal article) Kschonsak, Marc \| Chua, Han Chow \| Weidling, Claudia \| Chakouri, Nourdine \| Noland, Cameron L. \| Schott, Katharina \| Chang, Timothy \| Tam, Christine \| Patel, Nidhi \| Arthur, Christopher P. \| ... \| Payandeh, Jian Nature, volume 603, issue 7899, pages 180-186 (2022). 10.1038/s41586-021-04313-5 Cited by (19) \| Cite \| Source
Structure and function of the human NALCN-UNC79-UNC80-FAM155A-CaM complex (journal article) Chow Chua, Han \| Kschonsak, Marc \| Weidling, Claudia \| Chakouri, Nourdine \| Noland, Cameron L. \| Schott, Katharina \| Chang, Timothy \| Tam, Christine \| Patel, Nidhi \| Arthur, Christopher P. \| ... \| Payandeh, Jian Biophysical Journal, volume 121, issue 3, pages 96a- (2022). 10.1016/j.bpj.2021.11.2254 Cite \| Source
Taking away PAIN: enabling new structures of the Nav1.7 sodium channel by cryo-EM (journal article) Jao, Christine \| Arthur, Christopher \| Rohou, Alexis \| Kschonsak, Marc \| Ortwine, Daniel \| Sellers, Ben \| Dragovich, Peter \| Volgraf, Matthew \| Sutherlin, Dan \| Koth, Christopher \| ... \| Ciferri, Claudio Acta Crystallographica Section A Foundations and Advances, volume 77, issue a1, pages a16-a16 (2021). 10.1107/S0108767321099839 Cite \| Source
Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry (journal article) Kschonsak, Marc \| Rougé, Lionel \| Arthur, Christopher P. \| Hoangdung, Ho \| Patel, Nidhi \| Kim, Ingrid \| Johnson, Matthew C. \| Kraft, Edward \| Rohou, Alexis L. \| Gill, Avinash \| ... \| Ciferri, Claudio Cell, volume 184, issue 5, pages 1232-1244.e16 (2021). 10.1016/j.cell.2021.01.036 Cited by (32) \| Cite \| Source
Structure of the human sodium leak channel NALCN (journal article) Kschonsak, Marc \| Chua, Han Chow \| Noland, Cameron L. \| Weidling, Claudia \| Clairfeuille, Thomas \| Bahlke, Oskar Ørts \| Ameen, Aishat Oluwanifemi \| Li, Zhong Rong \| Arthur, Christopher P. \| Ciferri, Claudio \| ... \| Payandeh, Jian Nature, volume 587, issue 7833, pages 313-318 (2020). 10.1038/s41586-020-2570-8 Cited by (34) \| Cite \| Source
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab (journal article) Rougé, Lionel \| Chiang, Nancy \| Steffek, Micah \| Kugel, Christine \| Croll, Tristan I. \| Tam, Christine \| Estevez, Alberto \| Arthur, Christopher P. \| Koth, Christopher M. \| Ciferri, Claudio \| ... \| Rohou, Alexis Science, volume 367, issue 6483, pages 1224-1230 (2020). 10.1126/science.aaz9356 Cited by (107) \| Cite \| Source
Cryoelectron Microscopy Structure of a Yeast Centromeric Nucleosome at 2.7 Å Resolution (journal article) Migl, David \| Kschonsak, Marc \| Arthur, Christopher P. \| Khin, Yadana \| Harrison, Stephen C. \| Ciferri, Claudio \| Dimitrova, Yoana N. Structure, volume 28, issue 3, pages 363-370.e3 (2020). 10.1016/j.str.2019.12.002 Cited by (13) \| Cite \| Source
Structure of the secretory immunoglobulin A core (journal article) Kumar, Nikit \| Arthur, Christopher P. \| Ciferri, Claudio \| Matsumoto, Marissa L. Science, volume 367, issue 6481, pages 1008-1014 (2020). 10.1126/science.aaz5807 Cited by (84) \| Cite \| Source
Building Cryo-EM at Genentech to Enable Research and Drug Discovery (journal article) Estevez, Alberto \| Arthur, Chris \| Rouge, Lionel \| Kschonsak, Marc \| Rohou, Alexis \| Ciferri, Claudio Microscopy and Microanalysis, volume 25, issue S2, pages 1314-1315 (2019). 10.1017/S143192761900730X Cited by (2) \| Cite \| Source
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation (journal article) Holliday, Michael J. \| Witt, Axel \| Rodríguez Gama, Alejandro \| Walters, Benjamin T. \| Arthur, Christopher P. \| Halfmann, Randal \| Rohou, Alexis \| Dueber, Erin C. \| Fairbrother, Wayne J. Nature Communications, volume 10, issue 1 (2019). 10.1038/s41467-019-10953-z Cited by (27) \| Cite \| Source
Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy (journal article) Gao, Xinxin \| De Mazière, Ann \| Iaea, David B. \| Arthur, Christopher P. \| Klumperman, Judith \| Ciferri, Claudio \| Hannoush, Rami N. Scientific Reports, volume 9, issue 1 (2019). 10.1038/s41598-019-43285-5 Cited by (9) \| Cite \| Source
Structural basis of α-scorpion toxin action on Nav channels (journal article) Clairfeuille, Thomas \| Cloake, Alexander \| Infield, Daniel T. \| Llongueras, José P. \| Arthur, Christopher P. \| Li, Zhong Rong \| Jian, Yuwen \| Martin-Eauclaire, Marie-France \| Bougis, Pierre E. \| Ciferri, Claudio \| ... \| Payandeh, Jian Science, volume 363, issue 6433 (2019). 10.1126/science.aav8573 Cited by (129) \| Cite \| Source
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin (journal article) Xu, Hui \| Li, Tianbo \| Rohou, Alexis \| Arthur, Christopher P. \| Tzakoniati, Foteini \| Wong, Evera \| Estevez, Alberto \| Kugel, Christine \| Franke, Yvonne \| Chen, Jun \| ... \| Payandeh, Jian Cell, volume 176, issue 4, pages 702-715.e14 (2019). 10.1016/j.cell.2018.12.018 Cited by (121) \| Cite \| Source
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin (journal article) Xu, Hui \| Li, Tianbo \| Rohou, Alexis \| Arthur, Christopher P. \| Tzakoniati, Foteini \| Wong, Evera \| Estevez, Alberto \| Kugel, Christine \| Franke, Yvonne \| Chen, Jun \| ... \| Payandeh, Jian Cell, volume 176, issue 5, pages 1238-1239 (2019). 10.1016/j.cell.2019.01.047 Cited by (43) \| Cite \| Source
High-Throughput Protein Analysis Using Negative Stain Electron Microscopy and 2D Classification (book chapter) In High-Throughput Protein Production and Purification Arthur, Christopher P. \| Ciferri, Claudio Springer New York (2019) 10.1007/978-1-4939-9624-7_22 Cited by (1) \| Cite \| Source