Heidi Savage

ScholarGPS® ID: 40159969935193

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Cancer | Breast Cancer

Metrics Summary

Publication Count

Predicted Citations

2,569

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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ER +, HER2 − advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes (journal article) Chen, Jessica W. \| Jacot, William \| Cortés, Javier \| Krop, Ian E. \| Dent, Susan \| Harbeck, Nadia \| De Laurentiis, Michelino \| Diéras, Véronique \| Im, Young‐Hyuck \| Stout, Thomas J. \| ... \| Wilson, Timothy R. Molecular Oncology, volume 17, issue 10, pages 2000-2016 (2023). 10.1002/1878-0261.13416 Cite \| Source
Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancers (journal article) Hutchinson, Katherine E. \| Chen, Jessica W. \| Savage, Heidi M. \| Stout, Thomas J. \| Schimmoller, Frauke \| Cortés, Javier \| Dent, Susan \| Harbeck, Nadia \| Jacot, William \| Krop, Ian \| ... \| Wilson, Timothy R. Genome Medicine, volume 15, issue 1 (2023). 10.1186/s13073-023-01181-8 Cited by (8) \| Cite \| Source
Comparison of PIK3CA Mutation Prevalence in Breast Cancer Across Predicted Ancestry Populations (journal article) Chen, Jessica W. \| Murugesan, Karthikeyan \| Newberg, Justin Y. \| Sokol, Ethan S. \| Savage, Heidi M. \| Stout, Thomas J. \| Maund, Sophia L. \| Hutchinson, Katherine E. JCO Precision Oncology (2022). 10.1200/PO.22.00341 Cited by (3) \| Cite \| Source
Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients with PIK3CA -Mutant Cancers (journal article) Jhaveri, Komal \| Chang, Matthew T. \| Juric, Dejan \| Saura, Cristina \| Gambardella, Valentina \| Melnyk, Anton \| Patel, Manish R. \| Ribrag, Vincent \| Ma, Cynthia X. \| Aljumaily, Raid \| ... \| Hyman, David M. Clinical Cancer Research, volume 27, issue 2, pages 447-459 (2021). 10.1158/1078-0432.CCR-20-2657 Cited by (26) \| Cite \| Source
3O Mutation analysis of circulating tumour DNA from baseline and study discontinuation samples in SANDPIPER, a phase III study of taselisib or placebo with fulvestrant in oestrogen receptor-positive, human epidermal growth factor receptor 2-negative, PIK3 (journal article) Jacot, W. \| Savage, H.M. \| Dent, S. \| Cortés, J. \| Im, Y-H. \| Dieras, V.C. \| Harbeck, N. \| Krop, I.E. \| Chen, J. \| Sokol, E. \| ... \| Wilson, T.R. Annals of Oncology, volume 31 (2020). 10.1016/j.annonc.2020.03.139 Cited by (1) \| Cite \| Source
Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models (journal article) Moore, Heather M. \| Savage, Heidi M. \| O'Brien, Carol \| Zhou, Wei \| Sokol, Ethan S. \| Goldberg, Michael E. \| Metcalfe, Ciara \| Friedman, Lori S. \| Lackner, Mark R. \| Wilson, Timothy R. Molecular Cancer Therapeutics, volume 19, issue 1, pages 292-303 (2020). 10.1158/1535-7163.MCT-19-0284 Cited by (9) \| Cite \| Source
Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers (journal article) Wilson, Timothy R. \| Udyavar, Akshata R. \| Chang, Ching-Wei \| Spoerke, Jill M. \| Aimi, Junko \| Savage, Heidi M. \| Daemen, Anneleen \| O'Shaughnessy, Joyce A. \| Bourgon, Richard \| Lackner, Mark R. Molecular Cancer Research, volume 17, issue 1, pages 97-108 (2019). 10.1158/1541-7786.MCR-18-0619 Cited by (17) \| Cite \| Source
Tumor-Infiltrating Lymphocytes in Patients Receiving Trastuzumab/Pertuzumab-Based Chemotherapy: A TRYPHAENA Substudy (journal article) Ignatiadis, Michail \| Van den Eynden, Gert \| Roberto, Salgado \| Fornili, Marco \| Bareche, Yacine \| Desmedt, Christine \| Rothé, Françoise \| Maetens, Marion \| Venet, David \| Holgado, Esther \| ... \| Sotiriou, Christos JNCI: Journal of the National Cancer Institute, volume 111, issue 1, pages 69-77 (2019). 10.1093/jnci/djy076 Cited by (57) \| Cite \| Source
Targeted NGS profiling identifies genomic alterations associated with high-risk eBC (journal article) Wilson, T.R. \| Udyavar, A.R. \| Chang, C-W. \| Giltnane, J. \| Spoerke, J.M. \| Aimi, J. \| Savage, H. \| Daemen, A. \| Bourgon, R. \| Lackner, M.R. Annals of Oncology, volume 28, issue suppl_5 (2017). 10.1093/annonc/mdx362.007 Cited by (6) \| Cite \| Source \| Open Access
