Daniel Kirchhofer

ScholarGPS® ID: 38434332963079

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Metrics Summary

Publication Count

161

Predicted Citations

10,863

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region (journal article) Li, Yanjie \| Wei, Yuehua \| Ultsch, Mark \| Li, Wei \| Tang, Wanjian \| Tombling, Benjamin \| Gao, Xinxin \| Dimitrova, Yoana \| Gampe, Christian \| Fuhrmann, Jakob \| ... \| Kirchhofer, Daniel Nature Communications, volume 15, issue 1 (2024). 10.1038/s41467-024-48655-w Cite \| Source
Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform (journal article) Zhou, Lijuan \| Cai, Fei \| Li, Yanjie \| Gao, Xinxin \| Wei, Yuehua \| Fedorova, Anna \| Kirchhofer, Daniel \| Hannoush, Rami N. \| Zhang, Yingnan PLOS ONE, volume 19, issue 3, pages e0300135- (2024). 10.1371/journal.pone.0300135 Cited by (1) \| Cite \| Source
Hepsin promotes breast tumor growth signaling via the TGFβ‐EGFR axis (journal article) Belitškin, Denis \| Munne, Pauliina \| Pant, Shishir M. \| Anttila, Johanna M. \| Suleymanova, Ilida \| Belitškina, Kati \| Kirchhofer, Daniel \| Janetka, James \| Käsper, Taivo \| Jalil, Sami \| ... \| Klefström, Juha Molecular Oncology, volume 18, issue 3, pages 547-561 (2024). 10.1002/1878-0261.13545 Cited by (1) \| Cite \| Source
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration (journal article) Gerhardy, Stefan \| Ultsch, Mark \| Tang, Wanjian \| Green, Evan \| Holden, Jeffrey K. \| Li, Wei \| Estevez, Alberto \| Arthur, Chris \| Tom, Irene \| Rohou, Alexis \| Kirchhofer, Daniel Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-32760-9 Cited by (6) \| Cite \| Source
Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis (journal article) Witkowski, Marco \| Witkowski, Mario \| Friebel, Julian \| Buffa, Jennifer A \| Li, Xinmin S \| Wang, Zeneng \| Sangwan, Naseer \| Li, Lin \| DiDonato, Joseph A \| Tizian, Caroline \| ... \| Hazen, Stanley L Cardiovascular Research, volume 118, issue 10, pages 2367-2384 (2022). 10.1093/cvr/cvab263 Cited by (41) \| Cite \| Source
Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death (journal article) Zhang, Yan \| Wu, Congqing \| Li, Lan \| Pandeya, Ankit \| Zhang, Guoying \| Cui, Jian \| Kirchhofer, Daniel \| Wood, Jeremy P. \| Smyth, Susan S. \| Wei, Yinan \| Li, Zhenyu International Journal of Molecular Sciences, volume 23, issue 12, pages 6800- (2022). 10.3390/ijms23126800 Cited by (10) \| Cite \| Source
Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif (journal article) Ultsch, Mark \| Holliday, Michael J. \| Gerhardy, Stefan \| Moran, Paul \| Scales, Suzie J. \| Gupta, Nidhi \| Oltrabella, Francesca \| Chiu, Cecilia \| Fairbrother, Wayne \| Eigenbrot, Charles \| Kirchhofer, Daniel Communications Biology, volume 4, issue 1 (2021). 10.1038/s42003-021-02387-5 Cited by (10) \| Cite \| Source
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge (journal article) Maun, Henry R. \| Vij, Rajesh \| Walters, Benjamin T. \| Morando, Ashley \| Jackman, Janet K. \| Wu, Ping \| Estevez, Alberto \| Chen, Xiaocheng \| Franke, Yvonne \| Lipari, Michael T. \| ... \| Koerber, James T. Nature Communications, volume 11, issue 1 (2020). 10.1038/s41467-020-20143-x Cited by (14) \| Cite \| Source
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage (journal article) AhYoung, Andrew P. \| Eckard, Sterling C. \| Gogineni, Alvin \| Xi, Hongkang \| Lin, S. Jack \| Gerhardy, Stefan \| Cox, Christian \| Phung, Qui T. \| Hackney, Jason A. \| Katakam, Anand Kumar \| ... \| van Lookeren Campagne, Menno Communications Biology, volume 3, issue 1 (2020). 10.1038/s42003-020-01407-0 Cited by (6) \| Cite \| Source
Compositions and methods for treating cardiovascular disease (patent) Beresini, Maureen \| Burdick, Daniel \| Eigenbrot, Jr., Charles \| Kirchhofer, Daniel \| Lazarus, Robert \| Li, Wei \| Quinn, John \| Skelton, Nicholas \| Ultsch, Mark \| Zhang, Yingnan Patent Number: 10787484 (2020) Cite \| Source
Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering (journal article) Kirchhofer, Daniel \| Burdick, Daniel J. \| Skelton, Nicholas J. \| Zhang, Yingnan \| Ultsch, Mark Biochemical Society Transactions, volume 48, issue 4, pages 1323-1336 (2020). 10.1042/BST20190672 Cited by (7) \| Cite \| Source
Proprotein convertase 7 (PCSK7) reduces apoA‐V levels (journal article) Ashraf, Yahya \| Duval, Stéphanie \| Sachan, Vatsal \| Essalmani, Rachid \| Susan‐Resiga, Delia \| Roubtsova, Anna \| Hamelin, Josée \| Gerhardy, Stefan \| Kirchhofer, Daniel \| Tagliabracci, Vincent S. \| ... \| Seidah, Nabil G. The FEBS Journal, volume 287, issue 16, pages 3565-3578 (2020). 10.1111/febs.15212 Cited by (13) \| Cite \| Source
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy (journal article) Tom, Irene \| Pham, Victoria C. \| Katschke, Kenneth J. \| Li, Wei \| Liang, Wei-Ching \| Gutierrez, Johnny \| Ah Young, Andrew \| Figueroa, Isabel \| Eshghi, Shadi Toghi \| Lee, ChingWei V. \| ... \| Lill, Jennie R. Proceedings of the National Academy of Sciences, volume 117, issue 18, pages 9952-9963 (2020). 10.1073/pnas.1917608117 Cited by (36) \| Cite \| Source
Design of Organo-Peptides As Bipartite PCSK9 Antagonists (journal article) Burdick, Daniel J. \| Skelton, Nicholas J. \| Ultsch, Mark \| Beresini, Maureen H. \| Eigenbrot, Charles \| Li, Wei \| Zhang, Yingnan \| Nguyen, Huy \| Kong-Beltran, Monica \| Quinn, John G. \| Kirchhofer, Daniel ACS Chemical Biology, volume 15, issue 2, pages 425-436 (2020). 10.1021/acschembio.9b00899 Cited by (16) \| Cite \| Source
Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes (journal article) Gupta, Nidhi \| Wang, Xinhua \| Wen, Xiaohui \| Moran, Paul \| Paluch, Maciej \| Hass, Philip E. \| Heidersbach, Amy \| Haley, Benjamin \| Kirchhofer, Daniel \| Brezski, Randall J. \| ... \| Scales, Suzie J. Journal of the American Society of Nephrology, volume 31, issue 9, pages 2065-2082 (2020). 10.1681/ASN.2019080830 Cited by (18) \| Cite \| Source
An ancient mechanism of arginine-specific substrate cleavage: What's ‘up’ with NSP4? (journal article) AhYoung, Andrew P. \| Lin, S. Jack \| Gerhardy, Stefan \| van Lookeren Campagne, Menno \| Kirchhofer, Daniel Biochimie, volume 166 (2019). 10.1016/j.biochi.2019.03.020 Cited by (7) \| Cite \| Source
Anti-HtrA1 antibodies and methods of use thereof (patent) Kelley, Robert F. \| Kirchhofer, Daniel K. \| Lai, Joyce \| Lee, Chingwei V. \| Liang, Wei-Ching \| Lipari, Michael T. \| Loyet, Kelly M. \| Sai, Tao \| Van Lookeren Campagne, Menno \| Wu, Yan \| Fuh, Germaine Patent Number: 10421822 (2019) Cite \| Source
Anti-HtrA1 antibodies and methods of use thereof (patent) Kelley, Robert F. \| Kirchhofer, Daniel K. \| Lai, Joyce \| Lee, Chingwei V. \| Liang, Wei-Ching \| Lipari, Michael T. \| Loyet, Kelly M. \| Sai, Tao \| Van Lookeren Campagne, Menno \| Wu, Yan \| Fuh, Germaine Patent Number: 10421821 (2019) Cite \| Source
Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis (journal article) Wu, Congqing \| Lu, Wei \| Zhang, Yan \| Zhang, Guoying \| Shi, Xuyan \| Hisada, Yohei \| Grover, Steven P. \| Zhang, Xinyi \| Li, Lan \| Xiang, Binggang \| ... \| Li, Zhenyu Immunity, volume 50, issue 6, pages 1401-1411.e4 (2019). 10.1016/j.immuni.2019.04.003 Cited by (256) \| Cite \| Source
Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils (journal article) Heestermans, Marco \| Salloum-Asfar, Salam \| Streef, Tom \| Laghmani, El Houari \| Salvatori, Daniela \| Luken, Brenda M. \| Zeerleder, Sacha S. \| Spronk, Henri M. H. \| Korporaal, Suzanne J. \| Kirchhofer, Daniel \| ... \| van Vlijmen, Bart J. M. Blood, volume 133, issue 19, pages 2090-2099 (2019). 10.1182/blood-2018-06-853762 Cited by (24) \| Cite \| Source