Elaine Mai

ScholarGPS® ID: 41433228552341

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacology and Toxicology

Top Specialties

Cancer | Antibody | Trastuzumab

Metrics Summary

Publication Count

Predicted Citations

4,348

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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A novel, label‐free, pre‐equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells (journal article) Janezic, Eric M. \| Doan, Alexander \| Mai, Elaine \| Bravo, Daniel D. \| Wang, Jianyong \| Kim, Hok Seon \| Spiess, Christoph \| Bewley, Kathryn \| ElSohly, Adel \| Liang, Wei‐Ching \| ... \| Comps‐Agrar, Laetitia British Journal of Pharmacology (2023). 10.1111/bph.16258 Cite \| Source
Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development (journal article) Mai, Elaine \| Chan, Joyce \| Goon, Levina \| Ego, Braeden K. \| Bevers, Jack \| Wong, Tiffany \| Wong, Manda \| Corpuz, Racquel \| Xi, Hongkang \| Wu, Jia \| ... \| Comps-Agrar, Laetitia Journal of Translational Medicine, volume 19, issue 1 (2021). 10.1186/s12967-021-03189-3 Cited by (3) \| Cite \| Source
A novel method to produce synthetic murine CXCL10 for efficient screening of functional variants (journal article) Decalf, Jérémie \| Tom, Jeffrey \| Mai, Elaine \| Hernandez-Barry, Hilda \| Noland, Cameron L. \| Vollmar, Breanna S. \| Li, Alice \| Li, Hong \| Xie, Daniel \| Zhu, Lunchao \| ... \| Song, Aimin Bioorganic Chemistry, volume 116 (2021). 10.1016/j.bioorg.2021.105376 Cited by (1) \| Cite \| Source
Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer (journal article) Lo, Amy A. \| Johnston, Jennifer \| Li, Ji \| Mandikian, Danielle \| Hristopoulos, Maria \| Clark, Robyn \| Nickles, Dorothee \| Liang, Wei-Ching \| Hötzel, Kathy \| Dunlap, Debra \| ... \| Junttila, Teemu T. Molecular Cancer Therapeutics, volume 20, issue 4, pages 716-725 (2021). 10.1158/1535-7163.MCT-20-0490 Cited by (7) \| Cite \| Source
Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3 (journal article) Slaga, Dionysos \| Ellerman, Diego \| Lombana, T. Noelle \| Vij, Rajesh \| Li, Ji \| Hristopoulos, Maria \| Clark, Robyn \| Johnston, Jennifer \| Shelton, Amy \| Mai, Elaine \| ... \| Junttila, Teemu T. Science Translational Medicine, volume 10, issue 463 (2018). 10.1126/scitranslmed.aat5775 Cited by (94) \| Cite \| Source
Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis (journal article) Lewis Phillips, Gail D. \| Nishimura, Merry C. \| Lacap, Jennifer Arca \| Kharbanda, Samir \| Mai, Elaine \| Tien, Janet \| Malesky, Kimberly \| Williams, Simon P. \| Marik, Jan \| Phillips, Heidi S. Breast Cancer Research and Treatment, volume 164, issue 3, pages 581-591 (2017). 10.1007/s10549-017-4279-4 Cited by (49) \| Cite \| Source \| Open Access
Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates (journal article) Sukumaran, Siddharth \| Gadkar, Kapil \| Zhang, Crystal \| Bhakta, Sunil \| Liu, Luna \| Xu, Keyang \| Raab, Helga \| Yu, Shang-Fan \| Mai, Elaine \| Fourie-O’Donohue, Aimee \| ... \| Lin, Kedan Pharmaceutical Research, volume 32, issue 6, pages 1884-1893 (2015). 10.1007/s11095-014-1582-1 Cited by (42) \| Cite \| Source
Anti-CD20/CD3 T cell–dependent bispecific antibody for the treatment of B cell malignancies (journal article) Sun, Liping L. \| Ellerman, Diego \| Mathieu, Mary \| Hristopoulos, Maria \| Chen, Xiaocheng \| Li, Yijin \| Yan, Xiaojie \| Clark, Robyn \| Reyes, Arthur \| Stefanich, Eric \| ... \| Ebens, Allen J. Science Translational Medicine, volume 7, issue 287 (2015). 10.1126/scitranslmed.aaa4802 Cited by (227) \| Cite \| Source
Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates (journal article) Wada, Russ \| Erickson, Hans K. \| Lewis Phillips, Gail D. \| Provenzano, Carmela A. \| Leipold, Douglas D. \| Mai, Elaine \| Johnson, Holly \| Tibbitts, Jay Cancer Chemotherapy and Pharmacology, volume 74, issue 5, pages 969-980 (2014). 10.1007/s00280-014-2561-2 Cited by (26) \| Cite \| Source
Nonclinical Evaluation of the Serum Pharmacodynamic Biomarkers HGF and Shed MET following Dosing with the Anti-MET Monovalent Monoclonal Antibody Onartuzumab (journal article) Mai, Elaine \| Zheng, Zhong \| Chen, Youjun \| Peng, Jing \| Severin, Christophe \| Filvaroff, Ellen \| Romero, Mally \| Mallet, William \| Kaur, Surinder \| Gelzleichter, Thomas \| ... \| Young, Judy C. Molecular Cancer Therapeutics, volume 13, issue 2, pages 540-552 (2014). 10.1158/1535-7163.MCT-13-0494 Cited by (11) \| Cite \| Source \| Open Access