Phase I Dose-Escalation Study of Taselisib, an Oral PI3K Inhibitor, in Patients with Advanced Solid Tumors (journal article) Juric, Dejan \| Krop, Ian \| Ramanathan, Ramesh K. \| Wilson, Timothy R. \| Ware, Joseph A. \| Sanabria Bohorquez, Sandra M. \| Savage, Heidi M. \| Sampath, Deepak \| Salphati, Laurent \| Lin, Ray S. \| ... \| Baselga, José Cancer Discovery, volume 7, issue 7, pages 704-715 (2017). 10.1158/2159-8290.CD-16-1080 Cited by (125) \| Cite \| Source
The molecular landscape of high-risk early breast cancer: comprehensive biomarker analysis of a phase III adjuvant population (journal article) Wilson, Timothy R \| Yu, Jianjun \| Lu, Xuyang \| Spoerke, Jill M \| Xiao, Yuanyuan \| O’Brien, Carol \| Savage, Heidi M \| Huw, Ling-Yuh \| Zou, Wei \| Koeppen, Hartmut \| ... \| Lackner, Mark R npj Breast Cancer, volume 2, issue 1 (2016). 10.1038/npjbcancer.2016.22 Cited by (21) \| Cite \| Source \| Open Access
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant (journal article) Spoerke, Jill M. \| Gendreau, Steven \| Walter, Kimberly \| Qiu, Jiaheng \| Wilson, Timothy R. \| Savage, Heidi \| Aimi, Junko \| Derynck, Mika K. \| Chen, Meng \| Chan, Iris T. \| ... \| Lackner, Mark R. Nature Communications, volume 7, issue 1 (2016). 10.1038/ncomms11579 Cited by (238) \| Cite \| Source \| Open Access
Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models (journal article) Lin, Jie \| Sampath, Deepak \| Nannini, Michelle A. \| Lee, Brian B. \| Degtyarev, Michael \| Oeh, Jason \| Savage, Heidi \| Guan, Zhengyu \| Hong, Rebecca \| Kassees, Robert \| ... \| Lin, Kui Clinical Cancer Research, volume 19, issue 7, pages 1760-1772 (2013). 10.1158/1078-0432.CCR-12-3072 Cited by (229) \| Cite \| Source \| Open Access
Trastuzamab antibody drug conjugates demonstrate robust in vitro antitumor activity in HER2 amplified breast cancer cell lines (journal article) Mohan, Sankar \| O'Brien, Carol \| Savage, Heidi \| Phillips, Gail \| Stern, Howard \| Lackner, Mark \| Pandita, Ajay Clinical Cancer Research, volume 16, issue 19_Supplement, pages B19-B19 (2010). 10.1158/DIAG-10-B19 Cite \| Source
Molecular Biomarker Analyses Using Circulating Tumor Cells (journal article) Punnoose, Elizabeth A. \| Atwal, Siminder K. \| Spoerke, Jill M. \| Savage, Heidi \| Pandita, Ajay \| Yeh, Ru-Fang \| Pirzkall, Andrea \| Fine, Bernard M. \| Amler, Lukas C. \| Chen, Daniel S. \| Lackner, Mark R. PLoS ONE, volume 5, issue 9, pages e12517- (2010). 10.1371/journal.pone.0012517 Cited by (263) \| Cite \| Source \| Open Access
Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models (journal article) O'Brien, Carol \| Wallin, Jeffrey J. \| Sampath, Deepak \| GuhaThakurta, Debraj \| Savage, Heidi \| Punnoose, Elizabeth A. \| Guan, Jane \| Berry, Leanne \| Prior, Wei Wei \| Amler, Lukas C. \| ... \| Lackner, Mark R. Clinical Cancer Research, volume 16, issue 14, pages 3670-3683 (2010). 10.1158/1078-0432.CCR-09-2828 Cited by (229) \| Cite \| Source \| Open Access
Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer (journal article) Zha, Jiping \| O'Brien, Carol \| Savage, Heidi \| Huw, Ling-Yuh \| Zhong, Fiona \| Berry, Leanne \| Lewis Phillips, Gail D. \| Luis, Elizabeth \| Cavet, Guy \| Hu, Xiaolan \| ... \| Lackner, Mark R. Molecular Cancer Therapeutics, volume 8, issue 8, pages 2110-2121 (2009). 10.1158/1535-7163.MCT-09-0381 Cited by (73) \| Cite \| Source \| Open Access
In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models (journal article) Hoeflich, Klaus P. \| O'Brien, Carol \| Boyd, Zachary \| Cavet, Guy \| Guerrero, Steve \| Jung, Kenneth \| Januario, Tom \| Savage, Heidi \| Punnoose, Elizabeth \| Truong, Tom \| ... \| Lackner, Mark R. Clinical Cancer Research, volume 15, issue 14, pages 4649-4664 (2009). 10.1158/1078-0432.CCR-09-0317 Cited by (419) \| Cite \| Source \| Open Access
Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays (journal article) Boyd, Zachary S. \| Wu, Qun Jenny \| O'Brien, Carol \| Spoerke, Jill \| Savage, Heidi \| Fielder, Paul J. \| Amler, Lukas \| Yan, Yibing \| Lackner, Mark R. Molecular Cancer Therapeutics, volume 7, issue 12, pages 3695-3706 (2008). 10.1158/1535-7163.MCT-08-0810 Cited by (62) \| Cite \| Source \| Open Access