Jack A. Kauffman

ScholarGPS® ID: 38935315459966

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Medicinal Chemistry | Chemical Synthesis | Mathematical Optimization | Diabetes

Metrics Summary

Publication Count

Predicted Citations

1,189

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Erratum to “Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists” [Bioorg. Med. Chem. Lett. 47 (2021) 128172] (journal article) Zhang, Xuqing \| Zhu, Bin \| Guo, Lili \| Bakaj, Ivona \| Rankin, Matthew \| Ho, George \| Kauffman, Jack \| Lee, Seunghun P. \| Norquay, Lisa \| Macielag, Mark Bioorganic & Medicinal Chemistry Letters, volume 47 (2021). 10.1016/j.bmcl.2021.128232 Cite \| Source
Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists (journal article) Zhang, Xuqing \| Zhu, Bin \| Guo, Lili \| Bakaj, Ivona \| Rankin, Matthew \| Ho, George \| Kauffman, Jack \| Lee, Seunghun P. \| Norquay, Lisa \| Macielag, Mark Bioorganic & Medicinal Chemistry Letters, volume 47 (2021). 10.1016/j.bmcl.2021.128172 Cited by (3) \| Cite \| Source
Discovery of a Novel Series of Pyridone-Based EP3 Antagonists for the Treatment of Type 2 Diabetes (journal article) Zhang, Xuqing \| Zhu, Bin \| Guo, Lili \| Bakaj, Ivona \| Rankin, Matthew \| Ho, George \| Kauffman, Jack \| Lee, Seunghun P. \| Norquay, Lisa \| Macielag, Mark J. ACS Medicinal Chemistry Letters, volume 12, issue 3, pages 451-458 (2021). 10.1021/acsmedchemlett.0c00667 Cited by (3) \| Cite \| Source
Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1 R Inverse Agonists (journal article) Zhang, Yue-Mei \| Greco, Michael \| Le Blanc, Tonya \| Lang, Wensheng \| Kauffman, Jack \| Masucci, John \| Murray, William V. \| Demarest, Keith \| Macielag, Mark Joseph ACS Medicinal Chemistry Letters, volume 11, issue 12, pages 2504-2509 (2020). 10.1021/acsmedchemlett.0c00495 Cite \| Source
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1 ) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity (journal article) Zhang, Yue-Mei \| Greco, Michael N. \| Macielag, Mark J. \| Teleha, Christopher A. \| DesJarlais, Renee L. \| Tang, Yuting \| Ho, George \| Hou, Cuifen \| Chen, Cailin \| Zhao, Shuyuan \| ... \| Leonard, James Journal of Medicinal Chemistry, volume 61, issue 22, pages 10276-10298 (2018). 10.1021/acs.jmedchem.8b01467 Cited by (13) \| Cite \| Source
Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes (journal article) Zhang, Xuqing \| Wall, Mark \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana L. \| ... \| Demarest, Keith ACS Medicinal Chemistry Letters, volume 8, issue 5, pages 560-565 (2017). 10.1021/acsmedchemlett.7b00116 Cited by (8) \| Cite \| Source \| Open Access
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists (journal article) Zhang, Xuqing \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana \| Murray, William V. \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 27, issue 8, pages 1760-1764 (2017). 10.1016/j.bmcl.2017.02.069 Cited by (15) \| Cite \| Source
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1 ‘ Subsite and Its Implications to Structure-Based Drug Design. (journal article) Costanzo, Michael J. \| Almond, Harold R. \| Hecker, Leonard R. \| Schott, Mary R. \| Yabut, Stephen C. \| Zhang, Han-Cheng \| Andrade-Gordon, Patricia \| Corcoran, Thomas W. \| Giardino, Edward C. \| Kauffman, Jack A. \| ... \| Maryanoff, Bruce E. Journal of Medicinal Chemistry, volume 50, issue 23, pages 5868-5868 (2007). 10.1021/jm701211q Cited by (1) \| Cite \| Source \| Open Access
High-Throughput Screening for N-Type Calcium Channel Blockers Using a Scintillation Proximity Assay (journal article) Zhang, Sui-Po \| Kauffman, Jack \| Yagel, Susan K. \| Codd, Ellen E. SLAS Discovery, volume 11, issue 6, pages 672-677 (2006). 10.1177/1087057106289210 Cited by (11) \| Cite \| Source \| Open Access
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase (journal article) de Garavilla, Lawrence \| Greco, Michael N. \| Sukumar, Narayanasami \| Chen, Zhi-Wei \| Pineda, Agustin O. \| Mathews, F. Scott \| Di Cera, Enrico \| Giardino, Edward C. \| Wells, Grace I. \| Haertlein, Barbara J. \| ... \| Maryanoff, Bruce E. Journal of Biological Chemistry, volume 280, issue 18, pages 18001-18007 (2005). 10.1074/jbc.M501302200 Cited by (77) \| Cite \| Source \| Open Access