Functional Consequences of the Macrophage Stimulating Protein 689C Inflammatory Bowel Disease Risk Allele (journal article) Kauder, Steven E. \| Santell, Lydia \| Mai, Elaine \| Wright, Lilyan Y. \| Luis, Elizabeth \| N'Diaye, Elsa N. \| Lutman, Jeff \| Ratti, Navneet \| Sa, Susan M. \| Maun, Henry R. \| ... \| Egen, Jackson G. PLoS ONE, volume 8, issue 12, pages e83958- (2013). 10.1371/journal.pone.0083958 Cited by (18) \| Cite \| Source \| Open Access
Onartuzumab (MetMAb): Using Nonclinical Pharmacokinetic and Concentration–Effect Data to Support Clinical Development (journal article) Xiang, Hong \| Bender, Brendan C. \| Reyes, Arthur E. \| Merchant, Mark \| Jumbe, Nelson L. ‘Shasha’ \| Romero, Mally \| Davancaze, Teresa \| Nijem, Ihsan \| Mai, Elaine \| Young, Judy \| ... \| Damico-Beyer, Lisa A. Clinical Cancer Research, volume 19, issue 18, pages 5068-5078 (2013). 10.1158/1078-0432.CCR-13-0260 Cited by (30) \| Cite \| Source \| Open Access
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent (journal article) Merchant, Mark \| Ma, Xiaolei \| Maun, Henry R. \| Zheng, Zhong \| Peng, Jing \| Romero, Mally \| Huang, Arthur \| Yang, Nai-ying \| Nishimura, Merry \| Greve, Joan \| ... \| Yansura, Daniel G. Proceedings of the National Academy of Sciences, volume 110, issue 32 (2013). 10.1073/pnas.1302725110 Cited by (206) \| Cite \| Source \| Open Access
Characterization of The Drug-To-Antibody Ratio Distribution for Antibody–Drug Conjugates in Plasma/Serum (journal article) Xu, Keyang \| Liu, Luna \| Dere, Randall \| Mai, Elaine \| Erickson, Rebecca \| Hendricks, Angela \| Lin, Kedan \| Junutula, Jagath R \| Kaur, Surinder Bioanalysis, volume 5, issue 9, pages 1057-1071 (2013). 10.4155/bio.13.66 Cited by (92) \| Cite \| Source
133 Ron Receptor Tyrosine Kinase Agonist Antibodies Promote Epithelial Wound Healing in Mice and Are Potential Therapeutics for Inflammatory Bowel Disease (journal article) Kauder, Steven \| Santell, Lydia \| Zavala-Solorio, Jose \| Mai, Elaine \| Zhang, Juan \| Wright, Lilyan \| Hazen, Meredith \| Liang, Wei-Ching \| Wu, Yan \| Hongo, Jo-Anne \| ... \| Egen, Jackson G. Gastroenterology, volume 144, issue 5, pages S-32- (2013). 10.1016/S0016-5085(13)60113-4 Cite \| Source
Measuring potency of bispecific effector/target-linking antibodies for inducing cytotoxicity of tumor cells using an impedance-based assay platform (P2094) (journal article) Young, Judy \| Montgomery, Harley \| Sun, Laura \| Junttila, Teemu \| Mai, Elaine The Journal of Immunology, volume 190, issue 1_Supplement, pages 132.37-132.37 (2013). 10.4049/jimmunol.190.Supp.132.37 Cite \| Source
The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates (journal article) Erickson, Hans K. \| Lewis Phillips, Gail D. \| Leipold, Douglas D. \| Provenzano, Carmela A. \| Mai, Elaine \| Johnson, Holly A. \| Gunter, Bert \| Audette, Charlene A. \| Gupta, Manish \| Pinkas, Jan \| Tibbitts, Jay Molecular Cancer Therapeutics, volume 11, issue 5, pages 1133-1142 (2012). 10.1158/1535-7163.MCT-11-0727 Cited by (170) \| Cite \| Source \| Open Access
Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer (journal article) Junutula, Jagath R. \| Flagella, Kelly M. \| Graham, Richard A. \| Parsons, Kathryn L. \| Ha, Edward \| Raab, Helga \| Bhakta, Sunil \| Nguyen, Trung \| Dugger, Debra L. \| Li, Guangmin \| ... \| Sliwkowski, Mark X. Clinical Cancer Research, volume 16, issue 19, pages 4769-4778 (2010). 10.1158/1078-0432.CCR-10-0987 Cited by (263) \| Cite \| Source \| Open Access
Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice (journal article) Jumbe, Nelson L. \| Xin, Yan \| Leipold, Douglas D. \| Crocker, Lisa \| Dugger, Debra \| Mai, Elaine \| Sliwkowski, Mark X. \| Fielder, Paul J. \| Tibbitts, Jay Journal of Pharmacokinetics and Pharmacodynamics, volume 37, issue 3, pages 221-242 (2010). 10.1007/s10928-010-9156-2 Cited by (107) \| Cite \| Source
Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate (journal article) Lewis Phillips, Gail D. \| Li, Guangmin \| Dugger, Debra L. \| Crocker, Lisa M. \| Parsons, Kathryn L. \| Mai, Elaine \| Blättler, Walter A. \| Lambert, John M. \| Chari, Ravi V.J. \| Lutz, Robert J. \| ... \| Sliwkowski, Mark X. Cancer Research, volume 68, issue 22, pages 9280-9290 (2008). 10.1158/0008-5472.CAN-08-1776 Cited by (1,332) \| Cite \| Source \| Open Access