Focco Van Den Akker

ScholarGPS® ID: 38106841905973

Affiliation
Case Western Reserve University, Cleveland, United States
Affiliation History

Field
Life Sciences
Discipline
Biochemistry
Top Specialties
Crystal Structure | Guanylate Cyclase | Antimicrobial | Boronic Acid | Chemotherapy | Binding Protein | Crystallography | Infection
Metrics Summary
Publication Count
79
Predicted Citations
3,985
Predicted h-index
35
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI‐EtgA fusion protein (journal article)
Boorman, J. | Zeng, X. | Lin, J. | van den Akker, F.
Protein Science, volume 33, issue 3 (2024).
10.1002/pro.4930
Cite | Source
Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase (journal article)
Mack, Andrew R. | Kumar, Vijay | Taracila, Magdalena A. | Mojica, Maria F. | O'Shea, Margaret | Schinabeck, William | Silver, Galen | Hujer, Andrea M. | Papp-Wallace, Krisztina M. | Chen, Shuang | ... | Bonomo, Robert A.
Antimicrobial Agents and Chemotherapy, volume 67, issue 11 (2023).
10.1128/aac.00791-23
Cited by (1) | Cite | Source
Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water (journal article)
Alsenani, T. A. | Viviani, S. L. | Papp-Wallace, K. M. | Bonomo, R. A. | van den Akker, F.
Antimicrobial Agents and Chemotherapy, volume 67, issue 10 (2023).
10.1128/aac.00350-23
Cited by (2) | Cite | Source
Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds (journal article)
Kumar, Vijay | Boorman, Jacob | Greenlee, William J. | Zeng, Ximin | Lin, Jun | van den Akker, Focco
Protein Science, volume 32, issue 7 (2023).
10.1002/pro.4683
Cited by (1) | Cite | Source
Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury (journal article)
Zhou, Hua-Lin | Hausladen, Alfred | Anand, Puneet | Rajavel, Malligarjunan | Stomberski, Colin T. | Zhang, Rongli | Premont, Richard T. | Greenlee, William J. | van den Akker, Focco | Stamler, Jonathan S.
Journal of Medicinal Chemistry, volume 66, issue 8, pages 5657-5668 (2023).
10.1021/acs.jmedchem.2c02089
Cited by (1) | Cite | Source
Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses (journal article)
Alsenani, Tahani A. | Rodríguez, María Margarita | Ghiglione, Barbara | Taracila, Magdalena A. | Mojica, Maria F. | Rojas, Laura J. | Hujer, Andrea M. | Gutkind, Gabriel | Bethel, Christopher R. | Rather, Philip N. | ... | Bonomo, Robert A.
Antimicrobial Agents and Chemotherapy, volume 67, issue 1 (2023).
10.1128/aac.00930-22
Cited by (2) | Cite | Source
Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam (journal article)
Alsenani, T. A. | Viviani, S. L. | Kumar, V. | Taracila, M. A. | Bethel, C. R. | Barnes, M. D. | Papp-Wallace, K. M. | Shields, R. K. | Nguyen, M. H. | Clancy, C. J. | ... | van den Akker, F.
Antimicrobial Agents and Chemotherapy, volume 66, issue 4 (2022).
10.1128/aac.02414-21
Cited by (25) | Cite | Source
Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC β-Lactamase (journal article)
Taracila, Magdalena A. | Bethel, Christopher R. | Hujer, Andrea M. | Papp-Wallace, Krisztina M. | Barnes, Melissa D. | Rutter, Joseph D. | VanPelt, Jamie | Shurina, Ben A. | van den Akker, Focco | Clancy, Cornelius J. | ... | Bonomo, Robert A.
Antimicrobial Agents and Chemotherapy, volume 66, issue 4 (2022).
10.1128/aac.02124-21
Cited by (10) | Cite | Source
1063. ARGONAUT-V: Susceptibility of Multidrug-Resistant (MDR) Pseudomonas aeruginosa to Cefepime-Taniborbactam (journal article)
Mack, Andrew R | Bethel, Christopher | Marshall, Steven | Patel, Robin | Patel, Robin | van Duin, David | Fowler, Vance G | Rhoads, Daniel D | Jacobs, Michael | van den Akker, Focco | ... | Bonomo, Robert A
Open Forum Infectious Diseases, volume 8, issue Supplement_1, pages S623-S624 (2021).
10.1093/ofid/ofab466.1257
Cite | Source
1286. Taniborbactam Inhibits Cefepime-Hydrolyzing Variants of Pseudomonas -derived Cephalosporinase (PDC) (journal article)
Mack, Andrew R | Bethel, Christopher | Taracilla, Magdalena A | van den Akker, Focco | Miller, Brittany A | Uehara, Tsuyoshi | Six, David A | Papp-Wallace, Krisztina M | Bonomo, Robert A