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1 ‘ Subsite and Its Implications to Structure-Based Drug Design (journal article) Costanzo, Michael J. \| Almond, Harold R. \| Hecker, Leonard R. \| Schott, Mary R. \| Yabut, Stephen C. \| Zhang, Han-Cheng \| Andrade-Gordon, Patricia \| Corcoran, Thomas W. \| Giardino, Edward C. \| Kauffman, Jack A. \| ... \| Maryanoff, Bruce E. Journal of Medicinal Chemistry, volume 48, issue 6, pages 1984-2008 (2005). 10.1021/jm0303857 Cited by (57) \| Cite \| Source
High-Throughput siRNA-Based Functional Target Validation (journal article) Xin, Hong \| Bernal, Alejandro \| Amato, Frank A. \| Pinhasov, Albert \| Kauffman, Jack \| Brenneman, Douglas E. \| Derian, Claudia K. \| Andrade-Gordon, Patricia \| Plata-Salamán, Carlos R. \| Ilyin, Sergey E. SLAS Discovery, volume 9, issue 4, pages 286-293 (2004). 10.1177/1087057104263533 Cited by (28) \| Cite \| Source \| Open Access
Gene Expression Analysis for High Throughput Screening Applications (journal article) Pinhasov, Albert \| Mei, Jay \| Amaratunga, Dhammika \| Amato, Frank \| Lu, Hong \| Kauffman, Jack \| Xin, Hong \| Brenneman, Douglas \| Johnson, Dana \| Andrade-Gordon, Patricia \| Ilyin, Sergey Combinatorial Chemistry & High Throughput Screening, volume 7, issue 2, pages 133-140 (2004). 10.2174/138620704773120810 Cited by (13) \| Cite \| Source
Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone (journal article) Costanzo, Michael J. \| Yabut, Stephen C. \| Almond,, Harold R. \| Andrade-Gordon, Patricia \| Corcoran, Thomas W. \| de Garavilla, Lawrence \| Kauffman, Jack A. \| Abraham, William M. \| Recacha, Rosario \| Chattopadhyay, Debashish \| Maryanoff, Bruce E. Journal of Medicinal Chemistry, volume 46, issue 18, pages 3865-3876 (2003). 10.1021/jm030050p Cited by (79) \| Cite \| Source
Emerging paradigms in applied bioinformatics (journal article) Ilyin, Sergey E. \| Pinhasov, Albert \| Vaidya, Anil H. \| Amato, Frank A. \| Kauffman, Jack \| Xin, Hong \| Andrade-Gordon, Patricia \| Plata-Salamán, Carlos R. \| Brenneman, Douglas E. BIOSILICO, volume 1, issue 3, pages 86-88 (2003). 10.1016/S1478-5382(03)02315-1 Cited by (5) \| Cite \| Source
Nonpeptide Inhibitors of Cathepsin G: Optimization of a Novel β-Ketophosphonic Acid Lead by Structure-Based Drug Design (journal article) Greco, Michael N. \| Hawkins, Michael J. \| Powell, Eugene T. \| Almond,, Harold R. \| Corcoran, Thomas W. \| de Garavilla, Lawrence \| Kauffman, Jack A. \| Recacha, Rosario \| Chattopadhyay, Debashish \| Andrade-Gordon, Patricia \| Maryanoff, Bruce E. Journal of the American Chemical Society, volume 124, issue 15, pages 3810-3811 (2002). 10.1021/ja017506h Cited by (40) \| Cite \| Source
ChemInform Abstract: 1,2,4‐Triazolo[3,4‐a]pyridine as a Novel, Constrained Template for Fibrinogen Receptor (GPIIb/IIIa) Antagonists. (journal article) Lawson, Edward C. \| Hoekstra, William J. \| Addo, Michael F. \| Andrade‐Gordon, Patricia \| Damiano, Bruce P. \| Kauffman, Jack A. \| Mitchell, John A. \| Maryanoff, Bruce E. ChemInform, volume 33, issue 1 (2002). 10.1002/chin.200201148 Cite \| Source
Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design. (journal article) Greco, Michael N \| Hawkins, Michael J \| Powell, Eugene T \| Almond, Harold R \| Corcoran, Thomas W \| de Garavilla, Lawrence \| Kauffman, Jack A \| Recacha, Rosario \| Chattopadhyay, Debashish \| Andrade-Gordon, Patricia \| Maryanoff, Bruce E Journal of the American Chemical Society, volume 124, issue 15 (2002). Cited by (1) \| Cite
Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist (journal article) Damiano, Bruce P \| Mitchell, John A \| Giardino, Edward \| Corcoran, Thomas \| Haertlein, Barbara J \| de Garavilla, Lawrence \| Kauffman, Jack A \| Hoekstra, William J \| Maryanoff, Bruce E \| Andrade-Gordon, Patricia Thrombosis Research, volume 104, issue 2, pages 113-126 (2001). 10.1016/S0049-3848(01)00353-X Cited by (29) \| Cite \| Source
1,2,4-Triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists (journal article) Lawson, Edward C \| Hoekstra, William J \| Addo, Michael F \| Andrade-Gordon, Patricia \| Damiano, Bruce P \| Kauffman, Jack A \| Mitchell, John A \| Maryanoff, Bruce E Bioorganic & Medicinal Chemistry Letters, volume 11, issue 19, pages 2619-2622 (2001). 10.1016/S0960-894X(01)00529-7 Cited by (50) \| Cite \| Source