Xavier Lucas

ScholarGPS® ID: 40257528373040

Affiliation

University of Dundee, Dundee, United Kingdom

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Chemical Biology | Histone | Medicinal Chemistry

Metrics Summary

Publication Count

Predicted Citations

2,170

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Structure‐Based Design of a Macrocyclic PROTAC (journal article) Testa, Andrea \| Hughes, Scott J. \| Lucas, Xavier \| Wright, Jane E. \| Ciulli, Alessio Angewandte Chemie International Edition, volume 59, issue 4, pages 1727-1734 (2020). 10.1002/anie.201914396 Cited by (144) \| Cite \| Source
Structure‐Based Design of a Macrocyclic PROTAC (journal article) Testa, Andrea \| Hughes, Scott J. \| Lucas, Xavier \| Wright, Jane E. \| Ciulli, Alessio Angewandte Chemie, volume 132, issue 4, pages 1744-1751 (2020). 10.1002/ange.201914396 Cited by (15) \| Cite \| Source
Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase (journal article) Lucas, Xavier \| Van Molle, Inge \| Ciulli, Alessio Journal of Medicinal Chemistry, volume 61, issue 16, pages 7387-7393 (2018). 10.1021/acs.jmedchem.8b00842 Cited by (23) \| Cite \| Source
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation (journal article) Testa, Andrea \| Lucas, Xavier \| Castro, Guilherme V. \| Chan, Kwok-Ho \| Wright, Jane E. \| Runcie, Andrew C. \| Gadd, Morgan S. \| Harrison, William T. A. \| Ko, Eun-Jung \| Fletcher, Daniel \| Ciulli, Alessio Journal of the American Chemical Society, volume 140, issue 29, pages 9299-9313 (2018). 10.1021/jacs.8b05807 Cited by (106) \| Cite \| Source \| Open Access
Thioamide substitution to probe the hydroxyproline recognition of VHL ligands (journal article) Soares, Pedro \| Lucas, Xavier \| Ciulli, Alessio Bioorganic & Medicinal Chemistry, volume 26, issue 11, pages 2992-2995 (2018). 10.1016/j.bmc.2018.03.034 Cited by (14) \| Cite \| Source \| Open Access
Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach (journal article) Amato, Anastasia \| Lucas, Xavier \| Bortoluzzi, Alessio \| Wright, David \| Ciulli, Alessio ACS Chemical Biology, volume 13, issue 4, pages 915-921 (2018). 10.1021/acschembio.7b01093 Cited by (25) \| Cite \| Source \| Open Access
Targeting ligandable pockets on PHD zinc finger domains by a fragment-based approach. (journal article) Amato, Anastasia \| Lucas, Xavier \| Bortoluzzi, Alessio \| Wright, David \| Ciulli, Alessio ACS Chemical Biology (2018). 10.2210/pdb6fkp/pdb Cite \| Source
Beyond the BET Family: Targeting CBP/p300 with 4‐Acyl Pyrroles (journal article) Hügle, Martin \| Lucas, Xavier \| Ostrovskyi, Dmytro \| Regenass, Pierre \| Gerhardt, Stefan \| Einsle, Oliver \| Hau, Mirjam \| Jung, Manfred \| Breit, Bernhard \| Günther, Stefan \| Wohlwend, Daniel Angewandte Chemie, volume 129, issue 41, pages 12650-12654 (2017). 10.1002/ange.201705516 Cited by (2) \| Cite \| Source \| Open Access
Beyond the BET Family: Targeting CBP/p300 with 4‐Acyl Pyrroles (journal article) Hügle, Martin \| Lucas, Xavier \| Ostrovskyi, Dmytro \| Regenass, Pierre \| Gerhardt, Stefan \| Einsle, Oliver \| Hau, Mirjam \| Jung, Manfred \| Breit, Bernhard \| Günther, Stefan \| Wohlwend, Daniel Angewandte Chemie International Edition, volume 56, issue 41, pages 12476-12480 (2017). 10.1002/anie.201705516 Cited by (27) \| Cite \| Source \| Open Access
Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies (journal article) Lucas, Xavier \| Ciulli, Alessio Current Opinion in Structural Biology, volume 44 (2017). 10.1016/j.sbi.2016.12.015 Cited by (69) \| Cite \| Source \| Open Access
Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains (journal article) Bortoluzzi, Alessio \| Amato, Anastasia \| Lucas, Xavier \| Blank, Manuel \| Ciulli, Alessio Biochemical Journal, volume 474, issue 10, pages 1633-1651 (2017). 10.1042/BCJ20161053 Cited by (27) \| Cite \| Source \| Open Access
Structural basis of PROTAC cooperative recognition for selective protein degradation (journal article) Gadd, Morgan S \| Testa, Andrea \| Lucas, Xavier \| Chan, Kwok-Ho \| Chen, Wenzhang \| Lamont, Douglas J \| Zengerle, Michael \| Ciulli, Alessio Nature Chemical Biology, volume 13, issue 5, pages 514-521 (2017). 10.1038/nchembio.2329 Cited by (754) \| Cite \| Source \| Open Access
Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes (journal article) Hügle, Martin \| Lucas, Xavier \| Weitzel, Gerhard \| Ostrovskyi, Dmytro \| Breit, Bernhard \| Gerhardt, Stefan \| Schmidtkunz, Karin \| Jung, Manfred \| Schüle, Roland \| Einsle, Oliver \| ... \| Wohlwend, Daniel Data in Brief, volume 7 (2016). 10.1016/j.dib.2016.04.009 Cited by (1) \| Cite \| Source \| Open Access
4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1) (journal article) Hügle, Martin \| Lucas, Xavier \| Weitzel, Gerhard \| Ostrovskyi, Dmytro \| Breit, Bernhard \| Gerhardt, Stefan \| Einsle, Oliver \| Günther, Stefan \| Wohlwend, Daniel Journal of Medicinal Chemistry, volume 59, issue 4, pages 1518-1530 (2016). 10.1021/acs.jmedchem.5b01267 Cited by (53) \| Cite \| Source
StreptomeDB 2.0—an extended resource of natural products produced by streptomycetes (journal article) Klementz, Dennis \| Döring, Kersten \| Lucas, Xavier \| Telukunta, Kiran K. \| Erxleben, Anika \| Deubel, Denise \| Erber, Astrid \| Santillana, Irene \| Thomas, Oliver S. \| Bechthold, Andreas \| Günther, Stefan Nucleic Acids Research, volume 44, issue D1, pages D509-D514 (2016). 10.1093/nar/gkv1319 Cited by (65) \| Cite \| Source \| Open Access
4‐Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading (journal article) Lucas, Xavier \| Wohlwend, Daniel \| Hügle, Martin \| Schmidtkunz, Karin \| Gerhardt, Stefan \| Schüle, Roland \| Jung, Manfred \| Einsle, Oliver \| Günther, Stefan Angewandte Chemie, volume 125, issue 52, pages 14305-14309 (2013). 10.1002/ange.201307652 Cited by (8) \| Cite \| Source
4‐Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading (journal article) Lucas, Xavier \| Wohlwend, Daniel \| Hügle, Martin \| Schmidtkunz, Karin \| Gerhardt, Stefan \| Schüle, Roland \| Jung, Manfred \| Einsle, Oliver \| Günther, Stefan Angewandte Chemie International Edition, volume 52, issue 52, pages 14055-14059 (2013). 10.1002/anie.201307652 Cited by (103) \| Cite \| Source
The Role of the Ethynyl Substituent on the π–π Stacking Affinity of Benzene: A Theoretical Study (journal article) Lucas, Xavier \| Quiñonero, David \| Frontera, Antonio \| Deyà, Pere M. ChemPhysChem, volume 12, issue 2, pages 283-288 (2011). 10.1002/cphc.201000891 Cited by (3) \| Cite \| Source
Erroneous behaviour of the widely used MP2(full)/aug-cc-pVXZ (X=D,T) level of theory for evaluating the BSSE in ion–π complexes (journal article) Estarellas, Carolina \| Lucas, Xavier \| Frontera, Antonio \| Quiñonero, David \| Deyà, Pere M. Chemical Physics Letters, volume 489, issue 4-6, pages 254-258 (2010). 10.1016/j.cplett.2010.03.004 Cited by (19) \| Cite \| Source
Substituent Effects in Ion−π Interactions: Fine-Tuning via the Ethynyl Group (journal article) Lucas, Xavier \| Frontera, Antonio \| Quiñonero, David \| Deyà, Pere M. The Journal of Physical Chemistry A, volume 114, issue 4, pages 1926-1930 (2010). 10.1021/jp9089672 Cited by (24) \| Cite \| Source