Open Forum Infectious Diseases, volume 8, issue Supplement_1, pages S731-S732 (2021).
10.1093/ofid/ofab466.1478
Cite | Source
1055. ARGONAUT-IV: Susceptibility of Carbapenem-resistant Klebsiellae to Ceftibuten/VNRX-5236 (journal article)
Mack, Andrew R | Bethel, Christopher | Marshall, Steven | Patel, Robin | Patel, Robin | van Duin, David | Fowler, Vance G | Rhoads, Daniel D | Jacobs, Michael | van den Akker, Focco | ... | Bonomo, Robert A
Open Forum Infectious Diseases, volume 8, issue Supplement_1, pages S619-S620 (2021).
10.1093/ofid/ofab466.1249
Cite | Source
133. ARGONAUT-III: Susceptibility of Carbapenem-resistant Klebsiellae to Cefepime-Taniborbactam (journal article)
Mack, Andrew R | Bethel, Christopher | Marshall, Steven | Patel, Robin | Patel, Robin | van Duin, David | Fowler, Vance G | Rhoads, Daniel D | Jacobs, Michael | van den Akker, Focco | ... | Bonomo, Robert A
Open Forum Infectious Diseases, volume 8, issue Supplement_1, pages S81-S82 (2021).
10.1093/ofid/ofab466.133
Cite | Source
Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3 (journal article)
Kumar, Vijay | Viviani, Samantha L. | Ismail, Jeeda | Agarwal, Shreya | Bonomo, Robert A. | van den Akker, Focco
PLOS ONE, volume 16, issue 10, pages e0258359- (2021).
10.1371/journal.pone.0258359
Cited by (10) | Cite | Source
A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp. (journal article)
Goldberg, Joel A. | Kumar, Vijay | Spencer, Elizabeth J. | Hoyer, Denton | Marshall, Steven H. | Hujer, Andrea M. | Hujer, Kristine M. | Bethel, Christopher R. | Papp-Wallace, Krisztina M. | Perez, Federico | ... | Bonomo, Robert A.
European Journal of Medicinal Chemistry, volume 220 (2021).
10.1016/j.ejmech.2021.113436
Cited by (16) | Cite | Source
Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni (journal article)
Kumar, Vijay | Mathure, Snigdha A. | Lee, Mijoon | Boorman, Jacob | Zeng, Ximin | Lin, Jun | Hesek, Dusan | Lastochkin, Elena | Mobashery, Shahriar | van den Akker, Focco
Biochemistry, volume 60, issue 14, pages 1133-1144 (2021).
10.1021/acs.biochem.1c00027
Cited by (4) | Cite | Source
Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa (journal article)
Rajavel, Malligarjunan | Kumar, Vijay | Nguyen, Ha | Wyatt, Jacob | Marshall, Steven H. | Papp-Wallace, Krisztina M. | Deshpande, Prasad | Bhavsar, Satish | Yeole, Ravindra | Bhagwat, Sachin | ... | van den Akker, Focco
mBio, volume 12, issue 1 (2021).
10.1128/mBio.03058-20
Cited by (24) | Cite | Source
1256. In Vivo Activity and Structural Characterization of a New Generation γ-Lactam Siderophore Antibiotic Against Multidrug-Resistant Gram-Negative Bacteria and Acinetobacter spp (journal article)
Goldberg, Joel | Bethel, Christopher | Hujer, Andrea M | Marshall, Steven | Taracila, Magdalena A | Papp-Wallce, Krisztina M | Kumar, Vijay | van den Akker, Focco | Plummer, Mark | Bonomo, Robert A
Open Forum Infectious Diseases, volume 7, issue Supplement_1, pages S645-S645 (2020).
10.1093/ofid/ofaa439.1440
Cite | Source
1445. Deciphering the Role of the Y221H Ω-loop Substitution in Pseudomonas -derived Cephalosporinase (PDC) in Cephalosporin Resistance (journal article)
Mack, Andrew R | Barnes, Melissa D | Taracila, Magdalena A | Mojica, Maria F | Kumar, Vijay | Rutter, Joseph | van den Akker, Focco | Page, Malcolm | Haider, Shozeb | Bonomo, Robert A
Open Forum Infectious Diseases, volume 7, issue Supplement_1, pages S725-S726 (2020).
10.1093/ofid/ofaa439.1626
Cite | Source
Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (journal article)
Kumar, Vijay | Tang, Christie | Bethel, Christopher R. | Papp-Wallace, Krisztina M. | Wyatt, Jacob | Desarbre, Eric | Bonomo, Robert A. | van den Akker, Focco
Antimicrobial Agents and Chemotherapy, volume 64, issue 5 (2020).
10.1128/AAC.00106-20
Cited by (9) | Cite | Source
Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem (journal article)
Papp-Wallace, Krisztina M. | Kumar, Vijay | Zeiser, Elise T. | Becka, Scott A. | van den Akker, Focco
Antibiotics, volume 8, issue 3, pages 145- (2019).
10.3390/antibiotics8030145
Cited by (10) | Cite | Source